{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:54:24Z","timestamp":1780548864318,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003193","name":"Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu Slovenskej republiky","doi-asserted-by":"publisher","award":["VEGA1\/0092\/20"],"award-info":[{"award-number":["VEGA1\/0092\/20"]}],"id":[{"id":"10.13039\/501100003193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003193","name":"Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu Slovenskej republiky","doi-asserted-by":"publisher","award":["VEGA1\/0275\/19"],"award-info":[{"award-number":["VEGA1\/0275\/19"]}],"id":[{"id":"10.13039\/501100003193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.resp.2022.103888","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T14:10:06Z","timestamp":1647526206000},"page":"103888","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Modeling and simulation of vagal afferent input of the cough reflex"],"prefix":"10.1016","volume":"301","author":[{"given":"Lukas","family":"Martvon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Veternik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Simera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Kotmanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Babalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall F.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Pitts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Bolser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Poliacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2022.103888_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF00200329","article-title":"Simulations of a ventrolateral medullary neural network for respiratory rhythmogenesis inferred from spike train cross-correlation","volume":"70","author":"Balis","year":"1994","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.resp.2022.103888_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/jappl.1999.86.3.1017","article-title":"Influence of central antitussive drugs on the cough motor pattern","volume":"86","author":"Bolser","year":"1999","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.resp.2022.103888_bib3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1152\/jappl.2000.89.2.785","article-title":"Volume-timing relationships during cough and resistive loading in the cat","volume":"89","author":"Bolser","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2022.103888_bib4","series-title":"Cough: Causes, Mechanisms, and Therapy","first-page":"173","article-title":"Neurogenesis of cough","author":"Bolser","year":"2003"},{"key":"10.1016\/j.resp.2022.103888_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.resp.2006.01.008","article-title":"Neurogenesis of cough, other airway defensive behaviors and breathing. A holarchical system?","volume":"152","author":"Bolser","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"3","key":"10.1016\/j.resp.2022.103888_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.resp.2006.02.010","article-title":"Plasticity of brainstem mechanisms of cough","volume":"152","author":"Bonham","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2022.103888_bib7","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1162\/089976603322518768","article-title":"Hybrid integrate-and-fire model of a bursting neuron","volume":"15","author":"Breen","year":"2003","journal-title":"Neur Comput."},{"issue":"3","key":"10.1016\/j.resp.2022.103888_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.resp.2006.03.001","article-title":"Vagal afferent nerves regulating the cough reflex","volume":"152","author":"Canning","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"2","key":"10.1016\/j.resp.2022.103888_bib9","doi-asserted-by":"crossref","first-page":"R369","DOI":"10.1152\/ajpregu.00044.2010","article-title":"Encoding of the cough reflex in anesthetized guinea pigs","volume":"300","author":"Canning","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.resp.2022.103888_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1113\/jphysiol.2004.076885","article-title":"Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats","volume":"562","author":"Chen","year":"2004","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.resp.2022.103888_bib11","doi-asserted-by":"crossref","first-page":"R489","DOI":"10.1152\/ajpregu.00313.2017","article-title":"Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs","volume":"314","author":"Chou","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2022.103888_bib12","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3389\/fphys.2019.01110","article-title":"Vagal afferent processing by the paratrigeminal nucleus","volume":"10","author":"Driessen","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2022.103888_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuroscience.2012.05.053","article-title":"Cough-related neurons in the nucleus tractus solitarius of decerebrate cats","volume":"218","author":"Haji","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2022.103888_bib14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.resp.2018.02.009","article-title":"GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat","volume":"257","author":"Kotmanova","year":"2018","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2022.103888_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/syn.1096","article-title":"GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleus","volume":"42","author":"Len","year":"2001","journal-title":"Synapse"},{"issue":"2\u20133","key":"10.1016\/j.resp.2022.103888_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0034-5687(00)00158-4","article-title":"Respiratory neuronal assemblies","volume":"122","author":"Lindsey","year":"2000","journal-title":"Respir. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2022.103888_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.1991.sp018822","article-title":"Identification of neurons receiving input from pulmonary rapidly adapting receptors in the cat","volume":"443","author":"Lipski","year":"1991","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.resp.2022.103888_bib18","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1007\/s00429-014-0883-9","article-title":"Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents","volume":"220","author":"Mcgovern","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.resp.2022.103888_bib19","unstructured":"Macgregor, R.J. (1987). Neural and brain modeling. 1st ed. San Diego: Academic Press. inc.; 643 p. ISBN 0\u201312-464260\u20138."},{"issue":"Pt 2","key":"10.1016\/j.resp.2022.103888_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093153","article-title":"Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs","volume":"569","author":"Mazzone","year":"2005","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.resp.2022.103888_bib21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.brainresbull.2007.07.001","article-title":"The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbit","volume":"74","author":"Mutolo","year":"2007","journal-title":"Brain Res. Bull."},{"issue":"1\u20132","key":"10.1016\/j.resp.2022.103888_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainresbull.2009.05.022","article-title":"Role of excitatory amino acids in the mediation of tracheobronchial cough induced by citric acid inhalation in the rabbit","volume":"80","author":"Mutolo","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.resp.2022.103888_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nn1650","article-title":"Respiratory rhythm generation during gasping depends on persistent sodium current","volume":"9","author":"Paton","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.resp.2022.103888_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0034-5687(86)90058-7","article-title":"Background activity in pulmonary vagal C-fibers and its effects on breathing","volume":"64","author":"Pisarri","year":"1986","journal-title":"Respir. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2022.103888_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1152\/japplphysiol.00790.2015","article-title":"Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough","volume":"121","author":"Pitts","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2022.103888_bib26","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1152\/japplphysiol.00458.2011","article-title":"Blood pressure changes alter tracheobronchial cough: computational model of the respiratory- cough network and in vivo experiments in anesthetized cats","volume":"111","author":"Poliacek","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2022.103888_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.resp.2016.04.008","article-title":"The course of lung inflation alters the central pattern of tracheobronchial cough in cat-The evidence for volume feedback during cough","volume":"229","author":"Poliacek","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"6","key":"10.1016\/j.resp.2022.103888_bib28","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1152\/jn.00935.2016","article-title":"Microinjection of kynurenic acid in the rostral nucleus of the tractus solitarius disrupts spatiotemporal aspects of mechanically induced tracheobronchial cough","volume":"117","author":"Poliacek","year":"2017","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2022.103888_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.resp.2018.12.006","article-title":"The motor pattern of tracheobronchial cough is affected by inspiratory resistance and expiratory occlusion \u2013 The evidence for volume feedback during cough expiration","volume":"261","author":"Poliacek","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2022.103888_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2020.103547","article-title":"Volume feedback during cough in anesthetized cats, effects of occlusions and modulation summary","volume":"283","author":"Poliacek","year":"2021","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"165","key":"10.1016\/j.resp.2022.103888_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0079-6123(06)65013-9","article-title":"Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation","volume":"2007","author":"Rybak","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.resp.2022.103888_bib32","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1152\/jn.90416.2008","article-title":"Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments","volume":"100","author":"Rybak","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2022.103888_bib33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/pulp.1996.0045","article-title":"Brainstem respiratory networks and cough","volume":"9","author":"Shannon","year":"1996","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.resp.2022.103888_bib34","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1152\/jappl.1998.84.6.2020","article-title":"Ventrolateral medullary respiratory network and a model of cough motor pattern generation","volume":"84","author":"Shannon","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2022.103888_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1469-7793.2000.00207.x","article-title":"Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat","volume":"525","author":"Shannon","year":"2000","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.resp.2022.103888_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pupt.2004.09.022","article-title":"Production of reflex cough by brainstem respiratory networks","volume":"17","author":"Shannon","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2022.103888_bib37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.resp.2016.05.008","article-title":"Changes in vagal afferent drive alter tracheobronchial coughing in anesthetized cats","volume":"230","author":"Simera","year":"2016","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"5","key":"10.1016\/j.resp.2022.103888_bib38","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1152\/jn.00168.2009","article-title":"Influence of vagotomy on monosynaptic transmission at second-order nucleus tractus solitarius synapses","volume":"102","author":"Swartz","year":"2009","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2022.103888_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.1988.sp017212","article-title":"Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats","volume":"402","author":"Tatar","year":"1988","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2022.103888_bib40","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0165-1838(98)00140-4","article-title":"Receptor subtype specific effects of GABA agonists on neurons receiving aortic depressor nerve inputs within the nucleus of the solitary tract","volume":"73","author":"Zhang","year":"1998","journal-title":"J. Auton. Nerv. Syst."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904822000477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904822000477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:46:54Z","timestamp":1761605214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904822000477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":40,"alternative-id":["S1569904822000477"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2022.103888","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modeling and simulation of vagal afferent input of the cough reflex","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2022.103888","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103888"}}