{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:38:07Z","timestamp":1776724687188,"version":"3.51.2"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.resp.2016.08.001","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T05:51:52Z","timestamp":1470894712000},"page":"60-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Cerebral microvascular blood flow and CO2 reactivity in pulmonary arterial hypertension"],"prefix":"10.1016","volume":"233","author":[{"given":"Erika","family":"Treptow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayron F.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta P.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Clara","family":"Alencar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloara Vieira","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaquelina S.","family":"Ota-Arakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz E.","family":"Nery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia Rita","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Alberto","family":"Neder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2016.08.001_bib0005","doi-asserted-by":"crossref","first-page":"R1473","DOI":"10.1152\/ajpregu.91008.2008","article-title":"Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation","volume":"296","author":"Ainslie","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0010","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/PSY.0b013e31829f91da","article-title":"The interactive effects of cerebral perfusion and depression on cognitive function in older adults with heart failure","volume":"75","author":"Alosco","year":"2013","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.resp.2016.08.001_bib0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jns.2014.02.008","article-title":"Decreased physical activity predicts cognitive dysfunction and reduced cerebral blood flow in heart failure","volume":"339","author":"Alosco","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.resp.2016.08.001_bib0020","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2015.04.014","article-title":"Examining the regional and cerebral depth-dependent BOLD cerebrovascular reactivity response at 7T","volume":"114","author":"Bhogal","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.resp.2016.08.001_bib0025","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1212\/01.wnl.0000224699.75283.18","article-title":"Sildenafil increases cerebrovascular reactivity: a transcranial Doppler study","volume":"66","author":"Brenner","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.resp.2016.08.001_bib0030","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1212\/01.wnl.0000173835.12308.bb","article-title":"Sildenafil increases cerebrovascular reactivity: a transcranial Doppler study","volume":"65","author":"Diomedi","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.resp.2016.08.001_bib0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.sleep.2012.11.013","article-title":"Sleep apnea in precapillary pulmonary hypertension","volume":"14","author":"Dumitrascu","year":"2013","journal-title":"Sleep Med."},{"key":"10.1016\/j.resp.2016.08.001_bib0040","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2011.02.066","article-title":"Carbon dioxide influence on nitric oxide production in endothelial cells and astrocytes: cellular mechanisms","volume":"1386","author":"Fathi","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2016.08.001_bib0045","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.neuroimage.2012.03.049","article-title":"A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application","volume":"63","author":"Ferrari","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.resp.2016.08.001_bib0050","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1177\/2047487313494293","article-title":"Optimizing the evaluation of excess exercise ventilation for prognosis assessment in pulmonary arterial hypertension","volume":"21","author":"Ferreira","year":"2014","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0055","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/archneurpsyc.1928.02210120090008","article-title":"Cerebral circulation. III. The vasomotor control of cerebral vessels","volume":"19","author":"Forbes","year":"1928","journal-title":"Arch. Neuro Psychiatry"},{"key":"10.1016\/j.resp.2016.08.001_bib0060","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1183\/13993003.01032-2015","volume":"46","author":"Gali\u00e8","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2016.08.001_bib0065","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/euhj.1999.1742","article-title":"Cerebrovascular reactivity is impaired in patients with cardiac failure","volume":"21","author":"Georgiadis","year":"2000","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.resp.2016.08.001_bib0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/B978-0-444-53491-0.00016-X","article-title":"Autonomic nervous system control of the cerebral circulation","volume":"117","author":"Goadsby","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.resp.2016.08.001_bib0075","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00008506-200207000-00008","article-title":"Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study","volume":"14","author":"Gora","year":"2002","journal-title":"J. Neurosurg. Anesthesiol."},{"issue":"108","key":"10.1016\/j.resp.2016.08.001_bib0080","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1152\/japplphysiol.01269.2009","article-title":"Near-infrared spectroscopy and indocyanine green derived blood flow index for noninvasive measurement of muscle perfusion during exercise","volume":"1985","author":"Habazettl","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0085","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1378\/chest.07-0619","article-title":"Mixed-expired and end-tidal CO2 distinguish between ventilation and perfusion defects during exercise testing in patients with lung and heart diseases","volume":"132","author":"Hansen","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.resp.2016.08.001_bib0090","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1183\/09031936.00134506","article-title":"Prognostic value of blood gas analyses in patients with idiopathic pulmonary arterial hypertension","volume":"29","author":"Hoeper","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2016.08.001_bib0095","series-title":"The AAM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Iber","year":"2007"},{"issue":"116","key":"10.1016\/j.resp.2016.08.001_bib0100","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1152\/japplphysiol.00637.2013","article-title":"Hyperventilation, cerebral perfusion, and syncope","volume":"1985","author":"Immink","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/01.HYP.36.3.383","article-title":"Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans","volume":"36","author":"Jordan","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2016.08.001_bib0110","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1378\/chest.125.1.182","article-title":"Cerebral oxygenation during exercise in cardiac patients","volume":"125","author":"Koike","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.resp.2016.08.001_bib0115","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/00004647-199804000-00013","article-title":"Noninvasive measurement of regional cerebral blood flow by near-infrared spectroscopy and indocyanine green","volume":"18","author":"Kuebler","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.resp.2016.08.001_bib0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1161\/CIRCRESAHA.115.301146","article-title":"Pulmonary arterial hypertension: the clinical syndrome","volume":"115","author":"Lai","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2016.08.001_bib0125","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/ane.12279","article-title":"Regional cerebral blood flow following single-dose and continuous-dose tadalafil after stroke","volume":"130","author":"Lorberboym","year":"2014","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.resp.2016.08.001_bib0130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00408-014-9667-5","article-title":"Effects of exercise and vasodilators on cerebral tissue oxygenation in pulmonary hypertension","volume":"193","author":"M\u00fcller-Mottet","year":"2015","journal-title":"Lung"},{"key":"10.1016\/j.resp.2016.08.001_bib0135","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1183\/09031936.05.00034905","article-title":"Standardisation of the single-breath determination of carbon monoxide uptake in the lung","volume":"26","author":"Macintyre","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2016.08.001_bib0140","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2016.08.001_bib0145","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1183\/09059180.00007414","article-title":"The right ventricle in pulmonary arterial hypertension","volume":"23","author":"Naeije","year":"2014","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.resp.2016.08.001_bib0150","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1183\/09031936.00091609","article-title":"Clinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension","volume":"34","author":"Naeije","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2016.08.001_bib0155","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1513\/AnnalsATS.201412-558CC","article-title":"Exercise intolerance in pulmonary arterial hypertension. The role of cardiopulmonary exercise testing","volume":"12","author":"Neder","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"107","key":"10.1016\/j.resp.2016.08.001_bib0160","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1152\/japplphysiol.00573.2009","article-title":"Cerebral blood flow during exercise: mechanisms of regulation","volume":"1985","author":"Ogoh","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0165","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1183\/09031936.00090913","article-title":"Heart failure impairs cerebral oxygenation during exercise in patients with COPD","volume":"42","author":"Oliveira","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2016.08.001_bib0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.resp.2015.10.005","article-title":"Effects of heart failure on cerebral blood flow in COPD: Rest and exercise","volume":"221","author":"Oliveira","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1152\/jappl.1981.51.1.185","article-title":"Effect of CO2 set point on ventilatory response to exercise","volume":"51","author":"Oren","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0180","first-page":"601515","article-title":"Cerebral endothelial function determined by cerebrovascular reactivity to L-arginine","author":"Pretnar-Oblak","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.resp.2016.08.001_bib0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1378\/chest.89.1.39","article-title":"Augmented ventilatory response to exercise in pulmonary hypertension","volume":"89","author":"Theodore","year":"1986","journal-title":"Chest"},{"key":"10.1016\/j.resp.2016.08.001_bib0190","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/bja\/aet122","article-title":"Sympathetic regulation of cerebral blood flow in humans: a review","volume":"111","author":"ter Laan","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2016.08.001_bib0195","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s00134-002-1592-z","article-title":"Reproducibility of the blood flow index as noninvasive, bedside estimation of cerebral blood flow","volume":"29","author":"Wagner","year":"2003","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.resp.2016.08.001_bib0200","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1113\/jphysiol.2012.228551","article-title":"Regional brain blood flow in man during acute changes in arterial blood gases","volume":"590","author":"Willie","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2016.08.001_bib0205","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archneurpsyc.1930.02220120002001","article-title":"Cerebral circulation: XII. The effect on pial vessels of variations in the oxygen and carbon dioxide content of the blood","volume":"23","author":"Wolff","year":"1930","journal-title":"Arch. Neuro Psychiatry"},{"key":"10.1016\/j.resp.2016.08.001_bib0210","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.acra.2013.10.010","article-title":"Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion","volume":"21","author":"Zirak","year":"2014","journal-title":"Acad. Radiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481630132X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481630132X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:37:32Z","timestamp":1761604652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156990481630132X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":42,"alternative-id":["S156990481630132X"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2016.08.001","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebral microvascular blood flow and CO2 reactivity in pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2016.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}