{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:58:30Z","timestamp":1780549110273,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"am","delay-in-days":288,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD091658"],"award-info":[{"award-number":["R01HD091658"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.resp.2023.104033","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T06:19:43Z","timestamp":1675923583000},"page":"104033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Primary site of constriction during the compression phase of cough in healthy young adults"],"prefix":"10.1016","volume":"311","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-3866","authenticated-orcid":false,"given":"Ja Young","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hegland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2023.104033_bib1","unstructured":"Baken, R.J.,\u00a0Orlikoff, R.F. , 2000. Clinical Measurement of Speech and Voice. Singular Thomson Learning."},{"issue":"1","key":"10.1016\/j.resp.2023.104033_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02713631","article-title":"Cough: physiology, evaluation, and treatment","volume":"164","author":"Banner","year":"1986","journal-title":"Lung"},{"issue":"8","key":"10.1016\/j.resp.2023.104033_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mpaic.2011.05.002","article-title":"Anatomy of the larynx, trachea and bronchi","volume":"12","author":"Burdett","year":"2011","journal-title":"Anaesth. Intensive Care Med."},{"issue":"8","key":"10.1016\/j.resp.2023.104033_bib4","doi-asserted-by":"crossref","first-page":"a009720","DOI":"10.1101\/cshperspect.a009720","article-title":"Structure and function of the mucus clearance system of the lung","volume":"3","author":"Button","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"1","key":"10.1016\/j.resp.2023.104033_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.prrv.2005.11.009","article-title":"The physiology of cough","volume":"7","author":"Chang","year":"2006","journal-title":"Paediatr. Respir. Rev."},{"issue":"2","key":"10.1016\/j.resp.2023.104033_bib6","first-page":"285","article-title":"The big picture: gross anatomy","volume":"86","author":"Culligan","year":"2013","journal-title":"Yale J. Biol. Med."},{"issue":"2","key":"10.1016\/j.resp.2023.104033_bib7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pupt.2008.11.013","article-title":"The urge-to-cough and cough motor response modulation by the central effects of nicotine","volume":"22","author":"Davenport","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.resp.2023.104033_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11883-002-0010-x","article-title":"Recent developments in diagnosis and intervention for aspiration and dysphagia in stroke and other neuromuscular disorders","volume":"4","author":"Doggett","year":"2002","journal-title":"Curr. Atheroscler. Rep."},{"issue":"10","key":"10.1016\/j.resp.2023.104033_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01893103","article-title":"Anatomy and physiology of the pharynx","volume":"10","author":"Donner","year":"1985","journal-title":"Gastrointest. Radiol."},{"key":"10.1016\/j.resp.2023.104033_bib10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-3-540-79842-2_12","article-title":"Central mechanisms IV: conscious control of cough and the placebo effect","volume":"187","author":"Eccles","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.resp.2023.104033_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/00016488209130862","article-title":"Closure of the laryngeal vestibule during deglutition","volume":"93","author":"Ekberg","year":"1982","journal-title":"Acta Oto-Laryngol."},{"issue":"3","key":"10.1016\/j.resp.2023.104033_bib12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.resp.2006.02.016","article-title":"Cough motor mechanisms","volume":"152","author":"Fontana","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"2","key":"10.1016\/j.resp.2023.104033_bib13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.21037\/acs.2018.03.01","article-title":"Surgical anatomy of the trachea","volume":"7","author":"Furlow","year":"2018","journal-title":"Ann. Cardiothorac. Surg."},{"issue":"2","key":"10.1016\/j.resp.2023.104033_bib14","first-page":"121","article-title":"Surgical anatomy of the tracheobronchial tree","volume":"8","author":"Gabrielle","year":"2016","journal-title":"J. Thorac. Dis."},{"issue":"1","key":"10.1016\/j.resp.2023.104033_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/japplphysiol.01299.2011","article-title":"Volitional control of reflex cough","volume":"113","author":"Hegland","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2023.104033_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1044\/2014_AJSLP-14-0045","article-title":"Surface electrical stimulation perturbation context determines the presence of error reduction in swallowing hyolaryngeal kinematics","volume":"24","author":"Humbert","year":"2015","journal-title":"Am. J. Speech-Lang. Pathol."},{"key":"10.1016\/j.resp.2023.104033_bib17","first-page":"676","article-title":"The Interrelationships of pressure, flow, and volume during various respiratory maneuvers in normal and emphysematous subjects","volume":"83","author":"Hyatt","year":"1961","journal-title":"Am. Rev. Respir. Dis."},{"issue":"1","key":"10.1016\/j.resp.2023.104033_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/13873954.2021.1889608","article-title":"Dynamics of cough and particulate behaviour in the human airway","volume":"27","author":"Ilegbusi","year":"2021","journal-title":"Math. Comput. Model. Dyn. Syst."},{"issue":"1\u20132","key":"10.1016\/j.resp.2023.104033_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0034-5687(00)00205-X","article-title":"Central nervous pathways and control of the airways","volume":"125","author":"Jordan","year":"2001","journal-title":"Respir. Physiol."},{"issue":"4","key":"10.1016\/j.resp.2023.104033_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00455-001-0086-4","article-title":"Pharyngeal constriction in elderly dysphagic patients compared with young and elderly nondysphagic controls","volume":"16","author":"Kendall","year":"2001","journal-title":"Dysphagia"},{"issue":"8","key":"10.1016\/j.resp.2023.104033_bib21","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1136\/thx.2005.057901","article-title":"Differences in motor activation of voluntary and reflex cough in humans","volume":"61","author":"Lasserson","year":"2006","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.resp.2023.104033_bib22","first-page":"1168","article-title":"Two methods for quantifying pharyngeal residue on fluoroscopic swallow studies: reliability assessment","volume":"4","author":"Leonard","year":"2017","journal-title":"J. Otolaryngol. Rhinol."},{"issue":"1","key":"10.1016\/j.resp.2023.104033_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00455-009-9258-4","article-title":"Fluoroscopic surrogate for pharyngeal strength: the pharyngeal constriction ratio (PCR)","volume":"26","author":"Leonard","year":"2011","journal-title":"Dysphagia"},{"issue":"2\u20133","key":"10.1016\/j.resp.2023.104033_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.resp.2007.02.006","article-title":"Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways","volume":"157","author":"Lin","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"6","key":"10.1016\/j.resp.2023.104033_bib25","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/000348947408300611","article-title":"Physiology of cough","volume":"83","author":"Macklem","year":"1974","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"3","key":"10.1016\/j.resp.2023.104033_bib26","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pupt.2011.01.007","article-title":"Voluntary and reflex cough: similarities and differences","volume":"24","author":"Magni","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.resp.2023.104033_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1714562","article-title":"Aspiration pneumonia","volume":"380","author":"Mandell","year":"2019","journal-title":"New Engl. J. Med."},{"issue":"8","key":"10.1016\/j.resp.2023.104033_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1383\/anes.2005.6.8.253","article-title":"Anatomy of the larynx, trachea and bronchi","volume":"6","author":"Marchant","year":"2005","journal-title":"Anaesth. Intensive care Med."},{"issue":"4","key":"10.1016\/j.resp.2023.104033_bib29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.pmr.2008.06.001","article-title":"Anatomy and physiology of feeding and swallowing - normal and abnormal","volume":"19","author":"Matsuo","year":"2008","journal-title":"Phys. Med. Rehabil. Clin. North Am."},{"key":"10.1016\/j.resp.2023.104033_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02407121","article-title":"Neurophysiological basis of swallowing","volume":"1","author":"Miller","year":"1986","journal-title":"Dysphagia"},{"key":"10.1016\/j.resp.2023.104033_bib31","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1053\/apmr.2000.17829","article-title":"Motions of the posterior pharyngeal wall in human swallowing: a quantitative videofluorographic study","volume":"81","author":"Palmer","year":"2000","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"3","key":"10.1016\/j.resp.2023.104033_bib32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/pupt.2002.0358","article-title":"Central nervous mechanisms of cough","volume":"15","author":"Pantaleo","year":"2002","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.resp.2023.104033_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00455-012-9426-9","article-title":"Image-based measurement of post-swallow residue: the normalized residue ratio scale","volume":"28","author":"Pearson","year":"2013","journal-title":"Dysphagia"},{"key":"10.1016\/j.resp.2023.104033_bib34","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/lary.25788","article-title":"Computational analysis of swallowing mechanics underlying impaired epiglottic inversion","volume":"126","author":"Pearson","year":"2016","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.resp.2023.104033_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-0031-1277712","article-title":"Anatomy and physiology of the velopharyngeal mechanism","volume":"32","author":"Perry","year":"2011","journal-title":"Semin. Speech Lang."},{"issue":"1","key":"10.1016\/j.resp.2023.104033_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00408-013-9540-y","article-title":"Airway protective mechanisms","volume":"192","author":"Pitts","year":"2014","journal-title":"Lung"},{"issue":"3","key":"10.1016\/j.resp.2023.104033_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00455-007-9144-x","article-title":"Voluntary cough production and swallow dysfunction in Parkinson's disease","volume":"23","author":"Pitts","year":"2008","journal-title":"Dysphagia"},{"key":"10.1016\/j.resp.2023.104033_bib38","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1152\/japplphysiol.00087.2004","article-title":"Correspondence between laryngeal vocal fold movement and muscle activity during speech and nonspeech gestures","volume":"97","author":"Poletto","year":"2004","journal-title":"J. Appl. Physiol."},{"issue":"9\u201310","key":"10.1016\/j.resp.2023.104033_bib39","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/BF02439969","article-title":"Anatomical considerations of closure of the laryngeal vestibule during swallowing","volume":"254","author":"Reidenbach","year":"1997","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.resp.2023.104033_bib40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1745-9974-9-16","article-title":"The larynx in cough","volume":"9","author":"Sandhu","year":"2013","journal-title":"Cough"},{"key":"10.1016\/j.resp.2023.104033_bib41","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1164\/ajrccm.155.2.9032206","article-title":"Activation of intrinsic laryngeal muscles during cough","volume":"155","author":"Sant\u2019Ambrogio","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2023.104033_bib42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/nmo.13100","article-title":"The anatomy and physiology of normal and abnormal swallowing in oropharyngeal dysphagia","volume":"29","author":"Sasegbon","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"issue":"5\u20136","key":"10.1016\/j.resp.2023.104033_bib43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/pulp.1996.0045","article-title":"Brainstem respiratory networks and cough","volume":"9","author":"Shannon","year":"1996","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.resp.2023.104033_bib44","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1152\/jappl.1998.84.6.2020","article-title":"Ventrolateral medullary respiratory network and a model of cough motor pattern generation","volume":"84","author":"Shannon","year":"1998","journal-title":"J. Appl. Physiol."},{"issue":"6","key":"10.1016\/j.resp.2023.104033_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pupt.2004.09.022","article-title":"Production of reflex cough by brainstem respiratory networks","volume":"17","author":"Shannon","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.resp.2023.104033_bib46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1378\/chest.13-0596","article-title":"Concordance and discriminatory power of cough measurement devices for individuals with Parkinson disease","volume":"145","author":"Silverman","year":"2014","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.resp.2023.104033_bib47","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.apmr.2015.10.098","article-title":"Measurement of voluntary cough production and airway protection in Parkinson disease","volume":"97","author":"Silverman","year":"2016","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"4","key":"10.1016\/j.resp.2023.104033_bib48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1590\/1678-775720140132","article-title":"A framework for understanding shared substrates of airway protection","volume":"22","author":"Troche","year":"2014","journal-title":"J. Appl. Oral. Sci."},{"issue":"6","key":"10.1016\/j.resp.2023.104033_bib49","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00455-016-9734-6","article-title":"Reflex cough and disease duration as predictors of swallowing dysfunction in Parkinson's disease","volume":"31","author":"Troche","year":"2016","journal-title":"Dysphagia"},{"key":"10.1016\/j.resp.2023.104033_bib50","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1001\/archotol.1965.00750050631016","article-title":"An analysis of cough at the level of the larynx","volume":"81","author":"Von","year":"1965","journal-title":"Arch. Otolaryngol. Head. Neck Surg."},{"issue":"3","key":"10.1016\/j.resp.2023.104033_bib51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00455-018-9928-1","article-title":"Hidden in plain sight\": a descriptive review of laryngeal vestibule closure","volume":"34","author":"Vose","year":"2019","journal-title":"Dysphagia"},{"issue":"4","key":"10.1016\/j.resp.2023.104033_bib52","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.pupt.2006.11.006","article-title":"Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner","volume":"20","author":"Vovk","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.resp.2023.104033_bib53","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/00016486609127088","article-title":"The physical parameters of cough: the larynx in a normal single cough","volume":"61","author":"Yanagihara","year":"1966","journal-title":"Acta Oto-Laryngol."},{"issue":"2","key":"10.1016\/j.resp.2023.104033_bib54","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.otohns.2006.03.016","article-title":"Can a fluoroscopic estimation of pharyngeal constriction predict aspiration?","volume":"135","author":"Yip","year":"2006","journal-title":"Otolaryngol. -Head. Neck Surg."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823000216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823000216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T14:55:53Z","timestamp":1736434553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904823000216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":54,"alternative-id":["S1569904823000216"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2023.104033","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary site of constriction during the compression phase of cough in healthy young adults","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2023.104033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104033"}}