{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:48:26Z","timestamp":1761605306320,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.resp.2020.103441","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T21:17:12Z","timestamp":1587763032000},"page":"103441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Modulation of arachidonic acid-evoked cardiorespiratory effects by the central lipoxygenase pathway"],"prefix":"10.1016","volume":"278","author":[{"given":"Gokcen","family":"Guvenc-Bayram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcin","family":"Altinbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leman Gizem","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2020.103441_bib0005","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1139\/cjpp-2014-0043","article-title":"Activation of the central histaminergic system mediates arachidonic-acid-induced cardiovascular effects","volume":"92","author":"Altinbas","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2020.103441_bib0010","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.plefa.2008.04.007","article-title":"Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid","volume":"78","author":"Aydin","year":"2008","journal-title":"Prostag. Leukotr. Ess. Fatty Acids"},{"key":"10.1016\/j.resp.2020.103441_bib0015","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1471-4159.2007.04558.x","article-title":"Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models","volume":"102","author":"Bosetti","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2020.103441_bib0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1745-7254.2005.00043.x","article-title":"Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats","volume":"26","author":"Deng","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.resp.2020.103441_bib0025","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.autneu.2015.02.005","article-title":"Brain thromboxane A2 via arachidonic acid cascade induces the hypothalamic-pituitary-gonadal axis activation in rats","volume":"189","author":"Erkan","year":"2015","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.resp.2020.103441_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resp.2015.12.010","article-title":"The effects of centrally injected arachidonic acid on respiratory system: involvement of cyclooxygenase to thromboxane signaling pathway","volume":"225","author":"Erkan","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2020.103441_bib0035","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.resp.2017.04.006","article-title":"The acute cardiorespiratory effects of centrally injected arachidonic acid; the mediation of prostaglandin E, D and F2\u03b1","volume":"242","author":"Erkan","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2020.103441_bib0040","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0006-8993(87)91627-1","article-title":"Leukotriene production by cultured astroglial cells","volume":"435","author":"Hartung","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2020.103441_bib0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0165-5728(88)90005-7","article-title":"Primary rat astroglial cultures can generate leukotriene B4","volume":"19","author":"Hartung","year":"1988","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.resp.2020.103441_bib0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0301-0082(95)00016-O","article-title":"Arachidonic acid as a neurotoxic and neurotrophic substance","volume":"46","author":"Katsuki","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.resp.2020.103441_bib0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0090-6980(02)00035-7","article-title":"Mammalian arachidonate 15-lipoxygenases. Structure, function, and biological implications","volume":"68\u201369","author":"Kuhn","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.resp.2020.103441_bib0060","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1073\/pnas.81.19.6212","article-title":"Leukotrienes in the rat central nervous system","volume":"81","author":"Lindgren","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"year":"2011","series-title":"Guide for the Care and Use of Laboratory Animals","author":"NAC (National Academy of Sciences)","key":"10.1016\/j.resp.2020.103441_bib0065"},{"key":"10.1016\/j.resp.2020.103441_bib0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-3940(80)90322-5","article-title":"Leukotriene C elicits a prolonged excitation of cerebellar Purkinje neurons","volume":"8","author":"Palmer","year":"1980","journal-title":"Neurosci. Lett."},{"year":"2005","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.resp.2020.103441_bib0075"},{"key":"10.1016\/j.resp.2020.103441_bib0080","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ijdevneu.2011.03.009","article-title":"Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex","volume":"29","author":"Perez-Polo","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.resp.2020.103441_bib0085","first-page":"65","article-title":"Eicosanoids in synaptic transmission","volume":"8","author":"Piomelli","year":"1984","journal-title":"Crit. Rev. Neurobiol."},{"key":"10.1016\/j.resp.2020.103441_bib0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0090-6980(02)00032-1","article-title":"Arachidonate 5-lipoxygenase","volume":"68\u201369","author":"Radmark","year":"2002","journal-title":"Prostaglandins Other Lipid Media."},{"key":"10.1016\/j.resp.2020.103441_bib0095","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1067\/S0022-3476(03)00399-8","article-title":"In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism","volume":"143","author":"Rapoport","year":"2003","journal-title":"J. Pediatr."},{"key":"10.1016\/j.resp.2020.103441_bib0100","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1093\/jn\/138.12.2515","article-title":"Arachidonic acid and the brain","volume":"138","author":"Rapoport","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.resp.2020.103441_bib0105","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2174\/1567202612666150812150606","article-title":"The 5-lipoxygenase (5-LOX) inhibitor zileuton reduces inflammation and infarct size with improvement in neurological outcome following cerebral ischemia","volume":"12","author":"Silva","year":"2015","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.resp.2020.103441_bib0110","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.lfs.2004.05.009","article-title":"Cardiorespiratory effects of diazepamketamine, xylazine-ketamine and thiopentone anesthesia in male Wistar rats \u2013 a comparative analysis","volume":"75","author":"Sumitra","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2020.103441_bib0115","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1194\/jlr.M053058","article-title":"12\/15-Lipoxygenase metabolites of arachidonic acid activate PPAR\u03b3: a possible neuroprotective effect in ischemic brain","volume":"56","author":"Sun","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.resp.2020.103441_bib0120","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s11064-016-1994-x","article-title":"5-LOX inhibitor zileuton reduces inflammatory reaction and ischemic brain damage through the activation of PI3K\/Akt signaling pathway","volume":"41","author":"Tu","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.resp.2020.103441_bib0125","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/HYPERTENSIONAHA.112.192252","article-title":"Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats","volume":"61","author":"Waki","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2020.103441_bib0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1139\/Y11-003","article-title":"Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid","volume":"89","author":"Yalcin","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2020.103441_bib0135","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1440-1681.2008.05087.x","article-title":"Cardiovascular effects of centrally administered arachidonic acid in haemorrhage-induced hypotensive rats: investigation of a peripheral mechanism","volume":"36","author":"Yalcin","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2020.103441_bib0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.plefa.2011.05.003","article-title":"The role of the central arachidonic acid-thromboxane A2 cascade in cardiovascular regulation during hemorrhagic shock in rats","volume":"85","author":"Yalcin","year":"2011","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.resp.2020.103441_bib0145","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000075546","article-title":"Restoration of blood pressure by centrally injected U-46619, a thromboxane A2 analog, in haemorhaged hypotensive rats: investigation of different brain areas","volume":"70","author":"Yalcin","year":"2004","journal-title":"Pharmacology"},{"key":"10.1016\/j.resp.2020.103441_bib0150","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.npep.2007.07.002","article-title":"Cardiovascular effects of centrally injected melittin in hemorrhaged hypotensive rats: the investigation of peripheral mechanisms","volume":"41","author":"Yalcin","year":"2007","journal-title":"Neuropeptides"},{"key":"10.1016\/j.resp.2020.103441_bib0155","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1440-1681.2005.04291.x","article-title":"Involvement of brain thromboxane A2 in hypotension induced by haemorrhagein rats","volume":"32","author":"Yalcin","year":"2005","journal-title":"Clin. Exp. Pharmcol. Physiol."},{"key":"10.1016\/j.resp.2020.103441_bib0160","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0090-6980(02)00034-5","article-title":"Arachidonate 12-lipoxygenases","volume":"68\u201369","author":"Yoshimoto","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820300999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820300999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:43:27Z","timestamp":1761605007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904820300999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":32,"alternative-id":["S1569904820300999"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2020.103441","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of arachidonic acid-evoked cardiorespiratory effects by the central lipoxygenase pathway","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2020.103441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103441"}}