{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:44:09Z","timestamp":1761605049400,"version":"build-2065373602"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.resp.2016.10.007","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T12:06:22Z","timestamp":1476792382000},"page":"37-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Sexual dimorphism of cardiopulmonary regulation in the arcuate nucleus of the hypothalamus"],"prefix":"10.1016","volume":"245","author":[{"given":"Evelyn H.","family":"Schlenker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2016.10.007_bib0005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1439-0272.1987.tb01882.x","article-title":"Differences in prepubertal neonatally estrogenized or androgenized male rats","volume":"19","author":"Aguilar","year":"1987","journal-title":"Andrologia"},{"key":"10.1016\/j.resp.2016.10.007_bib0010","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1073\/pnas.131016298","article-title":"Excitatory versus inhibitory GABA as a divergence point in steroid-mediated sexual differentiation of the brain","volume":"98","author":"Auger","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"Pt. 4","key":"10.1016\/j.resp.2016.10.007_bib0015","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neubiorev.2014.08.009","article-title":"Is it useful to view the brain as a secondary sexual characteristic?","volume":"46","author":"Ball","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.resp.2016.10.007_bib0020","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0306-4522(88)90079-6","article-title":"Activation of hypothalamic arcuate but not paraventricular neurons following carotid body chemoreceptor stimulation in the rat","volume":"24","author":"Banks","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2016.10.007_bib0025","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1113\/JP270308","article-title":"Facilitation of breathing by leptin effects in the central nervous system","volume":"594","author":"Bassi","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0030","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/j.2040-4603.2011.tb00375.x","article-title":"Neuronal control of breathing: sex and stress hormones","volume":"1","author":"Behan","year":"2011","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0035","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0306-4522(01)00442-0","article-title":"Brainstem and hypothalamic areas activated by tissue hypoxia: fos-like immunoreactivity induced by carbon monoxide inhalation in the rat","volume":"108","author":"Bodineau","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2016.10.007_bib0040","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1152\/japplphysiol.00143.2006","article-title":"Plasticity in the nucleus tractus solitarius (NTS) and its influence on lung and airway reflexes","volume":"101","author":"Bonham","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0045","first-page":"R106","article-title":"Characterization of muscles from aspartic acid obese rats","volume":"249","author":"Burbach","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0050","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/j.2040-4603.2015.tb00661.x","article-title":"Gene targeting in neuroendocrinology","volume":"5","author":"Candlish","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fendo.2012.00169","article-title":"Arcuate AgRP neurons and the regulation of energy balance","volume":"3","author":"Cansell","year":"2012","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.resp.2016.10.007_bib0060","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.sleep.2014.06.023","article-title":"Impact of sleep-disordered breathing on metabolic dysfunctions in patients with polycystic ovary syndrome","volume":"15","author":"Chatterjee","year":"2014","journal-title":"Sleep Med."},{"key":"10.1016\/j.resp.2016.10.007_bib0065","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.neuroscience.2007.02.028","article-title":"An androgen-dependent sexual dimorphism visible at puberty in the rat hypothalamus","volume":"146","author":"Ciofi","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2016.10.007_bib0070","doi-asserted-by":"crossref","first-page":"R429","DOI":"10.1152\/ajpregu.00051.2015","article-title":"Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal","volume":"309","author":"Dampney","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0075","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000124268","article-title":"Developmental and sex-specific effects of low dose neonatal monosodium glutamate administration on mediobasal hypothalamic chemistry","volume":"42","author":"Dawson","year":"1986","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.resp.2016.10.007_bib0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12958-016-0173-x","article-title":"Genetic, hormonal and metabolic aspects of PCOS: an update","volume":"14","author":"De Leo","year":"2016","journal-title":"Reprod. Biol. Endocrinol. RB&E"},{"key":"10.1016\/j.resp.2016.10.007_bib0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.autneu.2012.06.001","article-title":"Parabrachial complex glutamate receptors modulate the cardiorespiratory response evoked from hypothalamic defense area","volume":"169","author":"Diaz-Casares","year":"2012","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.resp.2016.10.007_bib0090","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1203\/01.PDR.0000064584.67771.82","article-title":"The basomedial hypothalamus modulates the ventilatory response to hypoxia in neonatal rats","volume":"53","author":"Dreshaj","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.resp.2016.10.007_bib0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cne.1167","article-title":"Distribution of ionotropic glutamate receptor subunit mRNAs in the rat hypothalamus","volume":"434","author":"Eyigor","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2016.10.007_bib0100","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1002\/j.2040-4603.2012.tb00437.x","article-title":"Genetic diseases: congenital central hypoventilation, Rett, and Prader-Willi syndromes","volume":"2","author":"Gallego","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0105","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1440-1681.2000.03259.x","article-title":"Circumventricular organs: definition and role in the regulation of endocrine and autonomic function","volume":"27","author":"Ganong","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tem.2003.11.003","article-title":"Prader-Willi syndrome: advances in genetics, pathophysiology and treatment","volume":"15","author":"Goldstone","year":"2004","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"10.1016\/j.resp.2016.10.007_bib0115","doi-asserted-by":"crossref","first-page":"13109","DOI":"10.1073\/pnas.1512243112","article-title":"Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion","volume":"112","author":"Han","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.resp.2016.10.007_bib0120","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1111\/ejn.12996","article-title":"The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice","volume":"42","author":"Holloway","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2016.10.007_bib0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000054353","article-title":"Exogenous glutamate enhances glutamate receptor subunit expression during selective neuronal injury in the ventral arcuate nucleus of postnatal mice","volume":"68","author":"Hu","year":"1998","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.resp.2016.10.007_bib0130","article-title":"Rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD syndrome): a case report and literature review","author":"Ibanez-Mico","year":"2016","journal-title":"Neurologia (Barcelona, Spain)"},{"key":"10.1016\/j.resp.2016.10.007_bib0135","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1152\/jappl.2001.91.4.1886","article-title":"Estrogen receptor-\u03b1 antisense decreases brain estrogen receptor levels and affects ventilation in male and female rats","volume":"91","author":"Inamdar","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(84)91063-1","article-title":"Monosodium glutamate lesions in rat hypothalamus studied by immunohistochemistry for gonadotropin releasing hormone, neurotensin, tyrosine hydroxylase, and glutamic acid decarboxylase and by autoradiography for [3H] estradiol","volume":"308","author":"Jennes","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2016.10.007_bib0145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF00228119","article-title":"Sex differences in GABAA receptor binding in rat brain measured by an improved in vitro binding assay","volume":"81","author":"Juptner","year":"1990","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.resp.2016.10.007_bib0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cne.900640202","article-title":"Electrical stimulation of points in the forebrain and midbrain: the resultant alterations in respiration","volume":"64","author":"Kabat","year":"1936","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2016.10.007_bib0155","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1183\/13993003.00385-2015","article-title":"Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management","volume":"47","author":"Kaditis","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2016.10.007_bib0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/HYPERTENSIONAHA.113.01132","article-title":"Tonic gamma-aminobutyric acid-ergic activity in the hypothalamic arcuate nucleus is attenuated in the spontaneously hypertensive rat","volume":"62","author":"Kawabe","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2016.10.007_bib0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.resp.2010.08.001","article-title":"Modulation of cardiorespiratory function mediated by the paraventricular nucleus","volume":"174","author":"Kc","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0170","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/eat.20960","article-title":"Respiratory functions in adolescents hospitalized for anorexia nervosa: a prospective study","volume":"45","author":"Kerem","year":"2012","journal-title":"Intern. J. Eating Disord."},{"key":"10.1016\/j.resp.2016.10.007_bib0175","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1210\/en.2014-1017","article-title":"Hypothalamic molecular changes underlying natural reproductive senescence in the female rat","volume":"155","author":"Kermath","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.resp.2016.10.007_bib0180","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11154-013-9257-5","article-title":"Role of hypothalamic autophagy in the control of whole body energy balance","volume":"14","author":"Kim","year":"2013","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.resp.2016.10.007_bib0185","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1115360","article-title":"Neurogenesis in the hypothalamus of adult mice: potential role in energy balance","volume":"310","author":"Kokoeva","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.resp.2016.10.007_bib0190","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11011-016-9807-0","article-title":"Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome","volume":"31","author":"Kondo","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.resp.2016.10.007_bib0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/(SICI)1096-9861(19981109)401:1<65::AID-CNE5>3.0.CO;2-D","article-title":"Arcuate nucleus of the hypothalamus: effects of age and sex","volume":"401","author":"Leal","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2016.10.007_bib0200","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.autneu.2010.03.015","article-title":"Neural mechanism of electroacupuncture's hypotensive effects","volume":"157","author":"Li","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.resp.2016.10.007_bib0205","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s004310051246","article-title":"Growth hormone treatment increases CO(2) response, ventilation and central inspiratory drive in children with Prader-Willi syndrome","volume":"158","author":"Lindgren","year":"1999","journal-title":"Eur. J. Ped."},{"key":"10.1016\/j.resp.2016.10.007_bib0210","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0306-4530(80)90023-2","article-title":"Uncoupling of the sexual receptivity (lordosis) hormone relationships by estradiol benzoate and testosterone propionate injection in neonatal hamsters of both sexes","volume":"5","author":"Lisk","year":"1980","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.resp.2016.10.007_bib0215","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.yfrne.2011.02.009","article-title":"Cooperation of sex chromosomal genes and endocrine influences for hypothalamic sexual differentiation","volume":"32","author":"Majdic","year":"2011","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.resp.2016.10.007_bib0220","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-0034-1371090","article-title":"Rodent models of polycystic ovary syndrome: phenotypic presentation, pathophysiology, and the effects of different interventions","volume":"32","author":"Maliqueo","year":"2014","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.resp.2016.10.007_bib0225","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11154-012-9202-z","article-title":"Epigenetic mechanisms are involved in sexual differentiation of the brain","volume":"13","author":"Matsuda","year":"2012","journal-title":"Rev. Endocr. Metab. Dis."},{"key":"10.1016\/j.resp.2016.10.007_bib0230","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/meth.2000.1075","article-title":"Antisense oligodeoxynucleotides as a tool in developmental neuroendocrinology","volume":"22","author":"McCarthy","year":"2000","journal-title":"Methods (San Diego, Calif.)"},{"key":"10.1016\/j.resp.2016.10.007_bib0235","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0166-2236(02)02182-3","article-title":"Getting excited about GABA and sex differences in the brain","volume":"25","author":"McCarthy","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.resp.2016.10.007_bib0240","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.physbeh.2007.05.021","article-title":"Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight","volume":"92","author":"Meister","year":"2007","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.resp.2016.10.007_bib0245","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.resp.2015.06.009","article-title":"Hypoxic and hypercapnic ventilatory responses in rats with polycystic ovaries","volume":"217","author":"Montrezor","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0250","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jsbmb.2015.10.002","article-title":"The neuroendocrine genesis of polycystic ovary syndrome: a role for arcuate nucleus GABA neurons","volume":"160","author":"Moore","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.resp.2016.10.007_bib0255","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/humrep\/deu318","article-title":"Sleep disturbances in a community-based sample of women with polycystic ovary syndrome","volume":"30","author":"Moran","year":"2015","journal-title":"Hum. Reprod. (Oxford England)"},{"key":"10.1016\/j.resp.2016.10.007_bib0260","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/jsm.12802","article-title":"Gene expression profile of the neonatal female mouse brain after administration of testosterone propionate","volume":"12","author":"Nakachi","year":"2015","journal-title":"J. Sexual Med."},{"key":"10.1016\/j.resp.2016.10.007_bib0265","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-410473-0.00002-7","article-title":"Anorexia and hypothalamic degeneration","volume":"92","author":"Nilsson","year":"2013","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.resp.2016.10.007_bib0270","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neubiorev.2016.04.017","article-title":"Structural and molecular brain sexual differences: a tool to understand sex differences in health and disease","volume":"67","author":"Panzica","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.resp.2016.10.007_bib0275","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.yfrne.2007.07.001","article-title":"Effects of xenoestrogens on the differentiation of behaviorally-relevant neural circuits","volume":"28","author":"Panzica","year":"2007","journal-title":"Front Neuroendocrinology"},{"key":"10.1016\/j.resp.2016.10.007_bib0280","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/MOP.0000000000000118","article-title":"Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation: review and update","volume":"26","author":"Patwari","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"year":"1986","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.resp.2016.10.007_bib0285"},{"key":"10.1016\/j.resp.2016.10.007_bib0290","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000438903","article-title":"Cardiovascular disease and sleep-disordered breathing in acromegaly","volume":"103","author":"Powlson","year":"2016","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.resp.2016.10.007_bib0295","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1471-4159.1984.tb02745.x","article-title":"Uptake of exogenous aspartate into circumventricular organs but not other regions of adult mouse brain","volume":"42","author":"Price","year":"1984","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2016.10.007_bib0300","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/HYPERTENSIONAHA.115.06425","article-title":"Cardiovascular regulation by the arcuate nucleus of the hypothalamus: neurocircuitry and signaling systems","volume":"67","author":"Rahmouni","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2016.10.007_bib0305","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13023-016-0484-1","article-title":"ROHHAD syndrome and evolution of sleep disordered breathing","volume":"11","author":"Reppucci","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.resp.2016.10.007_bib0310","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12405","article-title":"Peripheral and central mechanisms involved in the hormonal control of male and female reproduction","volume":"28","author":"Rudolph","year":"2016","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.resp.2016.10.007_bib0315","doi-asserted-by":"crossref","first-page":"e79437","DOI":"10.1371\/journal.pone.0079437","article-title":"Microarray analysis of perinatal-estrogen-induced changes in gene expression related to brain sexual differentiation in mice","volume":"8","author":"Sakakibara","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2016.10.007_bib0320","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.autneu.2012.10.016","article-title":"Role of the hypothalamic arcuate nucleus in cardiovascular regulation","volume":"175","author":"Sapru","year":"2013","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.resp.2016.10.007_bib0325","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0034-5687(94)00085-E","article-title":"Endogenous opioids modulate ventilation in the obese Zucker rat","volume":"99","author":"Schlenker","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0330","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1152\/jappl.1986.61.2.780","article-title":"Aspartic acid administered neonatally affects ventilation of male and female rats differently","volume":"61","author":"Schlenker","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0335","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0031-9384(92)90183-3","article-title":"Control of ventilation in androgenized hypogonadal male rats","volume":"51","author":"Schlenker","year":"1992","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.resp.2016.10.007_bib0340","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/0031-9384(92)90468-H","article-title":"Perinatal estradiol benzoate administration affects control of ventilation in adult male rats","volume":"52","author":"Schlenker","year":"1992","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.resp.2016.10.007_bib0345","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0031-9384(97)80330-7","article-title":"Naloxone microinjected into the arcuate nucleus has differential effects on ventilation in male and female rats","volume":"62","author":"Schlenker","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.resp.2016.10.007_bib0350","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0006-8993(01)02011-X","article-title":"Cardiorespiratory and metabolic responses to injection of bicuculline into the hypothalamic paraventricular nucleus (PVN) of conscious rats","volume":"895","author":"Schlenker","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2016.10.007_bib0355","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0031-9384(88)90271-5","article-title":"Acute effects of aspartic acid on ventilation of male and female rats","volume":"42","author":"Schlenker","year":"1988","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.resp.2016.10.007_bib0360","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1152\/jappl.1996.81.5.1911","article-title":"Dextromethorphan affects ventilation differently in male and female rats","volume":"81","author":"Schlenker","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0365","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0034-5687(99)00044-4","article-title":"Gender-specific effects of CNQX administered into the arcuate nucleus on ventilatory patterns in rats","volume":"116","author":"Schlenker","year":"1999","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0370","doi-asserted-by":"crossref","first-page":"R653","DOI":"10.1152\/ajpregu.00386.2005","article-title":"Integration in the PVN: another piece of the puzzle","volume":"289","author":"Schlenker","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0375","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.resp.2012.02.007","article-title":"Effects of hypothyroidism on the respiratory system and control of breathing: human studies and animal models","volume":"181","author":"Schlenker","year":"2012","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0380","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.resp.2016.02.009","article-title":"Muscimol microinjected in the arcuate nucleus affects metabolism, body temperature & ventilation","volume":"227","author":"Schlenker","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0385","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature15378","article-title":"A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion","volume":"525","author":"Scott","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.resp.2016.10.007_bib0390","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF00423248","article-title":"Heart rate and breathing pattern: interactions and sex differences","volume":"50","author":"Sebert","year":"1983","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0395","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12020-015-0658-y","article-title":"Hypothalamic-autonomic control of energy homeostasis","volume":"50","author":"Seoane-Collazo","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.resp.2016.10.007_bib0400","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1152\/japplphysiol.01236.2001","article-title":"Neonatal sex steroids affect ventilatory responses to aspartic acid and NMDA receptor subunit 1 in rats","volume":"92","author":"Shi","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0405","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tins.2012.11.004","article-title":"Brainstem respiratory networks: building blocks and microcircuits","volume":"36","author":"Smith","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.resp.2016.10.007_bib0410","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.neuroscience.2005.12.040","article-title":"Respiratory activation of the genioglossus muscle involves both non-NMDA and NMDA glutamate receptors at the hypoglossal motor nucleus in vivo","volume":"138","author":"Steenland","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2016.10.007_bib0415","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1113\/jphysiol.2008.153163","article-title":"Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats","volume":"586","author":"Takakura","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2016.10.007_bib0420","doi-asserted-by":"crossref","DOI":"10.1038\/nature19325","article-title":"Locus coeruleus and dopaminergic consolidation of everyday memory","author":"Takeuchi","year":"2016","journal-title":"Nat. Adv."},{"key":"10.1016\/j.resp.2016.10.007_bib0425","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/cne.22308","article-title":"Projections of preB\u00f6tzinger complex neurons in adult rats","volume":"518","author":"Tan","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2016.10.007_bib0430","series-title":"Regulation of Breathing","first-page":"3","article-title":"The control of breathing: an uninhibited survey from the perspective of comparative physiology","author":"Tenney","year":"1995"},{"key":"10.1016\/j.resp.2016.10.007_bib0435","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2016.10.007_bib0440","series-title":"Regulation of Breathing","first-page":"264","article-title":"Hypothalamic involvement in respiratory and cardiovascular regulation","author":"Waldrop","year":"1995"},{"key":"10.1016\/j.resp.2016.10.007_bib0445","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.tem.2010.05.004","article-title":"Cellular mechanisms of estradiol-mediated sexual differentiation of the brain","volume":"21","author":"Wright","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.resp.2016.10.007_bib0450","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1037\/h0077564","article-title":"Modifications induced by neonatal steroids in reproductive organs and behavior of male rats","volume":"93","author":"Zadina","year":"1979","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.resp.2016.10.007_bib0455","doi-asserted-by":"crossref","first-page":"14966","DOI":"10.1523\/JNEUROSCI.0293-15.2015","article-title":"Dopamine\/tyrosine hydroxylase neurons of the hypothalamic arcuate nucleus release GABA, communicate with dopaminergic and other arcuate neurons, and respond to Dynorphin, Met-Enkephalin, and Oxytocin","volume":"35","author":"Zhang","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2016.10.007_bib0460","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2015.11.026","article-title":"Role of sex hormones in hypercapnia-induced activation of the locus coeruleus in female and male rats","volume":"313","author":"de Carvalho","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2016.10.007_bib0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902240102","article-title":"The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat","volume":"224","author":"van der Kooy","year":"1984","journal-title":"J. Comp. Neurol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904816301720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904816301720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:40:22Z","timestamp":1761604822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904816301720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":93,"alternative-id":["S1569904816301720"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2016.10.007","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sexual dimorphism of cardiopulmonary regulation in the arcuate nucleus of the hypothalamus","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2016.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}