{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:46:33Z","timestamp":1769082393811,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.resp.2020.103475","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T11:33:31Z","timestamp":1591356811000},"page":"103475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Oxygen supplementation increases the total work and muscle damage markers but reduces the inflammatory response in COPD patients"],"prefix":"10.1016","volume":"280","author":[{"given":"Daniela Rodrigues","family":"Andrade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly Critine","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Sampel","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Kuguimoto","family":"Andaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviani Aparecida","family":"Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Augusto","family":"de Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Gun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Augusto Rodrigues","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayron F.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wladimir Musetti","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2020.103475_bib0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.resp.2013.10.002","article-title":"Exercise-induced oxygen desaturation in COPD patients without resting hypoxemia","volume":"190","author":"Andrianopoulos","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2020.103475_bib0010","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1249\/00005768-198412000-00002","article-title":"Mechanisms of exercise-induced delayed onset muscular soreness: a brief review","volume":"16","author":"Armstrong","year":"1984","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.resp.2020.103475_bib0015","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s00421-016-3442-7","article-title":"High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients","volume":"116","author":"Azevedo Dde","year":"2016","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.resp.2020.103475_bib0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/thx.2005.041996","article-title":"Raised CRP levels mark metabolic and functional impairment in advanced COPD","volume":"61","author":"Broekhuizen","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2020.103475_bib0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40798-015-0032-x","article-title":"A systematic review of the acute effects of exercise on immune and inflammatory indices in untrained adults","volume":"1","author":"Brown","year":"2015","journal-title":"Sports Med. Open"},{"key":"10.1016\/j.resp.2020.103475_bib0030","first-page":"347","article-title":"Measurement of the acute inflammatory response to walking exercise in COPD: effects of pulmonary rehabilitation","volume":"2","author":"Canavan","year":"2007","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.resp.2020.103475_bib0035","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1378\/chest.08-0520","article-title":"Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD","volume":"134","author":"Casanova","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.resp.2020.103475_bib0040","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1164\/rccm.200209-1028OC","article-title":"Exercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in patients with chronic obstructive pulmonary disease","volume":"167","author":"Couillard","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2020.103475_bib0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1164\/rccm.200605-713OC","article-title":"C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease","volume":"175","author":"Dahl","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2020.103475_bib0050","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1152\/japplphysiol.01615.2011","article-title":"Effect of incremental exercise on airway and systemic inflammation in patients with COPD","volume":"112","author":"Davidson","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2020.103475_bib0055","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1183\/09031936.06.00109605","article-title":"C-reactive protein levels and clinically important predictive outcomes in stable COPD patients","volume":"27","author":"de Torres","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2020.103475_bib0060","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1152\/jappl.1999.87.6.1997","article-title":"Exercise-induced arterial hypoxemia","volume":"87","author":"Dempsey","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2020.103475_bib0065","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1519\/JSC.0000000000000834","article-title":"Time-to-Fatigue during incline treadmill running: implications for individualized training prescription","volume":"29","author":"Ferley","year":"2015","journal-title":"J. Strength Cond. Res."},{"key":"10.1016\/j.resp.2020.103475_bib0070","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ajcn\/71.5.1033","article-title":"Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives","volume":"71","author":"Gosker","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.resp.2020.103475_bib0075","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1249\/01.mss.0000188577.63910.51","article-title":"Cytokine responses at high altitude: effects of exercise and antioxidants at 4300\u2009m","volume":"38","author":"Hagobian","year":"2006","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.resp.2020.103475_bib0080","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/cyto.1999.0533","article-title":"High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein","volume":"12","author":"Hartmann","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.resp.2020.103475_bib0085","first-page":"R1697","article-title":"Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease","volume":"277","author":"Heunks","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2020.103475_bib0090","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1475-097X.2008.00795.x","article-title":"Enhanced exercise-induced plasma cytokine response and oxidative stress in COPD patients depend on blood oxygenation","volume":"28","author":"Jammes","year":"2008","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.resp.2020.103475_bib0095","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.jacc.2004.12.077","article-title":"The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review","volume":"45","author":"Kasapis","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.resp.2020.103475_bib0100","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/thx.2004.037531","article-title":"Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease","volume":"60","author":"Koechlin","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2020.103475_bib0105","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/thx.2006.059808","article-title":"C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease","volume":"61","author":"Man","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2020.103475_bib0110","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.rmed.2007.10.020","article-title":"Physiological responses to high intensity, constant-load arm exercise in COPD","volume":"102","author":"McKeough","year":"2008","journal-title":"Respir. Med."},{"key":"10.1016\/j.resp.2020.103475_bib0115","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/2047487312460520","article-title":"The dysfunction of ammonia in heart failure increases with an increase in the intensity of resistance exercise, even with the use of appropriate drug therapy","volume":"21","author":"Medeiros","year":"2014","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.resp.2020.103475_bib0120","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1152\/ajpregu.00404.2014","article-title":"Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors","volume":"308","author":"Medeiros","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2020.103475_bib0125","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005372.pub2","article-title":"Oxygen therapy during exercise training in chronic obstructive pulmonary disease","author":"Nonoyama","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.resp.2020.103475_bib0130","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1475-097X.2011.01054.x","article-title":"Effects of oxygen supplementation on cerebral oxygenation during exercise in chronic obstructive pulmonary disease patients not entitled to long-term oxygen therapy","volume":"32","author":"Oliveira","year":"2012","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.resp.2020.103475_bib0135","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3109\/15412550903341497","article-title":"Exertional desaturation in patients with chronic obstructive pulmonary disease","volume":"6","author":"Panos","year":"2009","journal-title":"COPD"},{"key":"10.1016\/j.resp.2020.103475_bib0140","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1164\/ajrccm\/147.3.592","article-title":"Muscular metabolism during oxygen supplementation in patients with chronic hypoxemia","volume":"147","author":"Payen","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2020.103475_bib0145","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2020.103475_bib0150","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5604\/20831862.1111434","article-title":"Effects of downhill and uphill exercises of equivalent submaximal intensities on selected blood cytokine levels and blood creatine kinase activity","volume":"31","author":"Pokora","year":"2014","journal-title":"Biol. Sport"},{"key":"10.1016\/j.resp.2020.103475_bib0155","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1152\/jappl.1999.86.3.1048","article-title":"Evidence of O2 supply-dependent VO2 max in the exercise-trained human quadriceps","volume":"86","author":"Richardson","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2020.103475_bib0160","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.rmed.2006.02.030","article-title":"Respiratory muscle energetics during exercise in healthy subjects and patients with COPD","volume":"100","author":"Scano","year":"2006","journal-title":"Respir. Med."},{"issue":"918-920","key":"10.1016\/j.resp.2020.103475_bib0165","first-page":"A919","article-title":"Effect of marathon running on inflammatory and hemostatic markers","volume":"88","author":"Siegel","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.resp.2020.103475_bib0170","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1161\/01.CIR.0000056767.69054.B3","article-title":"Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease","volume":"107","author":"Sin","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2020.103475_bib0175","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1378\/chest.122.5.1830","article-title":"Enhancement of exercise performance in COPD patients by hyperoxia: a call for research","volume":"122","author":"Snider","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.resp.2020.103475_bib0180","doi-asserted-by":"crossref","first-page":"19","DOI":"10.11606\/issn.2317-0190.v22i1a103896","article-title":"Muscle damage induced by neuromuscular electrical stimulation (NMES) with frequencies of 30 Hz and 100 Hz","volume":"22","author":"Souza","year":"2015","journal-title":"Acta Fisiatr."},{"key":"10.1016\/j.resp.2020.103475_bib0185","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4187\/respcare.03647","article-title":"Effects of oxygen supply during training on subjects with COPD who are normoxemic at rest and during exercise: a blinded randomized controlled trial","volume":"60","author":"Spielmanns","year":"2015","journal-title":"Respir. Care"},{"key":"10.1016\/j.resp.2020.103475_bib0190","first-page":"575","article-title":"Acute inflammatory and anabolic systemic responses to peak and constant-work-rate exercise bout in hospitalized patients with COPD","volume":"2","author":"Spruit","year":"2007","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.resp.2020.103475_bib0195","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1136\/bmj.289.6454.1249","article-title":"C reactive protein concentrations during long distance running","volume":"289","author":"Strachan","year":"1984","journal-title":"Br. Med. J."},{"key":"10.1016\/j.resp.2020.103475_bib0200","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.rmed.2006.06.017","article-title":"Distance and oxygen desaturation in 6-min walk test predict prognosis in COPD patients","volume":"101","author":"Takigawa","year":"2007","journal-title":"Respir. Med."},{"key":"10.1016\/j.resp.2020.103475_bib0205","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000332833","article-title":"Prevalence and prediction of exercise-induced oxygen desaturation in patients with chronic obstructive pulmonary disease","volume":"84","author":"van Gestel","year":"2012","journal-title":"Respiration"},{"key":"10.1016\/j.resp.2020.103475_bib0210","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.rmed.2005.03.028","article-title":"Systemic inflammatory response to exhaustive exercise in patients with chronic obstructive pulmonary disease","volume":"99","author":"van Helvoort","year":"2005","journal-title":"Respir. Med."},{"key":"10.1016\/j.resp.2020.103475_bib0215","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1164\/rccm.200512-1957OC","article-title":"Supplemental oxygen prevents exercise-induced oxidative stress in muscle-wasted patients with chronic obstructive pulmonary disease","volume":"173","author":"van Helvoort","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2020.103475_bib0220","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1378\/chest.06-1655","article-title":"Six-minute walking-induced systemic inflammation and oxidative stress in muscle-wasted COPD patients","volume":"131","author":"van Helvoort","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.resp.2020.103475_bib0225","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2020.103475_bib0230","first-page":"604","article-title":"Delivered oxygen concentrations using low-flow and high-flow nasal cannulas","volume":"50","author":"Wettstein","year":"2005","journal-title":"Respir. Care"},{"key":"10.1016\/j.resp.2020.103475_bib0235","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00408-012-9443-3","article-title":"Dynamic hyperinflation correlates with exertional oxygen desaturation in patients with chronic obstructive pulmonary disease","volume":"191","author":"Zafar","year":"2013","journal-title":"Lung"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820301336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820301336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:44:41Z","timestamp":1761605081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904820301336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":47,"alternative-id":["S1569904820301336"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2020.103475","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxygen supplementation increases the total work and muscle damage markers but reduces the inflammatory response in COPD patients","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2020.103475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103475"}}