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Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0335","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1523\/JNEUROSCI.6027-09.2010","article-title":"Glia contribute to the purinergic modulation of inspiratory rhythm-generating networks","volume":"30","author":"Huxtable","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0340","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2018.09.020","article-title":"Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preB\u00f6tzinger complex of the adult rabbit","volume":"1704","author":"Iovino","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2021.103766_bib0345","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/jphysiol.2005.098848","article-title":"Distinct rhythm generators for inspiration and expiration in the juvenile rat","volume":"570","author":"Janczewski","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0350","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1523\/JNEUROSCI.1595-12.2013","article-title":"Role of inhibition in respiratory pattern generation","volume":"33","author":"Janczewski","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2019.103266","article-title":"Development of central respiratory control in anurans: the role of neurochemicals in the emergence of air-breathing and the hypoxic response","volume":"270","author":"Janes","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103766_bib0360","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0034-5687(98)00079-6","article-title":"N-methyl-D-aspartate-mediated bulbospinal respiratory drive is pH\/P(CO2)-insensitive in turtle brainstem-spinal cord","volume":"113","author":"Johnson","year":"1998","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0365","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/jappl.1998.84.2.649","article-title":"Hypoxia, temperature, and pH\/CO2 effects on respiratory discharge from a turtle brain stem preparation","volume":"84","author":"Johnson","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0370","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/jphysiol.2002.019687","article-title":"Role of synaptic inhibition in turtle respiratory rhythm generation","volume":"544","author":"Johnson","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0375","doi-asserted-by":"crossref","first-page":"R901","DOI":"10.1152\/ajpregu.00912.2006","article-title":"Are pacemaker properties required for respiratory rhythm generation in adult turtle brain stems in vitro? Am","volume":"293","author":"Johnson","year":"2007","journal-title":"J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0380","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.resp.2014.11.004","article-title":"Respiratory neuron characterization reveals intrinsic bursting properties in isolated adult turtle brainstems (Trachemys scripta)","volume":"224","author":"Johnson","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103766_bib0385","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1152\/jn.01073.2015","article-title":"Testing the hypothesis of neurodegeneracy in respiratory network function with a priori transected arterially perfused brain stem preparation of rat","volume":"115","author":"Jones","year":"2016","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103766_bib0390","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1523\/JNEUROSCI.4143-12.2013","article-title":"Distinct inspiratory rhythm and pattern generating mechanisms in the preB\u00f6tzinger complex","volume":"33","author":"Kam","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0395","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.resp.2009.05.011","article-title":"Phylogenetic trends in respiratory rhythmogenesis: insights from ectothermic vertebrates","volume":"168","author":"Kinkead","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103766_bib0400","doi-asserted-by":"crossref","first-page":"R497","DOI":"10.1152\/ajpregu.1997.272.2.R497","article-title":"Role of pulmonary stretch receptor feedback in control of episodic breathing in the bullfrog","volume":"272","author":"Kinkead","year":"1997","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0405","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/31927","article-title":"A molecular timescale for vertebrate evolution","volume":"392","author":"Kumar","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.resp.2021.103766_bib0410","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1460-9568.2003.02417.x","article-title":"Nicotinic activation of reticulospinal cells involved in the control of swimming in lampreys","volume":"17","author":"Le Ray","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0415","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1523\/JNEUROSCI.3948-06.2007","article-title":"P2Y1 receptor modulation of the preB\u00f6tzinger complex inspiratory rhythm generating network in vitro","volume":"27","author":"Lorier","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0420","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1098\/rstb.2009.0068","article-title":"Serotonin targets inhibitory synapses to induce modulation of network functions","volume":"364","author":"Manzke","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond B Biol. Sci"},{"key":"10.1016\/j.resp.2021.103766_bib0425","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuroscience.2007.05.023","article-title":"Respiratory rhythms generated in the lamprey rhombencephalon","volume":"148","author":"Martel","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2021.103766_bib0430","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2007.07.015","article-title":"WAY-100635 has high selectivity for serotonin 5-HT1A versus dopamine D4 receptors","volume":"574","author":"Martel","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2021.103766_bib0435","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1517","article-title":"Sleep-disordered breathing after targeted ablation of preB\u00f6tzinger complex neurons","volume":"8","author":"McKay","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0440","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.ph.53.030191.000511","article-title":"Intermittent breathing in vertebrates","volume":"53","author":"Milsom","year":"1991","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0445","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1152\/ajpregu.00069.2010","article-title":"Adaptive trends in respiratory control: a comparative perspective","volume":"299","author":"Milsom","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0450","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.acthis.2018.08.014","article-title":"Central control of air breathing in fishes","volume":"120","author":"Milsom","year":"2018","journal-title":"Acta Histochem."},{"key":"10.1016\/j.resp.2021.103766_bib0455","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/j.2040-4603.2011.tb00318.x","article-title":"Hibernation and gas exchange","volume":"1","author":"Milsom","year":"2011","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0460","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/jn.1999.81.1.247","article-title":"A1 adenosine receptors modulate respiratory activity of the neonatal mouse via the cAMP-mediated signaling pathway","volume":"81","author":"Mironov","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103766_bib0465","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.resp.2016.08.007","article-title":"The neural control of respiration in lampreys","volume":"234","author":"Missaghi","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103766_bib0470","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1523\/JNEUROSCI.4611-10.2011","article-title":"PreB\u00f6tzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression","volume":"31","author":"Montandon","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0475","doi-asserted-by":"crossref","first-page":"32707","DOI":"10.1038\/srep32707","article-title":"Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors","volume":"6","author":"Montandon","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.resp.2021.103766_bib0480","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1242\/dev.00986","article-title":"Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain","volume":"131","author":"Murakami","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.resp.2021.103766_bib0485","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.resp.2017.05.008","article-title":"Brainstem mechanisms underlying the cough reflex and its regulation","volume":"243","author":"Mutolo","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103766_bib0490","doi-asserted-by":"crossref","first-page":"R227","DOI":"10.1152\/ajpregu.00579.2001","article-title":"Respiratory changes induced by kainic acid lesions in rostral ventral respiratory group of rabbits","volume":"283","author":"Mutolo","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0495","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1460-9568.2004.03850.x","article-title":"Respiratory responses evoked by blockades of ionotropic glutamate receptors within the B\u00f6tzinger complex and the pre-B\u00f6tzinger complex of the rabbit","volume":"21","author":"Mutolo","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0500","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.neuroscience.2007.09.028","article-title":"Opioid-induced depression in the lamprey respiratory network","volume":"150","author":"Mutolo","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2021.103766_bib0505","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neuroscience.2010.06.004","article-title":"Role of neurokinin receptors and ionic mechanisms within the respiratory network of the lamprey","volume":"169","author":"Mutolo","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2021.103766_bib0510","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1523\/JNEUROSCI.2764-11.2011","article-title":"Identification of a cholinergic modulatory and rhythmogenic mechanism within the lamprey respiratory network","volume":"31","author":"Mutolo","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0515","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1021\/cr078224o","article-title":"Serotonin receptors","volume":"108","author":"Nichols","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.resp.2021.103766_bib0520","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1113\/jphysiol.2012.231464","article-title":"Preinspiratory calcium rise in putative preB\u00f6tzinger complex astrocytes","volume":"590","author":"Okada","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0525","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2011.04.054","article-title":"Respiratory responses to somatostatin microinjections into the B\u00f6tzinger complex and the pre-B\u00f6tzinger complex of the rabbit","volume":"498","author":"Pantaleo","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2021.103766_bib0530","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.1523\/JNEUROSCI.1871-04.2004","article-title":"Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network","volume":"24","author":"Pe\u00f1a","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0535","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0891-0618(92)90046-S","article-title":"The serotoninergic system of the brain of the lamprey, Lampetra fluviatilis: an evolutionary perspective","volume":"5","author":"Pierre","year":"1992","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.resp.2021.103766_bib0540","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/1096-9861(20010226)431:1<105::AID-CNE1058>3.0.CO;2-P","article-title":"Distribution of choline acetyltransferase-immunoreactive structures in the lamprey brain","volume":"431","author":"Pombal","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2021.103766_bib0545","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1523\/JNEUROSCI.5271-08.2009","article-title":"Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J","volume":"29","author":"Ptak","year":"2009","journal-title":"Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0550","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s12035-015-9624-1","article-title":"Inhibitory effect of Endomorphin-2 binding to the mu-opioid receptor in the rat pre-b\u00f6tzinger complex on the breathing activity","volume":"54","author":"Qi","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103766_bib0555","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-neuro-080317-061756","article-title":"The dynamic basis of respiratory rhythm generation: one breath at a time","volume":"41","author":"Ramirez","year":"2018","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0560","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1113\/jphysiol.1996.sp021258","article-title":"Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice","volume":"491","author":"Ramirez","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0565","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1469-7793.1998.895bs.x","article-title":"Selective lesioning of the cat pre-B\u00f6tzinger complex in vivo eliminates breathing but not gasping","volume":"507","author":"Ramirez","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0570","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.conb.2016.08.003","article-title":"Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives","volume":"41","author":"Ramirez","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.resp.2021.103766_bib0575","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.physiol.60.1.385","article-title":"PreB\u00f6tzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation","volume":"60","author":"Rekling","year":"1998","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0580","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1242\/jeb.100.1.93","article-title":"Generation and maintenance of the respiratory rhythm","volume":"100","author":"Richter","year":"1982","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2021.103766_bib0585","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/cne.21348","article-title":"GABA distribution in lamprey is phylogenetically conserved","volume":"503","author":"Robertson","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2021.103766_bib0590","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00610158","article-title":"Respiratory motoneurons in lampreys","volume":"94","author":"Rovainen","year":"1974","journal-title":"J.Comp.Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0595","first-page":"2386","article-title":"Neural control of ventilation in the lamprey","volume":"36","author":"Rovainen","year":"1977","journal-title":"Fed. Proc."},{"key":"10.1016\/j.resp.2021.103766_bib0600","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/physrev.1979.59.4.1007","article-title":"Neurobiology of lampreys","volume":"59","author":"Rovainen","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2021.103766_bib0605","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0306-4522(83)90225-7","article-title":"Generation of respiratory activity by the lamprey brain exposed to picrotoxin and strychnine, and weak synaptic inhibition in motoneurons","volume":"10","author":"Rovainen","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2021.103766_bib0610","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00618120","article-title":"Respiratory bursts at the midline of the rostral medulla of the lamprey","volume":"157","author":"Rovainen","year":"1985","journal-title":"J. Comp. Physiol. [A]"},{"key":"10.1016\/j.resp.2021.103766_bib0615","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000113208","article-title":"Feeding and breathing in lampreys","volume":"48","author":"Rovainen","year":"1996","journal-title":"Brain Behav. Evol."},{"key":"10.1016\/j.resp.2021.103766_bib0620","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00614523","article-title":"Respiratory pattern generation in adult lampreys (Lampetra fluviatilis): interneurons and burst resetting","volume":"158","author":"Russell","year":"1986","journal-title":"J. Comp. Physiol. [A]"},{"key":"10.1016\/j.resp.2021.103766_bib0625","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1152\/jn.00669.2004","article-title":"5-HT prolongs ventral root bursting via presynaptic inhibition of synaptic activity during fictive locomotion in lamprey","volume":"93","author":"Schwartz","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103766_bib0630","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1152\/jn.1995.73.4.1452","article-title":"Pre-B\u00f6tzinger complex in the cat","volume":"73","author":"Schwarzacher","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103766_bib0635","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/brain\/awq327","article-title":"Neuroanatomical characteristics of the human pre-B\u00f6tzinger complex and its involvement in neurodegenerative brainstem diseases","volume":"134","author":"Schwarzacher","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.resp.2021.103766_bib0640","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1152\/jn.2000.83.3.1243","article-title":"Acetylcholine modulates respiratory pattern: effects mediated by M3-like receptors in preB\u00f6tzinger complex inspiratory neurons","volume":"83","author":"Shao","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103766_bib0645","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1152\/jn.2001.85.6.2461","article-title":"Mechanisms underlying regulation of respiratory pattern by nicotine in preB\u00f6tzinger complex","volume":"85","author":"Shao","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103766_bib0650","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/aps.2009.88","article-title":"Central cholinergic regulation of respiration: nicotinic receptors","volume":"30","author":"Shao","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.resp.2021.103766_bib0655","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41467-017-02723-6","article-title":"Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity","volume":"9","author":"Sheikhbahaei","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.resp.2021.103766_bib0660","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nn.3938","article-title":"Optogenetic perturbation of preB\u00f6tzinger complex inhibitory neurons modulates respiratory pattern","volume":"18","author":"Sherman","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.resp.2021.103766_bib0665","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1683005","article-title":"Pre-B\u00f6tzinger complex: a brainstem region that may generate respiratory rhythm in mammals","volume":"254","author":"Smith","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.resp.2021.103766_bib0670","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0034-5687(00)00155-9","article-title":"Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model","volume":"122","author":"Smith","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0675","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1152\/jn.00985.2007","article-title":"Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms","volume":"98","author":"Smith","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2021.103766_bib0680","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1469-7793.1999.00303.x","article-title":"Transient, reversible apnoea following ablation of the pre-B\u00f6tzinger complex in rats","volume":"520","author":"St Jacques","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103766_bib0685","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(00)01422-1","article-title":"Baclofen eliminates cluster lung breathing of the tadpole brainstem, in vitro","volume":"292","author":"Straus","year":"2000","journal-title":"Neurosci. 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