{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:41:50Z","timestamp":1770910910416,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.resp.2015.08.003","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T14:24:01Z","timestamp":1439562241000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Opposing actions of TRPV4 channel activation in the lung vasculature"],"prefix":"10.1016","volume":"219","author":[{"given":"Sun-Kui","family":"Ke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Bing","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Rong","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2015.08.003_bib0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yjmcc.2012.10.016","article-title":"TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals","volume":"54","author":"Adapala","year":"2013","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.resp.2015.08.003_bib0010","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.RES.0000247065.11756.19","article-title":"Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury","volume":"99","author":"Alvarez","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2015.08.003_bib0015","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/eurheartj\/ehp061","article-title":"Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis","volume":"30","author":"Antoniades","year":"2009","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.resp.2015.08.003_bib0020","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1073\/pnas.1012867108","article-title":"An aquaporin-4\/transient receptor potential vanilloid 4 (AQP4\/TRPV4) complex is essential for cell-volume control in astrocytes","volume":"108","author":"Benfenati","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2015.08.003_bib0025","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American\u2013European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination","volume":"149","author":"Bernard","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.resp.2015.08.003_bib0030","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1074\/jbc.M111.308411","article-title":"Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system","volume":"287","author":"Berrout","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.resp.2015.08.003_bib0035","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/apha.12355","article-title":"Functional TRPV1 and TRPV4 channels along different segments of the renal vasculature","volume":"213","author":"Chen","year":"2015","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.resp.2015.08.003_bib0040","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/FJC.0b013e3181f580d9","article-title":"Endothelium-dependent cerebral artery dilation mediated by transient receptor potential and Ca2+-activated K+ channels","volume":"57","author":"Earley","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.resp.2015.08.003_bib0045","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/01.RES.0000194321.60300.d6","article-title":"TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels","volume":"97","author":"Earley","year":"2005","journal-title":"Circ. Res."},{"issue":"July (17)","key":"10.1016\/j.resp.2015.08.003_bib0050","doi-asserted-by":"crossref","first-page":"H1096","DOI":"10.1152\/ajpheart.00241.2009","article-title":"TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure","volume":"297","author":"Earley","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2015.08.003_bib0055","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cardiores.2007.05.025","article-title":"Adiponectin is a novel humoral vasodilator","volume":"75","author":"Fesus","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.resp.2015.08.003_bib0060","doi-asserted-by":"crossref","first-page":"L923","DOI":"10.1152\/ajplung.00221.2007","article-title":"TRPV4 initiates the acute calcium-dependent permeability increases during ventilator-induced lung injury in isolated mouse lungs","volume":"293","author":"Hamanaka","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2015.08.003_bib0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.0000233356.10630.8a","article-title":"Transient receptor potential channels in cardiovascular function and disease","volume":"99","author":"Inoue","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2015.08.003_bib0070","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1165\/rcmb.2007-0192OC","article-title":"High vascular pressure-induced lung injury requires P450 epoxygenase- dependent activation of TRPV4","volume":"38","author":"Jian","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2015.08.003_bib0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ddmod.2011.04.001","article-title":"Tension measurement in isolated rat and mouse pulmonary artery","volume":"7","author":"Ko","year":"2010","journal-title":"Drug Discov. Today Dis. Models"},{"key":"10.1016\/j.resp.2015.08.003_bib0080","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1161\/01.ATV.0000225698.36212.6a","article-title":"Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation","volume":"26","author":"K\u00f6hler","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.resp.2015.08.003_bib0085","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bbadis.2007.02.013","article-title":"TRP channels in endothelial function and dysfunction","volume":"1772","author":"Kwan","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.resp.2015.08.003_bib0090","doi-asserted-by":"crossref","first-page":"e46065","DOI":"10.1371\/journal.pone.0046065","article-title":"11,12-EET stimulates the association of BK channel \u03b1 and \u03b2(1) subunits in mitochondria to induce pulmonary vasoconstriction","volume":"7","author":"Loot","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2015.08.003_bib0095","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1164\/rccm.200208-966WS","article-title":"Future research directions in acute lung injury: summary of a national heart, lung, and blood institute working group","volume":"167","author":"Matthay","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2015.08.003_bib0100","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1038\/emboj.2008.233","article-title":"Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction","volume":"27","author":"Mederos y Schnitzler","year":"2008","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.resp.2015.08.003_bib0105","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1097\/CCM.0b013e318287ef4a","article-title":"Pulmonary vascular dysfunction induced by high tidal volume mechanical ventilation","volume":"41","author":"Menendez","year":"2013","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.resp.2015.08.003_bib0110","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1096\/fj.06-5772com","article-title":"TRPV4-mediated regulation of epithelial permeability","volume":"20","author":"Reiter","year":"2006","journal-title":"FASEB J."},{"issue":"26","key":"10.1016\/j.resp.2015.08.003_bib0115","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1021\/ol062556i","article-title":"Unusual sterically controlled regioselective lithiation of 3-bromo-5-(4,4'- dimethyl) oxazolinylpyridine. Straightforward access to highly substituted nicotinic acid derivatives","volume":"8","author":"Robert","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.resp.2015.08.003_bib0120","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1523\/JNEUROSCI.0359-11.2011","article-title":"The polymodal ion channel TRPV4 modulates calcium flux, spiking rate and apoptosis of mouse retinal ganglion cells","volume":"19","author":"Ryskamp","year":"2011","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.resp.2015.08.003_bib0125","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1097\/HJH.0b013e32833c20d5","article-title":"Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide","volume":"28","author":"Schleifenbaum","year":"2010","journal-title":"J. Hypertens"},{"issue":"6081","key":"10.1016\/j.resp.2015.08.003_bib0130","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1216283","article-title":"Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function","volume":"336","author":"Sonkusare","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.resp.2015.08.003_bib0135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phrs.2013.09.005","article-title":"TRPV4 channel activation leads to endothelium- dependent relaxation mediated by nitric oxide and endothelium-derived hyperpolarizing factor in rat pulmonary artery","volume":"78","author":"Sukumaran","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.resp.2015.08.003_bib0140","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1537-1891(03)00007-7","article-title":"Role of Ca2+signaling in the regulation of endothelial permeability","volume":"39","author":"Tiruppathi","year":"2002","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.resp.2015.08.003_bib0145","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1056\/NEJMcp052699","article-title":"Clinical practice. Acute pulmonary edema","volume":"353","author":"Ware","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.resp.2015.08.003_bib0150","doi-asserted-by":"crossref","first-page":"C704","DOI":"10.1152\/ajpcell.00099.2013","article-title":"TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension","volume":"305","author":"Xia","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"6","key":"10.1016\/j.resp.2015.08.003_bib0155","doi-asserted-by":"crossref","first-page":"L555","DOI":"10.1152\/ajplung.00005.2011","article-title":"Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension","volume":"302","author":"Yang","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2015.08.003_bib0160","doi-asserted-by":"crossref","first-page":"L1267","DOI":"10.1152\/ajplung.00515.2005","article-title":"Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle","volume":"290","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2015.08.003_bib0165","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1161\/01.RES.0000187473.85419.3e","article-title":"Recent developments in vascular endothelial cell transient receptor potential channels","volume":"97","author":"Yao","year":"2005","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.resp.2015.08.003_bib0170","doi-asserted-by":"crossref","first-page":"C307","DOI":"10.1152\/ajpcell.00153.2011","article-title":"Role of thromboxane A2-activated nonselective cation channels in hypoxic pulmonary vasoconstriction of rat","volume":"302","author":"Yoo","year":"2012","journal-title":"Am. J. Physiol. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2015.08.003_bib0175","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/HYPERTENSIONAHA.112.197566","article-title":"Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction","volume":"61","author":"Zavaritskaya","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2015.08.003_bib0180","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1172\/JCI0214442","article-title":"Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite","volume":"109","author":"Zou","year":"2002","journal-title":"J. Clin. Invest."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481530032X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481530032X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:35:44Z","timestamp":1761604544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156990481530032X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":36,"alternative-id":["S156990481530032X"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2015.08.003","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opposing actions of TRPV4 channel activation in the lung vasculature","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2015.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}