{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:36:33Z","timestamp":1772627793636,"version":"3.50.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Research Grants Council, Hong Kong","award":["HKU 766110M"],"award-info":[{"award-number":["HKU 766110M"]}]},{"name":"Research Grants Council, Hong Kong","award":["HKU 7510\/06M"],"award-info":[{"award-number":["HKU 7510\/06M"]}]},{"name":"University Research Committee, HKU"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.resp.2014.09.014","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T07:36:11Z","timestamp":1412408171000},"page":"6-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Expressions of angiotensin and cytokine receptors in the paracrine signaling of the carotid body in hypoxia and sleep apnea"],"prefix":"10.1016","volume":"209","author":[{"given":"Man Lung","family":"Fung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2014.09.014_bib0005","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1469-7793.1998.773bj.x","article-title":"Angiotensin AT1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity","volume":"510","author":"Allen","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0010","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1152\/jappl.1997.83.1.95","article-title":"Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system","volume":"83","author":"Bao","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0015","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1183\/09031936.01.17407280","article-title":"Angiotensin converting enzyme in patients with sleep apnoea syndrome: plasma activity and gene polymorphisms","volume":"17","author":"Barcelo","year":"2001","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2014.09.014_bib0720","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"New Eng. J. Med."},{"key":"10.1016\/j.resp.2014.09.014_bib0620","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1128\/MCB.19.3.1950","article-title":"Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity","volume":"19","author":"Bonizzi","year":"1999","journal-title":"Mole. Cell Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0020","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.rmed.2003.07.008","article-title":"High levels of interleukin-6 in the exhaled breath condensate of patients with COPD","volume":"97","author":"Bucchioni","year":"2003","journal-title":"Respir. Med."},{"key":"10.1016\/j.resp.2014.09.014_bib0025","doi-asserted-by":"crossref","first-page":"L1314","DOI":"10.1152\/ajplung.00454.2001","article-title":"Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia","volume":"282","author":"Chen","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0030","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00424-001-0728-2","article-title":"Chronic hypoxia enhances endothelin-1-induced intracellular calcium elevation in rat carotid body chemoreceptors and up-regulates ETA receptor expression","volume":"443","author":"Chen","year":"2002","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0035","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1183\/09031936.00109906","article-title":"Exacerbations of chronic obstructive pulmonary disease","volume":"29","author":"Celli","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2014.09.014_bib0040","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S1357-2725(02)00262-5","article-title":"The renin\u2013angiotensin and the kallikrein\u2013kinin systems","volume":"35","author":"Campbell","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0045","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s00018-004-4246-1","article-title":"The angiotensin IV\/AT4 receptor","volume":"61","author":"Chai","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.resp.2014.09.014_bib0950","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.mad.2004.08.009","article-title":"Nuclear factor kappa B activation by NADPH oxidases","volume":"125","author":"Clark","year":"2004","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.resp.2014.09.014_bib0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00158109","article-title":"Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link","volume":"36","author":"Del Rio","year":"2010","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2014.09.014_bib0055","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2011.04.028","article-title":"Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia","volume":"1395","author":"Del Rio","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2014.09.014_bib0060","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1183\/09031936.00141511","article-title":"Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia","volume":"39","author":"Del Rio","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2014.09.014_bib0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-94-007-4584-1_28","article-title":"Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia","volume":"758","author":"Del Rio","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00043.2008","article-title":"Pathophysiology of sleep apnea","volume":"90","author":"Dempsey","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2014.09.014_bib0075","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1002\/jnr.22107","article-title":"Interleukin-6 increases intracellular Ca2+ concentration and induces catecholamine secretion in rat carotid body glomus cells","volume":"87","author":"Fan","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.resp.2014.09.014_bib0080","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1113\/expphysiol.2008.041152","article-title":"Lipopolysaccharide-induced carotid body inflammation in cats: functional manifestations, histopathology and involvement of tumour necrosis factor-alpha","volume":"93","author":"Fern\u00e1ndez","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0085","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.resp.2010.12.014","article-title":"Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome","volume":"175","author":"Fern\u00e1ndez","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0090","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1152\/jappl.1992.72.5.1978","article-title":"Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea","volume":"72","author":"Fletcher","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0095","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1161\/01.HYP.19.6.555","article-title":"Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats","volume":"19","author":"Fletcher","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2014.09.014_bib0110","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1152\/jappl.2001.90.4.1600","article-title":"Invited review: physiological consequences of intermittent hypoxia: systemic blood pressure","volume":"90","author":"Fletcher","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/sleep\/26.1.15","article-title":"Sympathetic overactivity in the etiology of hypertension of obstructive sleep apnea","volume":"26","author":"Fletcher","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.resp.2014.09.014_bib0120","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s004240000445","article-title":"Functional expression of angiotensin II receptors in type-I cells of the rat carotid body","volume":"441","author":"Fung","year":"2001","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2014.09.014_bib0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/joe.0.1730305","article-title":"Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors","volume":"173","author":"Fung","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.resp.2014.09.014_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874192400701010001","article-title":"Carotid Body AT4 Receptor expression and its upregulation in chronic hypoxia","volume":"1","author":"Fung","year":"2007","journal-title":"Open Cardiovasc. Med. J."},{"key":"10.1016\/j.resp.2014.09.014_bib0135","first-page":"23","article-title":"Mechanisms of maladaptive responses of peripheral chemoreceptors to intermittent hypoxia in sleep-disordered breathing","volume":"66","author":"Fung","year":"2014","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.resp.2014.09.014_bib0145","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: from natural stimuli to sensory discharges","volume":"74","author":"Gonzalez","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2014.09.014_bib0150","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1152\/jappl.1999.86.1.298","article-title":"Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia","volume":"86","author":"Greenberg","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0155","doi-asserted-by":"crossref","first-page":"R1282","DOI":"10.1152\/ajpregu.1989.257.6.R1282","article-title":"Peripheral arterial chemoreceptors and reflex control of sodium and water homeostasis","volume":"257","author":"Honig","year":"1989","journal-title":"Am. J. Physiol.\u2014Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0160","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.3109\/10641968909038181","article-title":"Measurement of angiotensin II concentration in rat plasma: pathophysiological applications","volume":"11","author":"Huang","year":"1989","journal-title":"Clin. Exp. Hypertens., A Theory Pract."},{"key":"10.1016\/j.resp.2014.09.014_bib0165","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4067\/S0716-97602005000400004","article-title":"Cardiovascular and ventilatory acclimatization induced by chronic intermittent hypoxia: a role for the carotid body in the pathophysiology of sleep apnea","volume":"38","author":"Iturriaga","year":"2005","journal-title":"Biol. Res."},{"key":"10.1016\/j.resp.2014.09.014_bib0170","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/j.1440-1681.2009.05213.x","article-title":"Carotid body potentiation induced by intermittent hypoxia: implications for cardiorespiratory changes induced by sleep apnoea","volume":"36","author":"Iturriaga","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0175","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1113\/expphysiol.2013.075820","article-title":"Intermittent hypoxia: endothelin-1 and hypoxic carotid body chemosensory potentiation","volume":"98","author":"Iturriaga","year":"2013","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0180","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1113\/expphysiol.2014.078873","article-title":"The human carotid body releases acetylcholine, ATP and cytokines during hypoxia","volume":"99","author":"K\u00e5hlin","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0185","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.resp.2004.11.007","article-title":"Changes in ventilatory responses to hypercapnia and hypoxia after intermittent hypoxia in humans","volume":"146","author":"Katayama","year":"2005","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0190","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1164\/ajrccm.153.2.8564092","article-title":"Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma","volume":"153","author":"Keatings","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2014.09.014_bib0200","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0167-0115(02)00068-X","article-title":"A locally generated angiotensin system in rat carotid body","volume":"107","author":"Lam","year":"2002","journal-title":"Regul. Pept."},{"key":"10.1016\/j.resp.2014.09.014_bib0205","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0303-7207(03)00087-X","article-title":"Chronic hypoxia activates a local angiotensin-generating system in rat carotid body","volume":"203","author":"Lam","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.resp.2014.09.014_bib0210","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/japplphysiol.00684.2003","article-title":"Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body","volume":"96","author":"Lam","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0215","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00418-008-0437-4","article-title":"Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body","volume":"130","author":"Lam","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0220","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00418-011-0900-5","article-title":"Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways","volume":"137","author":"Lam","year":"2012","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0225","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1113\/expphysiol.2013.074591","article-title":"Up-regulation of a local renin-angiotensin system in the carotid body during chronic intermittent hypoxia","volume":"99","author":"Lam","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0230","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1677\/joe.0.1670517","article-title":"Chronic hypoxia upregulates the expression and function of AT1 receptor in rat carotid body","volume":"167","author":"Leung","year":"2000","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.resp.2014.09.014_bib0235","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S1357-2725(01)00042-5","article-title":"Regulation of oxygen sensing in peripheral arterial chemoreceptors","volume":"33","author":"Lahiri","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0240","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1113\/jphysiol.2006.110700","article-title":"Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid body in heart failure: role of angiotensin II","volume":"575","author":"Li","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0245","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cardiores.2006.03.017","article-title":"Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits","volume":"71","author":"Li","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.resp.2014.09.014_bib0250","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.cardiores.2007.04.006","article-title":"NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits","volume":"75","author":"Li","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.resp.2014.09.014_bib0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1152\/ajplung.90383.2008","article-title":"Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body","volume":"296","author":"Liu","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0260","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1152\/ajplung.00132.2011","article-title":"Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity","volume":"301","author":"Liu","year":"2011","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0265","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.resp.2011.03.006","article-title":"A chronic pain: inflammation-dependent chemoreceptor adaptation in rat carotid body","volume":"178","author":"Liu","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0270","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/ham.2012.1011","article-title":"Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body","volume":"13","author":"Liu","year":"2012","journal-title":"High Altitude Med. Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0275","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.resp.2010.02.003","article-title":"Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor","volume":"171","author":"Marcus","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0280","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1152\/physrev.1994.74.3.543","article-title":"Peripheral chemoreceptors and cardiovascular regulation","volume":"74","author":"Marshall","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2014.09.014_bib0290","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1152\/jappl.2001.91.5.2143","article-title":"Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade","volume":"91","author":"Mazzeo","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0295","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1152\/ajpregu.00463.2003","article-title":"Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats","volume":"286","author":"McGuire","year":"2004","journal-title":"Am. J. Phys.\u2014Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0300","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1113\/jphysiol.2012.231084","article-title":"The human carotid body transcriptome with focus on oxygen sensing and inflammation\u2014a comparative analysis","volume":"15","author":"Mkrtchian","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0305","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0895-7061(02)03267-3","article-title":"Abnormal vasoactive hormones and 24-hour blood pressure in obstructive sleep apnea","volume":"16","author":"Moller","year":"2003","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.resp.2014.09.014_bib0315","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1113\/expphysiol.2009.049312","article-title":"Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors","volume":"95","author":"Nurse","year":"2010","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0320","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1113\/jphysiol.2013.269829","article-title":"Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors","volume":"592","author":"Nurse","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0325","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1073\/pnas.1734109100","article-title":"Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas","volume":"100","author":"Peng","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.resp.2014.09.014_bib0330","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1152\/japplphysiol.00876.2003","article-title":"Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups","volume":"97","author":"Peng","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0335","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1523\/JNEUROSCI.4768-08.2009","article-title":"NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia","volume":"29","author":"Peng","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2014.09.014_bib0340","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1152\/japplphysiol.00022.2011","article-title":"Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase","volume":"111","author":"Peng","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0345","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.resp.2011.03.024","article-title":"Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats","volume":"178","author":"Popa","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0350","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.resp.2013.02.017","article-title":"Inflammatory and immunomodulatory mechanisms in the carotid body","volume":"187","author":"Porzionato","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0355","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1089\/ars.2007.1732","article-title":"ROS signaling in systemic and cellular responses to chronic intermittent hypoxia","volume":"9","author":"Prabhakar","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2014.09.014_bib0360","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/physrev.00030.2011","article-title":"Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia inducible factors 1 and 2","volume":"92","author":"Prabhakar","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2014.09.014_bib0365","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1113\/jphysiol.2011.218156","article-title":"Losartan abolishes oxidative stress induced by intermittent hypoxia in humans","volume":"589","author":"Pialoux","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0370","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1113\/jphysiol.2004.072033","article-title":"Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia","volume":"560","author":"Rey","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0375","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.ph.40.030178.002113","article-title":"The renin\u2013angiotensin system","volume":"40","author":"Reid","year":"1978","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0380","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1111\/j.1460-9568.2007.05586.x","article-title":"IL-1beta inhibits IK and increases [Ca2+]i in the carotid body glomus cells and increases carotid sinus nerve \ufb01rings in the rat","volume":"25","author":"Shu","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2014.09.014_bib0385","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1152\/physrev.00012.2009","article-title":"The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis","volume":"90","author":"Teppema","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2014.09.014_bib0390","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1177\/002215540205001213","article-title":"Strong expression of interleukin-1 receptor type I in the rat carotid body","volume":"50","author":"Wang","year":"2002","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.resp.2014.09.014_bib0395","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ar.a.20310","article-title":"Morphological evidence for existence of IL-6 receptor alpha in the glomus cells of rat carotid body","volume":"288","author":"Wang","year":"2006","journal-title":"Anat. Rec., A: Discoveries Mol. Cell. Evol. Biol."},{"key":"10.1016\/j.resp.2014.09.014_bib0400","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1513\/pats.200408-039MS","article-title":"Local and systemic inflammation in chronic obstructive pulmonary disease","volume":"2","author":"Wouters","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2014.09.014_bib0405","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.resp.2011.03.025","article-title":"Immunosensory signalling by carotid body chemoreceptors","volume":"178","author":"Zapata","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.09.014_bib0410","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00418-007-0346-y","article-title":"Up-regulation of IL-1 receptor type I and tyrosine hydroxylase in the rat carotid body following intraperitoneal injection of IL-1beta","volume":"128","author":"Zhang","year":"2007","journal-title":"Histochem. Cell Biol."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904814002511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904814002511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:35:43Z","timestamp":1761604543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904814002511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":79,"alternative-id":["S1569904814002511"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2014.09.014","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expressions of angiotensin and cytokine receptors in the paracrine signaling of the carotid body in hypoxia and sleep apnea","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2014.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}