{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:32:40Z","timestamp":1761604360567,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.resp.2012.10.004","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T22:49:27Z","timestamp":1350082167000},"page":"257-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Age and hypothyroidism affect dopamine modulation of breathing and D2 receptor levels"],"prefix":"10.1016","volume":"185","author":[{"given":"Cory","family":"Sykora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitch","family":"Amor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Schlenker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2012.10.004_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/frne.2000.0208","article-title":"Thyroid hormones and the brain","volume":"22","author":"Anderson","year":"2001","journal-title":"Frontiers in Neuroendocrinology"},{"key":"10.1016\/j.resp.2012.10.004_bib0010","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0892-0362(91)90077-A","article-title":"Hyperactivity and spatial maze learning impairment of adult rats with temporary neonatal hypothyroidism","volume":"13","author":"Akaike","year":"1991","journal-title":"Neurotoxicology and Teratology"},{"key":"10.1016\/j.resp.2012.10.004_bib0015","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0034-5687(91)90071-P","article-title":"Effects of dopamine and domperidone on ventilation during isocapnic hypoxia in humans","volume":"85","author":"Bascom","year":"1991","journal-title":"Respiration Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0020","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.resp.2005.04.017","article-title":"Neurotransmitters in carotid body development","volume":"149","author":"Bairam","year":"2005","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0025","first-page":"182","article-title":"The physiology signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.resp.2012.10.004_bib0035","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0091-3057(90)90537-R","article-title":"The hypothyroid rat as a model of increased sensitivity to dopamine receptor agonists","volume":"37","author":"Cameron","year":"1990","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.resp.2012.10.004_bib0040","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/archinte.160.4.526","article-title":"Colorado thyroid disease prevalence study","volume":"160","author":"Cannaris","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.resp.2012.10.004_bib0045","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1471-4159.2010.06805.x","article-title":"RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors","volume":"114","author":"Celver","year":"2010","journal-title":"Journal of Neurochemistry"},{"issue":"6","key":"10.1016\/j.resp.2012.10.004_bib0050","doi-asserted-by":"crossref","first-page":"e00098","DOI":"10.1042\/AN20120013","article-title":"Dopamine D2 receptor-mediated Akt\/PKB signaling: initiation by D2S receptor and role in quinpirole-induced behavioral activation","volume":"4","author":"Chen","year":"2012","journal-title":"ASN Neuro"},{"key":"10.1016\/j.resp.2012.10.004_bib0055","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1601-183X.2010.00604.x","article-title":"Strain-specific proportion of the two isoforms of the dopamine D2 receptor in the mouse striatum: associated neural and behavioral phenotypes","volume":"9","author":"Colelli","year":"2010","journal-title":"Genes, Brain and Behavior"},{"key":"10.1016\/j.resp.2012.10.004_bib0060","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/0091-3057(86)90491-0","article-title":"Hypothyroism leads to increased dopamine receptor sensitivity and concentration","volume":"24","author":"Crocker","year":"1986","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.resp.2012.10.004_bib0065","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2337\/dc11-0064","article-title":"Bromocriptine: a sympatholytic, D2-dopamine agonist for the treatment of Type 2 diabetes","volume":"34","author":"DeFronzo","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.resp.2012.10.004_bib0070","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.ph.49.030187.001541","article-title":"Thyroid hormones and brain development","volume":"49","author":"Dussault","year":"1987","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0075","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1469-7793.1999.00383.x","article-title":"Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans","volume":"520","author":"Evans","year":"1999","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12031-010-9328-y","article-title":"Differential sensitiviy of A2A and especially D2 receptor trafficking to cocaine compared with lipid rafts in cotrasfected CHO cell lines. Novel actions of cocaine independent of the DA transporter","volume":"41","author":"Genedani","year":"2010","journal-title":"Journal of Molecular Neuroscience"},{"key":"10.1016\/j.resp.2012.10.004_bib0085","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: from natural stimuli to sensory discharges","volume":"74","author":"Gonzalez","year":"1994","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.resp.2012.10.004_bib0090","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1620\/tjem.196.219","article-title":"The effect of intracerebroventricular dopamine administration on the respiratory response to hypoxia","volume":"196","author":"Guner","year":"2002","journal-title":"Tohoku Journal of Experimental Medicine"},{"key":"10.1016\/j.resp.2012.10.004_bib0095","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0306-4522(95)00228-B","article-title":"Sex steroid hormones change the differential distribution of the isoforms of the D2 dopamine receptor messenger RNA in the rat brain","volume":"69","author":"Guivarc\u2019h","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2012.10.004_bib0100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1569-9048(03)00032-6","article-title":"Dopaminergic mechanisms of neural plasticity in respiratory control: transgenic approaches","volume":"135","author":"Huey","year":"2003","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0105","first-page":"43","article-title":"Dopaminergic neuronal systems modulate the central cardiovascular effects of TRH in rats","volume":"47","author":"Jedrusiak","year":"1995","journal-title":"Polish Journal of Pharmacology"},{"key":"10.1016\/j.resp.2012.10.004_bib0110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.sleep.2005.05.003","article-title":"Thyroxine replacement therapy reverses sleep-disordered breathing in patients with primary hypothyroidism","volume":"7","author":"Jha","year":"2006","journal-title":"Sleep Medicine"},{"issue":"1\u20132","key":"10.1016\/j.resp.2012.10.004_bib0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molbrainres.2004.07.015","article-title":"Differential regulation of short and long dopamine D2 receptor mRNA levels by hypoxia in the adrenals of 1-day-old and adult rabbits?","volume":"130","author":"Joseph","year":"2004","journal-title":"Brain Research \u2013 Molecular Brain Research"},{"key":"10.1016\/j.resp.2012.10.004_bib0120","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1152\/jn.00224.2002","article-title":"Dopamine modulates synaptic transmission in the nucleus of the solitary tract","volume":"88","author":"Kline","year":"2002","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0125","first-page":"1101","article-title":"Quinpirole elicits differential in vivo changes in the pre- and postsynaptic distributions of dopamine D2 receptors in mouse striatum: relation to cannabinoid-1 (CB1) receptor targeting","volume":"22","author":"Lane","year":"2012","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.resp.2012.10.004_bib0130","doi-asserted-by":"crossref","first-page":"7178","DOI":"10.1523\/JNEUROSCI.0008-12.2012","article-title":"Identification of two functionally distinct endosomal recycling pathways for dopamine D2 receptor","volume":"32","author":"Li","year":"2012","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.resp.2012.10.004_bib0135","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1152\/japplphysiol.00641.2002","article-title":"Neural correlates of voluntary breathing in humans","volume":"95","author":"McKay","year":"2003","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: from structure to function","volume":"78","author":"Missale","year":"1998","journal-title":"Physiological Reviews"},{"year":"2001","series-title":"A Stereotaxic Atlas of the Golden Hamster","author":"Morin","key":"10.1016\/j.resp.2012.10.004_bib0145"},{"key":"10.1016\/j.resp.2012.10.004_bib0150","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1365-2826.2005.01381.x","article-title":"Dopamine D2-like receptor function is converted from excitatory to inhibitory by thyroxine in the developmental hippocampus","volume":"17","author":"Oh-Nishi","year":"2005","journal-title":"Journal of Neuroendocrinology"},{"issue":"Suppl. 655","key":"10.1016\/j.resp.2012.10.004_bib0155","first-page":"P51","article-title":"PTU-induced hypothyroidism reduces hypoxic ventilatory drive by impairing carotid body chemsensitivity in adult rats","volume":"190","author":"Olea","year":"2007","journal-title":"Acta Physiologica"},{"key":"10.1016\/j.resp.2012.10.004_bib0160","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1172\/JCI107063","article-title":"Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone","volume":"51","author":"Oppenheimer","year":"1972","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.resp.2012.10.004_bib0165","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1152\/jappl.1997.83.4.1110","article-title":"Effects of haloperidol on ventilation during isocapnic hypoxia in humans","volume":"83","author":"Pedersen","year":"1997","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0175","unstructured":"Rugge, B., Balshem, H., Sehgal, R., Relevo, R., Gorman, P., Helfand, M., 2011. Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism. Agency for Healthcare Research and Quality (US) Report No. 11, Rockville (MD). Comparative. Effectiveness Reviews 24."},{"key":"10.1016\/j.resp.2012.10.004_bib0180","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cbpa.2007.08.020","article-title":"In hamsters dopamine D2 receptors affect ventilation during and following intermittent hypoxia","volume":"148","author":"Schlenker","year":"2007","journal-title":"Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0185","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.resp.2012.02.007","article-title":"Effects of hypothyroidism on the respiratory system and control of breathing human studies and animal models","volume":"181","author":"Schlenker","year":"2012","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0190","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0031-9384(94)90218-6","article-title":"Naloxone stimulates oxygen consumption but not ventilation in hypothyroid hamsters","volume":"56","author":"Schlenker","year":"1994","journal-title":"Physiology and Behavior"},{"key":"10.1016\/j.resp.2012.10.004_bib0200","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.resp.2011.10.013","article-title":"Hypothyroidism stimulates D2 receptor-mediated breathing in response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain","volume":"180","author":"Schlenker","year":"2012","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0205","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1262\/jrd.16057","article-title":"Effects of hypothyroidism on gonadal function after transition of short day photoperido in amle golden hamsters (Mesocricetus, auratus)","volume":"51","author":"Saita","year":"2005","journal-title":"Journal of Reproduction and Development"},{"key":"10.1016\/j.resp.2012.10.004_bib0210","first-page":"153","article-title":"The role of peripheral chemoreceptor activity on the respiratory responses to hypoxia and hypercapnia in anaesthetised rabbits with induced hypothyroidism","volume":"47","author":"Simsek","year":"2004","journal-title":"Chinese Journal of Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0215","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1074\/jbc.M110.166454","article-title":"Neurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism","volume":"286","author":"Thibault","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.resp.2012.10.004_bib0220","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.4161\/cc.7.14.6307","article-title":"Signaling by dopamine regulates D2 receptor trafficking at the membrane","volume":"7","author":"Tirotta","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.resp.2012.10.004_bib0225","first-page":"615","article-title":"Chronic exposure to short photoperiod inhibits free thyroxine index and plasma levels of TSH, T4 and triiodothyronine (T3) and cholesterol in female Syrian hamsters","volume":"71","author":"Vaughan","year":"1982","journal-title":"Comparative Biochemistry and Physiology Part B: Comparative Physiology"},{"key":"10.1016\/j.resp.2012.10.004_bib0230","doi-asserted-by":"crossref","first-page":"14752","DOI":"10.1523\/JNEUROSCI.4860-09.2009","article-title":"Neural cell adhesion molecule modulates dopaminergic signaling and behavior by regulating dopamine D2 receptor internalization","volume":"29","author":"Xiao","year":"2009","journal-title":"Journal of Neuroscience"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904812002820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904812002820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:29:19Z","timestamp":1761604159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904812002820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1569904812002820"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2012.10.004","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age and hypothyroidism affect dopamine modulation of breathing and D2 receptor levels","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2012.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}