{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:06:05Z","timestamp":1786554365715,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.resp.2017.04.011","type":"journal-article","created":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T10:01:06Z","timestamp":1493546466000},"page":"7-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Impairment of pulmonary diffusion correlates with hypoxemic burden in central sleep apnea heart failure patients"],"prefix":"10.1016","volume":"243","author":[{"given":"Henrik","family":"Fox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Koerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Horstkotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2017.04.011_bib0005","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jchf.2015.09.014","article-title":"Prevalence and predictors of sleep-disordered breathing in patients with stable chronic heart failure: the SchlaHF registry","volume":"4","author":"Arzt","year":"2016","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.resp.2017.04.011_bib0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.sleep.2016.10.006","article-title":"Improvements of central respiratory events, Cheyne-Stokes respiration and oxygenation in patients hospitalized for acute decompensated heart failure","volume":"27\u201328","author":"Basic","year":"2016","journal-title":"Sleep Med."},{"key":"10.1016\/j.resp.2017.04.011_bib0015","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. deliberations of the sleep apnea definitions task force of the american academy of sleep medicine","volume":"8","author":"Berry","year":"2012","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.resp.2017.04.011_bib0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/eurheartj\/ehq327","article-title":"Cheyne-Stokes respiration and obstructive sleep apnoea are independent risk factors for malignant ventricular arrhythmias requiring appropriate cardioverter-defibrillator therapies in patients with congestive heart failure","volume":"32","author":"Bitter","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.resp.2017.04.011_bib0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/thx.18.2.151","article-title":"Effect of variability in gas analysis on the reproducibility of the pulmonary diffusing capacity by the single breath method","volume":"18","author":"Cotes","year":"1963","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2017.04.011_bib0030","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1506459","article-title":"Adaptive servo-ventilation for central sleep apnea in systolic heart failure","volume":"373","author":"Cowie","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2017.04.011_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.resp.2017.01.010","article-title":"Positive airway pressure therapy in heart failure patients: Long-term effects on lung function","volume":"238","author":"Fox","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0040","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1161\/01.CIR.102.18.2214","article-title":"Quantitative general theory for periodic breathing in chronic heart failure and its clinical implications","volume":"102","author":"Francis","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2017.04.011_bib0045","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1378\/chest.125.2.669","article-title":"The pulmonary manifestations of left heart failure","volume":"125","author":"Gehlbach","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.resp.2017.04.011_bib0050","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1378\/chest.124.3.1090","article-title":"Alveolar-capillary membrane dysfunction in heart failure: evidence of a pathophysiologic role","volume":"124","author":"Guazzi","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.resp.2017.04.011_bib0055","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/j.2040-4603.2016.tb00698.x","article-title":"Lung structure and the intrinsic challenges of gas exchange","volume":"6","author":"Hsia","year":"2016","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0060","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.chest.2015.12.021","article-title":"SERVE-HF: more questions than answers","volume":"149","author":"Javaheri","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.resp.2017.04.011_bib0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijcard.2004.12.068","article-title":"Sleep disorders in systolic heart failure: a prospective study of 100 male patients. The final report","volume":"106","author":"Javaheri","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0070","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/eurjhf\/hfq183","article-title":"Prognostic impact of sleep disordered breathing and its treatment in heart failure: an observational study","volume":"13","author":"Jilek","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.resp.2017.04.011_bib0075","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1152\/jappl.1991.70.5.2014","article-title":"Sleep-induced periodic breathing and apnea: a theoretical study","volume":"70","author":"Khoo","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0080","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0034-5687(00)00157-2","article-title":"Determinants of ventilatory instability and variability","volume":"122","author":"Khoo","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0085","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0034-5687(83)90086-5","article-title":"Dependence of high altitude sleep apnea on ventilatory sensitivity to hypoxia","volume":"52","author":"Lahiri","year":"1983","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0090","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00392-015-0859-7","article-title":"The importance of sleep-disordered breathing in cardiovascular disease","volume":"104","author":"Linz","year":"2015","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0095","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1152\/jappl.1966.21.6.1839","article-title":"Cheyne-Stokes breathing produced by a model of the human respiratory system","volume":"21","author":"Longobardo","year":"1966","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.04.011_bib0100","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1113\/jphysiol.2006.116764","article-title":"Development of respiratory control instability in heart failure: a novel approach to dissect the pathophysiological mechanisms","volume":"577","author":"Manisty","year":"2006","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.resp.2017.04.011_bib0105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejheart.2006.08.003","article-title":"Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients","volume":"9","author":"Oldenburg","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.resp.2017.04.011_bib0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00059-013-4050-5","article-title":"Sleep-related breathing disorders and (resulting) cardiovascular diseases","volume":"39","author":"Oldenburg","year":"2014","journal-title":"Herz"},{"key":"10.1016\/j.resp.2017.04.011_bib0115","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/eurheartj\/ehv624","article-title":"Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients","volume":"37","author":"Oldenburg","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.resp.2017.04.011_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(91)90038-5","article-title":"Patterns of oxygenation during periodic breathing in preterm infants","volume":"26","author":"Poets","year":"1991","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.resp.2017.04.011_bib0125","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0022-3476(05)80919-9","article-title":"Arterial oxygen saturation in preterm infants at discharge from the hospital and six weeks later","volume":"120","author":"Poets","year":"1992","journal-title":"J. Pediatr."},{"key":"10.1016\/j.resp.2017.04.011_bib0130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2017.04.011_bib0135","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1161\/01.CIR.91.11.2769","article-title":"Reduced alveolar-capillary membrane diffusing capacity in chronic heart failure. Its pathophysiological relevance and relationship to exercise performance","volume":"91","author":"Puri","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2017.04.011_bib0140","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/sj.jp.7210762","article-title":"Periodic breathing and oxygen saturation in preterm infants at discharge","volume":"22","author":"Razi","year":"2002","journal-title":"J. Perinatol."},{"key":"10.1016\/j.resp.2017.04.011_bib0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1183\/09031936.00069712","article-title":"Consensus statement for inert gas washout measurement using multiple- and single- breath tests","volume":"41","author":"Robinson","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2017.04.011_bib0150","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1183\/09031936.00037106","article-title":"Sleep apnoea in heart failure","volume":"29","author":"Schulz","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2017.04.011_bib0155","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1161\/01.CIR.99.12.1574","article-title":"Influence of pulmonary capillary wedge pressure on central apnea in heart failure","volume":"99","author":"Solin","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2017.04.011_bib0160","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1378\/chest.07-1487","article-title":"Impaired pulmonary diffusing capacity and hypoxia in heart failure correlates with central sleep apnea severity","volume":"134","author":"Szollosi","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.resp.2017.04.011_bib0165","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1183\/09031936.00184412","article-title":"Severely reduced diffusion capacity in idiopathic pulmonary arterial hypertension: patient characteristics and treatment responses","volume":"42","author":"Trip","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2017.04.011_bib0170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-2000-7477","article-title":"Changes in cerebral blood volume and cerebral oxygenation during periodic breathing in term infants","volume":"31","author":"Urlesberger","year":"2000","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.resp.2017.04.011_bib0175","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.sleep.2014.03.024","article-title":"Sleep-disordered breathing and pulmonary function in obese children and adolescents","volume":"15","author":"Van Eyck","year":"2014","journal-title":"Sleep Med."},{"key":"10.1016\/j.resp.2017.04.011_bib0180","first-page":"317","article-title":"Periodic breathing with periodic oxygen variation in infancy","volume":"146","author":"von Czettritz","year":"1996","journal-title":"Wien. Med. Wochenschr."},{"key":"10.1016\/j.resp.2017.04.011_bib0185","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/0140-6736(92)92301-U","article-title":"Stress failure of pulmonary capillaries: role in lung and heart disease","volume":"340","author":"West","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.resp.2017.04.011_bib0190","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1203\/PDR.0b013e3180db29e5","article-title":"Postnatal development of periodic breathing cycle duration in term and preterm infants","volume":"62","author":"Wilkinson","year":"2007","journal-title":"Pediatr. Res."},{"issue":"46","key":"10.1016\/j.resp.2017.04.011_bib0195","article-title":"Determining the prevalence and predictors of sleep disordered breathing in patients with chronic heart failure: rationale and design of the SCHLA-HF registry","volume":"14","author":"Woehrle","year":"2014","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.resp.2017.04.011_bib0200","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1164\/ajrccm.152.6.8520761","article-title":"Hypocapnia and increased ventilatory responsiveness in patients with idiopathic central sleep apnea","volume":"152","author":"Xie","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2017.04.011_bib0205","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.109.902452","article-title":"Nocturnal rostral fluid shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure","volume":"121","author":"Yumino","year":"2010","journal-title":"Circulation"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904817300599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904817300599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:38:15Z","timestamp":1761604695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904817300599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":41,"alternative-id":["S1569904817300599"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2017.04.011","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impairment of pulmonary diffusion correlates with hypoxemic burden in central sleep apnea heart failure patients","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2017.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}