{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:26:43Z","timestamp":1782232003994,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.resp.2019.103312","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T01:52:43Z","timestamp":1569894763000},"page":"103312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Tidal breathing flow profiles during sleep in wheezing children measured by impedance pneumography"],"prefix":"10.1016","volume":"271","author":[{"given":"Javier","family":"Gracia-Tabuenca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville-Pekka","family":"Sepp\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milla","family":"Jauhiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Paassilta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Viik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Karjalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2019.103312_bib0005","series-title":"Chernick-Mellins Basic Mechanisms of Pediatric Respiratory Disease","first-page":"51","article-title":"Development of the thoracic cage","author":"Allen","year":"2002"},{"key":"10.1016\/j.resp.2019.103312_bib0010","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/ppul.20400","article-title":"Lung-function tests in neonates and infants with chronic lung disease: tidal breathing and respiratory control","volume":"41","author":"Baldwin","year":"2006","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2019.103312_bib0015","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1183\/09031936.98.12051008","article-title":"Detecting airways obstruction from the tidal flow profile","volume":"12","author":"Bates","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0020","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1034\/j.1399-3003.2000.16f26.x","article-title":"Tidal breath analysis for infant pulmonary function testing. ERS\/ATS task force on standards for infant respiratory function testing. European Respiratory Society\/American Thoracic Society","volume":"16","author":"Bates","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1164\/ajrccm\/140.2.363","article-title":"Relationship of nocturnal bronchoconstriction to sleep stages","volume":"140","author":"Bellia","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2019.103312_bib0030","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/ppul.1950180508","article-title":"Ability of new lung function tests to assess methacholine-induced airway obstruction in infants","volume":"18","author":"Benoist","year":"1994","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2019.103312_bib0035","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1164\/rccm.200605-642ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: pulmonary function testing in preschool children","volume":"175","author":"Beydon","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2019.103312_bib0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1081\/JAS-120002190","article-title":"Nocturnal worsening of asthma and sleep-disordered breathing","volume":"39","author":"Bohadana","year":"2002","journal-title":"J. Asthma"},{"key":"10.1016\/j.resp.2019.103312_bib0045","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1183\/09031936.94.07122154","article-title":"Tidal breathing analysis and response to salbutamol in awake young children with and without asthma","volume":"7","author":"Carlsen","year":"1994","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0050","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1152\/jappl.1989.67.5.2107","article-title":"Transition from dynamically maintained to relaxed end-expiratory volume in human infants","volume":"67","author":"Colin","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0055","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1183\/09031936.98.12030646","article-title":"Time to peak tidal expiratory flow and the neuromuscular control of expiration","volume":"12","author":"van der Ent","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0060","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1203\/00006450-198212000-00013","article-title":"Changes in respiratory pattern resulting from the use of a facemask to record respiration in newborn infants","volume":"16","author":"Fleming","year":"1982","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.resp.2019.103312_bib0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2008-1059630","article-title":"Sleep apneas in normal neonates and infants during the first 3 months of Life1","volume":"13","author":"Flores-Guevara","year":"1982","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.resp.2019.103312_bib0070","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1152\/jappl.2001.91.4.1687","article-title":"Analysis of the harmonic content of the tidal flow waveforms in infants","volume":"91","author":"Frey","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0075","series-title":"EMBEC & NBC 2017, IFMBE Proceedings","first-page":"306","article-title":"Nonlinear local projection filter for impedance pneumography","author":"Gracia","year":"2017"},{"key":"10.1016\/j.resp.2019.103312_bib0080","doi-asserted-by":"crossref","DOI":"10.1152\/japplphysiol.01007.2018","article-title":"Tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance pneumography","author":"Gracia-Tabuenca","year":"2019","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0085","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ppul.1950070104","article-title":"Changes in functional residual capacity in response to bronchodilator therapy among young asthmatic children","volume":"7","author":"Greenough","year":"1989","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2019.103312_bib0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01377349","article-title":"Children and nocturnal snoring: evaluation of the effects of sleep related respiratory resistive load and daytime functioning","volume":"139","author":"Guilleminault","year":"1982","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.resp.2019.103312_bib0095","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1152\/jappl.1979.46.5.998","article-title":"Maturation of ventilation and ventilatory pattern in normal sleeping infants","volume":"46","author":"Haddad","year":"1979","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0100","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/jappl.1979.46.6.1081","article-title":"Reduced lung volume during behavioral active sleep in the newborn","volume":"46","author":"Henderson-Smart","year":"1979","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0105","series-title":"Principles and Practice of Sleep Medicine","first-page":"237","article-title":"Respiratory physiology: central neural control of respiratory neurons and motoneurons during sleep","author":"Horner","year":"2010"},{"key":"10.1016\/j.resp.2019.103312_bib0110","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/ppul.20874","article-title":"Relative impact of respiratory muscle activity on tidal flow and end expiratory volume in healthy neonates","volume":"43","author":"Hutten","year":"2008","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2019.103312_bib0115","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/dev.21482","article-title":"An automated method for coding sleep states in human infants based on respiratory rate variability","volume":"58","author":"Isler","year":"2016","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.resp.2019.103312_bib0120","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1109\/TBME.2010.2046168","article-title":"Analysis of tidal breathing flow volume loops for automated lung-function diagnosis in infants","volume":"57","author":"Leonhardt","year":"2010","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.resp.2019.103312_bib0125","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1183\/09031936.93.06101496","article-title":"Lung function in awake healthy infants: the first five days of life","volume":"6","author":"Lodrup-Carlsen","year":"1993","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0130","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1152\/jappl.2000.88.6.1955","article-title":"Respiratory muscle activity measured with a noninvasive EMG technique: technical aspects and reproducibility","volume":"88","author":"Maarsingh","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0135","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00926-2016","article-title":"Measurement of tidal breathing flows in infants using impedance pneumography","volume":"49","author":"Malmberg","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0140","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1378\/chest.124.5.1812","article-title":"Respiratory inductance plethysmography in healthy 3- to 5-year-old children*","volume":"124","author":"Mayer","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.resp.2019.103312_bib0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/thx.36.2.135","article-title":"Tidal expiratory flow patterns in airflow obstruction","volume":"36","author":"Morris","year":"1981","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2019.103312_bib0150","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1183\/09031936.98.12051113","article-title":"Analysis of expiratory tidal flow patterns as a diagnostic tool in airflow obstruction","volume":"12","author":"Morris","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0155","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1152\/jappl.1982.52.5.1209","article-title":"Dynamics of breathing in infants","volume":"52","author":"Mortola","year":"1982","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0160","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1152\/jappl.1950.2.11.592","article-title":"Mechanics of breathing in man","volume":"2","author":"Otis","year":"1950","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0165","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1152\/jappl.1994.76.2.650","article-title":"Hering-Breuer reflex and respiratory system compliance in the first year of life: a longitudinal study","volume":"76","author":"Rabbette","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0170","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1152\/jappl.2001.90.2.705","article-title":"Methods for averaging irregular respiratory flow profiles in awake humans","volume":"90","author":"Sato","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0175","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1569-9048(03)00029-6","article-title":"Influence of preterm onset of inspiration on tidal breathing parameters in infants with and without CLD","volume":"135","author":"Schmalisch","year":"2003","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2019.103312_bib0180","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1006\/cbmr.1998.1493","article-title":"Comparative investigations of algorithms for the detection of breaths in newborns with disturbed respiratory signals","volume":"31","author":"Schmidt","year":"1998","journal-title":"Comput. Biomed. Res."},{"key":"10.1016\/j.resp.2019.103312_bib0185","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.sleep.2011.05.006","article-title":"Normative values of polysomnographic parameters in childhood and adolescence: cardiorespiratory parameters","volume":"12","author":"Scholle","year":"2011","journal-title":"Sleep Med."},{"key":"10.1016\/j.resp.2019.103312_bib0190","article-title":"Novel electrode configuration for highly linear impedance pneumography","volume":"58","author":"Sepp\u00e4","year":"2013","journal-title":"Biomed. Technol. Eng."},{"key":"10.1016\/j.resp.2019.103312_bib0195","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1088\/0967-3334\/32\/3\/005","article-title":"A method for suppressing cardiogenic oscillations in impedance pneumography","volume":"32","author":"Sepp\u00e4","year":"2011","journal-title":"Physiol. Meas."},{"key":"10.1016\/j.resp.2019.103312_bib0200","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1152\/japplphysiol.00657.2013","article-title":"Tidal breathing flow measurement in awake young children by using impedance pneumography","volume":"115","author":"Sepp\u00e4","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0205","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00989-2015","article-title":"Tidal flow variability measured by impedance pneumography relates to childhood asthma risk","author":"Sepp\u00e4","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0210","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1109\/TBME.2010.2051668","article-title":"Assessment of pulmonary flow using impedance pneumography","volume":"57","author":"Sepp\u00e4","year":"2010","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.resp.2019.103312_bib0215","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/thx.2010.152462","article-title":"Nocturnal asthma monitoring by chest wall electromyography","volume":"66","author":"Steier","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2019.103312_bib0220","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1152\/jappl.1981.51.3.557","article-title":"Changes in ventilation and chest wall mechanics during sleep in normal adolescents","volume":"51","author":"Tabachnik","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2019.103312_bib0225","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ppul.20236","article-title":"Polysomnographic values in children 2-9 years old: additional data and review of the literature","volume":"40","author":"Traeger","year":"2005","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2019.103312_bib0230","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1183\/09031936.96.09061306","article-title":"Improvement of tidal breathing pattern analysis in children with asthma by on-line automatic data processing","volume":"9","author":"van der Ent","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0235","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1569-9048(02)00206-9","article-title":"Modeling of the expiratory flow pattern of spontaneously breathing cats","volume":"134","author":"Walraven","year":"2003","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2019.103312_bib0240","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1183\/09031936.93.03060625","article-title":"The effect of hyperinflation on respiratory muscle work in acute induced asthma","volume":"3","author":"Wheatley","year":"1990","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2019.103312_bib0245","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1109\/JBHI.2013.2276083","article-title":"An evaluation of cardiorespiratory and movement features with respect to sleep-stage classification","volume":"18","author":"Willemen","year":"2014","journal-title":"IEEE J. Biomed. Health Inform."},{"key":"10.1016\/j.resp.2019.103312_bib0250","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1183\/09031936.98.12051118","article-title":"Tidal expired airflow patterns in adults with airway obstruction","volume":"12","author":"Williams","year":"1998","journal-title":"Eur. Respir. J."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904819301466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904819301466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:42:38Z","timestamp":1761604958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904819301466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":50,"alternative-id":["S1569904819301466"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2019.103312","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tidal breathing flow profiles during sleep in wheezing children measured by impedance pneumography","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2019.103312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103312"}}