{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T22:28:40Z","timestamp":1764541720946,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.resp.2012.09.005","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T18:01:14Z","timestamp":1348509674000},"page":"356-361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of clonidine on breathing during sleep and susceptibility to central apnoea"],"prefix":"10.1016","volume":"185","author":[{"given":"Abdul Ghani","family":"Sankri-Tarbichi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Grullon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Safwan","family":"Badr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.resp.2012.09.005_bib0005","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1152\/ajpregu.91008.2008","article-title":"Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation","volume":"296","author":"Ainslie","year":"2009","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.resp.2012.09.005_bib0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00562444","article-title":"Effect of clonidine on sleep patterns in man","volume":"12","author":"Autret","year":"1977","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.resp.2012.09.005_bib0015","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00424-007-0338-8","article-title":"Locus coeruleus noradrenergic neurons and CO2 drive to breathing","volume":"455","author":"Biancardi","year":"2008","journal-title":"Pflugers Archiv"},{"key":"10.1016\/j.resp.2012.09.005_bib0020","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1213\/ane.0b013e318187c83a","article-title":"A systemic review of obstructive sleep apnoea and its implications for anesthesiologists","volume":"107","author":"Chung","year":"2008","journal-title":"Anesthesia & Analgesia"},{"key":"10.1016\/j.resp.2012.09.005_bib0025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.pharmthera.2009.04.001","article-title":"Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis","volume":"123","author":"Fairbanks","year":"2009","journal-title":"Pharmacology & Therapeutics"},{"issue":"2","key":"10.1016\/j.resp.2012.09.005_bib0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/bja\/76.2.214","article-title":"Influence of oral clonidine on the ventilatory response to acute and sustained isocapnoic hypoxia in human males","volume":"76","author":"Foo","year":"1996","journal-title":"British Journal of Anaesthesia"},{"issue":"1","key":"10.1016\/j.resp.2012.09.005_bib0035","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00000542-198601000-00007","article-title":"Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation","volume":"64","author":"Ghignone","year":"1986","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.resp.2012.09.005_bib0040","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/00000542-198805000-00008","article-title":"Anesthesia for ophthalmic surgery in the elderly: the effects of clonidine on intraocular pressure, perioperative hemodynamics, and anesthetic requirement","volume":"68","author":"Ghignone","year":"1988","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2012.09.005_bib0045","first-page":"A5285","article-title":"Influence of alpha 2 receptors agonist on susceptibility to hypocapnic central apnoea during NREM sleep in healthy individuals","author":"Grullon","year":"2011","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"9","key":"10.1016\/j.resp.2012.09.005_bib0050","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/154405910608500915","article-title":"Oral clonidine pre-treatment and diazepam\/meperidine sedation","volume":"85","author":"Hall","year":"2006","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.resp.2012.09.005_bib0055","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1749-6632.1995.tb32435.x","article-title":"Effect of I1-imidazoline receptor activation on responses of hypoglossal and phrenic nerve to chemical stimulation","volume":"763","author":"Haxhiu","year":"1995","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.resp.2012.09.005_bib0065","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1164\/ajrccm\/145.2_Pt_1.435","article-title":"Effect of clonidine in obstructive sleep apnoea","volume":"145","author":"Issa","year":"1992","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/j.resp.2012.09.005_bib0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5664\/jcsm.27229","article-title":"Adaptive pressure support servoventilation: a novel treatment for sleep apnoea associated with use of opioids","volume":"4","author":"Javaheri","year":"2008","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"10.1016\/j.resp.2012.09.005_bib0075","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJM199608223350805","article-title":"Effect of theophylline on sleep-disordered breathing in heart failure","volume":"335","author":"Javaheri","year":"1996","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.resp.2012.09.005_bib0080","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1164\/rccm.200507-1035OC","article-title":"Acetazolamide improves central sleep apnoea in heart failure: a double-blind, prospective study","volume":"173","author":"Javaheri","year":"2006","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"1","key":"10.1016\/j.resp.2012.09.005_bib0085","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1113\/expphysiol.2005.031914","article-title":"Clonidine-evoked respiratory effects in anaesthetized rats","volume":"91","author":"Kaczynska","year":"2006","journal-title":"Experimental Physiology"},{"issue":"8","key":"10.1016\/j.resp.2012.09.005_bib0100","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1365-2044.1991.tb09709.x","article-title":"The effects of intravenous clonidine on ventilation","volume":"46","author":"Ooi","year":"1991","journal-title":"Anaesthesia"},{"key":"10.1016\/j.resp.2012.09.005_bib0105","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1213\/01.ANE.0000180194.30741.40","article-title":"Clonidine premedication in patients with sleep apnoea syndrome: a randomized, double-blind, placebo-controlled study","volume":"101","author":"Pawlik","year":"2005","journal-title":"Anesthesia and Analgesia"},{"issue":"6","key":"10.1016\/j.resp.2012.09.005_bib0110","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1213\/00000539-199106000-00007","article-title":"Ventilatory response to carbon dioxide after epidural clonidine injection","volume":"72","author":"Penon","year":"1991","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.resp.2012.09.005_bib0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/sleep\/29.1.95","article-title":"The determinants of the apnoea threshold during NREM sleep in normal subjects","volume":"29","author":"Rowley","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.resp.2012.09.005_bib0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1164\/rccm.200810-1658OC","article-title":"Increased propensity for central apnoea in patients with obstructive sleep apnoea: effect of nasal continuous positive airway pressure","volume":"181","author":"Salloum","year":"2010","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.resp.2012.09.005_bib0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1164\/rccm.200805-741OC","article-title":"Expiratory pharyngeal narrowing during central hypocapnic hypopnea","volume":"179","author":"Sankri-Tarbichi","year":"2009","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.resp.2012.09.005_bib0135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.resp.2011.11.003","article-title":"Dexmedetomidine and clonidine induce long-lasting activation of the respiratory rhythm generator of neonatal mice: possible implication for critical care","volume":"180","author":"Voituron","year":"2012","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"1","key":"10.1016\/j.resp.2012.09.005_bib0140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/japplphysiol.00440.2005","article-title":"Influence of arterial O2 on the susceptibility to posthyperventilation apnoea during sleep","volume":"100","author":"Xie","year":"2006","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.resp.2012.09.005_bib0150","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1152\/jappl.2000.89.1.192","article-title":"Effect of gender on the development of hypocapnic apnoea\/hypopnea during NREM sleep","volume":"89","author":"Zhou","year":"2000","journal-title":"Journal of Applied Physiology"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904812002601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904812002601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:29:14Z","timestamp":1761604154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904812002601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1569904812002601"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2012.09.005","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of clonidine on breathing during sleep and susceptibility to central apnoea","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2012.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}