{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:49:55Z","timestamp":1792457395747,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.resp.2018.12.001","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T12:19:49Z","timestamp":1543839589000},"page":"28-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. \u2013 Possible role in the treatment of asthma"],"prefix":"10.1016","volume":"260","author":[{"given":"Prafull Bandopant","family":"Ninave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita Dattatray","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2018.12.001_bib0005","first-page":"39","article-title":"Antinociceptive, anticonvulsant and anti-inflammatory activities of Zizyphus jujuba","volume":"14","author":"Acharya","year":"1994","journal-title":"Anc. Sci. Life"},{"key":"10.1016\/j.resp.2018.12.001_bib0010","first-page":"489","article-title":"The antifungal, cytotoxic, antitermite and insecticidal activities of Zizyphus jujube","volume":"24","author":"Ahmad","year":"2011","journal-title":"Pak. J. Pharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0015","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.fct.2009.11.045","article-title":"Anti-inflammatory activity of seed essential oil from Zizyphus jujuba","volume":"48","author":"Al-Reza","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.resp.2018.12.001_bib0020","first-page":"611","article-title":"Hypoglycemic and hypolipidemic effects of Zizyphus jujuba Lam. in streptozotocin-induced diabetic rats","volume":"4","author":"Anbarasi","year":"2013","journal-title":"Res. J. Pharma. Biol. Chem. Sci."},{"key":"10.1016\/j.resp.2018.12.001_bib0025","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jep.2012.05.007","article-title":"Evaluation of antiallergic and anti-anaphylactic activity of ethanolic extract of Sanseveiria trifasciata leaves (EEST) in rodents","volume":"142","author":"Andhare","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0030","first-page":"40","article-title":"Antipyretic activity of Zizyphus jujuba lam. leaves","volume":"3","author":"Balakrishnan","year":"2012","journal-title":"Int. J. Adv. Sci. Res. Dev."},{"key":"10.1016\/j.resp.2018.12.001_bib0035","series-title":"Pathophysiology of asthma, Asthma and COPD","first-page":"343","author":"Barnes","year":"2002"},{"key":"10.1016\/j.resp.2018.12.001_bib0040","first-page":"443","article-title":"Anti-stress activity of Ocimum sanctum Linn","volume":"73","author":"Bhargava","year":"1981","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.resp.2018.12.001_bib0045","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3240::AID-IMMU3240>3.0.CO;2-U","article-title":"Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma","volume":"28","author":"Braun","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.resp.2018.12.001_bib0050","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11882-013-0373-9","article-title":"Role of interleukin-13 in asthma","volume":"13","author":"Corren","year":"2013","journal-title":"Curr. Allergy Asthm R."},{"key":"10.1016\/j.resp.2018.12.001_bib0055","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/S0031-9422(00)83955-2","article-title":"Cyclic adenosine monophosphate in fruits of Zizyphus jujuba","volume":"19","author":"Cyong","year":"1980","journal-title":"Phytochemistry"},{"key":"10.1016\/j.resp.2018.12.001_bib0060","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/0031-9422(82)83005-7","article-title":"Identification of guanosine 3\u2032: 5\u2032-monophosphate in the fruit of Zizyphus jujuba","volume":"21","author":"Cyong","year":"1982","journal-title":"Phytochemistry"},{"key":"10.1016\/j.resp.2018.12.001_bib0065","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1248\/bpb.25.1179","article-title":"Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis","volume":"25","author":"Dai","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.resp.2018.12.001_bib0070","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/0970-2113.63609","article-title":"Role played by Th2 type cytokines in IgE mediated allergy and asthma","volume":"27","author":"Deo","year":"2010","journal-title":"Lung India: Off. Organ Indian Chest Soc."},{"key":"10.1016\/j.resp.2018.12.001_bib0075","doi-asserted-by":"crossref","first-page":"22","DOI":"10.9790\/0853-13942225","article-title":"Peripheral blood leukocyte counts as a marker of severity of functional lung impairment in OAD patients attending a tertiary care hospital in Manipur, India","volume":"13","author":"Devi","year":"2014","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"10.1016\/j.resp.2018.12.001_bib0080","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.4049\/jimmunol.172.11.7053","article-title":"Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model","volume":"172","author":"Duan","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.resp.2018.12.001_bib0085","series-title":"Handbook of Medicinal Herbs","author":"Duke","year":"2001"},{"key":"10.1016\/j.resp.2018.12.001_bib0090","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0091-3057(90)90354-K","article-title":"Is experimental catalepsy properly measured?","volume":"35","author":"Ferre","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.resp.2018.12.001_bib0095","first-page":"716","article-title":"Evaluation of antiasthmatic activity of Citrullus colocynthis fruit","volume":"8","author":"Genwa","year":"2017","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.resp.2018.12.001_bib0100","first-page":"42","article-title":"Effect of Randia Dumetorum Lam on clonidine and haloperidol-induced catalepsy in mice","volume":"2","author":"Ghaisas","year":"2008","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.resp.2018.12.001_bib0105","series-title":"Fundamentals of Experimental Pharmacology","author":"Ghosh","year":"2008"},{"key":"10.1016\/j.resp.2018.12.001_bib0110","first-page":"228","article-title":"Studies on antiallergic activity of ethanolic extract of Tephrosia purpurea Linn","volume":"37","author":"Gokhale","year":"2000","journal-title":"Indian J. Drugs Dermatol."},{"key":"10.1016\/j.resp.2018.12.001_bib0115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/rr41","article-title":"Th2 cytokines and asthma the role of interleukin-5 in allergic eosinophilic disease","volume":"2","author":"Greenfeder","year":"2001","journal-title":"Resp. Res."},{"key":"10.1016\/j.resp.2018.12.001_bib0120","doi-asserted-by":"crossref","first-page":"L973","DOI":"10.1152\/ajplung.00033.2003","article-title":"Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function","volume":"285","author":"Hamad","year":"2003","journal-title":"Am. J. Physiol.-Lung C"},{"key":"10.1016\/j.resp.2018.12.001_bib0125","series-title":"Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis","author":"Harborne","year":"2008"},{"key":"10.1016\/j.resp.2018.12.001_bib0130","first-page":"179","article-title":"Asthma medications: basic pharmacology and use in the athlete","volume":"35","author":"Houglum","year":"2000","journal-title":"J. Athl. Training"},{"key":"10.1016\/j.resp.2018.12.001_bib0135","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.2042-7158.1983.tb02864.x","article-title":"Involvement of histaminergic mechanisms in the cataleptogenic effect of clonidine in mice","volume":"35","author":"Jadhav","year":"1983","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0140","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S1995-7645(11)60163-6","article-title":"Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves","volume":"4","author":"Kapoor","year":"2011","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.resp.2018.12.001_bib0145","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1016\/0031-9422(74)80250-5","article-title":"A new sapogenin in the saponins of Zizyphus jujuba, Hovenia dulcis and Bacopa monniera","volume":"13","author":"Kawai","year":"1974","journal-title":"Phytochemistry"},{"key":"10.1016\/j.resp.2018.12.001_bib0150","series-title":"Practical Pharmacognosy: Techniques and Experiments","author":"Khandelwal","year":"2017"},{"key":"10.1016\/j.resp.2018.12.001_bib0155","series-title":"Indian Medicinal Plants: An Illustrated Dictionary","author":"Khare","year":"2011"},{"key":"10.1016\/j.resp.2018.12.001_bib0160","first-page":"1","article-title":"Protective effect of Zizyphus jujuba fruit extract against paracetamol and thioacetamide induced hepatic damage in rats","volume":"7","author":"Kumar","year":"2009","journal-title":"Internet J. Pharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0165","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.2042-7158.1980.tb13070.x","article-title":"Action of clonidine on the mast cells of rats","volume":"32","author":"Lakdawala","year":"1980","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0170","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbrc.2008.07.032","article-title":"Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma","volume":"374","author":"Lee","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.resp.2018.12.001_bib0175","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.intimp.2010.01.008","article-title":"Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma","volume":"10","author":"Lee","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0180","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02862","article-title":"Cytokine-mediated tissue injury in non-human primate models of viral infections","author":"Manickam","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.resp.2018.12.001_bib0185","first-page":"1","article-title":"Role of cytokines in pathophysiology of asthma","volume":"5","author":"Mehta","year":"2006","journal-title":"Iran. J. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2018.12.001_bib0190","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2012.04.019","article-title":"Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma","volume":"142","author":"Nirmal","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0195","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0031-9422(00)94587-4","article-title":"The structure of jujubosides A and B, the saponins isolated from the seeds of Zizyphus jujuba","volume":"17","author":"Otsuka","year":"1978","journal-title":"Phytochemistry"},{"key":"10.1016\/j.resp.2018.12.001_bib0200","first-page":"1460","article-title":"Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb","volume":"41","author":"Pungle","year":"2003","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.resp.2018.12.001_bib0205","series-title":"Compendium of Indian Medicinal Plants","author":"Rastogi","year":"1993"},{"key":"10.1016\/j.resp.2018.12.001_bib0210","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2147\/DDDT.S109489","article-title":"Update on new biologics for intractable eosinophilic asthma: impact of reslizumab","volume":"12","author":"Sahota","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.resp.2018.12.001_bib0215","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ptr.4809","article-title":"Zizyphus jujuba and its active component jujuboside B inhibit platelet aggregation","volume":"27","author":"Seo","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.resp.2018.12.001_bib0220","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bbrc.2015.05.104","article-title":"Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the T H 2 cytokines","volume":"463","author":"Shaik","year":"2015","journal-title":"Biochem. Biophys. Res. Comun."},{"issue":"1","key":"10.1016\/j.resp.2018.12.001_bib0225","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0091-3057(88)90316-4","article-title":"Alpha noradrenergic agonists promote catalepsy in the mouse","volume":"31","author":"Sukul","year":"1988","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.resp.2018.12.001_bib0230","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jps.2600810608","article-title":"Role of intracellular Ca2+ on histamine release from rat peritoneal mast cells","volume":"81","author":"Takei","year":"1992","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.resp.2018.12.001_bib0235","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/S2221-1691(11)60119-6","article-title":"Effect of Abrus precatorius leaves on milk induced leukocytosis and eosinophilia in the management of asthma","volume":"1","author":"Taur","year":"2011","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.resp.2018.12.001_bib0240","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0024-3205(90)90129-F","article-title":"Mast cells: the immune gate to the brain","volume":"46","author":"Theoharides","year":"1990","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2018.12.001_bib0245","first-page":"189","article-title":"Studies on anti-asthmatic and anti-anaphylactic activity of Albizzia lebbeck","volume":"9","author":"Tripathi","year":"1977","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.resp.2018.12.001_bib0250","first-page":"487","article-title":"Studies on anti-asthmatic activity of aqueous extract of Clerodendron phlomidis","volume":"1","author":"Vadnere","year":"2006","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.resp.2018.12.001_bib0255","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0975-3575(10)80012-4","article-title":"Anthelmintic activity of Zizyphus jujuba Mill & Lamk","volume":"2","author":"Veeresh","year":"2010","journal-title":"Pharmacogn. J."},{"key":"10.1016\/j.resp.2018.12.001_bib0260","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.tiv.2008.05.008","article-title":"Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization","volume":"22","author":"Verstraelen","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.resp.2018.12.001_bib0265","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.resp.2017.01.011","article-title":"Anti-asthmatic activity of osthole in an ovalbumin-induced asthma murine model","volume":"239","author":"Wang","year":"2017","journal-title":"Resp. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2018.12.001_bib0270","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1021\/np401022g","article-title":"Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy","volume":"77","author":"Xu","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.resp.2018.12.001_bib0275","article-title":"Jujuboside B reduces vascular tension by increasing Ca2+ influx and activating endothelial nitric oxide synthase","volume":"11","author":"Zhao","year":"2016","journal-title":"PLoS One"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904818303598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904818303598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:40:23Z","timestamp":1761604823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904818303598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":55,"alternative-id":["S1569904818303598"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2018.12.001","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. \u2013 Possible role in the treatment of asthma","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2018.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}