{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:13Z","timestamp":1787837173950,"version":"build-2784847793"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014738","name":"Vision Group on Science and Technology","doi-asserted-by":"publisher","award":["KSTePS\/VGST\/K-FIST L2\/2015-16\/GRD-522\/111\/2018-19\/226\/1 Dtd.24.09.2018"],"award-info":[{"award-number":["KSTePS\/VGST\/K-FIST L2\/2015-16\/GRD-522\/111\/2018-19\/226\/1 Dtd.24.09.2018"]}],"id":[{"id":"10.13039\/501100014738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014738","name":"Vision Group on Science and Technology","doi-asserted-by":"publisher","award":["KFIST-Level 2"],"award-info":[{"award-number":["KFIST-Level 2"]}],"id":[{"id":"10.13039\/501100014738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.resp.2020.103588","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T11:25:08Z","timestamp":1606476308000},"page":"103588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Hypoxia and its preconditioning on cardiac and vascular remodelling in experimental animals"],"prefix":"10.1016","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-3827","authenticated-orcid":false,"given":"Shrilaxmi","family":"Bagali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-2117","authenticated-orcid":false,"given":"Kusal K.","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.resp.2020.103588_bib0005","doi-asserted-by":"crossref","first-page":"884","DOI":"10.5551\/jat.RV17009","article-title":"The roles of hypoxia signaling in the pathogenesis of cardiovascular diseases","volume":"24","author":"Abe","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"issue":"7","key":"10.1016\/j.resp.2020.103588_bib0010","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1152\/japplphysiol.00012.2014","article-title":"VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries","volume":"117","author":"Adeoye","year":"2014","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0015","first-page":"77","article-title":"Effects of acute hypoxia on left and right ventricular contractility in chronic obstructive pulmonary disease","volume":"2","author":"Akg\u00fcl","year":"2007","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0020","first-page":"62","article-title":"Cardiac remodeling: concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment","volume":"106","author":"Azevedo","year":"2016","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.resp.2020.103588_bib0025","series-title":"Introductory Chapter: Primary Concept of Hypoxia and Anoxia, Hypoxia and Anoxia, Das KK and Biradar MS","author":"Bagali","year":"2018"},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0030","first-page":"31","article-title":"Tissue specific effects of chronic sustained on oxidative stress: role of Cilnidipine, a Dual L\/N type calcium channel blocker","volume":"8","author":"Bagali","year":"2019","journal-title":"JKIMSU"},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0035","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1164\/rccm.201302-0302OC","article-title":"Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1\u03b1","volume":"189","author":"Ball","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.resp.2020.103588_bib0040","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.amjhyper.2003.07.021","article-title":"Blood pressure response to hypoxia: role of nitric oxide synthase","volume":"16","author":"Barton","year":"2003","journal-title":"Am. J. Hypertens."},{"issue":"February(2 Pt 2)","key":"10.1016\/j.resp.2020.103588_bib0045","first-page":"H851","article-title":"Arterial expansive remodeling induced by high flow rates","volume":"272","author":"Ben Driss","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2020.103588_bib0050","series-title":"Carcinogenesis","first-page":"125","article-title":"The interaction between redox and hypoxic signalling pathways in the dynamic oxygen environment of cancer cells","author":"Bhatia","year":"2013"},{"key":"10.1016\/j.resp.2020.103588_bib0055","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1152\/japplphysiol.00366.2010","article-title":"Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia","volume":"109","author":"Bohuslavov\u00e1","year":"2010","journal-title":"J Appl Physiol (1985)"},{"issue":"9","key":"10.1016\/j.resp.2020.103588_bib0060","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/jcbfm.2012.94","article-title":"Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in \u03b21 integrins","volume":"32","author":"Boroujerdi","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"August(8)","key":"10.1016\/j.resp.2020.103588_bib0065","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1161\/01.ATV.0000229665.78997.0b","article-title":"Hypoxia converts human macrophages into triglyceride-loaded foam cells","volume":"26","author":"Bostr\u00f6m","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"Pt A","key":"10.1016\/j.resp.2020.103588_bib0070","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.expneurol.2016.07.004","article-title":"Physiological cerebrovascular remodelling in response to chronic mild hypoxia: a role for activated protein C","volume":"283","author":"Burnier","year":"2016","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0075","first-page":"L616","article-title":"Enhanced expression of inducible nitric oxide synthase without vasodilator effect in chronically infected lungs","volume":"277","author":"Cadogan","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"Pt 1","key":"10.1016\/j.resp.2020.103588_bib0080","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1113\/jphysiol.2003.045112","article-title":"Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans","volume":"551","author":"Calbet","year":"2003","journal-title":"J Physiol."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0085","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrcardio.2014.160","article-title":"Coronary microvascular dysfunction: mechanisms and functional assessment","volume":"12","author":"Camici","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"10.1016\/j.resp.2020.103588_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097084","article-title":"Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling","volume":"9","author":"Campen","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1164\/rccm.200401-006OC","article-title":"Severe pulmonary hypertension and chronic obstructive pulmonary disease","volume":"172","author":"Chaouat","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0100","doi-asserted-by":"crossref","DOI":"10.1177\/2045894018775056","article-title":"Pulmonary hypertension in chronic lung diseases: comparison to other pulmonary hypertension groups","volume":"8","author":"Chebib","year":"2018","journal-title":"Pulm. Circ."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0105","first-page":"274","article-title":"Effect of chronic hypoxia on left and right ventricular function and the expression of cardiac TRPC channels in Rats","volume":"30","author":"Chen","year":"2014","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"10.1016\/j.resp.2020.103588_bib0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fcell.2018.00132","article-title":"Reactive oxygen species formation in the brain at different oxygen levels: the role of hypoxia-inducible factors","volume":"6","author":"Chen","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0115","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"issue":"May(5)","key":"10.1016\/j.resp.2020.103588_bib0120","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jtcvs.2003.06.012","article-title":"Hypoxia: unique myocardial morphology?","volume":"127","author":"Corno","year":"2004","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.resp.2020.103588_bib0125","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1038\/ncomms14379","article-title":"Atmospheric oxygen regulation at low Proterozoic levels by incomplete oxidative weathering of sedimentary organic carbon","volume":"8","author":"Daines","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.resp.2020.103588_bib0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/ijp.IJP_312_17","article-title":"Subchronic hypoxia pretreatment on brain pathophysiology in unilateral common carotid artery occluded albino rats","volume":"50","author":"Das","year":"2018","journal-title":"Indian J. Pharmacol."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0135","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12975-012-0224-3","article-title":"Clinical application of preconditioning and postconditioning to achieve neuroprotection","volume":"4","author":"Dezfulian","year":"2013","journal-title":"Transl. Stroke Res."},{"issue":"4","key":"10.1016\/j.resp.2020.103588_bib0140","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1474-4422(09)70054-7","article-title":"Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use","volume":"8","author":"Dirnagl","year":"2009","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4172\/2368-0512.1000073","article-title":"Cardiac remodelling: General aspects and mechanisms","volume":"3","author":"Dorsa Pontes","year":"2016","journal-title":"Curr Res Cardiol"},{"issue":"11","key":"10.1016\/j.resp.2020.103588_bib0150","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1161\/ATVBAHA.117.309249","article-title":"Mechanical activation of hypoxia-inducible factor 1\u03b1 drives endothelial dysfunction at atheroprone sites","volume":"37","author":"Feng","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.resp.2020.103588_bib0155","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fphys.2018.00134","article-title":"Short-term sustained hypoxia elevates basal and hypoxia-induced ventilation but not the carotid body chemoreceptor activity in rats","volume":"9","author":"Flor","year":"2018","journal-title":"Front. Physiol."},{"issue":"May (1-2)","key":"10.1016\/j.resp.2020.103588_bib0160","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0006-8993(96)00092-3","article-title":"Hypoxia triggers neuroprotective alterations in hippocampal gene expression via a heme-containing sensor","volume":"719","author":"Gage","year":"1996","journal-title":"Brain Res."},{"issue":"February (1-2)","key":"10.1016\/j.resp.2020.103588_bib0165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3940(94)90455-3","article-title":"Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat","volume":"168","author":"Gidday","year":"1994","journal-title":"Neurosci. Lett."},{"issue":"March(3)","key":"10.1016\/j.resp.2020.103588_bib0170","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00004647-199903000-00011","article-title":"Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning","volume":"19","author":"Gidday","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"10","key":"10.1016\/j.resp.2020.103588_bib0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.freeradbiomed.2004.02.071","article-title":"Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species","volume":"36","author":"Goyal","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0180","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1164\/ajrccm\/142.1.221","article-title":"Decreased pulmonary vasoreactivity in an animal model of chronic Pseudomonas pneumonia","volume":"142","author":"Graham","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10456-017-9593-2","article-title":"Chronic mild hypoxia promotes profound vascular remodeling in spinal cord blood vessels, preferentially in white matter, via an \u03b15\u03b21 integrin-mediated mechanism","volume":"21","author":"Halder","year":"2018","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.resp.2020.103588_bib0190","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1152\/jappl.1993.75.4.1748","article-title":"Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure","volume":"75","author":"Hampl","year":"1993","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.resp.2020.103588_bib0195","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.dib.2018.04.116","article-title":"Data on vessel wall thickness measurements of intracranial arteries derived from human circle of Willis specimens","volume":"19","author":"Harteveld","year":"2018","journal-title":"Data Brief"},{"key":"10.1016\/j.resp.2020.103588_bib0200","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/01.RES.0000141145.78900.44","article-title":"Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis)","volume":"95","author":"Heil","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2020.103588_bib0205","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ccr.2006.08.026","article-title":"Recruitment of HIF-1\u03b1 and HIF-2\u03b1 to common target genes is differentially regulated in neuroblastoma: HIF-2\u03b1 promotes an aggressive phenotype","volume":"10","author":"Holmquist-Mengelbier","year":"2006","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.resp.2020.103588_bib0210","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1469-7580.2002.00096.x","article-title":"The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis?","volume":"201","author":"Hopkins","year":"2002","journal-title":"J. Anat."},{"issue":"Pt 1","key":"10.1016\/j.resp.2020.103588_bib0215","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1113\/jphysiol.2002.030676","article-title":"Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation","volume":"547","author":"Howell","year":"2003","journal-title":"J Physiol."},{"key":"10.1016\/j.resp.2020.103588_bib0220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.resp.2014.11.011","article-title":"Respiratory modulation of sympathetic activity is attenuated in adult rats conditioned with chronic hypobaric hypoxia","volume":"206","author":"Hsieh","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0225","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.RES.0000174287.17953.83","article-title":"Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation","volume":"97","author":"Hyvelin","year":"2005","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.resp.2020.103588_bib0230","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4196\/kjpp.2016.20.6.641","article-title":"Hypoxic pulmonary vasoconstriction and vascular contractility in monocrotaline-induced pulmonary arterial hypertensive rats","volume":"20","author":"Kim","year":"2016","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2020.103588_bib0235","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1158\/0008-5472.CAN-10-4142","article-title":"The hypoxia-associated factor switches cells from HIF-1\u03b1- to HIF-2\u03b1-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion","volume":"71","author":"Koh","year":"2011","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.resp.2020.103588_bib0240","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006137","article-title":"Relationship between Vascular Resistance and Sympathetic Nerve Fiber Density in Arterial Vessels in Children With Sleep Disordered Breathing","volume":"6","author":"Kontos","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"Pt 18","key":"10.1016\/j.resp.2020.103588_bib0245","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1242\/jeb.00976","article-title":"Structural and functional adaptation to hypoxia in the rat brain","volume":"207","author":"LaManna","year":"2004","journal-title":"J. Exp. Biol."},{"issue":"12","key":"10.1016\/j.resp.2020.103588_bib0250","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/00003246-198412000-00006","article-title":"Acute hemodynamic effects of controlled oxygen therapy in decompensated chronic obstructive pulmonary disease","volume":"12","author":"Lejeune","year":"1984","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.resp.2020.103588_bib0255","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pneurobio.2017.01.001","article-title":"Preconditioning in neuroprotection: from hypoxia to ischemia","volume":"157","author":"Li","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0260","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.mvr.2011.11.004","article-title":"Hypoxia induces angiogenic factors in brain microvascular endothelial cells","volume":"83","author":"Luo","year":"2012","journal-title":"Microvasc. Res."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0265","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0002-9149(69)90516-5","article-title":"Systemic blood pressure in white men born at sea level: changes after long residence at high altitudes","volume":"23","author":"Marticorena","year":"1969","journal-title":"Am. J. Cardiol."},{"issue":"June (8)","key":"10.1016\/j.resp.2020.103588_bib0270","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1097\/00001756-200106130-00030","article-title":"Cerebral protection by hypoxic preconditioning in a murine model of focal ischemia-reperfusion","volume":"12","author":"Miller","year":"2001","journal-title":"Neuroreport."},{"issue":"6 Suppl","key":"10.1016\/j.resp.2020.103588_bib0275","doi-asserted-by":"crossref","first-page":"39S","DOI":"10.1378\/chest.10-0087","article-title":"Pulmonary hypertension in COPD: epidemiology, significance, and management: pulmonary vascular disease: the global perspective","volume":"137","author":"Minai","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.resp.2020.103588_bib0280","first-page":"1","article-title":"Matrix metalloproteinases in coronary artery disease","volume":"64","author":"Mittal","year":"2014","journal-title":"Adv. Clin. Chem."},{"issue":"9","key":"10.1016\/j.resp.2020.103588_bib0285","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1113\/jphysiol.2013.262212","article-title":"Short-term sustained hypoxia induces changes in the coupling of sympathetic and respiratory activities in rats","volume":"592","author":"Moraes","year":"2014","journal-title":"J Physiol."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0290","first-page":"505","article-title":"Vascular remodeling","volume":"28","author":"Mulvany","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2020.103588_bib0295","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1513\/pats.200407-037MS","article-title":"Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease","volume":"2","author":"Naeije","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"issue":"June (1)","key":"10.1016\/j.resp.2020.103588_bib0300","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12931-020-01394-0","article-title":"Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice","volume":"21","author":"Neupane","year":"2020","journal-title":"Respir. Res."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0305","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1183\/09031936.00128706","article-title":"The effects of hypoxia on the cells of the pulmonary vasculature","volume":"30","author":"Pak","year":"2007","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0310","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/1871525717666190409120018","article-title":"Emblica officinalis (Amla) ameliorates high-fat diet induced alteration of cardiovascular pathophysiology","volume":"17","author":"Patil","year":"2019","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"issue":"6","key":"10.1016\/j.resp.2020.103588_bib0315","first-page":"H818","article-title":"Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features","volume":"236","author":"Rabinovitch","year":"1979","journal-title":"Am. J. Physiol."},{"issue":"16","key":"10.1016\/j.resp.2020.103588_bib0320","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1128\/MCB.00200-09","article-title":"Hypoxia-inducible factor 2 regulates hepatic lipid metabolism","volume":"29","author":"Rankin","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"32","key":"10.1016\/j.resp.2020.103588_bib0325","doi-asserted-by":"crossref","first-page":"8933","DOI":"10.1073\/pnas.1521544113","article-title":"Earth\u2019s oxygen cycle and the evolution of animal life","volume":"113","author":"Reinhard","year":"2016","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"10","key":"10.1016\/j.resp.2020.103588_bib0330","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1089\/ars.2010.3474","article-title":"Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke","volume":"14","author":"Rink","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"Suppl. 62","key":"10.1016\/j.resp.2020.103588_bib0335","first-page":"PA3071","article-title":"Maladaptive pulmonary vascular responses to chronic intermittent and sustained hypoxia in a rat hypertension model","volume":"52","author":"Rocher","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2020.103588_bib0340","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3389\/fphys.2017.00751","article-title":"Editorial: cardiac remodeling: new insights in physiological and pathological adaptations","volume":"8","author":"Roever","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2020.103588_bib0345","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12968-016-0229-2","article-title":"Expansive arterial remodeling of the carotid arteries and its effect on atherosclerotic plaque composition and vulnerability: an in-vivo black-blood 3T CMR study in symptomatic stroke patients","volume":"18","author":"Saam","year":"2016","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.resp.2020.103588_bib0350","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1152\/ajplegacy.1908.23.2.90","article-title":"Blood pressure with special reference to high altitudes","volume":"23","author":"Schneider","year":"1908","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2020.103588_bib0355","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fcell.2015.00042","article-title":"Hypoxia signaling pathways: modulators of oxygen-related organelles","volume":"3","author":"Sch\u00f6nenberger","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"issue":"September (38)","key":"10.1016\/j.resp.2020.103588_bib0360","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","article-title":"Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1","volume":"269","author":"Semenza","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"December (51)","key":"10.1016\/j.resp.2020.103588_bib0365","doi-asserted-by":"crossref","first-page":"32529","DOI":"10.1074\/jbc.271.51.32529","article-title":"Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1","volume":"271","author":"Semenza","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"5-6","key":"10.1016\/j.resp.2020.103588_bib0370","first-page":"415","article-title":"A two-phase model for flow of blood in narrow tubes with increased effective viscosity near the wall","volume":"38","author":"Sharan","year":"2001","journal-title":"Biorheology."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0375","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00109-013-0998-0","article-title":"Vascular remodeling in pulmonary hypertension","volume":"91","author":"Shimoda","year":"2013","journal-title":"J. Mol. Med. (Berl)."},{"key":"10.1016\/j.resp.2020.103588_bib0380","doi-asserted-by":"crossref","first-page":"L941","DOI":"10.1152\/ajplung.00528.2005","article-title":"HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes","volume":"291","author":"Shimoda","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2020.103588_bib0385","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00585531","article-title":"Effects of hypoxia on capillary density and fiber composition in rat skeletal muscle","volume":"370","author":"Sillau","year":"1977","journal-title":"Pfl\u00fcgers Archiv."},{"issue":"Pt 1","key":"10.1016\/j.resp.2020.103588_bib0390","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1469-7793.1999.00261.x","article-title":"Physiological adjustments and arteriolar remodelling within skeletal muscle during acclimation to chronic hypoxia in the rat","volume":"521","author":"Smith","year":"1999","journal-title":"J Physiol."},{"key":"10.1016\/j.resp.2020.103588_bib0395","first-page":"135","article-title":"Effects of hypoxia on muscle capillarity in rats","volume":"62","author":"Snyder","year":"1985","journal-title":"RespiratoryPhysiology."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0400","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/ars.2010.3266","article-title":"The effect of small changes in hematocrit on nitric oxide transport in arterioles","volume":"14","author":"Sriram","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0405","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1161\/01.RES.00000175934.68087.29","article-title":"Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal?","volume":"97","author":"Stenmark","year":"2005","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0410","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00441-010-0943-2","article-title":"Temporal alterations in cardiac fibroblast function following induction of pressure overload","volume":"340","author":"Stewart","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.resp.2020.103588_bib0415","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/01.mcp.0000174250.38188.6d","article-title":"Pulmonary hypertension in interstitial lung disease","volume":"11","author":"Strange","year":"2005","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"24","key":"10.1016\/j.resp.2020.103588_bib0420","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1136\/heartjnl-2012-301992","article-title":"Pulmonary hypertension: prevalence and mortality in the Armadale echocardiography cohort","volume":"98","author":"Strange","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.resp.2020.103588_bib0425","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fphys.2018.00609","article-title":"Inflammatory mediators drive adverse right ventricular remodeling and dysfunction and serve as potential biomarkers","volume":"9","author":"Sydykov","year":"2018","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.resp.2020.103588_bib0430","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/cvr\/28.3.312","article-title":"Acute ischaemic preconditioning and chronic hypoxia independently increase myocardial tolerance to ischaemia","volume":"28","author":"Tajima","year":"1994","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0435","doi-asserted-by":"crossref","first-page":"29","DOI":"10.7326\/0003-4819-102-1-29","article-title":"Hemodynamic response to oxygen therapy in chronic obstructive pulmonary disease","volume":"102","author":"Timms","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.resp.2020.103588_bib0440","series-title":"Reference Module in Biomedical Sciences","article-title":"Vascular function in health and diseases","author":"Touyz","year":"2014"},{"issue":"5","key":"10.1016\/j.resp.2020.103588_bib0445","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1164\/ajrccm.149.5.8173773","article-title":"Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility","volume":"149","author":"Tozzi","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.resp.2020.103588_bib0450","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2613.2006.00493.x","article-title":"Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats","volume":"87","author":"Vajner","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"issue":"5 Pt 1","key":"10.1016\/j.resp.2020.103588_bib0455","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1164\/ajrccm.157.5.9709050","article-title":"Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension","volume":"157","author":"van Suylen","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.resp.2020.103588_bib0460","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1164\/ajrccm.163.5.2003144","article-title":"Dissociation of pulmonary vascular remodeling and right ventricular pressure in tissue angiotensin-converting enzyme-deficient mice under conditions of chronic alveolar hypoxia","volume":"163","author":"van Suylen","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.resp.2020.103588_bib0465","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/ki.1996.205","article-title":"Sustained systemic arterial hypertension induced by extended hypobaric hypoxia","volume":"49","author":"Vaziri","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.resp.2020.103588_bib0470","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fped.2015.00058","article-title":"Hypoxic conditioning as a new therapeutic modality","volume":"3","author":"Verges","year":"2015","journal-title":"Front. Pediatr."},{"issue":"6","key":"10.1016\/j.resp.2020.103588_bib0475","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1172\/JCI11144","article-title":"Hypoxia-induced pulmonary vascular remodeling: a model for what human disease?","volume":"106","author":"Voelkel","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"Pt 1","key":"10.1016\/j.resp.2020.103588_bib0480","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2006.108753","article-title":"The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide","volume":"575","author":"Walsh","year":"2006","journal-title":"J Physiol."},{"issue":"15","key":"10.1016\/j.resp.2020.103588_bib0485","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1523\/JNEUROSCI.22-15-06401.2002","article-title":"Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt","volume":"22","author":"Wick","year":"2002","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.resp.2020.103588_bib0490","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/japplphysiol.00940.2005","article-title":"Chronic hypoxia and cerebral circulation","volume":"100","author":"Xu","year":"2006","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.resp.2020.103588_bib0495","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/569520","article-title":"Cardiac response to chronic intermittent hypoxia with a transition from adaptation to maladaptation: the role of hydrogen peroxide","volume":"2012","author":"Yin","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.resp.2020.103588_bib0500","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1002\/jcp.22640","article-title":"Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia","volume":"226","author":"Yuan","year":"2011","journal-title":"J. Cell Physiol."},{"issue":"11","key":"10.1016\/j.resp.2020.103588_bib0505","doi-asserted-by":"crossref","first-page":"R1347","DOI":"10.1152\/ajpregu.00164.2015","article-title":"Cardiac responses to hypoxia and reoxygenation in Drosophila","volume":"309","author":"Zarndt","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6","key":"10.1016\/j.resp.2020.103588_bib0510","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/MCA.0b013e328363244b","article-title":"Remodelling of small intramyocardial coronary arteries distal to total occlusions after myocardial infarction in pigs","volume":"24","author":"Zhao","year":"2013","journal-title":"Coron. Artery Dis."},{"issue":"1","key":"10.1016\/j.resp.2020.103588_bib0515","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1253\/circj.CJ-10-0305","article-title":"Normalized wall index specific and MRI-based stress analysis of atherosclerotic carotid plaques: a study comparing acutely symptomatic and asymptomatic patients","volume":"74","author":"Zhu","year":"2010","journal-title":"Circ. J."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820302470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904820302470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:18:41Z","timestamp":1778620721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904820302470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":103,"alternative-id":["S1569904820302470"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2020.103588","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia and its preconditioning on cardiac and vascular remodelling in experimental animals","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2020.103588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103588"}}