{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T11:28:58Z","timestamp":1747913338329,"version":"3.37.3"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K08248","21K08954"],"award-info":[{"award-number":["15K08248","21K08954"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.resp.2024.104251","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T08:09:14Z","timestamp":1710403754000},"page":"104251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Extracellular acidification attenuates bronchial contraction via an autocrine activation of EP2 receptor: Its diminishment in murine experimental asthma"],"prefix":"10.1016","volume":"324","author":[{"given":"Yoshihiko","family":"Chiba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamato","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsubasa","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Suto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiko","family":"Hanazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2024.104251_bib1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/sj.bjp.0702104","article-title":"Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth","volume":"125","author":"Belvisi","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2024.104251_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pupt.2011.12.012","article-title":"PGE2 receptor (EP4) agonists: potent dilators of human bronchi and future asthma therapy?","volume":"25","author":"Benyahia","year":"2012","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2024.104251_bib3","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1164\/ajrccm\/145.5.1087","article-title":"Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine","volume":"145","author":"Bj\u00f6rck","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2024.104251_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000312635","article-title":"Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females","volume":"153","author":"Blacqui\u00e8re","year":"2010","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.resp.2024.104251_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1076\/apab.105.1.19.13152","article-title":"Relationship between acid neutralization capacity of saliva and gastro-oesophageal reflux","volume":"105","author":"Bouchoucha","year":"1997","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.resp.2024.104251_bib6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1136\/thx.2010.158568","article-title":"EP4 receptor as a new target for bronchodilator therapy","volume":"66","author":"Buckley","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2024.104251_bib7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/sj.bjp.0702585","article-title":"Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats","volume":"127","author":"Chiba","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2024.104251_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1465-9921-6-4","article-title":"Involvement of RhoA-mediated Ca2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice","volume":"6","author":"Chiba","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.resp.2024.104251_bib9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1164\/rccm.200903-0325OC","article-title":"Down-regulation of miR-133a contributes to up-regulation of RhoA in bronchial smooth muscle cells","volume":"180","author":"Chiba","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2024.104251_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1165\/rcmb.2008-0162OC","article-title":"Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein","volume":"40","author":"Chiba","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2024.104251_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202623","article-title":"Augmented Pla2g4c\/Ptgs2\/Hpgds axis in bronchial smooth muscle tissues of experimental asthma","volume":"13","author":"Chiba","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2024.104251_bib12","doi-asserted-by":"crossref","first-page":"L786","DOI":"10.1152\/ajplung.00315.2020","article-title":"Attenuation of relaxing response induced by pituitary adenylate cyclase-activating polypeptide in bronchial smooth muscle of experimental asthma","volume":"319","author":"Chiba","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2024.104251_bib13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00408-022-00558-7","article-title":"Hyperresponsiveness to extracellular acidification-mediated contraction in isolated bronchial smooth muscles of murine experimental asthma","volume":"200","author":"Chiba","year":"2022","journal-title":"Lung"},{"key":"10.1016\/j.resp.2024.104251_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2023.104137","article-title":"Altered renin-angiotensin system gene expression in airways of antigen-challenged mice: ACE2 downregulation and unexpected increase in angiotensin 1-7","volume":"316","author":"Chiba","year":"2023","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104251_bib15","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1152\/japplphysiol.00688.2001","article-title":"Relaxation of guinea pig trachealis during electrical field stimulation increases with age","volume":"92","author":"Chitano","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104251_bib16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1139\/Y07-063","article-title":"Three paradigms of airway smooth muscle hyperresponsiveness in young guinea pigs","volume":"85","author":"Chitano","year":"2007","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.resp.2024.104251_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2020.106486","article-title":"Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts","volume":"152","author":"Corboz","year":"2021","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.resp.2024.104251_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.phrs.2013.08.001","article-title":"Montelukast prevents microparticle-induced inflammatory and functional alterations in human bronchial smooth muscle cells","volume":"76","author":"Fogli","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.resp.2024.104251_bib19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejphar.2017.03.060","article-title":"Decreased vasorelaxation induced by iloprost during acute inflammation in human internal mammary artery","volume":"804","author":"Foudi","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2024.104251_bib20","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1113\/EP091236","article-title":"More airway smooth muscle in males versus females in a mouse model of asthma: a blessing in disguise?","volume":"108","author":"Gill","year":"2023","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2024.104251_bib21","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1164\/ajrccm.161.3.9911005","article-title":"Endogenous airway acidification. Implications for asthma pathophysiology","volume":"161","author":"Hunt","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2024.104251_bib22","doi-asserted-by":"crossref","first-page":"L567","DOI":"10.1152\/ajplung.00415.2009","article-title":"Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells","volume":"299","author":"Ichimonji","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"Lond","key":"10.1016\/j.resp.2024.104251_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12950-019-0207-1","article-title":"Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone","volume":"16","author":"Kadowaki","year":"2019","journal-title":"J. Inflamm."},{"key":"10.1016\/j.resp.2024.104251_bib24","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.4049\/jimmunol.162.12.7470","article-title":"Effect of an orally active Th1\/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice","volume":"162","author":"Kato","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.resp.2024.104251_bib25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1164\/rccm.200607-940OC","article-title":"An investigation of airway acidification in asthma using induced sputum: a study of feasibility and correlation","volume":"175","author":"Kodric","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2024.104251_bib26","doi-asserted-by":"crossref","first-page":"13534","DOI":"10.3390\/ijms222413534","article-title":"The role of prostaglandin E1 as a pain mediator through facilitation of hyperpolarization-activated cyclic nucleotide-gated channel 2 via the EP2 receptor in trigeminal ganglion neurons of mice","volume":"22","author":"Kwon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.resp.2024.104251_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/nyas.13086","article-title":"Role of heme in bromine-induced lung injury","volume":"1374","author":"Lam","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.resp.2024.104251_bib28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/978-981-13-5895-1_16","article-title":"Regulation of airway smooth muscle contraction in health and disease","volume":"1124","author":"Lam","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2024.104251_bib29","doi-asserted-by":"crossref","first-page":"107S","DOI":"10.1016\/S0002-9343(97)00334-3","article-title":"Effects of gastroesophageal reflux on the oral cavity","volume":"103","author":"Lazarchik","year":"1997","journal-title":"Am. J. Med."},{"key":"10.1016\/j.resp.2024.104251_bib30","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1111\/bph.15178","article-title":"ARRIVE 2.0 and the British journal of pharmacology: updated guidance for 2020","volume":"177","author":"Lilley","year":"2020","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.resp.2024.104251_bib31","doi-asserted-by":"crossref","first-page":"L1181","DOI":"10.1152\/ajplung.00389.2001","article-title":"Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects","volume":"283","author":"Ma","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2024.104251_bib32","doi-asserted-by":"crossref","first-page":"L943","DOI":"10.1152\/ajplung.00277.2019","article-title":"Transient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGE2","volume":"318","author":"Marsh","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2024.104251_bib33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1034\/j.1399-3003.2000.16b25.x","article-title":"The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease","volume":"16","author":"Martin","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2024.104251_bib34","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/j.1365-2222.2005.02362.x","article-title":"Female mice are more susceptible to the development of allergic airway inflammation than male mice","volume":"35","author":"Melgert","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.resp.2024.104251_bib35","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1165\/rcmb.2022-0445OC","article-title":"Prorelaxant E-type prostanoid receptors functionally partition to different procontractile receptors in airway smooth muscle","volume":"69","author":"Nayak","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2024.104251_bib36","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.cellsig.2013.07.022","article-title":"Regulation of inflammation by extracellular acidification and proton-sensing GPCRs","volume":"25","author":"Okajima","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.resp.2024.104251_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/bph.14854","article-title":"Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension","volume":"177","author":"Ozen","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2024.104251_bib38","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"4","author":"Percie du Sert","year":"2020","journal-title":"BMJ Open Sci."},{"key":"10.1016\/j.resp.2024.104251_bib39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2003.12.034","article-title":"Acid stress in the pathology of asthma","volume":"113","author":"Ricciardolo","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.resp.2024.104251_bib40","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1164\/ajrccm.158.supplement_2.13tac160","article-title":"Structural and functional changes in the airway smooth muscle of asthmatic subjects","volume":"158","author":"Seow","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.resp.2024.104251_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12931-015-0296-1","article-title":"Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling","volume":"16","author":"Tang","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.resp.2024.104251_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.alit.2019.05.001","article-title":"Aspirin-exacerbated respiratory disease (AERD): current understanding of AERD","volume":"68","author":"Taniguchi","year":"2019","journal-title":"Allergol. Int."},{"key":"10.1016\/j.resp.2024.104251_bib43","doi-asserted-by":"crossref","first-page":"L964","DOI":"10.1152\/ajplung.00401.2007","article-title":"Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release","volume":"294","author":"Wang","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2024.104251_bib44","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2152\/jmi.57.260","article-title":"A nocturnal decline of salivary pH associated with airway hyperresponsiveness in asthma","volume":"57","author":"Watanabe","year":"2010","journal-title":"J. Med. Invest."},{"key":"10.1016\/j.resp.2024.104251_bib45","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1124\/pr.110.003517","article-title":"International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress","volume":"63","author":"Woodward","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.resp.2024.104251_bib46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pupt.2012.06.005","article-title":"Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension","volume":"26","author":"Wright","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2024.104251_bib47","doi-asserted-by":"crossref","first-page":"PL175","DOI":"10.1016\/0024-3205(94)00497-G","article-title":"The effects of extracellular pH on intracellular pH, Ca2+ and tension of canine tracheal smooth muscle strips","volume":"56","author":"Yamakage","year":"1995","journal-title":"Life Sci."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904824000442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904824000442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T16:20:38Z","timestamp":1712766038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904824000442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":47,"alternative-id":["S1569904824000442"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2024.104251","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular acidification attenuates bronchial contraction via an autocrine activation of EP2 receptor: Its diminishment in murine experimental asthma","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2024.104251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104251"}}