{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:44:53Z","timestamp":1775799893622,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001134","name":"Australia-India Strategic Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001636","name":"University College Cork","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.resp.2015.10.018","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T22:48:39Z","timestamp":1446763719000},"page":"76-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Diaphragm muscle weakness and increased UCP-3 gene expression following acute hypoxic stress in the mouse"],"prefix":"10.1016","volume":"226","author":[{"given":"Andrew J.","family":"O\u2019Leary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken D.","family":"O\u2019Halloran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2015.10.018_bib0005","first-page":"13","article-title":"Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete \u03b2-oxidation","volume":"25","author":"Aguer","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2015.10.018_bib0010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1164\/rccm.201205-0954SO","article-title":"Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms","volume":"187","author":"Batt","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2015.10.018_bib0015","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00376208","article-title":"Effects of endurance training at high altitude on diaphragm muscle properties","volume":"422","author":"Bigard","year":"1992","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0020","doi-asserted-by":"crossref","first-page":"e70524","DOI":"10.1371\/journal.pone.0070524","article-title":"Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model","volume":"8","author":"Bruells","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2015.10.018_bib0025","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1183\/09031936.00139512","article-title":"Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development","volume":"43","author":"Carberry","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2015.10.018_bib0030","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.4049\/jimmunol.1000701","article-title":"NF-\u03baB links CO2 sensing to innate immunity and inflammation in mammalian cells","volume":"185","author":"Cummins","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.resp.2015.10.018_bib0035","doi-asserted-by":"crossref","DOI":"10.7457\/cmep.v2i1.e5","article-title":"Acute vs chronic hypoxia: what are the consequences for skeletal muscle mass?","author":"Deldicque","year":"2013","journal-title":"Cell. Mol. Exerc. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0040","doi-asserted-by":"crossref","first-page":"R1659","DOI":"10.1152\/ajpregu.00550.2009","article-title":"Downregulation of Akt\/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia","volume":"298","author":"Favier","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0045","doi-asserted-by":"crossref","first-page":"R575","DOI":"10.1152\/ajpregu.00320.2009","article-title":"Mitochondrial content and distribution changes specific to mouse diaphragm after chronic normobaric hypoxia","volume":"298","author":"Gamboa","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0050","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00424-011-1057-8","article-title":"Muscle endurance and mitochondrial function after chronic normobaric hypoxia: contrast of respiratory and limb muscles","volume":"463","author":"Gamboa","year":"2012","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0055","doi-asserted-by":"crossref","first-page":"e0131068","DOI":"10.1371\/journal.pone.0131068","article-title":"Autophagy-associated atrophy and metabolic remodeling of the mouse diaphragm after short-term intermittent hypoxia","volume":"10","author":"Giordano","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2015.10.018_bib0060","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1164\/rccm.201412-2214OC","article-title":"Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients","volume":"191","author":"Hooijman","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2015.10.018_bib0065","doi-asserted-by":"crossref","DOI":"10.1186\/cc10023","article-title":"Clinical review: ventilator-induced diaphragmatic dysfunction\u2014human studies confirm animal model findings!","author":"Jaber","year":"2011","journal-title":"Crit. Care"},{"key":"10.1016\/j.resp.2015.10.018_bib0070","doi-asserted-by":"crossref","first-page":"C834","DOI":"10.1152\/ajpcell.00579.2003","article-title":"The molecular basis of skeletal muscle atrophy","volume":"287","author":"Jackman","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0075","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.freeradbiomed.2008.09.026","article-title":"Upregulation of uncoupling protein-3 in skeletal muscle during exercise: a potential antioxidant function","volume":"46","author":"Jiang","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2015.10.018_bib0080","doi-asserted-by":"crossref","first-page":"12485","DOI":"10.1073\/pnas.0806015105","article-title":"Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle","volume":"105","author":"Jurynec","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2015.10.018_bib0085","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.bbamcr.2012.02.018","article-title":"Understanding selenoprotein function and regulation through the use of rodent models","volume":"1823","author":"Kasaikina","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.resp.2015.10.018_bib0090","first-page":"11","article-title":"Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest","volume":"41","author":"Levett","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2015.10.018_bib0095","unstructured":"Lewis, P., Sheehan, D., O\u2019Halloran, K.D., 2014. Chronic sustained hypoxia induces temporal redox and metabolic remodelling and atrophy signalling in mouse diaphragm muscle, Physiology (London, UK) Proc. Physiol. Soc. 31, C11 (OC)."},{"key":"10.1016\/j.resp.2015.10.018_bib0100","doi-asserted-by":"crossref","DOI":"10.1007\/s12576-015-0381-8","article-title":"Improved tolerance of acute severe hypoxic stress in chronic hypoxic diaphragm is nitric oxide-dependent","author":"Lewis","year":"2015","journal-title":"J. Physiol. Sci."},{"issue":"122","key":"10.1016\/j.resp.2015.10.018_bib0105","article-title":"Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle","volume":"6","author":"Lewis","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1alpha: a key regulator of energy metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.resp.2015.10.018_bib0115","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1183\/09031936.00079810","article-title":"Chronic hypoxia increases rat diaphragm muscle endurance and sodium-potassium ATPase pump content","volume":"37","author":"McMorrow","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2015.10.018_bib0120","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00109-008-0308-4","article-title":"NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases","volume":"86","author":"Mourkioti","year":"2008","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.resp.2015.10.018_bib0125","first-page":"19","article-title":"Ventilator-induced diaphragmatic dysfunction","volume":"16","author":"Petrof","year":"2010","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.resp.2015.10.018_bib0130","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1152\/japplphysiol.00873.2014","article-title":"Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm","volume":"118","author":"Picard","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0135","doi-asserted-by":"crossref","first-page":"10605","DOI":"10.1074\/jbc.M110.211466","article-title":"Exercise increases mitochondrial PGC-1\u03b1 content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis","volume":"286","author":"Safdar","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2015.10.018_bib0140","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/ars.2009.2865","article-title":"Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins","volume":"12","author":"Shchedrina","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2015.10.018_bib0145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0034-5687(90)90060-C","article-title":"The effect of pH and hypoxia on function and intracellular pH of the rat diaphragm","volume":"79","author":"Shee","year":"1990","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0150","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1113\/jphysiol.2013.254698","article-title":"CrossTalk opposing view: the diaphragm muscle does not atrophy as a result of inactivity","volume":"591","author":"Sieck","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2015.10.018_bib0155","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/cc12792","article-title":"Diaphragm weakness in mechanically ventilated critically ill patients","volume":"17","author":"Supinski","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.resp.2015.10.018_bib0160","doi-asserted-by":"crossref","first-page":"E622","DOI":"10.1152\/ajpendo.2000.279.3.E622","article-title":"UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase","volume":"279","author":"Zhou","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815300720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904815300720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:37:45Z","timestamp":1761604665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904815300720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":32,"alternative-id":["S1569904815300720"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2015.10.018","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diaphragm muscle weakness and increased UCP-3 gene expression following acute hypoxic stress in the mouse","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2015.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}