{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:17:54Z","timestamp":1783649874005,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.resp.2012.10.003","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T17:40:43Z","timestamp":1349804443000},"page":"265-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Regulator of G-protein signaling 2 inhibits acid-induced mucin5AC hypersecretion in human airway epithelial cells"],"prefix":"10.1016","volume":"185","author":[{"given":"Chunyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor P.","family":"Kolosov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliy M.","family":"Perelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2012.10.003_bib0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1165\/ajrcmb.10.1.7507342","article-title":"CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells","volume":"10","author":"Cozens","year":"1994","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.resp.2012.10.003_bib0010","first-page":"487","article-title":"Regulated airway goblet cell mucin secretion","volume":"70","author":"Davis","year":"2008","journal-title":"Annual Review of Psychology"},{"issue":"1\u20133","key":"10.1016\/j.resp.2012.10.003_bib0015","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.resp.2008.05.015","article-title":"Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling","volume":"163","author":"Davis","year":"2008","journal-title":"Respiratory Physiology & Neurobiology"},{"key":"10.1016\/j.resp.2012.10.003_bib0020","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.lfs.2007.08.026","article-title":"Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptor","volume":"81","author":"Faisy","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.resp.2012.10.003_bib0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1172\/JCI8374","article-title":"Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo","volume":"106","author":"Finney","year":"2000","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.resp.2012.10.003_bib0030","doi-asserted-by":"crossref","first-page":"14389","DOI":"10.1073\/pnas.94.26.14389","article-title":"RGS2\/GOS8 is a selective inhibitor of Gqalpha function","volume":"94","author":"Heximer","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.resp.2012.10.003_bib0035","doi-asserted-by":"crossref","first-page":"19713","DOI":"10.1073\/pnas.1110226108","article-title":"\u03b22-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids","volume":"108","author":"Holden","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.resp.2012.10.003_bib0040","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/rmed.2000.0816","article-title":"Effects of naturally-occurring acid fog on inflammatory mediators in airway and pulmonary functions in asthmatic patients","volume":"94","author":"Honma","year":"2000","journal-title":"Respiratory Medicine"},{"key":"10.1016\/j.resp.2012.10.003_bib0045","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1152\/ajplung.00415.2009","article-title":"Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells","volume":"299","author":"Ichimonji","year":"2012","journal-title":"American Journal of Physiology \u2013 Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.resp.2012.10.003_bib0050","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1152\/ajpcell.2001.281.5.C1504","article-title":"Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea","volume":"281","author":"Jayaraman","year":"2001","journal-title":"American Journal of Physiology \u2013 Cell Physiology"},{"key":"10.1016\/j.resp.2012.10.003_bib0055","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1067\/mai.2002.122636","article-title":"Heterotrimeric G protein signaling: role in asthma and allergic inflammation","volume":"109","author":"Johnson","year":"2002","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.resp.2012.10.003_bib0060","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1165\/rcmb.2003-0211OC","article-title":"Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells","volume":"31","author":"Kemp","year":"2004","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.resp.2012.10.003_bib0065","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.1128\/MCB.02385-06","article-title":"Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway","volume":"27","author":"Kim","year":"2007","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.resp.2012.10.003_bib0070","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1164\/rccm.200607-940OC","article-title":"An investigation of airway acidification in asthma using induced sputum: a study of feasibility and correlation","volume":"175","author":"Kodric","year":"2007","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.resp.2012.10.003_bib0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature01905","article-title":"Proton-sensing G-protein-coupled receptors","volume":"425","author":"Ludwig","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.resp.2012.10.003_bib0080","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bbrc.2011.08.087","article-title":"Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells","volume":"413","author":"Matsuzaki","year":"2011","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.resp.2012.10.003_bib0085","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1165\/rcmb.2002-0012OC","article-title":"Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia","volume":"27","author":"Nlend","year":"2002","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.resp.2012.10.003_bib0090","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jaci.2004.07.060","article-title":"The role of protease activation of inflammation in allergic respiratory diseases","volume":"114","author":"Reed","year":"2004","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.resp.2012.10.003_bib0095","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0002-9343(01)00816-6","article-title":"Mechanisms of citric acid-induced bronchoconstriction","volume":"111","author":"Ricciardolo","year":"2001","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.resp.2012.10.003_bib0100","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2003.12.034","article-title":"Acid stress in the pathology of asthma","volume":"113","author":"Ricciardolo","year":"2004","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.resp.2012.10.003_bib0105","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1146\/annurev.biochem.69.1.795","article-title":"GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins","volume":"69","author":"Ross","year":"2000","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.resp.2012.10.003_bib0110","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1476-5381.2011.01807.x","article-title":"The G protein-coupled receptor OGR1 mediates diverse signaling and contraction of airway smooth muscle in response to small reductions in extracellular pH","volume":"166","author":"Saxena","year":"2012","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.resp.2012.10.003_bib0115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1165\/rcmb.2008-0280OC","article-title":"Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway","volume":"4","author":"Song","year":"2009","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.resp.2012.10.003_bib0120","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1556\/oh.2007.27986","article-title":"pH in expired breath condensate of patients with inflammatory airway diseases","volume":"148","author":"Szili","year":"2007","journal-title":"Orv Hetil"},{"key":"10.1016\/j.resp.2012.10.003_bib0125","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cellsig.2005.06.002","article-title":"Proton-sensing and lysolipid-sensitive G-protein-coupled receptors a novel type of multi-functional receptors","volume":"17","author":"Tomura","year":"2005","journal-title":"Cell Signal"},{"issue":"7","key":"10.1016\/j.resp.2012.10.003_bib0130","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1359\/jbmr.080236","article-title":"Cyclooxygenase-2 expression and prostaglandin E2 production in response ti acidic pH through OGR1 in a human osteoblastic cell line","volume":"23","author":"Tomura","year":"2008","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.resp.2012.10.003_bib0135","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/383172a0","article-title":"RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits","volume":"383","author":"Watson","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.resp.2012.10.003_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2012.05.004","article-title":"Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness","author":"Xie","year":"2012","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.resp.2012.10.003_bib0145","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/geno.1996.0377","article-title":"Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14","volume":"35","author":"Xu","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.resp.2012.10.003_bib0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jbt.20413","article-title":"Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca(2+) influx in human airway epithelial cells","volume":"26","author":"Yu","year":"2012","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"key":"10.1016\/j.resp.2012.10.003_bib0155","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0022-3565(24)29606-3","article-title":"Regulator of G protein signaling proteins: novel multifunctional drug targets","volume":"297","author":"Zhong","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904812002819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904812002819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:29:10Z","timestamp":1761604150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904812002819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1569904812002819"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2012.10.003","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.722337125.793503057","asserted-by":"object"}]},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulator of G-protein signaling 2 inhibits acid-induced mucin5AC hypersecretion in human airway epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2012.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}