{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:11:56Z","timestamp":1790622716480,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Galleon Pharmaceuticals"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.resp.2013.11.005","type":"journal-article","created":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T11:09:28Z","timestamp":1385291368000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Role of central and peripheral opiate receptors in the effects of fentanyl on analgesia, ventilation and arterial blood-gas chemistry in conscious rats"],"prefix":"10.1016","volume":"191","author":[{"given":"Fraser","family":"Henderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan B.","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Discala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veljko","family":"Puskovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh M.","family":"Baby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2013.11.005_bib0005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0006-8993(77)90817-4","article-title":"Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon","volume":"134","author":"Atweh","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2013.11.005_bib0010","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/00000542-199711000-00010","article-title":"Difficult or impossible ventilation after sufenidil-induced anaesthesia is caused primarily by vocal cord closure","volume":"87","author":"Bennett","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0015","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0028-3908(92)90034-M","article-title":"The neuropharmacology of loperamide-induced emesis in the ferret: the role of the area postrema, vagus, opiate and 5-HT3 receptors","volume":"31","author":"Bhandari","year":"1992","journal-title":"Neuropharmacology"},{"issue":"Suppl. 1","key":"10.1016\/j.resp.2013.11.005_bib0020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0024-3205(83)90530-1","article-title":"Quaternary derivatives of narcotic antagonists: stereochemical requirements at the chiral nitrogen for in vitro and in vivo activity","volume":"33","author":"Bianchetti","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2013.11.005_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/00000542-199003000-00023","article-title":"Fentanyl is devoid of major effects on coronary vasoreactivity and myocardial metabolism in experimental animals","volume":"72","author":"Blaise","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/00002018-199819030-00002","article-title":"Adverse effects of opioid agonists and agonist\u2013antagonists in anaesthesia","volume":"19","author":"Bowdle","year":"1998","journal-title":"Drug Saf."},{"key":"10.1016\/j.resp.2013.11.005_bib0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00213-002-1195-y","article-title":"Comparison of the discriminative and neuroendocrine effects of centrally penetrating kappa-opioid agonists in rhesus monkeys","volume":"164","author":"Butelman","year":"2002","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.resp.2013.11.005_bib0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(96)00363-9","article-title":"Quantitative autoradiography of peripheral opioid binding sites in rat lung","volume":"310","author":"Cabot","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0045","doi-asserted-by":"crossref","first-page":"R723","DOI":"10.1152\/ajpregu.00669.2004","article-title":"Brown adipose tissue thermogenesis contributes to fentanyl-evoked hyperthermia","volume":"288","author":"Cao","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.resp.2013.11.005_bib0050","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/WNR.0b013e32835271d1","article-title":"Paraventricular nucleus anandamide signaling alters eating and substrate oxidation","volume":"23","author":"Chapman","year":"2012","journal-title":"Neuroreport"},{"key":"10.1016\/j.resp.2013.11.005_bib0055","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/bja\/69.6.595","article-title":"Effect of fentanyl on ventilatory resistances during barbiturate general anaesthesia","volume":"69","author":"Cohendy","year":"1992","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2013.11.005_bib0060","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/153537020222700602","article-title":"\u03bc-1 Opioid receptor stimulation decreases body temperature in conscious, unrestrained neonatal rats","volume":"227","author":"Colman","year":"2002","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.resp.2013.11.005_bib0065","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00000542-199804000-00009","article-title":"Sex-related differences in the influence of morphine on ventilatory control in humans","volume":"88","author":"Dahan","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0070","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/ALN.0b013e3181c38c25","article-title":"Incidence, reversal, and prevention of opioid-induced respiratory depression","volume":"112","author":"Dahan","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0075","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2174\/1381612043453036","article-title":"Peripherally restricted opioid agonists as novel analgesic agents","volume":"10","author":"DeHaven-Hudkins","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.resp.2013.11.005_bib0080","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0022-3565(25)33602-5","article-title":"Subclasses of opioids based on body temperature change in rats: acute subcutaneous administration","volume":"225","author":"Geller","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0085","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(89)90703-6","article-title":"Fentanyl-induced airway hyperreactivity in the guinea pig","volume":"159","author":"Gentil","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2210-6-3","article-title":"Pharmacological profiles of opioid ligands at kappa opioid receptors","volume":"6","author":"Gharagozlou","year":"2006","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0095","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/pupt.2001.0305","article-title":"Endogenous opioids as mediators of asthma","volume":"14","author":"Groneberg","year":"2001","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0100","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0196-9781(99)00075-3","article-title":"Electron microscopic observation of mu-opioid receptor in the rat area postrema","volume":"20","author":"Guan","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.resp.2013.11.005_bib0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0163-7258(00)00059-0","article-title":"Neuropharmacology of control of respiratory rhythm and pattern in mature mammals","volume":"86","author":"Haji","year":"2000","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(03)00951-0","article-title":"Distribution of mu receptors in the ventral respiratory group neurons; immunohistochemical and pharmacological studies in decerebrate cats","volume":"351","author":"Haji","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2013.11.005_bib0115","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1113\/jphysiol.2009.171678","article-title":"Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo","volume":"587","author":"Hajiha","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2013.11.005_bib0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0952-0600(92)90036-G","article-title":"Opiate action in the pulmonary circulation","volume":"5","author":"Hakim","year":"1992","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0125","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-8993(91)90441-W","article-title":"Characterization of opioid-sensitive neurons in the anteroventral third ventricle region of polydipsic inbred mice in vitro","volume":"538","author":"Hattori","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2013.11.005_bib0130","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jpain.2008.09.011","article-title":"Methadone antinociception is dependent on peripheral opioid receptors","volume":"10","author":"He","year":"2009","journal-title":"J. Pain"},{"key":"10.1016\/j.resp.2013.11.005_bib0135","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-3565(24)29586-0","article-title":"Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist","volume":"297","author":"Huang","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0140","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.23870","article-title":"Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system","volume":"58","author":"Inglis","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.resp.2013.11.005_bib0145","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1096\/fasebj.7.8.8500693","article-title":"Sensory circumventricular organs and brain homeostatic pathways","volume":"7","author":"Johnson","year":"1993","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2013.11.005_bib0150","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1399-6576.2009.02115.x","article-title":"The potential for mu-opioid receptor agonists to be anti-emetic in humans: a review of clinical data","volume":"54","author":"Johnston","year":"2010","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.resp.2013.11.005_bib0155","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1164\/rccm.201001-0047OC","article-title":"Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats","volume":"182","author":"Kanbar","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2013.11.005_bib0160","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/00000542-198810000-00017","article-title":"The influence of fentanyl upon cerebral high-energy metabolites, lactate, and glucose during severe hypoxia in the rat","volume":"69","author":"Keykhah","year":"1988","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0165","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/00000542-199709000-00028","article-title":"Effects of intracoronary fentanyl on left ventricular mechanoenergetics in the excised cross-circulated canine heart","volume":"87","author":"Kohno","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0170","first-page":"H1537","article-title":"Role of nitrosyl factors in the hemodynamic adjustments to heat stress in the rat","volume":"273","author":"Kregel","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2013.11.005_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-3806(98)00149-7","article-title":"Mu- and delta-opioid receptor densities in respiratory-related brainstem regions of neonatal swine","volume":"112","author":"Laferriere","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.resp.2013.11.005_bib0180","first-page":"870","article-title":"Sufentanil-related respiratory depression and antinociception in the dog. Mediation by different receptor types","volume":"52","author":"Latasch","year":"2002","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.resp.2013.11.005_bib0185","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-2999(02)01715-6","article-title":"Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal","volume":"445","author":"Lewanowitsch","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0190","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0006-8993(02)04117-3","article-title":"Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates","volume":"964","author":"Lewanowitsch","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2013.11.005_bib0195","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.lfs.2005.05.062","article-title":"Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide","volume":"78","author":"Lewanowitsch","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2013.11.005_bib0200","first-page":"849","article-title":"Reduced nociceptive effects of intravenous serotonin (5-HT) in the spontaneously hypertensive rat","volume":"A13","author":"Lewis","year":"1991","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.resp.2013.11.005_bib0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0022-3565(25)20062-3","article-title":"Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms","volume":"232","author":"Ling","year":"1985","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0210","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0306-4522(03)00591-8","article-title":"Presynaptic delta opioid receptors differentially modulate rhythm and pattern generation in the ventral respiratory group of the rat","volume":"121","author":"Lonergan","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2013.11.005_bib0215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1569-9048(03)00173-3","article-title":"Mu opioid receptors in rat ventral medulla: effects of endomorphin-1 on phrenic nerve activity","volume":"138","author":"Lonergan","year":"2003","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2013.11.005_bib0220","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00495865","article-title":"The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties","volume":"319","author":"Magnan","year":"1982","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0225","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1213\/00000539-198912000-00012","article-title":"Fentanyl inhibits the canine carotid chemoreceptor reflex","volume":"69","author":"Mayer","year":"1989","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2013.11.005_bib0230","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.resp.2013.07.007","article-title":"l-Cysteine ethyl ester reverses the deleterious effects of morphine on arterial blood-gas chemistry in tracheotomized rats","volume":"189","author":"Mendoza","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2013.11.005_bib0235","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/bja\/63.6.710","article-title":"Cerebral effects of fentanyl in dogs","volume":"63","author":"Milde","year":"1989","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2013.11.005_bib0240","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1213\/00000539-199002000-00002","article-title":"Effects of sufentanil on cerebral circulation and metabolism in dogs","volume":"70","author":"Milde","year":"1990","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2013.11.005_bib0245","first-page":"31","article-title":"Comparison of hemodynamic effects of morphine, butorphanol, buprenorphine and pentazocine on ICU patients","volume":"32","author":"Mitaka","year":"1985","journal-title":"Bull. Tokyo Med. Dent. Univ."},{"key":"10.1016\/j.resp.2013.11.005_bib0250","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1139\/y99-001","article-title":"On the barometric method for measurements of ventilation, and its use in small animals","volume":"76","author":"Mortola","year":"1998","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0255","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/01.RES.72.1.20","article-title":"Endothelin as a neuropeptide. Cardiovascular effects in the brainstem of normotensive rats","volume":"72","author":"Mosqueda-Garcia","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2013.11.005_bib0260","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.4065\/83.10.1116","article-title":"Development of peripheral opioid antagonists\u2019 new insights into opioid effects","volume":"83","author":"Moss","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.resp.2013.11.005_bib0265","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF03178274","article-title":"Transdermal fentanyl: pharmacology and toxicology","volume":"5","author":"Nelson","year":"2009","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.resp.2013.11.005_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-6576.1989.tb02849.x","article-title":"Chest wall rigidity during fentanyl and midazolam-fentanyl induction: ventiltory and hemodynamic effects","volume":"33","author":"Niedhart","year":"1989","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.resp.2013.11.005_bib0275","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1073\/pnas.73.10.3729","article-title":"Opiate receptor: autoradiographic localization in rat brain","volume":"73","author":"Pert","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.resp.2013.11.005_bib0280","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cpt1978233281","article-title":"Hemodynamic and respiratory effects of morphine and butorphanol","volume":"23","author":"Popio","year":"1978","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0285","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0026-895X(25)09932-8","article-title":"Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors","volume":"45","author":"Raynor","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0290","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0304-3959(00)00365-1","article-title":"Peripheral and preemptive opioid antinociception in a mouse visceral pain model","volume":"89","author":"Reichert","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.resp.2013.11.005_bib0295","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/000331978203300108","article-title":"Effect of fentanyl on myocardial metabolism during ischemia","volume":"33","author":"Reneman","year":"1982","journal-title":"Angiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0300","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF03008710","article-title":"Respiratory mechanical properties during fentanyl and alfentanil anaesthesia","volume":"39","author":"Ruiz Neto","year":"1992","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.resp.2013.11.005_bib0305","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1097\/00000542-199905000-00017","article-title":"Sex differences in morphine-induced ventilatory depression reside within the peripheral chemoreflex loop","volume":"90","author":"Sarton","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0310","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12272-013-0072-z","article-title":"A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats","volume":"36","author":"Savi\u0107 Vujovi\u0107","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.resp.2013.11.005_bib0315","first-page":"296","article-title":"Effect of butorphanol and morphine on pulmonary mechanics, arterial blood pressure and venous plasma histamine in the anesthetized dog","volume":"233","author":"Schurig","year":"1978","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0320","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1164\/ajrccm\/142.4.895","article-title":"Differential roles of opioid receptors in respiration, respiratory disease, and opiate-induced respiratory depression","volume":"142","author":"Shook","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2013.11.005_bib0325","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coph.2008.12.009","article-title":"Peripheral mechanisms of opioid analgesia","volume":"9","author":"Stein","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0330","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1378\/chest.107.1.139","article-title":"Alveolar-arterial oxygen gradient in the assessment of acute pulmonary embolism","volume":"107","author":"Stein","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.resp.2013.11.005_bib0335","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainresrev.2008.12.017","article-title":"Peripheral mechanisms of pain and analgesia","volume":"60","author":"Stein","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.resp.2013.11.005_bib0340","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1210\/en.2010-0195","article-title":"Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in rats","volume":"151","author":"Stengel","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.resp.2013.11.005_bib0345","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/00000542-199604000-00036","article-title":"Alveolar oxygen partial pressure, alveolar carbon dioxide partial pressure, and the alveolar gas equation","volume":"84","author":"Story","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0350","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0022-3565(24)37867-X","article-title":"Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception","volume":"287","author":"Su","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.resp.2013.11.005_bib0355","first-page":"379","article-title":"Effects of fentanyl on pulmonary airway dynamics in the rabbit","volume":"35","author":"Taguchi","year":"1986","journal-title":"Masui"},{"issue":"2 Suppl.","key":"10.1016\/j.resp.2013.11.005_bib0360","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.36076\/ppj.2008\/11\/S133","article-title":"Opioid pharmacology","volume":"11","author":"Trescot","year":"2008","journal-title":"Pain Physician"},{"key":"10.1016\/j.resp.2013.11.005_bib0365","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/0024-3205(83)90325-9","article-title":"Receptor binding, antagonist, and withdrawal precipitating properties of opiate antagonists","volume":"32","author":"Valentino","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2013.11.005_bib0370","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fphys.2013.00094","article-title":"Practical aspects of estimating energy components in rodents","volume":"4","author":"van Klinken","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2013.11.005_bib0375","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3959(99)00068-8","article-title":"Antagonistic effects of naloxone and naloxonazine on sufentanil-induced antinociception and respiratory depression in rats","volume":"1983","author":"Verborgh","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.resp.2013.11.005_bib0380","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0091-3057(98)00238-X","article-title":"The effects of intravenous naltrindole and naltrindole 5\u2032-isothiocyanate on sufentanil-induced respiratory depression and antinociception in rats","volume":"63","author":"Verborgh","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.resp.2013.11.005_bib0385","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1399-6576.1997.tb04806.x","article-title":"Interaction between sufentanil and U-50488H with respect to antinociception and respiratory depression in rats","volume":"41","author":"Verborgh","year":"1997","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.resp.2013.11.005_bib0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.47.1.1","article-title":"Some statistical methods useful in circulation research","volume":"47","author":"Wallenstein","year":"1980","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2013.11.005_bib0395","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(03)00182-4","article-title":"Morphological evidence of endomorphin as an agonist for the mu-opioid receptor in the rat spinal cord","volume":"341","author":"Wang","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2013.11.005_bib0400","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0014-2999(82)90177-7","article-title":"Opioids increase laryngeal resistance and motoneuron activity in the recurrent laryngeal nerve","volume":"80","author":"Willette","year":"1982","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0405","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(83)90463-6","article-title":"Pulmonary resistance and compliance changes evoked by pulmonary opiate receptor stimulation","volume":"91","author":"Willette","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0410","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0160-5402(87)90033-7","article-title":"The in situ isolated larynx for evaluating peripheral opiate receptor antagonists","volume":"17","author":"Willette","year":"1987","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.resp.2013.11.005_bib0415","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00000542-197808000-00012","article-title":"Tracheal constriction by morphine and by fentanyl in man","volume":"49","author":"Yasuda","year":"1978","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2013.11.005_bib0420","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0306-3623(90)91013-H","article-title":"Multiple opioid receptors mediate the respiratory depressant effects of fentanyl-like drugs in the rat","volume":"21","author":"Yeadon","year":"1990","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.resp.2013.11.005_bib0425","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.resp.2013.02.028","article-title":"Co-activation of \u03bc- and \u03b4-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite","volume":"186","author":"Young","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2013.11.005_bib0430","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/S0024-3205(00)00434-3","article-title":"Lung opioid receptors: pharmacology and possible target for nebulized morphine in dyspnea","volume":"66","author":"Zebraski","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2013.11.005_bib0435","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0014-5793(96)00312-2","article-title":"The region in the mu opioid receptor conferring selectivity for sufentanil over the delta receptor is different from that over the kappa receptor","volume":"384","author":"Zhu","year":"1996","journal-title":"FEBS Lett."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904813003819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904813003819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:31:28Z","timestamp":1761604288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904813003819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":87,"alternative-id":["S1569904813003819"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2013.11.005","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of central and peripheral opiate receptors in the effects of fentanyl on analgesia, ventilation and arterial blood-gas chemistry in conscious rats","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2013.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}