{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:29:08Z","timestamp":1782743348341,"version":"3.54.5"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Kansas State University SMILE","award":["HL-1-108328"],"award-info":[{"award-number":["HL-1-108328"]}]},{"name":"Kansas State University SMILE","award":["HL-2-108328"],"award-info":[{"award-number":["HL-2-108328"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.resp.2017.01.009","type":"journal-article","created":{"date-parts":[[2017,1,22]],"date-time":"2017-01-22T08:30:16Z","timestamp":1485073816000},"page":"33-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats"],"prefix":"10.1016","volume":"238","author":[{"given":"Clark T.","family":"Holdsworth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott K.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trenton D.","family":"Colburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Fees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse C.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy I.","family":"Musch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2017.01.009_bib0005","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/iub.246","article-title":"Molecular biology of KATP channels and implications for health and disease","volume":"61","author":"Akrouh","year":"2009","journal-title":"IUBMB Life"},{"key":"10.1016\/j.resp.2017.01.009_bib0010","doi-asserted-by":"crossref","first-page":"H3131","DOI":"10.1152\/ajpheart.2000.279.6.H3131","article-title":"Spinotrapezius muscle microcirculatory function: effects of surgical exteriorization","volume":"279","author":"Bailey","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0015","first-page":"H1594","article-title":"Activation of ATP-sensitive potassium channels contributes to reactive hyperemia in humans","volume":"271","author":"Banitt","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1023\/A:1007835003493","article-title":"Vascular ATP-dependent potassium channels, nitric oxide, and human forearm reactive hyperemia","volume":"14","author":"Bank","year":"2000","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.resp.2017.01.009_bib0025","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.2337\/dc07-0843","article-title":"Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes","volume":"30","author":"Bauer","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.resp.2017.01.009_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0034-5687(01)00195-5","article-title":"Dynamics of microvascular oxygen pressure across the rest-exercise transition in rat skeletal muscle","volume":"126","author":"Behnke","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1569-9048(02)00183-0","article-title":"Dynamics of oxygen uptake following exercise onset in rat skeletal muscle","volume":"133","author":"Behnke","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.resp.2004.12.009","article-title":"Effects of aging on microvascular oxygen pressures in rat skeletal muscle","volume":"146","author":"Behnke","year":"2005","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0045","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1007\/s001250050615","article-title":"Blockade of vascular ATP-sensitive potassium channels reduces the vasodilator response to ischaemia in humans","volume":"39","author":"Bijlstra","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.resp.2017.01.009_bib0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jbio.201100082","article-title":"Microvascular and mitochondrial PO2 simultaneously measured by oxygen-dependent delayed luminescence","volume":"5","author":"Bodmer","year":"2012","journal-title":"J. Biophoton."},{"key":"10.1016\/j.resp.2017.01.009_bib0055","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1046\/j.1440-1681.2002.03650.x","article-title":"Functional roles of KATP channels in vascular smooth muscle","volume":"29","author":"Brayden","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0060","doi-asserted-by":"crossref","first-page":"e18191","DOI":"10.1371\/journal.pone.0018191","article-title":"Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS\/calmodulin\/CaMKII signaling cascade","volume":"6","author":"Chai","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2017.01.009_bib0065","doi-asserted-by":"crossref","first-page":"H738","DOI":"10.1152\/ajpheart.2001.281.2.H738","article-title":"Selective blockade of mitochondrial KATP channels does not impair myocardial oxygen consumption","volume":"281","author":"Chen","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0070","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1136\/hrt.72.2_Suppl.S36","article-title":"Symptoms and quality of life in heart failure: the muscle hypothesis","volume":"72","author":"Coats","year":"1994","journal-title":"Br. Heart J."},{"key":"10.1016\/j.resp.2017.01.009_bib0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1161\/01.RES.87.2.112","article-title":"Inhibition by protein kinase C of the KNDP subtype of vascular smooth muscle ATP-sensitive potassium channel","volume":"87","author":"Cole","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2017.01.009_bib0080","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1113\/expphysiol.2009.048223","article-title":"The effects of antioxidants on microvascular oxygenation and blood flow in skeletal muscle of young rats","volume":"94","author":"Copp","year":"2009","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0085","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/jappl.1996.80.1.261","article-title":"Composition and size of type I, IIA, IID\/X, and IIB fibers and citrate synthase activity of rat muscle","volume":"80","author":"Delp","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0090","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0008-6363(02)00545-X","article-title":"Dynamics of microvascular oxygen partial pressure in contracting skeletal muscle of rats with chronic heart failure","volume":"56","author":"Diederich","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.resp.2017.01.009_bib0095","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/apha.12656","article-title":"Conducted dilatation to ATP and K(+) in rat skeletal muscle arterioles","volume":"219","author":"Dora","year":"2017","journal-title":"Acta Physiol. Oxf. Engl."},{"key":"10.1016\/j.resp.2017.01.009_bib0100","doi-asserted-by":"crossref","first-page":"H22","DOI":"10.1152\/ajpheart.2001.280.1.H22","article-title":"Role of KATP+ channels in regulation of systemic, pulmonary, and coronary vasomotor tone in exercising swine","volume":"280","author":"Duncker","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0003-2697(02)00384-6","article-title":"Oxyphor R2 and G2: phosphors for measuring oxygen by oxygen-dependent quenching of phosphorescence","volume":"310","author":"Dunphy","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.resp.2017.01.009_bib0110","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1093\/eurheartj\/ehv301","article-title":"Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or other oral glucose-lowering medications: a retrospective registry study on 127, 555 patients from the Nationwide OsMed Health-DB Database","volume":"36","author":"Fadini","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.resp.2017.01.009_bib0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/cs1040039","article-title":"Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm","volume":"104","author":"Farouque","year":"2003","journal-title":"Clin. Sci."},{"key":"10.1016\/j.resp.2017.01.009_bib0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.resp.2005.02.002","article-title":"Muscle blood flow-O2 uptake interaction and their relation to on-exercise dynamics of O2 exchange","volume":"147","author":"Ferreira","year":"2005","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1748-1716.2006.01598.x","article-title":"Muscle microvascular oxygenation in chronic heart failure: role of nitric oxide availability","volume":"188","author":"Ferreira","year":"2006","journal-title":"Acta Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0130","first-page":"57","article-title":"Experimental myocardial infarction in the rat: qualitative and quantitative changes during pathologic evolution","volume":"90","author":"Fishbein","year":"1978","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.resp.2017.01.009_bib0135","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00027.2009","article-title":"Muscle KATP channels: recent insights to energy sensing and myoprotection","volume":"90","author":"Flagg","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2017.01.009_bib0140","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/cs0970569","article-title":"Oxygen uptake kinetics during exercise in chronic heart failure: influence of peripheral vascular reserve","volume":"97","author":"Hepple","year":"1999","journal-title":"Clin. Sci."},{"key":"10.1016\/j.resp.2017.01.009_bib0145","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1152\/japplphysiol.90642.2008","article-title":"Effects of antioxidants on contracting spinotrapezius muscle microvascular oxygenation and blood flow in aged rats","volume":"105","author":"Herspring","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0150","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mvr.2012.11.006","article-title":"The NO donor sodium nitroprusside: evaluation of skeletal muscle vascular and metabolic dysfunction","volume":"85","author":"Hirai","year":"2013","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.resp.2017.01.009_bib0155","doi-asserted-by":"crossref","first-page":"H690","DOI":"10.1152\/ajpheart.00901.2013","article-title":"Skeletal muscle microvascular oxygenation dynamics in heart failure: exercise training and nitric oxide-mediated function","volume":"306","author":"Hirai","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0160","doi-asserted-by":"crossref","first-page":"H1419","DOI":"10.1152\/ajpheart.00469.2015","article-title":"Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization","volume":"309","author":"Hirai","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0165","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1152\/jappl.1992.73.2.728","article-title":"Role of O2 in regulating tissue respiration in dog muscle working in situ","volume":"73","author":"Hogan","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0170","doi-asserted-by":"crossref","first-page":"H1434","DOI":"10.1152\/ajpheart.00772.2014","article-title":"Acute inhibition of ATP-sensitive K+ channels impairs skeletal muscle vascular control in rats during treadmill exercise","volume":"308","author":"Holdsworth","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.resp.2015.11.012","article-title":"Modulation of rat skeletal muscle microvascular O2 pressure via KATP channel inhibition following the onset of contractions","volume":"222","author":"Holdsworth","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"7","key":"10.1016\/j.resp.2017.01.009_bib0180","first-page":"137","article-title":"Hypoxia does not activate ATP-sensitive K+ channels in arteriolar muscle cells","volume":"1994","author":"Jackson","year":"2000","journal-title":"Microcirc. N. Y. N"},{"key":"10.1016\/j.resp.2017.01.009_bib0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1744-8069-5-12","article-title":"Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation","volume":"5","author":"Kawano","year":"2009","journal-title":"Mol. Pain"},{"key":"10.1016\/j.resp.2017.01.009_bib0190","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.2004.071993","article-title":"Inhibition of KATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle","volume":"561","author":"Keller","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0195","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/01.RES.74.3.471","article-title":"Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells","volume":"74","author":"Kubo","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2017.01.009_bib0200","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2337\/diacare.22.10.1647","article-title":"Interaction of sulfonylureas and exercise on glucose homeostasis in type 2 diabetic patients","volume":"22","author":"Larsen","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.resp.2017.01.009_bib0205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00005344-200002000-00001","article-title":"Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease","volume":"35","author":"Maier","year":"2000","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.resp.2017.01.009_bib0210","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1253\/circj.71.465","article-title":"Blood flow redistribution during exercise contributes to exercise tolerance in patients with chronic heart failure","volume":"71","author":"Miyazaki","year":"2007","journal-title":"Circ. J."},{"key":"10.1016\/j.resp.2017.01.009_bib0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10863-009-9265-z","article-title":"Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate","volume":"42","author":"Montoya-P\u00e9rez","year":"2010","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.resp.2017.01.009_bib0220","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/dom.12302","article-title":"Association between first-line monotherapy with sulphonylurea versus metformin and risk of all-cause mortality and cardiovascular events: a retrospective, observational study","volume":"16","author":"Morgan","year":"2014","journal-title":"Diabetes Obes. Metab."},{"issue":"Pt. 1","key":"10.1016\/j.resp.2017.01.009_bib0225","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1113\/jphysiol.1995.sp020789","article-title":"Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels","volume":"486","author":"Murphy","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0230","first-page":"H411","article-title":"Skeletal muscle blood flow abnormalities in rats with a chronic myocardial infarction: rest and exercise","volume":"262","author":"Musch","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0235","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/jappl.1988.64.3.1153","article-title":"Glycogen concentrations and endurance capacity of rats with chronic heart failure","volume":"64","author":"Musch","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0240","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1248\/bpb.17.1341","article-title":"Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats","volume":"17","author":"Nakai","year":"1994","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.resp.2017.01.009_bib0245","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/01.RES.68.1.280","article-title":"ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction","volume":"68","author":"Nichols","year":"1991","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2017.01.009_bib0250","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/305147a0","article-title":"ATP-regulated K+ channels in cardiac muscle","volume":"305","author":"Noma","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.resp.2017.01.009_bib0255","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1152\/japplphysiol.01040.2014","article-title":"Differential effects of age and type 2 diabetes on dynamic vs. peak response of pulmonary oxygen uptake during exercise","volume":"118","author":"O\u2019Connor","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0260","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.resp.2006.08.008","article-title":"Effects of Type II diabetes on muscle microvascular oxygen pressures","volume":"156","author":"Padilla","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0265","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/HJR.0b013e32833f3aa5","article-title":"Exercise intolerance in chronic heart failure: mechanisms and therapies. Part II","volume":"17","author":"Piepoli","year":"2010","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.resp.2017.01.009_bib0270","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/HJR.0b013e3283361dc5","article-title":"Exercise intolerance in chronic heart failure: mechanisms and therapies. Part I","volume":"17","author":"Piepoli","year":"2010","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.resp.2017.01.009_bib0275","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/10739680490437487","article-title":"Measurement of muscle microvascular oxygen pressures: compartmentalization of phosphorescent probe","volume":"11","author":"Poole","year":"2004","journal-title":"Microcirculation"},{"key":"10.1016\/j.resp.2017.01.009_bib0280","doi-asserted-by":"crossref","first-page":"H1050","DOI":"10.1152\/ajpheart.00943.2011","article-title":"Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance","volume":"302","author":"Poole","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0285","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1152\/jappl.1998.85.1.310","article-title":"Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus","volume":"85","author":"Regensteiner","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0290","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1172\/JCI118237","article-title":"Myoglobin O\u2082 desaturation during exercise. Evidence of limited O\u2082 transport","volume":"96","author":"Richardson","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2017.01.009_bib0295","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/japplphysiol.00308.2003","article-title":"Effects of chronic heart failure on skeletal muscle capillary hemodynamics at rest and during contractions","volume":"95","author":"Richardson","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0300","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1126\/science.3420417","article-title":"Imaging of phosphorescence: a novel method for measuring oxygen distribution in perfused tissue","volume":"241","author":"Rumsey","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.resp.2017.01.009_bib0305","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jcmg.2014.12.033","article-title":"Association of exercise intolerance in type 2 diabetes with skeletal muscle blood flow reserve","volume":"8","author":"Sacre","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.resp.2017.01.009_bib0310","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1152\/japplphysiol.01639.2005","article-title":"Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise","volume":"100","author":"Schrage","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0315","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.regpep.2008.02.008","article-title":"INGAP-PP up-regulates the expression of genes and proteins related to K+ ATP channels and ameliorates Ca2+ handling in cultured adult rat islets","volume":"148","author":"Silva","year":"2008","journal-title":"Regul. Pept."},{"key":"10.1016\/j.resp.2017.01.009_bib0320","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1503\/cmaj.050748","article-title":"Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: a population-based cohort study","volume":"174","author":"Simpson","year":"2006","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.resp.2017.01.009_bib0325","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1113\/jphysiol.2009.172221","article-title":"Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles","volume":"587","author":"Sindler","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0330","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI0214270","article-title":"Role of sarcolemmal KATP channels in cardioprotection against ischemia\/reperfusion injury in mice","volume":"109","author":"Suzuki","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2017.01.009_bib0335","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1161\/01.RES.76.1.53","article-title":"ATP-sensitive K+ channels mediate alpha 2D-adrenergic receptor contraction of arteriolar smooth muscle and reversal of contraction by hypoxia","volume":"76","author":"Tateishi","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2017.01.009_bib0340","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1172\/JCI119448","article-title":"ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle","volume":"99","author":"Thomas","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2017.01.009_bib0345","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1152\/jappl.1994.76.3.1098","article-title":"Contribution of potassium channels to active hyperemia of the canine diaphragm","volume":"76","author":"Vanelli","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0350","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1113\/jphysiol.2010.199562","article-title":"Alteration in skeletal muscle afferents in rats with chronic heart failure","volume":"588","author":"Wang","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0355","doi-asserted-by":"crossref","first-page":"C385","DOI":"10.1152\/ajpcell.00485.2010","article-title":"Hypoxia. 2. Hypoxia regulates cellular metabolism","volume":"300","author":"Wheaton","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0360","doi-asserted-by":"crossref","first-page":"C135","DOI":"10.1152\/ajpcell.1977.233.5.C135","article-title":"Effect of oxygen tension on cellular energetics","volume":"233","author":"Wilson","year":"1977","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2017.01.009_bib0365","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nchembio821","article-title":"Nitric oxide activates TRP channels by cysteine S-nitrosylation","volume":"2","author":"Yoshida","year":"2006","journal-title":"Nat. Chem. Biol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904816303378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904816303378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:37:44Z","timestamp":1761604664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904816303378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":73,"alternative-id":["S1569904816303378"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2017.01.009","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2017.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}