{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:19:32Z","timestamp":1773886772585,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.resp.2015.09.001","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T11:48:30Z","timestamp":1442058510000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Hydrogen sulfide attenuates hypoxia-induced respiratory suppression in anesthetized adult rats"],"prefix":"10.1016","volume":"220","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2015.09.001_bib0005","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2015.09.001_bib0010","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0169-328X(99)00189-8","article-title":"Bcl-2 prolongs neuronal survival during hypoxia-induced apoptosis","volume":"72","author":"Banasiak","year":"1999","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.resp.2015.09.001_bib0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408448409029321","article-title":"A critical review of the literature on hydrogen sulfide toxicity","volume":"13","author":"Beauchamp","year":"1984","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.resp.2015.09.001_bib0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/aob\/mcf118","article-title":"Antioxidants, oxidative damage and oxygen deprivation stress: a review","volume":"91","author":"Blokhina","year":"2003","journal-title":"Ann. Bot."},{"key":"10.1016\/j.resp.2015.09.001_bib0025","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1681\/ASN.2008121269","article-title":"Hydrogen sulfide-induced hypometabolism prevents renal ischemia\/reperfusion injury","volume":"20","author":"Bos","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.resp.2015.09.001_bib0030","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1440-1681.2009.05289.x","article-title":"Hydrogen sulfide protects H9c2 cells against chemical hypoxia induced cell injuries","volume":"37","author":"Chen","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0035","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuroscience.2012.12.047","article-title":"Site-specific hydrogen sulfide-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats","volume":"233","author":"Chen","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2015.09.001_bib0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2013.07.009","article-title":"KATP channels of parafacial respiratory group (pFRG) neurons are involved in H2S-mediated central inhibition of respiratory rhythm in medullary slices of neonatal rats","volume":"1527","author":"Chen","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2015.09.001_bib0045","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1074\/jbc.M808026200","article-title":"H2S biogenesis by human cystathionine gammalyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia","volume":"284","author":"Chiku","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2015.09.001_bib0050","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neulet.2008.04.020","article-title":"Long-term hypothermia reduces infarct volume in aged rats after focal ischemia","volume":"438","author":"Florian","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2015.09.001_bib0055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.bi.44.070175.001051","article-title":"Superoxide dismutases","volume":"44","author":"Fridovich","year":"1975","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.resp.2015.09.001_bib0060","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbrc.2004.04.094","article-title":"Endogenous hydrogen sulfide regulation of myocardial injury induced by iso-proterenol","volume":"318","author":"Geng","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.resp.2015.09.001_bib0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0034-5687(99)00072-9","article-title":"Brainstem amino acid neurotransmitters and hypoxic ventilatory response","volume":"118","author":"Hoop","year":"1999","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0070","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.neuroscience.2008.08.025","article-title":"Endogenous hydrogen sulfide is involved in regulation of respiration inmedullary slice of neonatal rats","volume":"156","author":"Hu","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2015.09.001_bib0075","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/ars.2008.2132","article-title":"A source of hydrogen sulfide and a mechanism of its release in the brain","volume":"11","author":"Ishigami","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2015.09.001_bib0080","doi-asserted-by":"crossref","first-page":"H801","DOI":"10.1152\/ajpheart.00377.2008","article-title":"Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling","volume":"295","author":"Jha","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0085","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/lt.21810","article-title":"Role of hydrogen sulfide hepatic ischemia-reperfusion-induced injury in rats","volume":"15","author":"Kang","year":"2009","journal-title":"Liver Transpl."},{"key":"10.1016\/j.resp.2015.09.001_bib0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/MN:26:1:013","article-title":"Hydrogen sulfide as a neuromodulator","volume":"26","author":"Kimura","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0095","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidatstress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2015.09.001_bib0100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","volume":"41","author":"Kimura","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.resp.2015.09.001_bib0105","first-page":"327","article-title":"Bcl-2\/Bax: a rheostat that regulates an anti-oxidant pathway and cell death","volume":"4","author":"Korsmeyer","year":"1993","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.resp.2015.09.001_bib0110","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/WNR.0000000000000090","article-title":"Effects of H2S on the central regulation of respiration in adult rats","volume":"25","author":"Li","year":"2014","journal-title":"Neuroreport"},{"key":"10.1016\/j.resp.2015.09.001_bib0115","first-page":"74","article-title":"The effect of oxidative stress in myocardial cell injury in mice exposed to chronic intermittent hypoxia","volume":"123","author":"Liu","year":"2010","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.resp.2015.09.001_bib0120","first-page":"4","article-title":"Hydrogen sulfide (H2S)\u2014the third gas of interest forpharmacologists","volume":"59","author":"Lowicka","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.resp.2015.09.001_bib0125","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1517","article-title":"Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons","volume":"8","author":"McKay","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.resp.2015.09.001_bib0130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.resp.2013.05.001","article-title":"The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullar respiratory centers of neonatal rats subjected to in utero cigarette smoke exposure","volume":"188","author":"Nie","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.resp.2010.04.006","article-title":"Protect effect of hydrogen sulfide on hypoxic respiratory suppression in medullary slice of neonatal rats","volume":"171","author":"Pan","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0140","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.resp.2011.06.013","article-title":"Protective action of endogenously generated H2S on hypoxia-induced respiratory suppression and its relation to antioxidation and down-regulation of c-fos mRNA in medullary slices of neonatal rats","volume":"178","author":"Pan","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0145","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2005"},{"key":"10.1016\/j.resp.2015.09.001_bib0150","doi-asserted-by":"crossref","first-page":"R491","DOI":"10.1152\/ajpregu.00614.2005","article-title":"Free radical biology and medicine: it\u2019s a gas, man!","volume":"291","author":"Pryor","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2015.09.001_bib0155","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.addr.2009.02.002","article-title":"Effects of nitrite on modulating ROS generation following ischemia and reperfusion","volume":"61","author":"Raat","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.resp.2015.09.001_bib0160","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.pa.32.040192.000545","article-title":"Toxicology of hydrogen sulfide","volume":"32","author":"Reiffenstein","year":"1992","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.resp.2015.09.001_bib0165","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2015.09.001_bib0170","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1098\/rstb.1985.0168","article-title":"Oxidative stress: damage to intact cells and organs","volume":"311","author":"Sies","year":"1985","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B"},{"key":"10.1016\/j.resp.2015.09.001_bib0175","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1683005","article-title":"Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals","volume":"254","author":"Smith","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.resp.2015.09.001_bib0180","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1098\/rstb.2009.0082","article-title":"Chemosensory pathways in the brainstem controlling cardiorespiratory activity","volume":"364","author":"Spyer","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B"},{"key":"10.1016\/j.resp.2015.09.001_bib0185","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2060267","article-title":"Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat","volume":"206","author":"Stipanuk","year":"1982","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2015.09.001_bib0190","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.resp.2015.09.001_bib0195","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0006-8993(97)01249-3","article-title":"Effects of NMDA and non-NMDA receptor antagonists on the medullary inspiratory neuronal activity during spontaneous augmented breaths in anesthetized rats","volume":"781","author":"Takeda","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2015.09.001_bib0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuint.2009.08.008","article-title":"Hydrogen sulfide: a novel signaling molecule in the central nervous system","volume":"56","author":"Tan","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.resp.2015.09.001_bib0205","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.brainres.2009.07.010","article-title":"The effects of indomethacin on caspases, glutathione level and lipid peroxidation in the newborn rats with hypoxic-ischemic cerebral injury","volume":"1289","author":"Taskin","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2015.09.001_bib0210","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroscience.2010.02.006","article-title":"Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel\/protein kinase C\/extracellular signal-regulated kinase\/heat shock protein 90pathway","volume":"167","author":"Tay","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2015.09.001_bib0215","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/152308603768295249","article-title":"The gasotransmitter role of hydrogen sulfide","volume":"5","author":"Wang","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2015.09.001_bib0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/BSR20100003","article-title":"Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection","volume":"31","author":"Wang","year":"2011","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.resp.2015.09.001_bib0225","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2015.09.001_bib0230","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1745-7254.2008.00796.x","article-title":"Hydrogen sulfide regulates lung tissue-oxidized glutathione and total antioxidant capacity in hypoxic rats","volume":"29","author":"Wei","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.resp.2015.09.001_bib0235","doi-asserted-by":"crossref","first-page":"e24966","DOI":"10.1371\/journal.pone.0024966","article-title":"Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy","volume":"6","author":"Xie","year":"2011","journal-title":"PLoS One"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815300380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815300380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T12:18:10Z","timestamp":1567167490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904815300380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":47,"alternative-id":["S1569904815300380"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2015.09.001","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide attenuates hypoxia-induced respiratory suppression in anesthetized adult rats","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2015.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}