{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:19:41Z","timestamp":1783372781434,"version":"3.54.6"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.resp.2017.03.012","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T16:45:22Z","timestamp":1491583522000},"page":"86-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Nasal highflow eliminates CO2 from lower airways"],"prefix":"10.1016","volume":"242","author":[{"given":"Jens","family":"Br\u00e4unlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Goldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Wirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2017.03.012_bib0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000342027","article-title":"Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients","volume":"85","author":"Br\u00e4unlich","year":"2013","journal-title":"Respiration"},{"key":"10.1016\/j.resp.2017.03.012_bib0010","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2147\/COPD.S104616","article-title":"Nasal highflow improves ventilation in patients with COPD","volume":"11","author":"Br\u00e4unlich","year":"2016","journal-title":"COPD"},{"key":"10.1016\/j.resp.2017.03.012_bib0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40248-015-0019-y","article-title":"Nasal high-flow versus non-invasive ventilation in stable hypercapnic COPD: a preliminary report","volume":"10","author":"Br\u00e4unlich","year":"2015","journal-title":"Multidiscip. Respir. Med."},{"key":"10.1016\/j.resp.2017.03.012_bib0020","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa1503326","article-title":"High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure","volume":"372","author":"Frat","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2017.03.012_bib0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ppul.21326","article-title":"High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model","volume":"46","author":"Frizzola","year":"2011","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2017.03.012_bib0030","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1183\/13993003.01883-2015","article-title":"High-flow nasal oxygen for bronchoalveolar lavage in acute respiratory failure patients","volume":"47","author":"La Combe","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2017.03.012_bib0035","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1164\/rccm.201402-0364OC","article-title":"Nasal high-flow versus venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome","volume":"190","author":"Maggiore","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2017.03.012_bib0040","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1152\/japplphysiol.00934.2014","article-title":"Nasal high flow clears anatomical dead space in upper airway models","volume":"118","author":"M\u00f6ller","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.03.012_bib0045","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1089\/jamp.2015.1219","article-title":"Aerosol therapy in adults receiving high flow nasal cannula oxygen therapy","volume":"29","author":"R\u00e9miniac","year":"2016","journal-title":"J. Aerosol. Med. Pulm. Drug Deliv."},{"key":"10.1016\/j.resp.2017.03.012_bib0050","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2044.2007.05026.x","article-title":"Performance of six types of oxygen delivery devices at varying respiratory rates","volume":"62","author":"Wagstaff","year":"2007","journal-title":"Anaesthesia"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904817300824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904817300824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:39:00Z","timestamp":1761604740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904817300824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":10,"alternative-id":["S1569904817300824"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2017.03.012","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nasal highflow eliminates CO2 from lower airways","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2017.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}