{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:42:23Z","timestamp":1761604943335,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.resp.2014.05.001","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T13:16:13Z","timestamp":1399641373000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Lung mechanical changes following bronchoaspiration in a porcine model: Differentiation of direct and indirect mechanisms"],"prefix":"10.1016","volume":"199","author":[{"given":"Gergely H.","family":"Fodor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Pet\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1niel","family":"\u00c9rces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1d\u00e1m L.","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barna","family":"Babik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2014.05.001_bib0005","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/ALN.0b013e318173f64f","article-title":"Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization","volume":"108","author":"Amigoni","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.05.001_bib0010","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/ALN.0b013e318297d487","article-title":"Unilateral acid aspiration augments the effects of ventilator lung injury in the contralateral lung","volume":"119","author":"Amigoni","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.05.001_bib0015","doi-asserted-by":"crossref","first-page":"R177","DOI":"10.1186\/cc11659","article-title":"Effects of respiratory mechanics on the capnogram phases: importance of dynamic compliance of the respiratory system","volume":"16","author":"Babik","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.resp.2014.05.001_bib0020","first-page":"569416","article-title":"Cytotoxicity and induction of inflammation by pepsin in acid in bronchial epithelial cells","author":"Bathoorn","year":"2011","journal-title":"Int. J. Inflam."},{"key":"10.1016\/j.resp.2014.05.001_bib0025","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1034\/j.1399-3003.1999.13e19.x","article-title":"Volumetric capnography in patients with acute lung injury: effects of positive end-expiratory pressure","volume":"13","author":"Blanch","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2014.05.001_bib0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1213\/ane.0b013e31819bcbb5","article-title":"The effects of lung recruitment on the Phase III slope of volumetric capnography in morbidly obese patients","volume":"109","author":"Bohm","year":"2009","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2014.05.001_bib0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/archsurg.1973.01350130051011","article-title":"Aspiration pneumonia. Clinical outcome following documented aspiration","volume":"106","author":"Cameron","year":"1973","journal-title":"Arch. Surg."},{"key":"10.1016\/j.resp.2014.05.001_bib0040","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1164\/ajrccm.155.3.9117033","article-title":"PEEP and low tidal volume ventilation reduce lung water in porcine pulmonary edema","volume":"155","author":"Colmenero-Ruiz","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0045","first-page":"227","article-title":"Nebulised adrenaline in acute severe asthma: comparison with salbutamol","volume":"71","author":"Coupe","year":"1987","journal-title":"Eur. J. Respir. Dis."},{"key":"10.1016\/j.resp.2014.05.001_bib0050","doi-asserted-by":"crossref","first-page":"L699","DOI":"10.1152\/ajplung.00229.2004","article-title":"Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates","volume":"288","author":"Davidson","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0055","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/bja\/83.3.453","article-title":"Pulmonary aspiration of gastric contents in anaesthesia","volume":"83","author":"Engelhardt","year":"1999","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2014.05.001_bib0060","doi-asserted-by":"crossref","first-page":"L191","DOI":"10.1152\/ajplung.00274.2012","article-title":"Airway epithelium is a predominant source of endogenous airway GABA and contributes to relaxation of airway smooth muscle tone","volume":"304","author":"Gallos","year":"2013","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0065","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1152\/jappl.1991.70.4.1511","article-title":"Neutrophil accumulations due to pulmonary thromboxane synthesis mediate acid aspiration injury","volume":"70","author":"Goldman","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0070","first-page":"13","article-title":"Leukocytes mediate acid aspiration-induced multiorgan edema","volume":"114","author":"Goldman","year":"1993","journal-title":"Surgery"},{"key":"10.1016\/j.resp.2014.05.001_bib0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1152\/jappl.1981.51.2.335","article-title":"Increased pulmonary vascular permeability following acid aspiration","volume":"51","author":"Grimbert","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1152\/jappl.1992.72.1.168","article-title":"Input impedance and peripheral inhomogeneity of dog lungs","volume":"72","author":"Hantos","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0085","first-page":"H2528","article-title":"Invasive hemodynamics and force\u2013frequency relationships in open- versus closed-chest mice","volume":"273","author":"Hoit","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0090","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1213\/00000539-198907000-00017","article-title":"Acute acid aspiration lung injury in the rat: biphasic pathogenesis","volume":"69","author":"Kennedy","year":"1989","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2014.05.001_bib0095","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/00000542-199210000-00023","article-title":"The role of neutrophils, oxidants, and proteases in the pathogenesis of acid pulmonary injury","volume":"77","author":"Knight","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.05.001_bib0100","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1399-6576.2008.01581.x","article-title":"Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury","volume":"52","author":"Ko","year":"2008","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.resp.2014.05.001_bib0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.pupt.2006.11.010","article-title":"Acid-sensitive vagal sensory pathways and cough","volume":"20","author":"Kollarik","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2014.05.001_bib0110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0300-9572(79)90012-1","article-title":"Gas exchange, pulmonary mechanics and haemodynamics in adult respiratory distress syndrome: experimental results in Lewe miniature pigs","volume":"7","author":"Kuckelt","year":"1979","journal-title":"Resuscitation"},{"key":"10.1016\/j.resp.2014.05.001_bib0115","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1152\/japplphysiol.01535.2012","article-title":"Pulmonary surfactant synthesis after unilateral lung injury in mice","volume":"116","author":"Lamonica","year":"2014","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2014.05.001_bib0120","first-page":"305","article-title":"Aspiration pneumonia: a ten-year review","volume":"45","author":"LeFrock","year":"1979","journal-title":"Am. Surg."},{"key":"10.1016\/j.resp.2014.05.001_bib0125","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1152\/jappl.1996.80.5.1841","article-title":"Airway inhomogeneities contribute to apparent lung tissue mechanics during constriction","volume":"80","author":"Lutchen","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0130","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1056\/NEJM200103013440908","article-title":"Aspiration pneumonitis and aspiration pneumonia","volume":"344","author":"Marik","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0135","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/MCP.0b013e32834397d6","article-title":"Pulmonary aspiration syndromes","volume":"17","author":"Marik","year":"2011","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0140","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00000542-198803000-00005","article-title":"Capsaicin sensitive afferents contribute to acute airway edema following tracheal instillation of hydrochloric acid or gastric juice in the rat","volume":"68","author":"Martling","year":"1988","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.05.001_bib0145","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1399-6576.2008.01842.x","article-title":"Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury","volume":"53","author":"Marumo","year":"2009","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.resp.2014.05.001_bib0150","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/j.jss.2010.10.015","article-title":"A porcine model of acute lung injury by instillation of gastric fluid","volume":"166","author":"Meers","year":"2011","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.resp.2014.05.001_bib0155","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0002-9378(16)39829-5","article-title":"The aspiration of stomach contents into the lungs during obstetric anesthesia","volume":"52","author":"Mendelson","year":"1946","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.resp.2014.05.001_bib0160","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1164\/ajrccm.157.1.9602095","article-title":"Role of CD11b in focal acid-induced pneumonia and contralateral lung injury in rats","volume":"157","author":"Motosugi","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0165","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/08820130701361053","article-title":"The role of alveolar macrophages in the pathogenesis of aspiration pneumonitis","volume":"36","author":"Nader-Djalal","year":"2007","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.resp.2014.05.001_bib0170","first-page":"321","article-title":"Pulmonary inflammation and airway hyperresponsiveness in a mouse model of asthma complicated by acid aspiration","volume":"59","author":"Nemzek","year":"2009","journal-title":"Comp. Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0175","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12245-009-0088-9","article-title":"Correlations between capnographic waveforms and peak flow meter measurement in emergency department management of asthma","volume":"2","author":"Nik Hisamuddin","year":"2009","journal-title":"Int. J. Emerg. Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0180","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1097\/00000542-199611000-00021","article-title":"Soluble complement receptor type 1 inhibited the systemic organ injury caused by acid instillation into a lung","volume":"85","author":"Nishizawa","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.05.001_bib0185","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1399-6576.1986.tb02373.x","article-title":"Aspiration during anaesthesia: a computer-aided study of 185,358 anaesthetics","volume":"30","author":"Olsson","year":"1986","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.resp.2014.05.001_bib0190","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1183\/09031936.06.00105005","article-title":"Crackle-sound recording to monitor airway closure and recruitment in ventilated pigs","volume":"27","author":"Petak","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2014.05.001_bib0195","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1152\/jappl.1998.84.5.1680","article-title":"Repeated measurements of airway and parenchymal mechanics in rats by using low-frequency oscillations","volume":"84","author":"Petak","year":"1998","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2014.05.001_bib0200","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/CCM.0b013e31820a856b","article-title":"Aspiration-induced lung injury","volume":"39","author":"Raghavendran","year":"2011","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0205","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1164\/ajrccm.159.2.9804022","article-title":"Bronchoconstriction induced by citric acid inhalation in guinea pigs: role of tachykinins, bradykinin, and nitric oxide","volume":"159","author":"Ricciardolo","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0210","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s00134-006-0117-6","article-title":"PEEP has beneficial effects on inflammation in the injured and no deleterious effects on the noninjured lung after unilateral lung acid instillation","volume":"32","author":"Schreiber","year":"2006","journal-title":"Intens. Care Med."},{"key":"10.1016\/j.resp.2014.05.001_bib0215","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1099-0496(200002)29:2<94::AID-PPUL3>3.0.CO;2-B","article-title":"Ventilation inhomogeneity assessed by nitrogen washout and ventilation-perfusion mismatch by capnography in stable and induced airway obstruction","volume":"29","author":"Stromberg","year":"2000","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2014.05.001_bib0220","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/0016-5085(84)90082-9","article-title":"Comparison of airway responses following tracheal or esophageal acidification in the cat","volume":"87","author":"Tuchman","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1016\/j.resp.2014.05.001_bib0225","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00000542-199301000-00010","article-title":"Clinical significance of pulmonary aspiration during the perioperative period","volume":"78","author":"Warner","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.05.001_bib0230","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1152\/jappl.1997.83.4.1090","article-title":"Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway","volume":"83","author":"Weiser","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.05.001_bib0235","first-page":"728","article-title":"Tracheal mucosal damage after aspiration. A scanning electron microscope study","volume":"124","author":"Wynne","year":"1981","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2014.05.001_bib0240","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0196-0644(96)70005-7","article-title":"Utility of the expiratory capnogram in the assessment of bronchospasm","volume":"28","author":"Yaron","year":"1996","journal-title":"Ann. Emerg. Med."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904814001141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904814001141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:32:49Z","timestamp":1761604369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904814001141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":48,"alternative-id":["S1569904814001141"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2014.05.001","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung mechanical changes following bronchoaspiration in a porcine model: Differentiation of direct and indirect mechanisms","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2014.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}