{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:04:54Z","timestamp":1774526694170,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.resp.2011.10.017","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T01:18:19Z","timestamp":1320715099000},"page":"112-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells"],"prefix":"10.1016","volume":"180","author":[{"given":"Masanori","family":"Asada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukimasa","family":"Hatachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Nagatomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuo","family":"Yamaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2011.10.017_bib0005","first-page":"103","article-title":"Effects of N-acetylcysteine on asthma exacerbation","volume":"9","author":"Aliyali","year":"2010","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.1016\/j.resp.2011.10.017_bib0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.antiviral.2009.05.003","article-title":"Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells","volume":"83","author":"Asada","year":"2009","journal-title":"Antiviral Res."},{"key":"10.1016\/j.resp.2011.10.017_bib0015","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/bbrc.2000.4093","article-title":"Blocking intercellular adhesion molecule-1 on human epithelial cells decreases respiratory syncytial virus infection","volume":"280","author":"Behera","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.resp.2011.10.017_bib0020","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1128\/AAC.47.11.3470-3477.2003","article-title":"Antiviral activity of RhoA-derived peptides against respiratory syncytial virus is dependent on formation of peptide dimmers","volume":"47","author":"Budge","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.resp.2011.10.017_bib0025","doi-asserted-by":"crossref","first-page":"12463","DOI":"10.1074\/jbc.M108504200","article-title":"Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase","volume":"277","author":"Chikumi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2011.10.017_bib0030","series-title":"Fields Virology","first-page":"1601","article-title":"Respiratory syncytial virus and metapneumovirus","author":"Collins","year":"2006"},{"key":"10.1016\/j.resp.2011.10.017_bib0035","series-title":"Fields Virology","first-page":"25","article-title":"Principles of virology","author":"Condit","year":"2006"},{"key":"10.1016\/j.resp.2011.10.017_bib0040","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1128\/JVI.75.18.8772-8780.2001","article-title":"Heparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5","volume":"75","author":"Dechecchi","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.resp.2011.10.017_bib0045","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0378-4347(00)83921-3","article-title":"Determination of S-carbomethylcysteine in serum by reversed-phase ion-pair liquid chromatography with column switching following pre-column derivatization with o-phtalaldehyde","volume":"428","author":"De Schutter","year":"1988","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.resp.2011.10.017_bib0050","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1128\/JVI.73.8.6610-6617.1999","article-title":"Identification of a linear heparin binding domain for human respiratory syncytial virus attachment glycoprotein G","volume":"73","author":"Feldman","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.resp.2011.10.017_bib0055","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1378\/chest.100.5.1377","article-title":"Respiratory syncytial virus infection among intubated adults in a university medical intensive care unit","volume":"100","author":"Guidry","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.resp.2011.10.017_bib0060","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/viro.2000.0293","article-title":"Iduronic acid-containing glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infection","volume":"271","author":"Hallak","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.resp.2011.10.017_bib0065","series-title":"Textbook of Respiratory Medicine","first-page":"748","article-title":"Viral infections","author":"Hayden","year":"1988"},{"key":"10.1016\/j.resp.2011.10.017_bib0070","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/mt.2008.137","article-title":"Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema","volume":"16","author":"Hegab","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.resp.2011.10.017_bib0075","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-3476(79)80647-2","article-title":"The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice","volume":"95","author":"Henderson","year":"1979","journal-title":"J. Pediatr."},{"key":"10.1016\/j.resp.2011.10.017_bib0080","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000151729","article-title":"Tiotropium bromide attenuates respiratory syncytial virus replication in epithelial cells","volume":"76","author":"Iesato","year":"2008","journal-title":"Respiration"},{"key":"10.1016\/j.resp.2011.10.017_bib0085","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1046\/j.1365-2125.2003.01788.x","article-title":"Effect of carbocisteine on cough reflex to capsaicin in asthmatic patients","volume":"55","author":"Ishiura","year":"2003","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.resp.2011.10.017_bib0090","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1023\/B:MCBI.0000038215.89821.7f","article-title":"Down-regulation of inducible nitric oxide synthase by lysophosphatidic acid in human respiratory epithelial cells","volume":"262","author":"Kadowaki","year":"2004","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.resp.2011.10.017_bib0095","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc1143","article-title":"The emerging role of lysophosphatidic acid in cancer","volume":"3","author":"Mills","year":"2003","journal-title":"Nat. Rev."},{"key":"10.1016\/j.resp.2011.10.017_bib0100","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/oxfordjournals.jbchem.a021401","article-title":"The small GTPase Rho: cellular functions and signal transduction","volume":"120","author":"Narumiya","year":"1996","journal-title":"J. Biochem."},{"key":"10.1016\/j.resp.2011.10.017_bib0105","first-page":"L472","article-title":"Respiratory syncytial virus-induced cytokine production by a human bronchial epithelial cell line","volume":"265","author":"Noah","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2011.10.017_bib0110","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1348-0421.1987.tb01340.x","article-title":"A microplate method for isolation of viruses from infants and children with acute respiratory infections","volume":"31","author":"Numazaki","year":"1987","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.resp.2011.10.017_bib0115","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1128\/JVI.73.9.7262-7270.1999","article-title":"RhoA interacts with the fusion glycoprotein of respiratory syncytial virus and facilitates virus-induced syncytium formation","volume":"73","author":"Pastey","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.resp.2011.10.017_bib0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/71503","article-title":"A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3","volume":"6","author":"Pastey","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.resp.2011.10.017_bib0125","doi-asserted-by":"crossref","first-page":"26734","DOI":"10.1074\/jbc.272.42.26734","article-title":"Hydroxyl radicals depolymerize glomerular heparan sulfate in vitro and in experimental nephrotic syndrome","volume":"272","author":"Raats","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2011.10.017_bib0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1152\/physrev.2001.81.1.153","article-title":"Small GTP-binding proteins","volume":"81","author":"Takai","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2011.10.017_bib0135","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1111\/j.1532-5415.2007.01373.x","article-title":"Carbocisteine improves quality of life in patients with chronic obstructive pulmonary disease","volume":"55","author":"Tatsumi","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.resp.2011.10.017_bib0140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1513\/pats.200502-014AW","article-title":"Cytokines and respiratory syncytial virus infection","volume":"2","author":"Tripp","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2011.10.017_bib0145","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1523\/JNEUROSCI.17-13-04987.1997","article-title":"Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix","volume":"17","author":"Wu","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2011.10.017_bib0150","doi-asserted-by":"crossref","first-page":"18977","DOI":"10.1074\/jbc.M100254200","article-title":"RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway","volume":"276","author":"Yamaguchi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2011.10.017_bib0155","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ejphar.2010.09.056","article-title":"Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells","volume":"650","author":"Yamaya","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2011.10.017_bib0160","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1532-5415.2005.00592_9.x","article-title":"Carbocisteine reduces frequency of common colds and exacerbations in COPD patients","volume":"54","author":"Yasuda","year":"2006","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.resp.2011.10.017_bib0165","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1183\/09031936.06.00058505","article-title":"Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells","volume":"28","author":"Yasuda","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2011.10.017_bib0170","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/S0140-6736(08)60869-7","article-title":"Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE study): a randomised placebo-controlled study","volume":"371","author":"Zheng","year":"2008","journal-title":"Lancet"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904811003673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904811003673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:24:58Z","timestamp":1761603898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904811003673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1569904811003673"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2011.10.017","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2011.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}