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Neurosci."},{"key":"10.1016\/j.resp.2017.05.008_bib0420","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12576-016-0475-y","article-title":"The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology","volume":"67","author":"Ikeda","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.resp.2017.05.008_bib0425","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0301-0082(98)00046-X","article-title":"Control of abdominal muscles","volume":"56","author":"Iscoe","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0430","first-page":"203","article-title":"Effects of medullary midline lesions on cough and other airway reflexes in anaesthetized cats","volume":"47","author":"Jaku\u0161","year":"1998","journal-title":"Physiol. Res."},{"key":"10.1016\/j.resp.2017.05.008_bib0435","doi-asserted-by":"crossref","first-page":"387","DOI":"10.33549\/physiolres.930000.49.387","article-title":"Kainic acid lesions to the lateral tegmental field of medulla: effects on cough, expiration and aspiration reflexes in anesthetized cats","volume":"49","author":"Jaku\u0161","year":"2000","journal-title":"Physiol. Res."},{"key":"10.1016\/j.resp.2017.05.008_bib0440","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.resp.2007.10.014","article-title":"Brainstem circuitry of tracheal-bronchial cough: c-fos study in anesthetized cats","volume":"160","author":"Jakus","year":"2008","journal-title":"Respir. Physiol. 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Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0525","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1745-9974-9-8","article-title":"Molecular signaling and targets from itch: lessons for cough","volume":"9","author":"Lavinka","year":"2013","journal-title":"Cough"},{"key":"10.1016\/j.resp.2017.05.008_bib0530","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1152\/japplphysiol.00423.2009","article-title":"Desensitization of the cough reflex by exercise and voluntary isocapnic hyperpnea","volume":"108","author":"Lavorini","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0535","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0034-5687(00)00204-8","article-title":"Afferent properties and reflex functions of bronchopulmonary C-fibers","volume":"125","author":"Lee","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0540","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1152\/japplphysiol.00470.2016","article-title":"Generation of active expiration by serotoninergic mechanisms of the ventral medulla of rats","volume":"121","author":"Lemes","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0545","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0304-3940(86)90421-0","article-title":"In vivo release of substance P in the nucleus tractus solitarii increases during hypoxia","volume":"69","author":"Lindefors","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2017.05.008_bib0550","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0034-5687(84)90077-X","article-title":"Effects of carotid chemoreceptor excitation on medullary expiratory neurons in cats","volume":"57","author":"Lipski","year":"1984","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0555","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.1991.sp018822","article-title":"Identification of neurons receiving input from pulmonary rapidly adapting receptors in the cat","volume":"443","author":"Lipski","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0560","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s00424-013-1284-2","article-title":"New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?","volume":"465","author":"Liu","year":"2013","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2017.05.008_bib0565","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.pain.2008.04.025","article-title":"The Kyoto protocol of IASP basic pain terminology","volume":"137","author":"Loeser","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.resp.2017.05.008_bib0570","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/000348947408300611","article-title":"Physiology of cough","volume":"83","author":"Macklem","year":"1974","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.resp.2017.05.008_bib0575","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pupt.2011.01.007","article-title":"Voluntary and reflex cough: similarities and differences","volume":"24","author":"Magni","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2017.05.008_bib0580","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S1471-4892(02)00151-0","article-title":"Central nervous system control of the airways: pharmacological implications","volume":"2","author":"Mazzone","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.resp.2017.05.008_bib0585","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1152\/ajpregu.00007.2002","article-title":"Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs","volume":"283","author":"Mazzone","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0590","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2017.05.008_bib0595","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093153","article-title":"Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs","volume":"569","author":"Mazzone","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0600","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1523\/JNEUROSCI.4597-10.2011","article-title":"Investigation of the neural control of cough and cough suppression in humans using functional brain imaging","volume":"31","author":"Mazzone","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2017.05.008_bib0605","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0034-5687(97)00081-9","article-title":"Modulation of the synaptic drive to respiratory premotor and motor neurons","volume":"110","author":"McCrimmon","year":"1997","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0610","series-title":"A Cytoarchitectonic Atlas of the Rhomboencephalon of the Rabbit","author":"Meessen","year":"1949"},{"key":"10.1016\/j.resp.2017.05.008_bib0615","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0006-8993(83)91198-8","article-title":"Origin of the expiratory inhibition of nucleus tractus solitarius inspiratory neurones","volume":"263","author":"Merrill","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2017.05.008_bib0620","series-title":"Central Nervous Control Mechanisms in Breathing","first-page":"239","article-title":"Is there reciprocal inhibition between medullary inspiratory and expiratory neurones?","author":"Merrill","year":"1979"},{"key":"10.1016\/j.resp.2017.05.008_bib0625","doi-asserted-by":"crossref","first-page":"R269","DOI":"10.1152\/ajpregu.1993.265.2.R269","article-title":"Laryngeal afferent inputs to the nucleus of the solitary tract","volume":"265","author":"Mifflin","year":"1993","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0630","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s002210050889","article-title":"Excitatory and inhibitory synaptic inputs shape the discharge pattern of pump neurons of the nucleus tractus solitarii in the rat","volume":"129","author":"Miyazaki","year":"1999","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.resp.2017.05.008_bib0635","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1152\/jn.00193.2012","article-title":"Contribution of the retrotrapezoid nucleus\/parafacial respiratory region to the expiratory-sympathetic coupling in response to peripheral chemoreflex in rats","volume":"108","author":"Moraes","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2017.05.008_bib0640","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/nn1357","article-title":"Respiratory control by ventral surface chemoreceptor neurons in rats","volume":"7","author":"Mulkey","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.resp.2017.05.008_bib0645","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.coph.2011.05.006","article-title":"Targeting peripheral afferent nerve terminals for cough and dyspnea","volume":"11","author":"Muroi","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.resp.2017.05.008_bib0650","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.autneu.2016.06.004","article-title":"The strange case of the ear and the heart: the auricular vagus nerve and its influence on cardiac control","volume":"199","author":"Murray","year":"2016","journal-title":"Auton. 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