{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:53:15Z","timestamp":1784749995503,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005890","name":"Ministry of Health of the People's Republic of China","doi-asserted-by":"publisher","award":["201002012"],"award-info":[{"award-number":["201002012"]}],"id":[{"id":"10.13039\/501100005890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730054"],"award-info":[{"award-number":["81730054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BLJ18J007"],"award-info":[{"award-number":["BLJ18J007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.resp.2020.103534","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T11:35:06Z","timestamp":1598873706000},"page":"103534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Pulmonary function tests at low altitude predict pulmonary pressure response to short-term high altitude exposure"],"prefix":"10.1016","volume":"282","author":[{"given":"Yuanqi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexue","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhu","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbin","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhengyuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsheng","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2020.103534_bib0005","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1440-1843.2007.01031.x","article-title":"Evaluation of the relationship between radiological abnormalities and both pulmonary function and pulmonary hypertension in coal workers\u2019 pneumoconiosis","volume":"12","author":"Akkoca Yildiz","year":"2007","journal-title":"Respirology"},{"key":"10.1016\/j.resp.2020.103534_bib0010","doi-asserted-by":"crossref","first-page":"H2646","DOI":"10.1152\/ajpheart.00053.2012","article-title":"Pulmonary artery pressure and cardiac function in children and adolescents after rapid ascent to 3450 m","volume":"302","author":"Allemann","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2020.103534_bib0015","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1183\/09031936.00140109","article-title":"Small airway obstruction in severe pulmonary arterial hypertension correlates with increased airway CD8+ T-cells and fractalkine expression","volume":"34","author":"Ars","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2020.103534_bib0020","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1161\/CIRCULATIONAHA.106.650796","article-title":"Effect of altitude on the heart and the lungs","volume":"116","author":"Bartsch","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2020.103534_bib0025","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1183\/09031936.00105110","article-title":"Effects of cigarette smoke and hypoxia on pulmonary circulation in the guinea pig","volume":"38","author":"Ferrer","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2020.103534_bib0030","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41598-017-14947-z","article-title":"Subclinical pulmonary dysfunction contributes to high altitude pulmonary edema susceptibility in healthy non-mountaineers","volume":"7","author":"Gupta","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.resp.2020.103534_bib0035","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/01.CIR.44.5.759","article-title":"Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema","volume":"44","author":"Hultgren","year":"1971","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2020.103534_bib0040","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1172\/JCI106554","article-title":"Pulmonary artery pressure and alveolar gas exchange in man during acclimatization to 12,470 ft","volume":"50","author":"Kronenberg","year":"1971","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.resp.2020.103534_bib0045","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/apha.12749","article-title":"The principal pathways involved in the in vivo modulation of hypoxic pulmonary vasoconstriction, pulmonary arterial remodelling and pulmonary hypertension","volume":"219","author":"Kylhammar","year":"2017","journal-title":"Acta Physiol."},{"key":"10.1016\/j.resp.2020.103534_bib0050","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1007\/s00421-011-1864-9","article-title":"Variability in pulmonary function following rapid altitude ascent to the Amundsen-Scott South Pole station","volume":"111","author":"Lalande","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.resp.2020.103534_bib0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1411532","article-title":"Lung-function trajectories leading to chronic obstructive pulmonary disease","volume":"373","author":"Lange","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2020.103534_bib0060","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1183\/13993003.01684-2015","article-title":"Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics","volume":"47","author":"Lau","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2020.103534_bib0065","first-page":"7","article-title":"Lung function, inflammation, and Endothelin-1 in congenital heart disease-associated pulmonary arterial hypertension","author":"Low","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.resp.2020.103534_bib0070","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1001\/jama.2017.16192","article-title":"Does this patient have acute mountain sickness?: The rational clinical examination systematic review","volume":"318","author":"Meier","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.resp.2020.103534_bib0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2020.103534_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2018.06.004","article-title":"Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: recommendations from the american society of echocardiography","volume":"32","author":"Mitchell","year":"2019","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.resp.2020.103534_bib0085","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1113\/expphysiol.2012.069112","article-title":"Pulmonary hypertension and the right ventricle in hypoxia","volume":"98","author":"Naeije","year":"2013","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2020.103534_bib0090","doi-asserted-by":"crossref","DOI":"10.1007\/s00296-019-04370-0","article-title":"Reduced diffusing capacity for carbon monoxide predicts borderline pulmonary arterial pressure in patients with systemic sclerosis","author":"Ninagawa","year":"2019","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.resp.2020.103534_bib0095","first-page":"1277","article-title":"Echocardiographic assessment of cardiac performance in response to high altitude and development of subclinical pulmonary edema in healthy climbers","volume":"29","author":"Page","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.resp.2020.103534_bib0100","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/japplphysiol.00677.2009","article-title":"Airway responses to methacholine and exercise at high altitude in healthy lowlanders","volume":"108","author":"Pellegrino","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2020.103534_bib0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12931-018-0911-z","article-title":"Heterogeneous burden of lung disease in smokers with borderline airflow obstruction","volume":"19","author":"Pirozzi","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.resp.2020.103534_bib0110","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jcmg.2013.08.007","article-title":"RV contractility and exercise-induced pulmonary hypertension in chronic mountain sickness: a stress echocardiographic and tissue Doppler imaging study","volume":"6","author":"Pratali","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.resp.2020.103534_bib0115","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/ppul.10363","article-title":"Lower airway obstruction, bronchial hyperresponsiveness, and primary pulmonary hypertension in children","volume":"37","author":"Rastogi","year":"2004","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.resp.2020.103534_bib0120","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/jamainternmed.2015.2735","article-title":"Clinical and Radiologic Disease in Smokers With Normal Spirometry","volume":"175","author":"Regan","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.resp.2020.103534_bib0125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1089\/ham.2017.0164","article-title":"The 2018 lake louise acute mountain sickness score","volume":"19","author":"Roach","year":"2018","journal-title":"High Alt. Med. Biol."},{"key":"10.1016\/j.resp.2020.103534_bib0130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.resp.2020.103534_bib0135","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1378\/chest.09-2962","article-title":"Tobacco smoke: a risk factor for pulmonary arterial hypertension? A case-control study","volume":"138","author":"Schiess","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.resp.2020.103534_bib0140","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jacc.2018.06.049","article-title":"Declining lung function and cardiovascular risk: the ARIC study","volume":"72","author":"Silvestre","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.resp.2020.103534_bib0145","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1152\/japplphysiol.00394.2016","article-title":"Pulmonary artery pressure and arterial oxygen saturation in people living at high or low altitude: systematic review and meta-analysis","volume":"121","author":"Soria","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2020.103534_bib0150","first-page":"51","article-title":"Tobacco smoke exposure in early life and adolescence in relation to lung function","author":"Thacher","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2020.103534_bib0155","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/jez029","article-title":"The feasibility and clinical implication of tricuspid regurgitant velocity and pulmonary flow acceleration time evaluation for pulmonary pressure assessment during exercise stress echocardiography","author":"Wierzbowska-Drabik","year":"2019","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.resp.2020.103534_bib0160","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/thoraxjnl-2011-200623","article-title":"Smoking, acute mountain sickness and altitude acclimatisation: a cohort study","volume":"67","author":"Wu","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2020.103534_bib0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1183\/09059180.00011104","article-title":"High-altitude pulmonary hypertension","volume":"18","author":"Xu","year":"2009","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.resp.2020.103534_bib0170","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijcard.2014.12.044","article-title":"High altitude-induced borderline pulmonary hypertension impaired cardiorespiratory fitness in healthy young men","volume":"181","author":"Yang","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.resp.2020.103534_bib0175","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/ATVBAHA.118.312280","article-title":"Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor","volume":"39","author":"Zhu","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.resp.2020.103534_bib0180","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.rmed.2007.05.012","article-title":"Prediction of pulmonary hypertension in idiopathic pulmonary fibrosis","volume":"101","author":"Zisman","year":"2007","journal-title":"Respir. Med."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820301920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820301920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:18:03Z","timestamp":1777619883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904820301920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":36,"alternative-id":["S1569904820301920"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2020.103534","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary function tests at low altitude predict pulmonary pressure response to short-term high altitude exposure","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2020.103534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103534"}}