{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:46:38Z","timestamp":1770741998489,"version":"3.49.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.resp.2021.103783","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T18:31:25Z","timestamp":1631125885000},"page":"103783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416\/hypoxia model of pulmonary hypertension"],"prefix":"10.1016","volume":"295","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-3445","authenticated-orcid":false,"given":"Daniel T.","family":"Cannon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5194-9126","authenticated-orcid":false,"given":"Leonardo","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma K.","family":"Gutierrez-Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-9157","authenticated-orcid":false,"given":"Natalie K.","family":"Gilmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy D.","family":"Bigby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen C.","family":"Breen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2021.103783_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062702","article-title":"Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension","volume":"8","author":"Ahn","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2021.103783_bib0010","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1378\/chest.09-1140","article-title":"Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry","volume":"137","author":"Badesch","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.resp.2021.103783_bib0015","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1165\/rcmb.2012-0506OC","article-title":"Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension","volume":"50","author":"Batt","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2021.103783_bib0020","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.rmed.2007.06.014","article-title":"Skeletal muscle dysfunction in patients with idiopathic pulmonary arterial hypertension","volume":"101","author":"Bauer","year":"2007","journal-title":"Respir. Med."},{"key":"10.1016\/j.resp.2021.103783_bib0025","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.21037\/jtd.2019.11.66","article-title":"Relationship of soluble ST2 to pulmonary hypertension severity in patients undergoing cardiac resynchronization therapy","volume":"11","author":"Beaudoin","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.resp.2021.103783_bib0030","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1378\/chest.11-1460","article-title":"An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry","volume":"142","author":"Benza","year":"2012","journal-title":"Chest"},{"issue":"1985","key":"10.1016\/j.resp.2021.103783_bib0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1152\/japplphysiol.00756.2014","article-title":"Diaphragm muscle weakness in mice is early-onset post-myocardial infarction and associated with elevated protein oxidation","volume":"118","author":"Bowen","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114101","article-title":"Skeletal muscle abnormalities in pulmonary arterial hypertension","volume":"9","author":"Breda","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2021.103783_bib0045","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2147\/COPD.S130790","article-title":"Sarcopenia correlates with systemic inflammation in COPD","volume":"12","author":"Byun","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.resp.2021.103783_bib0050","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ijcard.2012.12.031","article-title":"Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension","volume":"168","author":"Carlomagno","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.resp.2021.103783_bib0055","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fimmu.2019.00364","article-title":"IL33: roles in allergic inflammation and therapeutic perspectives","volume":"10","author":"Chan","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.resp.2021.103783_bib0060","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2008.01.024","article-title":"Pulmonary arterial hypertension","volume":"51","author":"Chin","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.resp.2021.103783_bib0065","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1164\/rccm.201103-0412OC","article-title":"A novel murine model of severe pulmonary arterial hypertension","volume":"184","author":"Ciuclan","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0070","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/physrev.1972.52.1.129","article-title":"Dynamic properties of mammalian skeletal muscles","volume":"52","author":"Close","year":"1972","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2021.103783_bib0075","first-page":"2383","article-title":"The TLR and IL-1 signalling network at a glance","volume":"127","author":"Cohen","year":"2014","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.resp.2021.103783_bib0080","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1164\/rccm.201003-0354OC","article-title":"Diaphragm muscle fiber weakness in pulmonary hypertension","volume":"183","author":"de Man","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11010-012-1485-6","article-title":"Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension","volume":"373","author":"Enache","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.resp.2021.103783_bib0090","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1378\/chest.15-0300","article-title":"Five-Year outcomes of patients enrolled in the REVEAL Registry","volume":"148","author":"Farber","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.resp.2021.103783_bib0095","doi-asserted-by":"crossref","first-page":"C552","DOI":"10.1152\/ajpcell.00065.2010","article-title":"Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue","volume":"299","author":"Ferreira","year":"2010","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0100","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1161\/HYPERTENSIONAHA.118.11157","article-title":"IL-33 (Interleukin 33)\/sST2 Axis in hypertension and heart failure","volume":"72","author":"Ghali","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2021.103783_bib0105","doi-asserted-by":"crossref","first-page":"L225","DOI":"10.1152\/ajplung.00264.2010","article-title":"TNF\/TNFR1 signaling mediates doxorubicin-induced diaphragm weakness","volume":"300","author":"Gilliam","year":"2011","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0110","doi-asserted-by":"crossref","first-page":"L977","DOI":"10.1152\/ajplung.00362.2011","article-title":"A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects","volume":"302","author":"Gomez-Arroyo","year":"2012","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0115","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1513\/AnnalsATS.201312-425FR","article-title":"Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction","volume":"11","author":"Gomez-Arroyo","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2021.103783_bib0120","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.202003-0576UP","article-title":"Update in pulmonary vascular diseases and right ventricular dysfunction in 2019","author":"Goncharova","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0125","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fimmu.2017.00475","article-title":"The ST2\/IL-33 Axis in immune cells during inflammatory diseases","volume":"8","author":"Griesenauer","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.resp.2021.103783_bib0130","doi-asserted-by":"crossref","DOI":"10.1007\/s00408-013-9472-6","article-title":"Exercise capacity affects quality of life in patients with pulmonary hypertension","author":"Halank","year":"2013","journal-title":"Lung"},{"key":"10.1016\/j.resp.2021.103783_bib0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.it.2009.03.003","article-title":"Interleukin-33 - cytokine of dual function or novel alarmin?","volume":"30","author":"Haraldsen","year":"2009","journal-title":"Trends Immunol."},{"key":"10.1016\/j.resp.2021.103783_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169146","article-title":"Superoxide dismutase\/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension","volume":"12","author":"Himori","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2021.103783_bib0145","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.190.10.1541","article-title":"The absence of interleukin 1 receptor-related T1\/ST2 does not affect T helper cell type 2 development and its effector function","volume":"190","author":"Hoshino","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.resp.2021.103783_bib0150","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1165\/rcmb.2018-0232OC","article-title":"Carbonic anhydrase inhibition ameliorates inflammation and experimental pulmonary hypertension","volume":"61","author":"Hudalla","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2021.103783_bib0155","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1164\/rccm.200510-1668OC","article-title":"Pulmonary arterial hypertension in France: results from a national registry","volume":"173","author":"Humbert","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.109.911818","article-title":"Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era","volume":"122","author":"Humbert","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2021.103783_bib0165","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.imbio.2017.12.002","article-title":"Elimination of eosinophils using anti-IL-5 receptor alpha antibodies effectively suppresses IL-33-mediated pulmonary arterial hypertrophy","volume":"223","author":"Ikutani","year":"2018","journal-title":"Immunobiology"},{"key":"10.1016\/j.resp.2021.103783_bib0170","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2020.34.s1.06620","article-title":"Interleukin\u201033 dependent endothelial cell hyperproliferation and vascular remodeling in sugen\/hypoxia mice","volume":"34","author":"Indralingam","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2021.103783_bib0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ebiom.2018.07.004","article-title":"IL-33-HIF1alpha Axis in hypoxic pulmonary hypertension","volume":"33","author":"Kumar","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.resp.2021.103783_bib0180","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.immuni.2016.01.009","article-title":"Poor repair of skeletal muscle in aging mice reflects a defect in local, Interleukin-33-Dependent accumulation of regulatory t cells","volume":"44","author":"Kuswanto","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.resp.2021.103783_bib0185","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrcardio.2017.84","article-title":"Epidemiology and treatment of pulmonary arterial hypertension","volume":"14","author":"Lau","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.resp.2021.103783_bib0190","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1161\/01.CIR.102.14.1690","article-title":"Cardiac-specific overexpression of tumor necrosis factor-alpha causes oxidative stress and contractile dysfunction in mouse diaphragm","volume":"102","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2021.103783_bib0195","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin-33 in health and disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.resp.2021.103783_bib0200","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ebiom.2018.06.003","article-title":"IL-33 initiates vascular remodelling in hypoxic pulmonary hypertension by up-regulating HIF-1alpha and VEGF expression in vascular endothelial cells","volume":"33","author":"Liu","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.resp.2021.103783_bib0205","doi-asserted-by":"crossref","first-page":"e772","DOI":"10.1097\/CCM.0000000000000685","article-title":"Effects of controlled mechanical ventilation on sepsis-induced diaphragm dysfunction in rats","volume":"42","author":"Maes","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0210","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/thx.2009.117168","article-title":"Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension","volume":"65","author":"Mainguy","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2021.103783_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027993","article-title":"Assessment of daily life physical activities in pulmonary arterial hypertension","volume":"6","author":"Mainguy","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2021.103783_bib0220","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00109-014-1244-0","article-title":"Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension","volume":"93","author":"Malenfant","year":"2015","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.resp.2021.103783_bib0225","doi-asserted-by":"crossref","first-page":"L1070","DOI":"10.1152\/ajplung.00135.2012","article-title":"Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction","volume":"303","author":"Manders","year":"2012","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0230","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1183\/13993003.02052-2014","article-title":"The striated muscles in pulmonary arterial hypertension: adaptations beyond the right ventricle","volume":"46","author":"Manders","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2021.103783_bib0235","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1183\/09031936.00205114","article-title":"Quadriceps muscle fibre dysfunction in patients with pulmonary arterial hypertension","volume":"45","author":"Manders","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2021.103783_bib0240","doi-asserted-by":"crossref","first-page":"L20","DOI":"10.1152\/ajplung.00113.2016","article-title":"Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension","volume":"311","author":"Manders","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0245","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/B978-032304048-8.50070-0","article-title":"Neuromuscular and chest wall disorders","author":"Mayer","year":"2008","journal-title":"Pediatric Respir. Med. (Second Edition)"},{"key":"10.1016\/j.resp.2021.103783_bib0250","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1183\/09059180.00008211","article-title":"REVEAL: a contemporary US pulmonary arterial hypertension registry","volume":"21","author":"McGoon","year":"2012","journal-title":"Eur. Respire. Rev."},{"key":"10.1016\/j.resp.2021.103783_bib0255","doi-asserted-by":"crossref","first-page":"D51","DOI":"10.1016\/j.jacc.2013.10.023","article-title":"Pulmonary arterial hypertension: epidemiology and registries","volume":"62","author":"McGoon","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.resp.2021.103783_bib0260","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","volume":"53","author":"McLaughlin","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.resp.2021.103783_bib0265","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1164\/rccm.201903-0656CI","article-title":"Beyond the lungs: systemic manifestations of pulmonary arterial hypertension","volume":"201","author":"Nickel","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0270","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1113\/jphysiol.2011.209924","article-title":"(-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle","volume":"589","author":"Nogueira","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0275","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1183\/13993003.01448-2015","article-title":"Role of interleukin-1 receptor 1\/MyD88 signalling in the development and progression of pulmonary hypertension","volume":"48","author":"Parpaleix","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2021.103783_bib0280","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1183\/09031936.00092306","article-title":"An epidemiological study of pulmonary arterial hypertension","volume":"30","author":"Peacock","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2021.103783_bib0285","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","article-title":"High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle","volume":"810","author":"Pesta","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.resp.2021.103783_bib0290","first-page":"111","article-title":"Prognostic stratification in pulmonary hypertension: a multi-biomarker approach","volume":"36","author":"Placido","year":"2017","journal-title":"Rev. Port. Cardiol."},{"key":"10.1016\/j.resp.2021.103783_bib0295","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1164\/rccm.201402-0383OC","article-title":"Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension","volume":"190","author":"Potus","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0300","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1378\/chest.11-0793","article-title":"Inflammation in pulmonary arterial hypertension","volume":"141","author":"Price","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.resp.2021.103783_bib0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075415","article-title":"Nuclear factor kappa-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension","volume":"8","author":"Price","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2021.103783_bib0310","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ccm.2007.06.003","article-title":"Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity","volume":"28","author":"Remels","year":"2007","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.resp.2021.103783_bib0315","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI30634","article-title":"IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system","volume":"117","author":"Sanada","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2021.103783_bib0320","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrcardio.2011.87","article-title":"Mechanisms of disease: pulmonary arterial hypertension","volume":"8","author":"Schermuly","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.resp.2021.103783_bib0325","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCHEARTFAILURE.109.873240","article-title":"Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling","volume":"2","author":"Seki","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.resp.2021.103783_bib0330","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2014.06.111","article-title":"Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension","volume":"451","author":"Shao","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.resp.2021.103783_bib0335","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1136\/thx.2009.130260","article-title":"Systemic inflammation and comorbidity in COPD: a result of\u2019 overspill\u2019 of inflammatory mediators from the lungs? Review of the evidence","volume":"65","author":"Sinden","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2021.103783_bib0340","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190392","article-title":"Diaphragm function does not independently predict exercise intolerance in patients with precapillary pulmonary hypertension after adjustment for right ventricular function","volume":"39","author":"Spiesshoefer","year":"2019","journal-title":"Biosci. Rep."},{"issue":"1985","key":"10.1016\/j.resp.2021.103783_bib0345","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1152\/japplphysiol.00607.2012","article-title":"Impaired exercise capacity and skeletal muscle function in a mouse model of pulmonary inflammation","volume":"114","author":"Tang","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0350","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jcp.25097","article-title":"Selective life-long skeletal myofiber-targeted VEGF gene ablation impairs exercise capacity in adult mice","volume":"231","author":"Tang","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0355","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1096\/fj.00-0343com","article-title":"Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension","volume":"15","author":"Taraseviciene-Stewart","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2021.103783_bib0360","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molmed.2016.11.005","article-title":"Targeting vascular remodeling to treat pulmonary arterial hypertension","volume":"23","author":"Thompson","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.resp.2021.103783_bib0365","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1164\/rccm.201809-1631LE","article-title":"IL-1 blockade reduces inflammation in pulmonary arterial hypertension and right ventricular failure: a single-arm, open-label, phase IB\/II Pilot Study","volume":"199","author":"Trankle","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2021.103783_bib0370","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1165\/ajrcmb.11.6.7946395","article-title":"Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline","volume":"11","author":"Voelkel","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2021.103783_bib0375","doi-asserted-by":"crossref","first-page":"H402","DOI":"10.1152\/ajpheart.00653.2011","article-title":"Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure","volume":"302","author":"Wust","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2021.103783_bib0380","doi-asserted-by":"crossref","first-page":"R1025","DOI":"10.1152\/ajpregu.00126.2011","article-title":"Effect of pulmonary TNF-alpha overexpression on mouse isolated skeletal muscle function","volume":"301","author":"Zuo","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904821001695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904821001695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:45:43Z","timestamp":1761605143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904821001695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":76,"alternative-id":["S1569904821001695"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2021.103783","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416\/hypoxia model of pulmonary hypertension","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2021.103783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103783"}}