{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:51:36Z","timestamp":1761605496125,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.resp.2023.104071","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T12:29:23Z","timestamp":1683203363000},"page":"104071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Multiple sensor theory in airway mechanosensory units"],"prefix":"10.1016","volume":"313","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-2336","authenticated-orcid":false,"given":"Jerry","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2023.104071_bib1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1113\/jphysiol.1933.sp003053","article-title":"Afferent impulses in the vagus and their effect on respiration","volume":"79","author":"Adrian","year":"1933","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib2","doi-asserted-by":"crossref","first-page":"H1740","DOI":"10.1152\/ajpheart.00557.2015","article-title":"Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function","volume":"309","author":"Ardell","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/j.2040-4603.2021.tb00156.x","article-title":"Air hunger: a primal sensation and a primary element of dyspnea","volume":"11","author":"Banzett","year":"2021","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-323-91534-2.00008-4","article-title":"Dyspnea","volume":"188","author":"Binks","year":"2022","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.resp.2023.104071_bib5","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.resp.2023.104071_bib6","series-title":"Handbook of Physiology","article-title":"Reflexes evoked from tracheobronchial tree and lungs","author":"Coleridge","year":"1986"},{"key":"10.1016\/j.resp.2023.104071_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/B978-0-323-91534-2.00006-0","article-title":"Respiratory-cardiovascular interactions","volume":"188","author":"Fisher","year":"2022","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.resp.2023.104071_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1212\/WNL.51.1.48","article-title":"Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial","volume":"51","author":"Handforth","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.resp.2023.104071_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1889.sp000294","article-title":"On the regulation of respiration. Part I. Experimental","volume":"10","author":"Head","year":"1889","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/j.pain.0000000000000865","article-title":"Pain and respiration: a systematic review","volume":"158","author":"Jafari","year":"2017","journal-title":"Pain"},{"issue":"147","key":"10.1016\/j.resp.2023.104071_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1152\/ajplegacy.1946.147.1.100","article-title":"A unitary analysis of pulmonary volume receptors","author":"Knowlton","year":"1946","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1152\/japplphysiol.00252.2006","article-title":"Central pathways of pulmonary and lower airway vagal afferents","volume":"101","author":"Kubin","year":"2006","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2023.104071_bib13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1152\/ajplegacy.1946.147.1.90","article-title":"Excitation and inhibition of phrenic motoneurones by inflation of the lungs","volume":"147","author":"Larrabee","year":"1946","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib14","doi-asserted-by":"crossref","first-page":"R1059","DOI":"10.1152\/ajpregu.00125.2013","article-title":"Spectrum of myelinated pulmonary afferents (II).","volume":"305","author":"Liu","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3389\/fphys.2016.00588","article-title":"Slowly adapting sensory units have more receptors in large airways than in small airways in rabbits","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib16","doi-asserted-by":"crossref","first-page":"23111","DOI":"10.1038\/s41598-021-02563-x","article-title":"A single baroreceptor unit consists of multiple sensors","volume":"11","author":"Liu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.resp.2023.104071_bib17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1152\/jappl.1969.27.6.775","article-title":"A linear approximation of the transfer function of pulmonary mechanoreceptors of the frog","volume":"27","author":"Mckean","year":"1969","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.biopsych.2008.04.036","article-title":"Vagus nerve stimulation: 2-year outcomes for bipolar versus unipolar treatment-resistant depression","volume":"64","author":"Nierenberg","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.resp.2023.104071_bib19","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3389\/fphys.2019.01176","article-title":"Hypothesis: pulmonary afferent activity patterns during slow, deep breathing contribute to the neural induction of physiological relaxation","volume":"10","author":"Noble","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature20793","article-title":"Piezo2 senses airway stretch and mediates lung inflation-induced apnoea","volume":"541","author":"Nonomura","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.resp.2023.104071_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.ph.43.030181.000445","article-title":"Sensory inputs to the medulla","volume":"43","author":"Pack","year":"1981","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/physrev.1973.53.1.159","article-title":"Vagal sensory receptors and their reflex effects","volume":"53","author":"Paintal","year":"1973","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2023.104071_bib23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1146\/annurev.ph.49.030187.003143","article-title":"Nervous receptors of the tracheobronchial tree","volume":"49","author":"Sant'Ambrogio","year":"1987","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib24","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1152\/japplphysiol.00222.2006","article-title":"Transduction mechanisms in airway sensory nerves","volume":"101","author":"Taylor-Clark","year":"2006","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2023.104071_bib25","series-title":"Breathing: Hering-Breuer centenary synosium: a Ciba Foundation symposium","article-title":"The two original papers by Hering and Breuer submitted by Hering to the K. K. Akadmie Der Wissenschaften Zu Wien in 1968","author":"Ullmann","year":"1970"},{"key":"10.1016\/j.resp.2023.104071_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tins.2020.09.010","article-title":"Interventions and Manipulations of Interoception","volume":"44","author":"Weng","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.resp.2023.104071_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0034-5687(00)00201-2","article-title":"Airway receptors","volume":"125","author":"Widdicombe","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib28","unstructured":"Yu, J. Multiple sensor theory in airway mechanosensory units. In: Okada, Y., ed. The 15th Oxford Conference on Modelling and Control of Breathing, 2022a Odawara, Japan. 43."},{"key":"10.1016\/j.resp.2023.104071_bib29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.resp.2004.12.007","article-title":"Airway mechanosensors","volume":"148","author":"Yu","year":"2005","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2023.104071_bib30","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1152\/japplphysiol.00903.2015","article-title":"Deflation-activated receptors, not classical inflation-activated receptors, mediate the Hering-Breuer deflation reflex","volume":"121","author":"Yu","year":"2016","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2023.104071_bib31","doi-asserted-by":"crossref","first-page":"R724","DOI":"10.1152\/ajpregu.00136.2020","article-title":"Spectrum of myelinated pulmonary afferents (III): cracking intermediate adapting receptors","volume":"319","author":"Yu","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib32","doi-asserted-by":"crossref","first-page":"1044577","DOI":"10.3389\/fphys.2022.1044577","article-title":"Multiple sensor theory in cardiovascular mechanosensory units","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2023.104071_bib33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/B978-0-323-91534-2.00014-X","article-title":"Regulation of breathing by cardiopulmonary afferents","volume":"188","author":"Yu","year":"2022","journal-title":"Handb. Clin. Neurol."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823000599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823000599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:48:29Z","timestamp":1761605309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904823000599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":33,"alternative-id":["S1569904823000599"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2023.104071","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple sensor theory in airway mechanosensory units","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2023.104071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104071"}}