{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:29:52Z","timestamp":1789964992802,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Laboratory of Excellence GR-Ex fellowship"},{"name":"\u201cInvestissement d\u2019avenir\u201d of the French National Research agency","award":["ANR-11-IDEX-0005-02"],"award-info":[{"award-number":["ANR-11-IDEX-0005-02"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.resp.2017.07.002","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T18:02:04Z","timestamp":1500487324000},"page":"98-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Increased ventilation in female erythropoietin-deficient mouse line is not progesterone and estrous stage-dependent"],"prefix":"10.1016","volume":"245","author":[{"given":"Florine","family":"Jeton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Soliz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Richalet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Pichon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Voituron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2017.07.002_bib0005","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1152\/japplphysiol.00143.2015","article-title":"Endogenous brain erythropoietin is a potent sex-specific respiratory stimulant in adult and newborn mice","volume":"118","author":"Ballot","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0010","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0034-5687(70)90056-3","article-title":"Control of breathing in experimental anemia","volume":"10","author":"Bartlett","year":"1970","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0015","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood-2002-02-0605","article-title":"Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy","volume":"100","author":"Binley","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.resp.2017.07.002_bib0020","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1152\/japplphysiol.00397.2016","article-title":"Membrane progesterone receptor-beta, but not \u2212alpha, in dorsal brain stem establishes sex-specific chemoreflex responses and reduces apnea frequency in adult mice","volume":"121","author":"Boukari","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0025","series-title":"Erythropoietin. Cold Spring Harbor Perspectives in Medicine 3, a011619","author":"Bunn","year":"2013"},{"key":"10.1016\/j.resp.2017.07.002_bib0030","doi-asserted-by":"crossref","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2017.07.002_bib0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1542\/peds.16.1.81","article-title":"A barometric method for measuring ventilation in newborn infants","volume":"16","author":"Drorbaugh","year":"1955","journal-title":"Pediatrics"},{"key":"10.1016\/j.resp.2017.07.002_bib0040","doi-asserted-by":"crossref","first-page":"R801","DOI":"10.1152\/ajpregu.00119.2008","article-title":"Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia. American journal of physiology","volume":"296","author":"Hasnaoui-Saadani","year":"2009","journal-title":"Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.resp.2013.01.003","article-title":"Epo deficiency alters cardiac adaptation to chronic hypoxia","volume":"186","author":"El Hasnaoui-Saadani","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0034-5687(78)90103-2","article-title":"A theoretical analysis of the barometric method for measurement of tidal volume","volume":"32","author":"Epstein","year":"1978","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1749-6632.2009.05028.x","article-title":"The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphism","volume":"1177","author":"Gassmann","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.resp.2017.07.002_bib0060","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000362279","article-title":"Hypoxia-induced gene expression of aquaporin-4, cyclooxygenase-2 and hypoxia-inducible factor 1alpha in rat cortical astroglia is inhibited by 17beta-estradiol and progesterone","volume":"99","author":"Habib","year":"2014","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.resp.2017.07.002_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2016.12.004","article-title":"Efficient breathing at neonatal ages: a sex and Epo-dependent issue","author":"Iturri","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0070","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cbpa.2014.10.009","article-title":"Control of breathing and the circulation in high-altitude mammals and birds. Comparative biochemistry and physiology","volume":"186","author":"Ivy","year":"2015","journal-title":"Part A Mol. Integr. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0075","first-page":"319","article-title":"Barometric measurement of tidal volume: effects of pattern and nasal temperature","volume":"49","author":"Jacky","year":"1980","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0080","doi-asserted-by":"crossref","first-page":"R806","DOI":"10.1152\/ajpregu.2000.278.4.R806","article-title":"Gender differentiation of the chemoreflex during growth at high altitude: functional and neurochemical studies. American journal of physiology","volume":"278","author":"Joseph","year":"2000","journal-title":"Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0085","doi-asserted-by":"crossref","first-page":"R765","DOI":"10.1152\/ajpregu.00398.2001","article-title":"Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats","volume":"282","author":"Joseph","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0090","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1210\/en.2006-1394","article-title":"Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase\/Akt pathway","volume":"148","author":"Kazi","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.resp.2017.07.002_bib0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4939-2095-2_3","article-title":"Erythropoiesis: from molecular pathways to system properties","volume":"844","author":"Koulnis","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2017.07.002_bib0100","doi-asserted-by":"crossref","first-page":"e100421","DOI":"10.1371\/journal.pone.0100421","article-title":"The nuclear progesterone receptor reduces post-sigh apneas during sleep and increases the ventilatory response to hypercapnia in adult female mice","volume":"9","author":"Marcouiller","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2017.07.002_bib0105","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ijcard.2016.11.111","article-title":"Factors influencing brain natriuretic peptide levels in healthy pregnant women","volume":"228","author":"Mayama","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1152\/jappl.1987.62.1.158","article-title":"Increased HVR in pregnancy: relationship to hormonal and metabolic changes","volume":"62","author":"Moore","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0115","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1139\/y99-001","article-title":"On the barometric method for measurements of ventilation, and its use in small animals","volume":"76","author":"Mortola","year":"1998","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2017.07.002_bib0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00005344-200407000-00013","article-title":"17-beta estradiol attenuates hypoxic induction of HIF-1alpha and erythropoietin in Hep3B cells","volume":"44","author":"Mukundan","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.resp.2017.07.002_bib0125","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00005344-200402000-00023","article-title":"17-beta estradiol independently regulates erythropoietin synthesis and NOS activity during hypoxia","volume":"43","author":"Mukundan","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.resp.2017.07.002_bib0130","first-page":"29","article-title":"Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice","volume":"4","author":"Pichon","year":"2016","journal-title":"Hypoxia"},{"key":"10.1016\/j.resp.2017.07.002_bib0135","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1152\/jappl.2001.91.6.2579","article-title":"Erythropoiesis in women during 11days at 4,300m is not affected by menstrual cycle phase","volume":"91","author":"Reeves","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0140","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fcell.2015.00042","article-title":"Hypoxia signaling pathways: modulators of oxygen-related organelles","volume":"3","author":"Schonenberger","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.resp.2017.07.002_bib0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0010-7824(83)80008-0","article-title":"Binding of the anti-progestin RU-486 to rat ovary steroid receptors","volume":"28","author":"Schreiber","year":"1983","journal-title":"Contraception"},{"key":"10.1016\/j.resp.2017.07.002_bib0150","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12884-016-1138-y","article-title":"Self-reported pregnancy-related health problems and self-rated health status in Rwandan women postpartum: a population-based cross-sectional study","volume":"16","author":"Semasaka","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.resp.2017.07.002_bib0155","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.neurobiolaging.2014.09.024","article-title":"Estrogen receptor-mediated resveratrol actions on blood-brain barrier of ovariectomized mice","volume":"36","author":"Shin","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.resp.2017.07.002_bib0160","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093328","article-title":"Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies","volume":"568","author":"Soliz","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0165","doi-asserted-by":"crossref","first-page":"R1837","DOI":"10.1152\/ajpregu.90967.2008","article-title":"Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin","volume":"296","author":"Soliz","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-94-007-4584-1_8","article-title":"Erythropoietin and the sex-dimorphic chemoreflex pathway","volume":"758","author":"Soliz","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2017.07.002_bib0175","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.resp.2012.07.018","article-title":"Erythropoietin and respiratory control at adulthood and during early postnatal life","volume":"185","author":"Soliz","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2017.07.002_bib0180","doi-asserted-by":"crossref","first-page":"e00223","DOI":"10.1002\/phy2.223","article-title":"Catalyzing role of erythropoietin on the nitric oxide central pathway during the ventilatory responses to hypoxia","volume":"2","author":"Voituron","year":"2014","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.resp.2017.07.002_bib0185","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuroscience.2012.11.042","article-title":"Post-stroke estradiol treatment enhances neurogenesis in the subventricular zone of rats after permanent focal cerebral ischemia","volume":"231","author":"Zheng","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2017.07.002_bib0190","first-page":"51","article-title":"Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia","volume":"80","author":"Ziello","year":"2007","journal-title":"Yale J. Biolo. Med."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481730215X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990481730215X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:38:55Z","timestamp":1761604735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156990481730215X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":38,"alternative-id":["S156990481730215X"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2017.07.002","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased ventilation in female erythropoietin-deficient mouse line is not progesterone and estrous stage-dependent","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2017.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}