{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:39:51Z","timestamp":1792784391732,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Science Research Fund"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.resp.2014.10.013","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T18:08:16Z","timestamp":1414174096000},"page":"61-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats"],"prefix":"10.1016","volume":"205","author":[{"given":"Nobuo","family":"Umezawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Arisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Sakuraba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazu-ichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-ichi","family":"Kuwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2014.10.013_bib0005","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.96.2.748","article-title":"Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems","volume":"96","author":"Date","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2014.10.013_bib0010","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2014.10.013_bib0015","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/00000542-199311000-00004","article-title":"The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers","volume":"79","author":"Egan","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.10.013_bib0020","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1152\/ajplegacy.1971.221.2.535","article-title":"Relationship between phrenic nerve activity and ventilation","volume":"221","author":"Eldridge","year":"1971","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2014.10.013_bib0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neures.2004.07.009","article-title":"Dopaminergic modulation on respiratory rhythm in rat brainstem-spinal cord preparation","volume":"50","author":"Fujii","year":"2004","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.resp.2014.10.013_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/157015910790909502","article-title":"General anesthetic actions on GABA(A) receptors","volume":"8","author":"Garcia","year":"2010","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.resp.2014.10.013_bib0035","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2012.10.028","article-title":"The respiratory chemoreception conundrum: light at the end of the tunnel?","volume":"1511","author":"Guyenet","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2014.10.013_bib0040","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.lfs.2009.06.010","article-title":"Ventrolateral lesions at the ponto-medullary junction and the effects of noradrenaline on respiratory rhythm in rat brainstem\u2014spinal cord preparations","volume":"85","author":"Ito","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2014.10.013_bib0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1213\/01.ANE.0000117226.45704.65","article-title":"A nuronal mechanism of propofol-induced central respiratory depression in newborn rats","volume":"99","author":"Kashiwagi","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2014.10.013_bib0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/ALN.0b013e31817f5baf","article-title":"Neural mechanisms of sevoflurane-induced respiratory depression in newborn rats","volume":"109","author":"Kuribayashi","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.10.013_bib0055","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1213\/ANE.0b013e31828842f0","article-title":"The impact of hypothermia on emergence from isoflurane anesthesia in orexin neuron-ablated mice","volume":"116","author":"Kuroki","year":"2013","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2014.10.013_bib0060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.resp.2010.02.006","article-title":"State-dependent central chemoreception: a role of orexin","volume":"173","author":"Kuwaki","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.10.013_bib0065","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0006-8993(97)01476-5","article-title":"Effects of extracellular calcium and magnesium on central respiratory control in the brainstem-spinal cord of neonatal rat","volume":"786","author":"Kuwana","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2014.10.013_bib0070","first-page":"55","article-title":"Expression of orexin A and B in the porcine hypothalamus during the oestrous cycle","volume":"64","author":"Maleszka","year":"2013","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2014.10.013_bib0075","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2014.10.013_bib0080","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/bja\/aeh217","article-title":"Effects of propofol and sevoflurane on the excitability of rat spinal motoneurones and nociceptive reflexes in vitro","volume":"93","author":"Matute","year":"2004","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2014.10.013_bib0085","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1476-5381.1985.tb09439.x","article-title":"A pharmacological study on respiratory rhythm in the isolated brainstem-spinal cord preparation of the newborn rat","volume":"86","author":"Murakoshi","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2014.10.013_bib0090","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/japplphysiol.00679.2006","article-title":"Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice","volume":"102","author":"Nakamura","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2014.10.013_bib0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","article-title":"Distribution of orexin neurons in the adult rat brain","volume":"827","author":"Nambu","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2014.10.013_bib0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0034-5687(00)00161-4","article-title":"Multiple sites for central chemoreception: their roles in response sensitivity and in sleep and wakefulness","volume":"122","author":"Nattie","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2014.10.013_bib0105","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (Orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2014.10.013_bib0110","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.resp.2014.10.013_bib0115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrn2092","article-title":"The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness","volume":"8","author":"Sakurai","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.resp.2014.10.013_bib0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00540-010-1071-6","article-title":"Effects of orexin-A on propofol anesthesia in rats","volume":"25","author":"Shirasaka","year":"2011","journal-title":"J. Anesth."},{"key":"10.1016\/j.resp.2014.10.013_bib0125","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.cmet.2009.09.013","article-title":"Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system","volume":"10","author":"Sthiuchi","year":"2009","journal-title":"Cell. Metab."},{"key":"10.1016\/j.resp.2014.10.013_bib0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.resp.2014.06.006","article-title":"Orexin induces excitation of respiratory neuronal network in the isolated brainstem-spinal cord of neonatal rat","volume":"17","author":"Sugita","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2014.10.013_bib0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00000542-200507000-00012","article-title":"Sevoflurane enhances gamma-aminobutyric acid type A receptor function and overall inhibition of inspiratory premotor neurons in a decerebrate dog model","volume":"103","author":"Stucke","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.10.013_bib0140","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/00000542-199311000-00005","article-title":"Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery","volume":"79","author":"Westmoreland","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2014.10.013_bib0145","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nchembio.1340","article-title":"A propofol binding site on mammalian GABAA receptors identified by photolabeling","volume":"9","author":"Yip","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.resp.2014.10.013_bib0150","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1523\/JNEUROSCI.22-15-06303.2002","article-title":"Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance","volume":"22","author":"Yang","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2014.10.013_bib0155","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1213\/ANE.0b013e3182645ea3","article-title":"Orexin-A facilitates emergence from propofol anesthesia in the rat","volume":"115","author":"Zhang","year":"2012","journal-title":"Anesth. Analg."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904814002857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904814002857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:33:49Z","timestamp":1761604429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904814002857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":31,"alternative-id":["S1569904814002857"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2014.10.013","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2014.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}