{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:20:01Z","timestamp":1762323601748,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.resp.2013.04.014","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T06:50:39Z","timestamp":1366699839000},"page":"214-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Osthole improves acute lung injury in mice by up-regulating Nrf-2\/thioredoxin 1"],"prefix":"10.1016","volume":"188","author":[{"given":"Xiang-Jun","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Jie","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dun-Quan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Ying","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ri-He","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan-Di","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa-Guang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2013.04.014_bib0005","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1124\/mol.105.011296","article-title":"Nuclear factor-kappaB decoys suppress endotoxin-induced lung injury","volume":"67","author":"Baetz","year":"2005","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.resp.2013.04.014_bib0010","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1183\/09031936.98.11030745","article-title":"Reactive oxygen species in acute lung injury","volume":"11","author":"Chabot","year":"1998","journal-title":"European Respiratory Journal"},{"key":"10.1016\/j.resp.2013.04.014_bib0015","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.brainres.2010.09.052","article-title":"Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats","volume":"1363","author":"Chao","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.resp.2013.04.014_bib0020","doi-asserted-by":"crossref","first-page":"L1083","DOI":"10.1152\/ajplung.2000.279.6.L1083","article-title":"Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharide","volume":"279","author":"Chignard","year":"2000","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.resp.2013.04.014_bib0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/187153006777442413","article-title":"The lung in sepsis: guilty or innocent?","volume":"6","author":"Costa","year":"2006","journal-title":"Endocrine, Metabolic & Immune Disorders Drug Targets"},{"key":"10.1016\/j.resp.2013.04.014_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/03009739009178581","article-title":"Intrapulmonary deposition of aerosolized Evans blue dye and liposomes in an experimental porcine model of early ARDS","volume":"95","author":"Forsgren","year":"1990","journal-title":"Upsala Journal of Medical Sciences"},{"key":"10.1016\/j.resp.2013.04.014_bib0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jconrel.2011.05.013","article-title":"Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury","volume":"154","author":"Furukawa","year":"2011","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.resp.2013.04.014_bib0040","first-page":"2916","article-title":"Mitochondrial induction of adult T cell leukemia derived factor (ADF\/hTx) after oxidative stresses in retinal pigment epithelial cells","volume":"35","author":"Gauntt","year":"1994","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"Suppl 1","key":"10.1016\/j.resp.2013.04.014_bib0045","first-page":"S23L S26","article-title":"Role of oxidant stress in the adult respiratory distress syndrome: evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury","volume":"6","author":"Gonzalez","year":"1996","journal-title":"Shock"},{"key":"10.1016\/j.resp.2013.04.014_bib0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/bdrb.21005","article-title":"Nrf2-mediated resistance to oxidant-induced redox disruption in embryos","volume":"95","author":"Harris","year":"2012","journal-title":"Birth Defects Research. Part B, Developmental and Reproductive Toxicology"},{"key":"10.1016\/j.resp.2013.04.014_bib0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2011.11.027","article-title":"Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats","volume":"1433","author":"He","year":"2012","journal-title":"Brain Research"},{"key":"10.1016\/j.resp.2013.04.014_bib0060","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1189\/jlb.1104694","article-title":"LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM","volume":"79","author":"Heo","year":"2006","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.resp.2013.04.014_bib0065","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bbrc.2005.07.007","article-title":"Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma","volume":"334","author":"Ichiki","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.resp.2013.04.014_bib0070","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1093\/hmg\/dds131","article-title":"DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway","volume":"21","author":"Im","year":"2012","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.resp.2013.04.014_bib0075","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1124\/mol.64.5.1018","article-title":"Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element","volume":"64","author":"Jowsey","year":"2003","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.resp.2013.04.014_bib0080","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1124\/jpet.105.085092","article-title":"Osthole-mediated cell differentiation through bone morphogenetic protein-2\/p38 and extracellular signal-regulated kinase 1\/2 pathway in human osteoblast cells","volume":"314","author":"Kuo","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.resp.2013.04.014_bib0085","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2007.04.019","article-title":"15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells","volume":"223","author":"Lim","year":"2007","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.resp.2013.04.014_bib0090","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1523\/JNEUROSCI.15-10-06747.1995","article-title":"Localization of thioredoxin in the rat brain and functional implications","volume":"15","author":"Lippoldt","year":"1995","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.resp.2013.04.014_bib0095","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuint.2010.05.011","article-title":"Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production","volume":"57","author":"Liu","year":"2010","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.resp.2013.04.014_bib0100","article-title":"A polysaccharide fraction of adlay seed (Coix lachryma-jobi L.) induces apoptosis in human non-small cell lung cancer A549 cells","author":"Lu","year":"2012","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.resp.2013.04.014_bib0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2009.02.022","article-title":"Osthole suppresses seizures in the mouse maximal electroshock seizure model","volume":"607","author":"Luszczki","year":"2009","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.resp.2013.04.014_bib0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1248\/bpb.25.260","article-title":"Antipruritic effect of Cnidii monnieri fructus (fruits of Cnidium monnieri CUSSON)","volume":"25","author":"Matsuda","year":"2002","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.resp.2013.04.014_bib0115","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0006-291X(05)81536-0","article-title":"Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor\/human thioredoxin","volume":"186","author":"Mitsui","year":"1992","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.resp.2013.04.014_bib0120","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.rmed.2008.09.013","article-title":"The role of glutathione-S-transferase polymorphisms on clinical outcome of ALI\/ARDS patient treated with N-acetylcysteine","volume":"103","author":"Moradi","year":"2009","journal-title":"Respiratory Medicine"},{"key":"10.1016\/j.resp.2013.04.014_bib0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/j.resp.2013.04.014_bib0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/gt.2008.126","article-title":"Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma","volume":"16","author":"Munemasa","year":"2009","journal-title":"Gene Therapy"},{"key":"10.1016\/j.resp.2013.04.014_bib0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11418-008-0277-5","article-title":"Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7","volume":"63","author":"Nakamura","year":"2009","journal-title":"Journal of Natural Medicine"},{"key":"10.1016\/j.resp.2013.04.014_bib0140","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.freeradbiomed.2010.02.024","article-title":"Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2\/Trx axis","volume":"48","author":"Niso-Santano","year":"2010","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.resp.2013.04.014_bib0145","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1378\/chest.128.3.1539","article-title":"Quantitative real-time polymerase chain reaction detection of lymph node lung cancer micrometastasis using carcinoembryonic antigen marker","volume":"128","author":"Nosotti","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.resp.2013.04.014_bib0150","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0006-2952(02)01606-4","article-title":"Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway","volume":"65","author":"Okamoto","year":"2003","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.resp.2013.04.014_bib0155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.imlet.2011.05.007","article-title":"Upregulation of heme oxygenase-1 via PI3K\/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages","volume":"139","author":"Park","year":"2011","journal-title":"Immunology Letters"},{"key":"10.1016\/j.resp.2013.04.014_bib0160","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1164\/ajrccm.155.2.9032182","article-title":"Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity, and mortality","volume":"155","author":"Quinlan","year":"1997","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.resp.2013.04.014_bib0165","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1183\/09031936.98.12061486","article-title":"Reactive oxygen species in acute lung injury","volume":"12","author":"Ruffmann","year":"1998","journal-title":"European Respiratory Journal"},{"key":"10.1016\/j.resp.2013.04.014_bib0170","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":"Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.resp.2013.04.014_bib0175","doi-asserted-by":"crossref","first-page":"14960","DOI":"10.1073\/pnas.93.25.14960","article-title":"Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene","volume":"93","author":"Venugopal","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.resp.2013.04.014_bib0180","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.freeradbiomed.2011.12.006","article-title":"Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage","volume":"52","author":"Wang","year":"2012","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.resp.2013.04.014_bib0185","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1271\/bbb.100110","article-title":"Effects of osthole on migration and invasion in breast cancer cells","volume":"74","author":"Yang","year":"2010","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"10.1016\/j.resp.2013.04.014_bib0190","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ejps.2011.09.020","article-title":"Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice","volume":"44","author":"Zhang","year":"2011","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.resp.2013.04.014_bib0195","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1164\/ajrccm.161.2.9901048","article-title":"Prevention of rabbit acute lung injury by surfactant, inhaled nitric oxide, and pressure support ventilation","volume":"161","author":"Zhou","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904813001195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904813001195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:30:39Z","timestamp":1761604239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904813001195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S1569904813001195"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2013.04.014","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osthole improves acute lung injury in mice by up-regulating Nrf-2\/thioredoxin 1","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2013.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}