{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:29:35Z","timestamp":1778862575999,"version":"3.51.4"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006108","name":"Cultural and Educational Grant Agency of the Ministry of Education Science Research and Sport of the Slovak Republic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["1\/0020\/19"],"award-info":[{"award-number":["1\/0020\/19"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.resp.2023.104043","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T02:38:26Z","timestamp":1677983906000},"page":"104043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Influence of combined voltage-gated sodium channel NaV1.7 and NaV1.8 inhibitors on cough in a guinea pig model"],"prefix":"10.1016","volume":"312","author":[{"given":"Mariana","family":"Brozmanova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2725-2561","authenticated-orcid":false,"given":"Tomas","family":"Buday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janka","family":"Jakusova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Melegova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Plevkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2023.104043_bib1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1152\/physrev.00052.2017","article-title":"The role of voltage-gated sodium channels in pain signaling","volume":"99","author":"Bennett","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2023.104043_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2019.103267","article-title":"The voltage-gated sodium channel NaV1.8 blocker A-803467 inhibits cough in the guinea pig","volume":"270","author":"Brozmanova","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2023.104043_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2022.103856","article-title":"The effect of the voltage-gated sodium channel NaV1.7 blocker PF-05089771 on cough in the guinea pig","volume":"299","author":"Brozmanova","year":"2022","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2023.104043_bib4","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1124\/pr.111.005116","article-title":"Antitussive drugs\u2014past, present, and future","volume":"66","author":"Dicpinigaitis","year":"2014","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.resp.2023.104043_bib5","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.chest.2017.05.016","article-title":"Translating cough mechanisms into better cough suppressants","volume":"152","author":"Keller","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.resp.2023.104043_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/membranes11070511","article-title":"The changes in expression of NaV1.7 and NaV1.8 and the effects of the inhalation of their blockers in healthy and ovalbumin-sensitized guinea pig airways","volume":"11","author":"Kocmalova","year":"2021","journal-title":"Membranes"},{"key":"10.1016\/j.resp.2023.104043_bib7","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1113\/JP275698","article-title":"Different role of TTX-sensitive voltage-gated sodium channel (Na V 1) subtypes in action potential initiation and conduction in vagal airway nociceptors: Na V 1s in vagal airway afferent nerves","volume":"596","author":"Kollarik","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2023.104043_bib8","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1113\/jphysiol.2007.146365","article-title":"Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs: VGSCs in vagal pulmonary nociceptors versus non-nociceptors","volume":"586","author":"Kwong","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2023.104043_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pupt.2019.02.002","article-title":"Heterogeneity of cough neurobiology: clinical implications","volume":"55","author":"Mazzone","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2023.104043_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00408-013-9533-x","article-title":"Targeting voltage gated sodium channels NaV1.7, NaV1.8, and NaV1.9 for treatment of pathological cough","volume":"192","author":"Muroi","year":"2014","journal-title":"Lung"},{"key":"10.1016\/j.resp.2023.104043_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pupt.2019.03.002","article-title":"Targeting C-fibers for peripheral acting anti-tussive drugs","volume":"56","author":"Patil","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2023.104043_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174192","article-title":"Antitussive effects of NaV 1.7 blockade in Guinea pigs","volume":"907","author":"Yu","year":"2021","journal-title":"Eur. J. Pharmacol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823000319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823000319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:47:43Z","timestamp":1761605263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904823000319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":12,"alternative-id":["S1569904823000319"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2023.104043","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of combined voltage-gated sodium channel NaV1.7 and NaV1.8 inhibitors on cough in a guinea pig model","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2023.104043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104043"}}