{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:45:32Z","timestamp":1770140732797,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL131716"],"award-info":[{"award-number":["HL131716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2OD023854"],"award-info":[{"award-number":["OT2OD023854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.resp.2021.103805","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T02:02:33Z","timestamp":1634868153000},"page":"103805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat"],"prefix":"10.1016","volume":"296","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-2776","authenticated-orcid":false,"given":"Tabitha Y.","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-8152","authenticated-orcid":false,"given":"Matthew C.","family":"Pertzborn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie J.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Nicholas","family":"Musselwhite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald C.","family":"Bolser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2021.103805_bib0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000196018","article-title":"Sulfur dioxide-induced bronchoconstriction in the isolated perfused and ventilated guinea-pig lung","volume":"59","author":"Atzori","year":"1992","journal-title":"Respiration"},{"key":"10.1016\/j.resp.2021.103805_bib0010","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1152\/jappl.1988.64.6.2458","article-title":"Respiratory pattern changes produced by intercostal muscle\/rib vibration","volume":"64","author":"Bolser","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0015","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pupt.2011.01.008","article-title":"Functional implications of the multiple afferent pathways regulating cough","volume":"24","author":"Canning","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2021.103805_bib0020","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2003.057885","article-title":"Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea\u2010pigs","volume":"557","author":"Canning","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.resp.2006.03.001","article-title":"Vagal afferent nerves regulating the cough reflex","volume":"152","author":"Canning","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103805_bib0030","first-page":"R489","article-title":"Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs","volume":"314","author":"Chou","year":"2018","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fphys.2012.00403","article-title":"Modulation of the cough reflex by GABAA receptors in the caudal ventral respiratory group of the rabbit","volume":"3","author":"Cinelli","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00408-011-9352-x","article-title":"Cough reflex in lung transplant recipients","volume":"190","author":"Duarte","year":"2012","journal-title":"Lung"},{"key":"10.1016\/j.resp.2021.103805_bib0045","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1378\/chest.07-2934","article-title":"Restoration of cough reflex in lung transplant recipients","volume":"134","author":"Duarte","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.resp.2021.103805_bib0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s40792-019-0686-6","article-title":"Anatomical consideration of the cardiac plexus to prevent grave bradycardiac arrhythmias associated with lung cancer surgery: a case report","volume":"5","author":"Fukui","year":"2019","journal-title":"Surg. Case Rep."},{"key":"10.1016\/j.resp.2021.103805_bib0055","first-page":"227","article-title":"Influence of sulphur dioxide breathing on defensive reflexes of the airways","volume":"70","author":"Hanacek","year":"1987","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.resp.2021.103805_bib0060","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000194614","article-title":"Influence of lung stretch receptors on the cough reflex in rabbits","volume":"45","author":"Han\u00e1\u010dek","year":"1984","journal-title":"Respiration"},{"key":"10.1016\/j.resp.2021.103805_bib0065","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.resp.2006.02.014","article-title":"Regulation of cough by secondary sensory inputs","volume":"152","author":"Hanacek","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103805_bib0070","series-title":"Die Selbststeuerung der Atmung durch den Nervus Vagus Sitzber.","author":"Hering","year":"1868"},{"key":"10.1016\/j.resp.2021.103805_bib0075","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1164\/ajrccm\/140.1.58","article-title":"The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients","volume":"140","author":"Higenbottam","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2021.103805_bib0080","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1113\/jphysiol.1969.sp008756","article-title":"The role of the vagus nerves in the respiratory and circulatory reactions to anaphylaxis in rabbits","volume":"201","author":"Karczewski","year":"1969","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0085","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/pupt.1999.0207","article-title":"Pharmacological regulation of the cough reflex--from experimental models to antitussive effects in Man","volume":"12","author":"Karlsson","year":"1999","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2021.103805_bib0090","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/jappl.1988.65.3.1007","article-title":"Afferent neural pathways in cough and reflex bronchoconstriction","volume":"65","author":"Karlsson","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0095","first-page":"483","article-title":"The clinical physiology of the human bronchi: III. The effect of vagus section on the cough reflex, bronchial caliber, and clearance of bronchial secretions","volume":"29","author":"Klassen","year":"1951","journal-title":"Surgery"},{"key":"10.1016\/j.resp.2021.103805_bib0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/pulp.1993.1023","article-title":"A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man","volume":"6","author":"Laude","year":"1993","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.resp.2021.103805_bib0105","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1378\/chest.120.4.1114","article-title":"Airway inflammation as an assessment of chronic nonproductive cough","volume":"120","author":"Lee","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.resp.2021.103805_bib0110","first-page":"315","article-title":"Cough","author":"Leith","year":"2011","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0115","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1113\/JP279152","article-title":"Mechanisms underlying the stimulatory effect of inhaled sulfur dioxide on vagal bronchopulmonary C\u2010fibres","volume":"598","author":"Lin","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0120","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2021.103805_bib0125","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1152\/jappl.1989.67.4.1428","article-title":"Reflex responses to capsaicin: intravenous, aerosol, and intratracheal administration","volume":"67","author":"Palecek","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0130","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1152\/japplphysiol.00790.2015","article-title":"Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough","volume":"121","author":"Pitts","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0135","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.resp.2016.04.008","article-title":"The course of lung inflation alters the central pattern of tracheobronchial cough in cat-The evidence for volume feedback during cough","volume":"229","author":"Poliacek","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103805_bib0140","first-page":"43","article-title":"Airway receptors in cough","volume":"20","author":"Sant\u2019Ambrogio","year":"1984","journal-title":"Bull. Eur. Physiopathol. Respir."},{"key":"10.1016\/j.resp.2021.103805_bib0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.resp.2016.05.008","article-title":"Changes in vagal afferent drive alter tracheobronchial coughing in anesthetized cats","volume":"230","author":"Simera","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2021.103805_bib0150","doi-asserted-by":"crossref","DOI":"10.1111\/tid.12973","article-title":"Microbiological findings in bronchoalveolar lavage fluid from lung transplant patients in Sweden","volume":"20","author":"Stj\u00e4rne Aspelund","year":"2018","journal-title":"Transpl. Infect. Dis."},{"key":"10.1016\/j.resp.2021.103805_bib0155","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.1988.sp017212","article-title":"Lung C\u2010fibre receptor activation and defensive reflexes in anaesthetized cats","volume":"402","author":"Tatar","year":"1988","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.resp.2021.103805_bib0160","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1152\/jappl.1994.76.6.2672","article-title":"Laryngeal and tracheobronchial cough in anesthetized dogs","volume":"76","author":"Tatar","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0165","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0034-5687(91)90082-T","article-title":"Laryngeal afferent activity and reflexes in the guinea pig","volume":"86","author":"Tsubone","year":"1991","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0170","first-page":"4667","article-title":"Laryngeal and tracheal afferent nerve stimulation evokes swallowing in anaesthetized guinea pigs","volume":"591","author":"Tsujimura","year":"2013","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.resp.2021.103805_bib0175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0034-5687(96)00014-X","article-title":"Vagal bronchopulmonary C-fibers and acute ventilatory response to inhaled irritants","volume":"104","author":"Wang","year":"1996","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.1954.sp005033","article-title":"Respiratory reflexes from the trachea and bronchi of the cat","volume":"123","author":"Widdicombe","year":"1954","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0185","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1113\/jphysiol.1954.sp005162","article-title":"The site of pulmonary stretch receptors in the cat","volume":"125","author":"Widdicombe","year":"1954","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2021.103805_bib0190","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/S0091-6749(96)70021-0","article-title":"Sensory neurophysiology of the cough reflex","volume":"98","author":"Widdicombe","year":"1996","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.resp.2021.103805_bib0195","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0034-5687(98)00076-0","article-title":"Afferent receptors in the airways and cough","volume":"114","author":"Widdicombe","year":"1998","journal-title":"Respir. Physiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904821001919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904821001919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:47:32Z","timestamp":1761605252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904821001919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":39,"alternative-id":["S1569904821001919"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2021.103805","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2021.103805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103805"}}