{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:59:03Z","timestamp":1769641143172,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81401109"],"award-info":[{"award-number":["81401109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81401019"],"award-info":[{"award-number":["81401019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31070939"],"award-info":[{"award-number":["31070939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31000648"],"award-info":[{"award-number":["31000648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["GK201402024"],"award-info":[{"award-number":["GK201402024"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.resp.2015.08.008","type":"journal-article","created":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T10:46:13Z","timestamp":1440845173000},"page":"78-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Interleukin-1\u03b2 promotes the neurogenesis of carotid bodies by stimulating the activation of ERK1\/2"],"prefix":"10.1016","volume":"219","author":[{"given":"Fen","family":"Xue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShanShan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Wu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai-Ren","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2015.08.008_bib0005","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jad.2015.04.044","article-title":"IL-6, IL-18, sIL-2R, and TNFalpha proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation","volume":"182","author":"Al-Hakeim","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.resp.2015.08.008_bib0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1742-2094-9-121","article-title":"Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1beta release through the inhibition of Nogo-A expression","volume":"9","author":"Chao","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.resp.2015.08.008_bib0015","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/sj.bjp.0706766","article-title":"Moclobemide upregulated Bcl-2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular-regulated kinase pathway","volume":"148","author":"Chiou","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2015.08.008_bib0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biocel.2014.07.018","article-title":"Interleukin-1beta promotes the LC3-mediated secretory function of osteoclast precursors by stimulating the Ca(2)(+)-dependent activation of ERK","volume":"54","author":"Chung","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.resp.2015.08.008_bib0025","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.resp.2015.08.008_bib0030","doi-asserted-by":"crossref","first-page":"e25213","DOI":"10.1371\/journal.pone.0025213","article-title":"PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1alpha expression in MCF-7 breast cancer cells","volume":"6","author":"Du","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2015.08.008_bib0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1566-0702(00)00219-8","article-title":"Vagal immune-to-brain communication: a visceral chemosensory pathway","volume":"85","author":"Goehler","year":"2000","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.resp.2015.08.008_bib0040","article-title":"Upregulation of IL-1beta\/TGF-beta1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture","author":"Honda","year":"2014","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.resp.2015.08.008_bib0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.resp.2014.11.011","article-title":"Respiratory modulation of sympathetic activity is attenuated in adult rats conditioned with chronic hypobaric hypoxia","volume":"206","author":"Hsieh","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2015.08.008_bib0050","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.brainres.2005.08.059","article-title":"Effects of prolonged hypobaric hypoxia on carotid nerve endings and glomus cells. Changes in intercellular coupling","volume":"1076","author":"Jiang","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2015.08.008_bib0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ydbio.2005.04.004","article-title":"Mash1 is required for glomus cell formation in the mouse carotid body","volume":"283","author":"Kameda","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.resp.2015.08.008_bib0060","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1073\/pnas.0708092105","article-title":"IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress","volume":"105","author":"Koo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2015.08.008_bib0065","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00418-011-0900-5","article-title":"Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways","volume":"137","author":"Lam","year":"2012","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.resp.2015.08.008_bib0070","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00418-008-0437-4","article-title":"Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body","volume":"130","author":"Lam","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.resp.2015.08.008_bib0075","first-page":"271","article-title":"Differential expressions and roles of hypoxia-inducible factor-1alpha, -2alpha and -3alpha in the rat carotid body during chronic and intermittent hypoxia","volume":"23","author":"Lam","year":"2008","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.resp.2015.08.008_bib0080","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/rheumatology\/ker327","article-title":"Hypoxia differentially affects IL-1beta-stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1alpha-dependent manner","volume":"51","author":"Lee","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.resp.2015.08.008_bib0085","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1016\/j.biomaterials.2012.06.044","article-title":"The role of Ras-ERK-IL-1beta signaling pathway in upregulation of elastin expression by human coronary artery smooth muscle cells cultured in 3D scaffolds","volume":"33","author":"Lin","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.resp.2015.08.008_bib0090","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","article-title":"Cellular mechanism of oxygen sensing","volume":"63","author":"Lopez-Barneo","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2015.08.008_bib0095","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/bjp.2008.40","article-title":"A nitric oxide\/Ca(2+)\/calmodulin\/ERK1\/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1beta in human astrocytoma cells","volume":"153","author":"Meini","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2015.08.008_bib0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2007.02.018","article-title":"ERK-dependent and -independent pathways trigger human neural progenitor cell migration","volume":"221","author":"Moors","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.resp.2015.08.008_bib0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2012.09.006","article-title":"Signal processing at mammalian carotid body chemoreceptors","volume":"24","author":"Nurse","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.resp.2015.08.008_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-71857-1_1","article-title":"The mammalian carotid body","volume":"102","author":"Pallot","year":"1987","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"10.1016\/j.resp.2015.08.008_bib0115","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cell.2007.07.043","article-title":"Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body","volume":"131","author":"Pardal","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.resp.2015.08.008_bib0120","first-page":"105","article-title":"Paroxetine up-regulates neurogenesis in hippocampus-derived neural stem cell from fetal rats","volume":"375","author":"Peng","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.resp.2015.08.008_bib0125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2013.12.013","article-title":"An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia","volume":"156","author":"Platero-Luengo","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.resp.2015.08.008_bib0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.resp.2013.02.017","article-title":"Inflammatory and immunomodulatory mechanisms in the carotid body","volume":"187","author":"Porzionato","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2015.08.008_bib0135","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1111\/j.1460-9568.2007.05586.x","article-title":"IL-1beta inhibits IK and increases [Ca2+]i in the carotid body glomus cells and increases carotid sinus nerve firings in the rat","volume":"25","author":"Shu","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2015.08.008_bib0140","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ni1078","article-title":"Elaborate interactions between the immune and nervous systems","volume":"5","author":"Steinman","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.resp.2015.08.008_bib0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuroscience.2013.07.061","article-title":"IL-1beta induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFkappaB\/Ca(2)(+)-calmodulin\/ERK mitogen-activated protein kinase signaling pathway","volume":"252","author":"Sticozzi","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2015.08.008_bib0150","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1007\/s11064-007-9390-1","article-title":"Hypoxia\/reoxygenation stimulates proliferation through PKC-dependent activation of ERK and Akt in mouse neural progenitor cells","volume":"32","author":"Sung","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.resp.2015.08.008_bib0155","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1177\/002215540205001213","article-title":"Strong expression of interleukin-1 receptor type I in the rat carotid body","volume":"50","author":"Wang","year":"2002","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.resp.2015.08.008_bib0160","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ar.a.20310","article-title":"Morphological evidence for existence of IL-6 receptor alpha in the glomus cells of rat carotid body","volume":"288","author":"Wang","year":"2006","journal-title":"Anat. Rec. A Discov. Mol. Cell. Evol. Biol."},{"key":"10.1016\/j.resp.2015.08.008_bib0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2013.03.003","article-title":"Sustained IL-1beta expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+neural precursor cells","volume":"32","author":"Wu","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.resp.2015.08.008_bib0170","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.cr.7310126","article-title":"Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation","volume":"17","author":"Xiao","year":"2007","journal-title":"Cell Res."},{"key":"10.1016\/j.resp.2015.08.008_bib0175","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00418-007-0346-y","article-title":"Up-regulation of IL-1 receptor type I and tyrosine hydroxylase in the rat carotid body following intraperitoneal injection of IL-1beta","volume":"128","author":"Zhang","year":"2007","journal-title":"Histochem. Cell Biol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815300379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815300379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:35:16Z","timestamp":1761604516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904815300379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":35,"alternative-id":["S1569904815300379"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2015.08.008","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-1\u03b2 promotes the neurogenesis of carotid bodies by stimulating the activation of ERK1\/2","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2015.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}