{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:02:34Z","timestamp":1777651354145,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.resp.2012.08.004","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T15:36:07Z","timestamp":1344612967000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparative embryology of the carotid body"],"prefix":"10.1016","volume":"185","author":[{"given":"Steven C.","family":"Hempleman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Warburton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2012.08.004_bib0005","first-page":"535","article-title":"The topographical anatomy and blood supply of the carotid body region of the domestic fowl","volume":"126","author":"Abdel-Magied","year":"1978","journal-title":"Journal of Anatomy"},{"key":"10.1016\/j.resp.2012.08.004_bib0010","series-title":"The Comparative Morphology of the Carotid Body and Carotid Sinus","author":"Adams","year":"1958"},{"key":"10.1016\/j.resp.2012.08.004_bib0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.901140103","article-title":"The placodal relations of the glossopharyngeal nerve in the sheep: a contribution to the early development of the carotid body","volume":"114","author":"Batten","year":"1960","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.resp.2012.08.004_bib0020","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1523\/JNEUROSCI.19-06-02131.1999","article-title":"BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons","volume":"19","author":"Brady","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.resp.2012.08.004_bib0025","series-title":"Endless Forms Most Beautiful: The New Science of Evo Devo","author":"Carroll","year":"2006"},{"key":"10.1016\/j.resp.2012.08.004_bib0030","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"issue":"23","key":"10.1016\/j.resp.2012.08.004_bib0035","doi-asserted-by":"crossref","first-page":"10555","DOI":"10.1073\/pnas.1005129107","article-title":"Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function","volume":"107","author":"Chen","year":"2010","journal-title":"Proceedings of The National Academy of Sciences"},{"key":"10.1016\/j.resp.2012.08.004_bib0040","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1242\/dev.00866","article-title":"Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways","volume":"130","author":"Dauger","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.resp.2012.08.004_bib0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ydbio.2012.02.035","article-title":"Neural crest progenitors and stem cells: from early development to adulthood","volume":"366","author":"Dupin","year":"2012","journal-title":"Developmental Biology"},{"key":"10.1016\/j.resp.2012.08.004_bib0050","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1523\/JNEUROSCI.16-17-05361.1996","article-title":"Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing","volume":"16","author":"Erickson","year":"1996","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.resp.2012.08.004_bib0055","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.220.4594.268","article-title":"Neural crest and the origin of vertebrates: a new head","volume":"220","author":"Gans","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.resp.2012.08.004_bib0060","article-title":"The origin and evolution of the ectodermal placodes","author":"Graham","year":"2012","journal-title":"Journal of Anatomy"},{"key":"10.1016\/j.resp.2012.08.004_bib0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00519376","article-title":"Fine structure of the carotid body of the midterm human fetus","volume":"138","author":"Hervonen","year":"1972","journal-title":"Z Anat Entwicklungsgesch"},{"key":"10.1016\/j.resp.2012.08.004_bib0070","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/dev.127.8.1607","article-title":"Fate of the mammalian cardiac neural crest","volume":"127","author":"Jiang","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.resp.2012.08.004_bib0075","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1242\/jeb.01564","article-title":"Development of oxygen sensing in the gills of zebrafish","volume":"208","author":"Jonz","year":"2005","journal-title":"Journal of Experimental Biology"},{"key":"10.1016\/j.resp.2012.08.004_bib0080","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.resp.2006.01.004","article-title":"Ontogenesis of chemoreception in aquatic vertebrates","volume":"154","author":"Jonz","year":"2006","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"10.1016\/j.resp.2012.08.004_bib0085","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1242\/jeb.010587","article-title":"Commentary. New developments on gill innervation: insights from a model vertebrate","volume":"211","author":"Jonz","year":"2008","journal-title":"The Journal of Experimental Biology"},{"key":"10.1016\/j.resp.2012.08.004_bib0090","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/BF00313532","article-title":"Ontogeny of the carotid body and glomus cells distributed in the wall of the common carotid artery and its branches in the chicken","volume":"261","author":"Kameda","year":"1990","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/j.resp.2012.08.004_bib0095","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/cne.903480405","article-title":"Electron microscopic study on the development of the carotid body and glomus cell groups distributed in the wall of the common carotid artery and its branches in the chicken","volume":"348","author":"Kameda","year":"1994","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.resp.2012.08.004_bib0100","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jemt.10194","article-title":"Carotid body and glomus cells distributed in the wall of the common carotid artery in the bird","volume":"59","author":"Kameda","year":"2002","journal-title":"Microscopy Research and Technique"},{"key":"10.1016\/j.resp.2012.08.004_bib0105","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ydbio.2005.04.004","article-title":"Mash1 is required for glomus cell formation in the mouse carotid body","volume":"283","author":"Kameda","year":"2005","journal-title":"Developmental Biology"},{"key":"10.1016\/j.resp.2012.08.004_bib0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/0-387-31311-7_14","article-title":"Dual origins of the mouse carotid body revealed by targeted disruption of Hoxa3 and Mash1","volume":"580","author":"Kameda","year":"2006","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.resp.2012.08.004_bib0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/BF00271988","article-title":"Distribution and ontogeny of chromogranin A and tyrosine hydroxylase in the carotid body and glomus cells located in the wall of the common carotid artery and its branches in the chicken","volume":"94","author":"Kameda","year":"1990","journal-title":"Histochemistry"},{"key":"10.1016\/j.resp.2012.08.004_bib0120","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ydbio.2007.12.002","article-title":"FRS2 alpha 2F\/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve","volume":"314","author":"Kameda","year":"2008","journal-title":"Developmental Biology"},{"key":"10.1016\/j.resp.2012.08.004_bib0125","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/dbio.2002.0689","article-title":"Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos","volume":"247","author":"Kameda","year":"2002","journal-title":"Developmental Biology"},{"key":"10.1016\/j.resp.2012.08.004_bib0130","doi-asserted-by":"crossref","DOI":"10.1002\/dvdy.23819","article-title":"Hes1 is required for the development of the superior cervical ganglion of the sympathetic trunk and the carotid body","author":"Kameda","year":"2012","journal-title":"Developmental Dynamics"},{"key":"10.1016\/j.resp.2012.08.004_bib0135","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/cne.903480404","article-title":"Glomus cell differentiation in the carotid body region of chick embryos studied by neuron-specific class III beta-tubulin isotype and Leu-7 monoclonal antibodies","volume":"348","author":"Kameda","year":"1994","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.resp.2012.08.004_bib0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1679\/aohc.53.245","article-title":"Ultrastructural study on cell differentiation of the rabbit carotid body","volume":"53","author":"Kariya","year":"1990","journal-title":"Archives of Histology and Cytology"},{"key":"10.1016\/j.resp.2012.08.004_bib0145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.resp.2005.02.007","article-title":"Regulation of respiratory neuron development by neurotrophic and transcriptional signaling mechanisms","volume":"149","author":"Katz","year":"2005","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"10.1016\/j.resp.2012.08.004_bib0150","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/aja.1001440303","article-title":"A light and electron microscopic study on the embryonic development of the rat carotid body","volume":"144","author":"Kondo","year":"1975","journal-title":"American Journal of Anatomy"},{"key":"10.1016\/j.resp.2012.08.004_bib0155","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00274965","article-title":"Origin and development of the catecholamine-storing cells of the human fetal carotid body","volume":"37","author":"Korkala","year":"1973","journal-title":"Histochemie"},{"key":"10.1016\/j.resp.2012.08.004_bib0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jmor.1052040106","article-title":"Comparative studies on the vascular organization of carotid labyrinths of anurans and caudate","volume":"204","author":"Kusakabe","year":"1990","journal-title":"The Journal of Morphology"},{"key":"10.1016\/j.resp.2012.08.004_bib0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jemt.10195","article-title":"Carotid labyrinth of amphibians","volume":"59","author":"Kusakabe","year":"2002","journal-title":"Microscopy Research and Technique"},{"key":"10.1016\/j.resp.2012.08.004_bib0170","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/286663a0","article-title":"The ontogeny of the neural crest in avian embryo chimaeras","volume":"286","author":"Le Douarin","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.resp.2012.08.004_bib0175","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.3952494","article-title":"Cell line segregation during peripheral nervous system ontogeny","volume":"231","author":"Le Douarin","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.resp.2012.08.004_bib0180","first-page":"125","article-title":"Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos","volume":"34","author":"Le Lievre","year":"1975","journal-title":"Journal of Embryology and Experimental Morphology"},{"key":"10.1016\/j.resp.2012.08.004_bib0185","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.resp.2007.02.007","article-title":"Periperal arterial chemoreceptors and the evolution of the carotid body","volume":"157","author":"Milsom","year":"2007","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"10.1016\/j.resp.2012.08.004_bib0190","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000143021","article-title":"The development of the carotid body in Gallus domesticus. A descriptive study","volume":"68","author":"Murillo-Ferrol","year":"1967","journal-title":"Acta Anatomica"},{"key":"10.1016\/j.resp.2012.08.004_bib0195","article-title":"Innervation and pharmacology of the gills","volume":"vol. 10, Part A","author":"Nilsson","year":"1984"},{"issue":"2","key":"10.1016\/j.resp.2012.08.004_bib0200","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cell.2007.07.043","article-title":"Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body","volume":"131","author":"Pardal","year":"2007","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.resp.2012.08.004_bib0205","first-page":"95","article-title":"The carotid body, a neurogenic niche in the adult peripheral nervous system","volume":"148","author":"Pardal","year":"2010","journal-title":"Archives Italiennes de Biologie"},{"issue":"3","key":"10.1016\/j.resp.2012.08.004_bib0210","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00303435","article-title":"Demonstration of the neural crest origin of type I (APUD) cells in the avian carotid body, using a cytochemical marker system","volume":"34","author":"Pearse","year":"1973","journal-title":"Histochemie"},{"key":"10.1016\/j.resp.2012.08.004_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1937-6448(08)01001-0","article-title":"Trophic factors in the carotid body","volume":"269","author":"Porzionato","year":"2008","journal-title":"International Review of Cell and Molecular Biology"},{"issue":"1","key":"10.1016\/j.resp.2012.08.004_bib0220","first-page":"89","article-title":"The development of the rat carotid body","volume":"99","author":"Rogers","year":"1965","journal-title":"Journal of Anatomy, London"},{"issue":"6","key":"10.1016\/j.resp.2012.08.004_bib0225","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3109\/15513819209024239","article-title":"Glomic cells and their peptides in the carotid body of the human fetus","volume":"12","author":"Scraggs","year":"1992","journal-title":"Pediatric Pathology"},{"key":"10.1016\/j.resp.2012.08.004_bib0230","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/aja.1000340103","article-title":"The origin and development of the carotid body","volume":"34","author":"Smith","year":"1924","journal-title":"American Journal of Anatomy"},{"key":"10.1016\/j.resp.2012.08.004_bib0235","first-page":"143","article-title":"The development of the nerve network in the fetal human carotid body and its subsequent function in cardiac disease","volume":"4","author":"Smith","year":"1993","journal-title":"Cardioscience"},{"key":"10.1016\/j.resp.2012.08.004_bib0240","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1523\/JNEUROSCI.4312-04.2005","article-title":"Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation","volume":"25","author":"Villadiego","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.resp.2012.08.004_bib0245","article-title":"Cardiovascular system","volume":"vol. 2","author":"West","year":"1981"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481200225X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481200225X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:28:15Z","timestamp":1761604095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156990481200225X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S156990481200225X"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2012.08.004","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative embryology of the carotid body","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2012.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}