{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:02:50Z","timestamp":1768435370392,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00c3\u00a7\u00c3\u00a3o de Aperfei\u00c3\u00a7oamento de Pessoal de N\u00c3\u00advel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010661","name":"Southeastern Ontario Academic Medical Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.resp.2019.04.008","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T11:55:03Z","timestamp":1555588503000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of bi-level positive airway pressure on ventilatory and perceptual responses to exercise in comorbid heart failure-COPD"],"prefix":"10.1016","volume":"266","author":[{"given":"Aline","family":"Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila A.","family":"Sperandio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Mazzuco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Clara N.","family":"Alencar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio F.","family":"Arbex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayron","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wladimir","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcides","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz E.","family":"Nery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis E.","family":"O.Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Alberto","family":"Neder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2019.04.008_bib0005","first-page":"453","article-title":"Does lung diffusion impairment affect exercise capacity in patients with heart failure?","volume":"88","author":"Agostoni","year":"2002","journal-title":"Heart Br. Card. Soc."},{"key":"10.1016\/j.resp.2019.04.008_bib0010","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pupt.2006.03.001","article-title":"Cardiopulmonary interaction in heart failure","volume":"20","author":"Agostoni","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2019.04.008_bib0015","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jacc.2018.06.074","article-title":"Positive pressure ventilation in the cardiac intensive care unit","volume":"72","author":"Alviar","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40248-015-0008-1","article-title":"Non invasive ventilation as an additional tool for exercise training","volume":"10","author":"Ambrosino","year":"2015","journal-title":"Multidiscip. Respir. Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/rccm.167.2.211","article-title":"ATS\/ACCP Statement on cardiopulmonary exercise testing","volume":"167","author":"American Thoracic Society, American College of Chest Physicians","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/952741","article-title":"Lungs in heart failure","volume":"2012","author":"Apostolo","year":"2012","journal-title":"Pulm. Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0035","first-page":"1","article-title":"Exercise ventilation in COPD: influence of systolic heart failure","author":"Arbex","year":"2016","journal-title":"COPD"},{"key":"10.1016\/j.resp.2019.04.008_bib0040","first-page":"161","article-title":"Non-invasive ventilation in patients with heart failure: a systematic review and meta-analysis","volume":"108","author":"Bittencourt","year":"2017","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0045","doi-asserted-by":"crossref","first-page":"H2465","DOI":"10.1152\/ajpheart.91520.2007","article-title":"Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure","volume":"294","author":"Borghi-Silva","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0050","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM198905183202005","article-title":"Bronchial hyperresponsiveness to methacholine in patients with impaired left ventricular function","volume":"320","author":"Cabanes","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.resp.2013.06.017","article-title":"Dynamic pulmonary hyperinflation occurs without expiratory flow limitation in chronic heart failure during exercise","volume":"189","author":"Chiari","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0060","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1183\/09031936.00125011","article-title":"The resistive and elastic work of breathing during exercise in patients with chronic heart failure","volume":"39","author":"Cross","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.04.008_bib0065","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1183\/16000617.0048-2016","article-title":"Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors","volume":"25","author":"Dub\u00e9","year":"2016","journal-title":"Eur. Respir. Rev. Off. J. Eur. Respir. Soc."},{"key":"10.1016\/j.resp.2019.04.008_bib0070","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/1479972311423111","article-title":"Developing the model of pulmonary rehabilitation for chronic heart failure","volume":"8","author":"Evans","year":"2011","journal-title":"Chron. Respir. Dis."},{"key":"10.1016\/j.resp.2019.04.008_bib0075","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.rmed.2010.04.024","article-title":"Generic, symptom based, exercise rehabilitation; integrating patients with COPD and heart failure","volume":"104","author":"Evans","year":"2010","journal-title":"Respir. Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1164\/rccm.201504-0841OC","article-title":"Common mechanisms of Dyspnea in chronic interstitial and obstructive lung disorders","volume":"193","author":"Faisal","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0085","article-title":"Effects of noninvasive ventilation with bilevel positive airway pressure on exercise tolerance and dyspnea in heart failure patients","author":"Gomes Neto","year":"2017","journal-title":"Hell. J. Cardiol. HJC Hell. Kardiologike Epitheorese."},{"key":"10.1016\/j.resp.2019.04.008_bib0090","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijcard.2009.03.041","article-title":"Ventilatory efficiency and dyspnea on exertion improvements are related to reduced pulmonary pressure in heart failure patients receiving Sildenafil","volume":"144","author":"Guazzi","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0095","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/956081","article-title":"Inspiratory capacity during exercise: measurement, analysis, and interpretation","volume":"2013","author":"Guenette","year":"2013","journal-title":"Pulm. Med."},{"issue":"106","key":"10.1016\/j.resp.2019.04.008_bib0100","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1152\/japplphysiol.90744.2008","article-title":"Effect of biventricular pacing on ventilatory and perceptual responses to exercise in patients with stable chronic heart failure","volume":"1985","author":"Laveneziana","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0105","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1378\/chest.14-0800","article-title":"Recent advances in dyspnea","volume":"147","author":"Mahler","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.resp.2019.04.008_bib0110","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00005768-199703000-00004","article-title":"Interval training in patients with severe chronic heart failure: analysis and recommendations for exercise procedures","volume":"29","author":"Meyer","year":"1997","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.resp.2019.04.008_bib0115","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/14779072.2018.1510319","article-title":"Current challenges in managing comorbid heart failure and COPD","volume":"16","author":"Neder","year":"2018","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.resp.2019.04.008_bib0120","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/ajrccm\/138.5.1185","article-title":"Effect of continuous positive airway pressure on respiratory sensation in patients with chronic obstructive pulmonary disease during submaximal exercise","volume":"138","author":"O\u2019Donnell","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2019.04.008_bib0125","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1164\/ajrccm.160.6.9808134","article-title":"Ventilatory assistance improves exercise endurance in stable congestive heart failure","volume":"160","author":"O\u2019Donnell","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccm.2013.09.008","article-title":"Chronic obstructive pulmonary disease: clinical integrative physiology","volume":"35","author":"O\u2019Donnell","year":"2014","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0135","first-page":"82","article-title":"Advances in the evaluation of respiratory pathophysiology during exercise in chronic lung diseases","volume":"8","author":"O\u2019Donnell","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0140","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative strategies for lung function tests","volume":"26","author":"Pellegrino","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.04.008_bib0145","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1164\/ajrccm\/141.2.281","article-title":"Continuous positive airway pressure reduces work of breathing and dyspnea during weaning from mechanical ventilation in severe chronic obstructive pulmonary disease","volume":"141","author":"Petrof","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2019.04.008_bib0150","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/01.CIR.93.5.940","article-title":"Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training","volume":"93","author":"Piepoli","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2019.04.008_bib0155","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/HJR.0b013e32833f3aa5","article-title":"Exercise intolerance in chronic heart failure: mechanisms and therapies. Part II","volume":"17","author":"Piepoli","year":"2010","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.resp.2019.04.008_bib0160","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/eurjhf\/hfr017","article-title":"Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation","volume":"13","author":"Piepoli","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.resp.2019.04.008_bib0165","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1513\/AnnalsATS.201610-803FR","article-title":"Cardiopulmonary exercise testing in patients with heart failure with specific comorbidities","volume":"14","author":"Piepoli","year":"2017","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2019.04.008_bib0170","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1378\/chest.105.4.1053","article-title":"Respiratory muscle rest using nasal BiPAP ventilation in patients with stable severe COPD","volume":"105","author":"Renston","year":"1994","journal-title":"Chest"},{"key":"10.1016\/j.resp.2019.04.008_bib0175","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijcard.2016.09.077","article-title":"Physiological and sensory consequences of exercise oscillatory ventilation in heart failure-COPD","volume":"224","author":"Rocha","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0180","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201704-0675OC","article-title":"Excess ventilation in COPD-heart failure overlap: implications for dyspnea and exercise intolerance","author":"Rocha","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0185","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/BF01706208","article-title":"Intrinsic positive end-expiratory pressure (PEEPi)","volume":"21","author":"Rossi","year":"1995","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.resp.2019.04.008_bib0190","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1093\/eurheartj\/ehi291","article-title":"Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease","volume":"26","author":"Rutten","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.resp.2019.04.008_bib0195","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1183\/09031936.98.11020416","article-title":"Partitioning of the elastic work of inspiration in patients with COPD during exercise","volume":"11","author":"Sliwinski","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.04.008_bib0200","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1113\/EP087183","article-title":"Ventilatory constraints influence physiological dead space in heart failure","volume":"104","author":"Smith","year":"2019","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0205","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1152\/jappl.1980.49.3.511","article-title":"Pulmonary mechanics during exercise in subjects with chronic airflow obstruction","volume":"49","author":"Stubbing","year":"1980","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0210","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S1807-59322007000200004","article-title":"The impact of noninvasive ventilation during the physical training in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)","volume":"62","author":"Toledo","year":"2007","journal-title":"Clin. Sao Paulo Braz."},{"issue":"115","key":"10.1016\/j.resp.2019.04.008_bib0215","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1152\/japplphysiol.00195.2013","article-title":"The physiological basis of rehabilitation in chronic heart and lung disease","volume":"1985","author":"Vogiatzis","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.04.008_bib0220","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1164\/ajrccm.156.3.9702104","article-title":"Inspiratory muscle mechanics of patients with chronic obstructive pulmonary disease during incremental exercise","volume":"156","author":"Yan","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904819300187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904819300187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:43:14Z","timestamp":1761604994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904819300187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":44,"alternative-id":["S1569904819300187"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2019.04.008","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of bi-level positive airway pressure on ventilatory and perceptual responses to exercise in comorbid heart failure-COPD","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2019.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}