{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:52:32Z","timestamp":1761605552714,"version":"build-2065373602"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"am","delay-in-days":226,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.resp.2021.103743","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T05:01:08Z","timestamp":1626238868000},"page":"103743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Adenosine A2a receptors modulate TrkB receptor-dependent respiratory plasticity in neonatal rats"],"prefix":"10.1016","volume":"294","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-321X","authenticated-orcid":false,"given":"Stephen M.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8447-1832","authenticated-orcid":false,"given":"Ranveer M.S.","family":"Vasdev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-4065","authenticated-orcid":false,"given":"McKayla M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti J.","family":"Watters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2021.103743_bib0005","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1152\/jn.00619.2016","article-title":"Adenosine-dependent phrenic motor facilitation is inflammation resistant","volume":"117","author":"Agosto-Marlin","year":"2017","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103743_bib0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.resp.2008.03.005","article-title":"Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats","volume":"162","author":"Baker-Herman","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nn1166","article-title":"BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia","volume":"7","author":"Baker-Herman","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0020","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/j.2040-4603.2011.tb00375.x","article-title":"Neuronal control of breathing: sex and stress hormones","volume":"1","author":"Behan","year":"2011","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.resp.2008.06.006","article-title":"Sex steroidal hormones and respiratory control","volume":"164","author":"Behan","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0030","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1073\/pnas.0305712101","article-title":"Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons","volume":"101","author":"Bocchiaro","year":"2004","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2021.103743_bib0035","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jphysparis.2007.05.008","article-title":"Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro","volume":"100","author":"Bouvier","year":"2006","journal-title":"J. Physiol. Paris"},{"key":"10.1016\/j.resp.2021.103743_bib0040","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1460-9568.2008.06345.x","article-title":"Brain-derived neurotrophic factor enhances fetal respiratory rhythm frequency in the mouse preB\u00f6tzinger complex in vitro","volume":"28","author":"Bouvier","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/physiol.00012.2013","article-title":"Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function","volume":"29","author":"Dale","year":"2014","journal-title":"Physiology"},{"key":"10.1016\/j.resp.2021.103743_bib0050","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.expneurol.2016.05.012","article-title":"Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation","volume":"287","author":"Dale","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.resp.2021.103743_bib0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4419-5692-7_45","article-title":"Multiple pathways to long-lasting phrenic motor facilitation","volume":"669","author":"Dale-Nagle","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2021.103743_bib0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/nyas.12085","article-title":"Hypoxia-induced phrenic long-term facilitation: emergent properties","volume":"1279","author":"Devinney","year":"2013","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.resp.2021.103743_bib0065","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1523\/JNEUROSCI.4122-15.2016","article-title":"Sustained hypoxia elicits competing spinal mechanisms of phrenic motor facilitation","volume":"36","author":"Devinney","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.resp.2013.05.026","article-title":"Apnea of prematurity--perfect storm","volume":"189","author":"Di Fiore","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0075","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1523\/JNEUROSCI.15-05-03458.1995","article-title":"Modulation of inspiratory drive to phrenic motoneurons by presynaptic adenosine A1 receptors","volume":"15","author":"Dong","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0080","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1523\/JNEUROSCI.0433-17.2017","article-title":"Nongenomic actions of 17-\u03b2 estradiol restore respiratory neuroplasticity in young ovariectomized female rats","volume":"37","author":"Dougherty","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0085","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuropharm.2016.09.018","article-title":"Divergent cAMP signaling differentially regulates serotonin-induced spinal motor plasticity","volume":"113","author":"Fields","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.resp.2021.103743_bib0090","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1152\/jn.00374.2015","article-title":"Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling","volume":"114","author":"Fields","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103743_bib0095","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.neuropharm.2008.01.011","article-title":"Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine","volume":"54","author":"Fontinha","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.resp.2021.103743_bib0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.expneurol.2016.05.022","article-title":"Respiratory neuroplasticity - Overview, significance and future directions","volume":"287","author":"Fuller","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.resp.2021.103743_bib0105","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.resp.2009.09.015","article-title":"Prenatal nicotine exposure alters respiratory long-term facilitation in neonatal rats","volume":"169","author":"Fuller","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1183\/20734735.000716","article-title":"Common respiratory conditions of the newborn","volume":"12","author":"Gallacher","year":"2016","journal-title":"Breathe (Sheff)"},{"key":"10.1016\/j.resp.2021.103743_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060695","article-title":"Post-hypoxic recovery of respiratory rhythm generation is gender dependent","volume":"8","author":"Garcia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2021.103743_bib0120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.expneurol.2012.06.028","article-title":"Neonatal caffeine treatment up-regulates adenosine receptors in brainstem and hypothalamic cardio-respiratory related nuclei of rat pups","volume":"237","author":"Gaytan","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.resp.2021.103743_bib0125","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1152\/japplphysiol.00183.2009","article-title":"Spinal NMDA receptor activation is necessary for de novo, but not the maintenance of, A2a receptor-mediated phrenic motor facilitation","volume":"107","author":"Golder","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0130","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1523\/JNEUROSCI.3570-07.2008","article-title":"Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation","volume":"28","author":"Golder","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0135","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1113\/jphysiol.2010.201657","article-title":"Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation","volume":"589","author":"Hoffman","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0140","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.neuroscience.2013.06.068","article-title":"Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation","volume":"250","author":"Hoffman","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2021.103743_bib0145","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1113\/jphysiol.2009.180075","article-title":"Spinal adenosine A2(A) receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxia","volume":"588","author":"Hoffman","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0150","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1152\/japplphysiol.00098.2012","article-title":"Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis","volume":"113","author":"Hoffman","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuropharm.2014.04.006","article-title":"Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP","volume":"83","author":"Jer\u00f3nimo-Santos","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.resp.2021.103743_bib0160","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1152\/japplphysiol.01361.2011","article-title":"7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome","volume":"112","author":"Johnson","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0165","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.resp.2019.04.014","article-title":"Respiratory frequency plasticity during development","volume":"266","author":"Johnson","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0170","doi-asserted-by":"crossref","first-page":"R1356","DOI":"10.1152\/ajpregu.00884.2007","article-title":"Chronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats","volume":"294","author":"Julien","year":"2008","journal-title":"Am. J. Physiol. Reg. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0175","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1095-6433(01)00393-2","article-title":"Plasticity in respiratory motor control: intermittent hypoxia and hypercapnia activate opposing serotonergic and noradrenergic modulatory systems","volume":"130","author":"Kinkead","year":"2001","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0180","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1460-9568.2011.07754.x","article-title":"Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens","volume":"34","author":"Li","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0185","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/cne.23164","article-title":"Postnatal development of brain-derived neurotrophic factor (BDNF) and tyrosine protein kinase B (TrkB) receptor immunoreactivity in multiple brain stem respiratory-related nuclei of the rat","volume":"521","author":"Liu","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2021.103743_bib0190","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuroscience.2006.06.036","article-title":"Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output","volume":"142","author":"Lovett-Barr","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2021.103743_bib0195","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuroscience.2007.12.003","article-title":"Respiratory long-term facilitation following intermittent hypoxia requires reactive oxygen species formation","volume":"152","author":"MacFarlane","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2021.103743_bib0200","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1113\/jphysiol.2009.176982","article-title":"Episodic spinal serotonin receptor activation elicits long-lasting phrenic motor facilitation by an NADPH oxidase-dependent mechanism","volume":"587","author":"MacFarlane","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0205","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2013.03.044","article-title":"Modulatory effects of the novel TrkB receptor agonist 7,8-dihydroxyflavone on synaptic transmission and intrinsic neuronal excitability in mouse visual cortex in vitro","volume":"709","author":"Marongiu","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2021.103743_bib0210","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1152\/japplphysiol.00459.2005","article-title":"Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats","volume":"100","author":"Mayer","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resp.2019.02.006","article-title":"Development of ventilatory long-term facilitation is dependent on estrous cycle stage in adult female rats","volume":"264","author":"McIntosh","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0220","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1469-7793.2001.0483f.x","article-title":"Changes in cat medullary neurone firing rates and synchrony following induction of respiratory long-term facilitation","volume":"532","author":"Morris","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0225","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.resp.2004.01.011","article-title":"Implications of hypoxic hypometabolism during mammalian ontogenesis","volume":"141","author":"Mortola","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0230","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1152\/japplphysiol.00060.2012","article-title":"Severe acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism","volume":"112","author":"Nichols","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0235","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.resp.2012.11.010","article-title":"Hypoxia-induced ventilatory responses in conscious mice: gender differences in ventilatory roll-off and facilitation","volume":"185","author":"Palmer","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0240","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.resp.2019.01.004","article-title":"Circulatory control of phrenic motor plasticity","volume":"265","author":"Perim","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0245","doi-asserted-by":"crossref","first-page":"R709","DOI":"10.1152\/ajpregu.00393.2017","article-title":"Cross-talk inhibition between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA","volume":"314","author":"Perim","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0250","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/JP276731","article-title":"Protein kinase C\u03b4 constrains the S-pathway to phrenic motor facilitation elicited by spinal 5-HT7 receptors or severe acute intermittent hypoxia","volume":"597","author":"Perim","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0255","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1152\/japplphysiol.00546.2019","article-title":"Spinal AMP kinase activity differentially regulates phrenic motor plasticity","volume":"128","author":"Perim","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0260","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.resp.2013.06.022","article-title":"Breathing challenges in Rett syndrome: lessons learned from humans and animal models","volume":"189","author":"Ramirez","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0265","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/B978-0-444-63488-7.00011-2","article-title":"Intermittent hypoxia-induced respiratory long-term facilitation is dominated by enhanced burst frequency, not amplitude, in spontaneously breathing urethane-anesthetized neonatal rats","volume":"212","author":"Reid","year":"2014","journal-title":"Prog. Brain Res."},{"issue":"13","key":"10.1016\/j.resp.2021.103743_bib0270","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fncel.2019.00365","article-title":"The purinome and the preB\u00f6tzinger Complex - a m\u00e9nage of unexplored mechanisms that may modulate\/shape the hypoxic ventilatory response","volume":"21","author":"Reklow","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0275","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1469-7793.1999.567ae.x","article-title":"Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats","volume":"514","author":"Richter","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0280","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1113\/JP275462","article-title":"Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation","volume":"596","author":"Seven","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0285","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1095-6433(99)00057-4","article-title":"Neonatal tolerance to hypoxia: a comparative-physiological approach","volume":"123","author":"Singer","year":"1999","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0290","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1683005","article-title":"Pre-B\u00f6tzinger complex: a brainstem region that may generate respiratory rhythm in mammals","volume":"254","author":"Smith","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.resp.2021.103743_bib0295","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa012657","article-title":"Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants","volume":"347","author":"Stoll","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2021.103743_bib0300","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1001\/jama.292.19.2357","article-title":"Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection","volume":"292","author":"Stoll","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.resp.2021.103743_bib0305","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/j.1476-5381.2010.01002.x","article-title":"Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats","volume":"161","author":"Takahashi","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2021.103743_bib0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092557","article-title":"Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells","volume":"9","author":"Tamagnini","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2021.103743_bib0315","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1523\/JNEUROSCI.23-20-07685.2003","article-title":"Expression of functional tyrosine kinase B receptors by rhythmically active respiratory neurons in the pre-B\u00f6tzinger complex of neonatal mice","volume":"23","author":"Thoby-Brisson","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103743_bib0320","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.resp.2017.11.008","article-title":"Pharmacological modulation of hypoxia-induced respiratory neuroplasticity","volume":"256","author":"Turner","year":"2018","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0325","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/18715273113129990061","article-title":"TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia","volume":"12","author":"Uluc","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.resp.2021.103743_bib0330","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.resp.2004.04.012","article-title":"Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets","volume":"141","author":"Wilson","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0335","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.resp.2019.04.006","article-title":"Mechanisms underlying a critical period of respiratory development in the rat","volume":"264","author":"Wong-Riley","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103743_bib0340","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-019-0543-8","article-title":"Activation of TrkB\/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage","volume":"26","author":"Wu","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.resp.2021.103743_bib0345","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/1440-1681.12129","article-title":"Acute intermittent hypoxia induced neural plasticity in respiratory motor control","volume":"40","author":"Xing","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2021.103743_bib0350","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2174\/18715273113129990089","article-title":"Small molecules activating TrkB receptor for treating a variety of CNS disorders","volume":"12","author":"Zeng","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.resp.2021.103743_bib0355","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2007.05.003","article-title":"Spinal cord injury in neonates alters respiratory motor output via supraspinal mechanisms","volume":"206","author":"Zimmer","year":"2007","journal-title":"Exp. Neurol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904821001282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904821001282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:48:19Z","timestamp":1761605299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904821001282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":71,"alternative-id":["S1569904821001282"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2021.103743","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenosine A2a receptors modulate TrkB receptor-dependent respiratory plasticity in neonatal rats","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2021.103743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103743"}}