{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:55:38Z","timestamp":1761605738558,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.resp.2023.104122","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T13:42:21Z","timestamp":1689860541000},"page":"104122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CNS-oxygen toxicity and blood glucose levels in MnSOD enzyme knockdown mice"],"prefix":"10.1016","volume":"316","author":[{"given":"Ricarina","family":"Rabinovitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirit","family":"Eynan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2023.104122_bib1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1152\/japplphysiol.91109.2008","article-title":"Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity","volume":"106","author":"Allen","year":"2009","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2023.104122_bib2","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13961","article-title":"Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements","volume":"7","author":"Ari","year":"2019","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.resp.2023.104122_bib3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s004210050145","article-title":"Recovery time constant in central nervous system O2 toxicity in the rat","volume":"75","author":"Arieli","year":"1997","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.resp.2023.104122_bib4","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1152\/jappl.1994.77.4.1903","article-title":"Prediction of central nervous system oxygen toxicity in rats","volume":"77","author":"Arieli","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2023.104122_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1152\/japplphysiol.00434.2001","article-title":"Modeling pulmonary and CNS O2 toxicity and estimation of parameters for humans","volume":"92","author":"Arieli","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2023.104122_bib6","first-page":"1153","article-title":"CNS oxygen toxicity in closed-circuit diving: signs and symptoms before loss of consciousness","volume":"77","author":"Arieli","year":"2006","journal-title":"Aviat. Space Environ. Med"},{"key":"10.1016\/j.resp.2023.104122_bib7","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.3390\/ijms24065969","article-title":"Elevations of extracellular vesicles and inflammatory biomarkers in closed circuit SCUBA divers","volume":"24","author":"Arya","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.resp.2023.104122_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0024-3205(82)90399-X","article-title":"Influence of blood glucose on convulsive seizures from hyperbaric oxygen","volume":"31","author":"Beckman","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2023.104122_bib9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0006-8993(97)00442-3","article-title":"Starvation and dehydration attenuate CNS oxygen toxicity in rats","volume":"761","author":"Bitterman","year":"1997","journal-title":"Brain Res"},{"issue":"18","key":"10.1016\/j.resp.2023.104122_bib10","doi-asserted-by":"crossref","first-page":"9755","DOI":"10.3390\/ijerph18189755","article-title":"Oxidative Stress and Inflammation, MicroRNA, and Hemoglobin Variations after Administration of Oxygen at Different Pressures and Concentrations: A Randomized Trial","volume":"18","author":"Bosco","year":"2021","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.resp.2023.104122_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2009.03.076","article-title":"Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha","volume":"456","author":"Bullock","year":"2009","journal-title":"Neurosci. Let."},{"issue":"5","key":"10.1016\/j.resp.2023.104122_bib12","first-page":"1391","article-title":"The role of hyperglycemia in the induction of oxidative stress and inflammatory process","volume":"27","author":"de Carvalho, Vidigal","year":"2012","journal-title":"Nutr. Hosp."},{"key":"10.1016\/j.resp.2023.104122_bib13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1196\/annals.1427.021","article-title":"Mitochondria and hypoxia-induced gene expression mediated by hypoxia-inducible factors","volume":"1147","author":"Chavez","year":"2008","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"11","key":"10.1016\/j.resp.2023.104122_bib14","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1152\/japplphysiol.00922.2012","article-title":"Pulsed high oxygen induces a hypoxic-like response in human umbilical endothelial cells and in humans","volume":"113","author":"Cimino","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2023.104122_bib15","doi-asserted-by":"crossref","first-page":"R829","DOI":"10.1152\/ajpregu.00506.2012","article-title":"Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats","volume":"304","author":"D\u2019Agostino","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2023.104122_bib16","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1007\/s00421-011-2229-0","article-title":"Is glucose-6-phosphate dehydrogenase deficiency a risk factor for hyperbaric oxygen exposure","volume":"112","author":"Eynan","year":"2012","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.resp.2023.104122_bib17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1152\/japplphysiol.00154.2015","article-title":"Alteration of blood glucose levels in the rat following exposure to hyperbaric oxygen","volume":"119","author":"Eynan","year":"2015","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2023.104122_bib18","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3390\/ijms22010458","article-title":"Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the \"Normobaric Oxygen Paradox\"","volume":"22","author":"Fratantonio","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.resp.2023.104122_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.bi.64.070195.000525","article-title":"Superoxide radical and superoxide dismutases","volume":"64","author":"Fridovich","year":"1995","journal-title":"Annu Rev. Biochem"},{"key":"10.1016\/j.resp.2023.104122_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbrc.2013.04.034","article-title":"Hypoxia-inducible factor 1\u03b1 mediates the down-regulation of superoxide dismutase 2 in von Hippel-Lindau deficient renal clear cell carcinoma","volume":"435","author":"Gao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.resp.2023.104122_bib21","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1528-1167.2010.02593.x","article-title":"Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose","volume":"51","author":"Gasior","year":"2010","journal-title":"Epilepsia"},{"year":"1999","series-title":"Free Radicals in Biology and Medicine","author":"Halliwell","key":"10.1016\/j.resp.2023.104122_bib22"},{"key":"10.1016\/j.resp.2023.104122_bib23","doi-asserted-by":"crossref","first-page":"17478","DOI":"10.1073\/pnas.1209281109","article-title":"Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1\u03b1-dependent function","volume":"109","author":"Huang","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"22","key":"10.1016\/j.resp.2023.104122_bib24","doi-asserted-by":"crossref","first-page":"8767","DOI":"10.3390\/ijms21228767","article-title":"Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases","volume":"21","author":"Jensen","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.resp.2023.104122_bib25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"MOLL CELL"},{"key":"10.1016\/j.resp.2023.104122_bib26","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1073\/pnas.93.18.9782","article-title":"Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice","volume":"93","author":"Lebovitz","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.resp.2023.104122_bib27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.expneurol.2004.08.036","article-title":"Multiple effects of hyperbaric oxygen on the expression of HIF-1\u03b1 and apoptotic genes in a global ischemia-hypotension rat model","volume":"191","author":"Li","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.resp.2023.104122_bib28","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1096\/fasebj.8.13.7926364","article-title":"Glucose transporter proteins in brain","volume":"8","author":"Maher","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2023.104122_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1620\/tjem.216.127","article-title":"Enhancement of glucose toxicity by hyperbaric oxygen exposure in diabetic rats","volume":"216","author":"Matsunami","year":"2008","journal-title":"Tohoku J. Exp. Med"},{"key":"10.1016\/j.resp.2023.104122_bib30","first-page":"177","article-title":"Oxidative stress and gene expression of antioxidant enzymes in the streptozotocin-induced diabetic rats under hyperbaric oxygen exposure","volume":"3","author":"Matsunami","year":"2009","journal-title":"Int J. Clin. Exp. Pathol."},{"key":"10.1016\/j.resp.2023.104122_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.33549\/physiolres.931711","article-title":"Antioxidant status and lipid peroxidation in diabetic rats under hyperbaric oxygen exposure","volume":"59","author":"Matsunami","year":"2010","journal-title":"Physiol. Res"},{"key":"10.1016\/j.resp.2023.104122_bib32","first-page":"87","article-title":"Cerebral and blood glucose in central oxygen poisoning","volume":"5","author":"Nolan","year":"1978","journal-title":"Undersea Biomed. Res"},{"key":"10.1016\/j.resp.2023.104122_bib33","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1152\/physrev.1983.63.4.1481","article-title":"Brain metabolism: a perspective from the blood-brain barrier","volume":"63","author":"Pardridge","year":"1983","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2023.104122_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fncel.2019.00172","article-title":"2-deoxyglucose and beta-hydroxybutyrate: metabolic agents for seizure control","volume":"13","author":"Rho","year":"2019","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.resp.2023.104122_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ab.2019.03.010","article-title":"Ponceau S waste: Ponceau S staining for total protein normalization","volume":"575","author":"Sander","year":"2019","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.resp.2023.104122_bib36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1471-4914(01)02090-1","article-title":"Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology","volume":"7","author":"Semenza","year":"2001","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.resp.2023.104122_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/0-306-46825-5_12","article-title":"Hypoxia, HIF-1, and the pathophysiology of common human diseases","volume":"475","author":"Semenza","year":"2000","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1016\/j.resp.2023.104122_bib38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10571-012-9803-9","article-title":"Hypoxia inducible factor-1: its potential role in cerebral ischemia","volume":"32","author":"Singh","year":"2012","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.resp.2023.104122_bib39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.redox.2016.10.018","article-title":"Brain adaptation to hypoxia and hyperoxia in mice","volume":"11","author":"Terraneo","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.resp.2023.104122_bib40","first-page":"147","article-title":"Blood glucose as a predictive measure for central nervous system oxygen toxicity in conscious rats","volume":"13","author":"Torbati","year":"1986","journal-title":"Undersea Biomed. Res"},{"issue":"12","key":"10.1016\/j.resp.2023.104122_bib41","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.3390\/nu12123906","article-title":"Glycemic Variability and CNS Inflammation: Reviewing the Connection","volume":"12","author":"Watt","year":"2020","journal-title":"Nutrients"},{"issue":"43","key":"10.1016\/j.resp.2023.104122_bib42","doi-asserted-by":"crossref","first-page":"28510","DOI":"10.1074\/jbc.273.43.28510","article-title":"Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice","volume":"273","author":"Williams","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2023.104122_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2019.109375","article-title":"Hyperbaric oxygen toxicity in brain: A case of hyperoxia induced hypoglycemic brain syndrome. Med Hypotheses","volume":"132","author":"Wilson","year":"2019","journal-title":"Med Hypothesis"}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823001106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904823001106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:49:58Z","timestamp":1761605398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904823001106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":43,"alternative-id":["S1569904823001106"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2023.104122","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CNS-oxygen toxicity and blood glucose levels in MnSOD enzyme knockdown mice","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2023.104122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104122"}}