{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:41:59Z","timestamp":1788838919430,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"US EPA-Duke University Cooperative agreement","award":["# CT826514"],"award-info":[{"award-number":["# CT826514"]}]},{"DOI":"10.13039\/501100001677","name":"National Institute of Health","doi-asserted-by":"publisher","award":["HL038095"],"award-info":[{"award-number":["HL038095"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.resp.2015.03.007","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T14:46:58Z","timestamp":1428245218000},"page":"20-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse"],"prefix":"10.1016","volume":"212-214","author":[{"given":"M. Allen","family":"McAlexander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Gavett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Kollarik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Undem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2015.03.007_bib0005","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0900591106","article-title":"A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma","volume":"106","author":"Caceres","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.resp.2015.03.007_bib0010","doi-asserted-by":"crossref","DOI":"10.1152\/japplphysiol.00313.2006","article-title":"Reflex regulation of airway smooth muscle tone","author":"Canning","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jaci.2005.04.005","article-title":"Allergen-induced substance P synthesis in large-diameter sensory neurons innervating the lungs","volume":"116","author":"Chuaychoo","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.resp.2015.03.007_bib0020","doi-asserted-by":"crossref","first-page":"L709","DOI":"10.1152\/ajplung.1999.276.5.L709","article-title":"Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils","volume":"276","author":"Costello","year":"1999","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0025","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1152\/jappl.1991.71.6.2255","article-title":"Dysfunction of M2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge","volume":"71","author":"Fryer","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/enrs.1997.3732","article-title":"Metal and sulfate composition of residual oil fly ash determines airway hyperreactivity and lung injury in rats","volume":"72","author":"Gavett","year":"1997","journal-title":"Environ. Res."},{"key":"10.1016\/j.resp.2015.03.007_bib0035","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1164\/ajrccm.160.6.9901053","article-title":"Residual oil fly ash amplifies allergic cytokines, airway responsiveness, and inflammation in mice","volume":"160","author":"Gavett","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2015.03.007_bib0040","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1113\/jphysiol.2003.042028","article-title":"Capsaicin-sensitive and -insensitive vagal bronchopulmonary C-fibres in the mouse","volume":"551","author":"Kollarik","year":"2003","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.resp.2015.03.007_bib0045","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1172\/JCI115651","article-title":"Airway response to electrical field stimulation in sensitized inbred mice. Passive transfer of increased responsiveness with peribronchial lymph nodes","volume":"89","author":"Larsen","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2015.03.007_bib0050","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1164\/rccm.200311-1488OC","article-title":"Is interleukin-13 critical in maintaining airway hyperresposiveness in allergen-challenged mice?","volume":"170","author":"Leigh","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2015.03.007_bib0055","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1152\/ajpregu.00007.2002","article-title":"Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs","volume":"283","author":"Mazzone","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0060","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093153","article-title":"Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs","volume":"569","author":"Mazzone","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0034-5687(00)00207-3","article-title":"Transmission in autonomic ganglia","volume":"125","author":"Myers","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0070","doi-asserted-by":"crossref","first-page":"L775","DOI":"10.1152\/ajplung.00353.2001","article-title":"Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways","volume":"282","author":"Myers","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0075","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1113\/jphysiol.2010.195339","article-title":"Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs","volume":"588","author":"Nassenstein","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0080","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1165\/rcmb.2003-0373OC","article-title":"Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone","volume":"30","author":"Park","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2015.03.007_bib0085","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1113\/jphysiol.2012.237115","article-title":"Activation of mouse bronchopulmonary C-fibres by serotonin and allergen-ovalbumin challenge","volume":"590","author":"Potenzieri","year":"2012","journal-title":"J. Physiol."},{"issue":"Pt 2","key":"10.1016\/j.resp.2015.03.007_bib0090","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1113\/jphysiol.1996.sp021234","article-title":"Immunomodulation of afferent neurons in guinea-pig isolated airway","volume":"491","author":"Riccio","year":"1996","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.resp.2015.03.007_bib0095","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.186.3.449","article-title":"Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice","volume":"186","author":"Takeda","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.resp.2015.03.007_bib0100","doi-asserted-by":"crossref","first-page":"L599","DOI":"10.1152\/ajplung.00324.2002","article-title":"Receptors and pathways mediating the effects of prostaglandin E2 on airway tone","volume":"284","author":"Tilley","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0105","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1073\/pnas.1411032111","article-title":"Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways","volume":"111","author":"Trankner","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2015.03.007_bib0110","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1067\/mai.2000.110153","article-title":"Neural integration and allergic disease","volume":"106","author":"Undem","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.resp.2015.03.007_bib0115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1152\/jappl.1999.86.1.294","article-title":"Methacholine causes reflex bronchoconstriction","volume":"86","author":"Wagner","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0120","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1113\/jphysiol.2009.173054","article-title":"Mast cell\u2013cholinergic nerve interaction in mouse airways","volume":"587","author":"Weigand","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2015.03.007_bib0125","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.192.3.455","article-title":"Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice","volume":"192","author":"Williams","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.resp.2015.03.007_bib0130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1152\/japplphysiol.01367.2007","article-title":"Sensitizing effects of chronic exposure and acute inhalation of ovalbumin aerosol on pulmonary C fibers in rats","volume":"105","author":"Zhang","year":"2008","journal-title":"J. Appl. Physiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815000749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815000749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:34:34Z","timestamp":1761604474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904815000749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":26,"alternative-id":["S1569904815000749"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2015.03.007","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2015.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}