{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:32Z","timestamp":1787237852672,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.resp.2024.104300","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T05:57:14Z","timestamp":1720936634000},"page":"104300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Cardiorespiratory failure induced by inhalation of aerosolized fentanyl in anesthetized rats"],"prefix":"10.1016","volume":"327","author":[{"given":"Jianguo","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2024.104300_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1213\/00000539-199609000-00034","article-title":"Upper airway closure: a primary source of difficult ventilation with sufentanil induction of anesthesia","volume":"83","author":"Abrams","year":"1996","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2024.104300_bib2","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/00000542-199711000-00010","article-title":"Difficult or impossible ventilation after sufentanil-induced anesthesia is caused primarily by vocal cord closure","volume":"87","author":"Bennett","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1183\/09031936.93.01020184","article-title":"Effects of brain hypoxia on ventilation","volume":"1","author":"Berkenbosch","year":"1988","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2024.104300_bib4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3109\/15563650.2016.1157722","article-title":"Could chest wall rigidity be a factor in rapid death from illicit fentanyl abuse?","volume":"54","author":"Burns","year":"2016","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.resp.2024.104300_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0034-5687(01)00240-7","article-title":"Modulation of breathing by mu1 and mu2 opioid receptor stimulation in neonatal and adult rats","volume":"127","author":"Colman","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2024.104300_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1213\/ane.0b013e31816a66a4","article-title":"Sex-specific responses to opiates: animal and human studies","volume":"107","author":"Dahan","year":"2008","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2024.104300_bib7","doi-asserted-by":"crossref","first-page":"904","DOI":"10.15585\/mmwr.mm6634a3","article-title":"Overdose deaths related to fentanyl and its analogs - Ohio, January-February 2017","volume":"66","author":"Daniulaityte","year":"2017","journal-title":"Mmwr. Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.resp.2024.104300_bib8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.5664\/jcsm.5704","article-title":"Medium increased risk for central sleep apnea but not obstructive sleep apnea in long-term opioid users: a systematic review and meta-analysis","volume":"12","author":"Filiatrault","year":"2016","journal-title":"J. Clin. Sleep. Med.\u00a0JCSM\u00a0Off. Publ. Am. Acad. Sleep. Med."},{"key":"10.1016\/j.resp.2024.104300_bib9","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1213\/00000539-196911000-00018","article-title":"Comparative effects of morphine and fentanyl on isolated heart muscle","volume":"48","author":"Goldberg","year":"1969","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2024.104300_bib10","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1097\/ALN.0000000000003156","article-title":"Severe hypoxemia prevents spontaneous and naloxone-induced breathing recovery after fentanyl overdose in awake and sedated rats","volume":"132","author":"Haouzi","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1152\/jappl.1988.65.3.1087","article-title":"Effect of stimulation of pulmonary C-fiber receptors on canine respiratory muscles","volume":"65","author":"Haxhiu","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104300_bib12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s00101-018-0454-1","article-title":"[Influence of rocuronium dose on the effectiveness of mask ventilation: a prospective, randomized clinical trial]","volume":"67","author":"Hellmund","year":"2018","journal-title":"Der Anaesthesist"},{"key":"10.1016\/j.resp.2024.104300_bib13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1520\/JFS13045J","article-title":"Fentanyl-related deaths: demographics, circumstances, and toxicology of 112 cases","volume":"36","author":"Henderson","year":"1991","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.resp.2024.104300_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1213\/00000539-198108000-00005","article-title":"Cardiovascular effects of and catecholamine responses to high dose fentanyl-O2 for induction of anesthesia in patients with ischemic coronary artery disease","volume":"60","author":"Hicks","year":"1981","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2024.104300_bib15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/bja\/34.4.260","article-title":"A review of the chemical features associated with strong morphine-like activity","volume":"34","author":"Janssen","year":"1962","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2024.104300_bib16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.pmn.2010.02.001","article-title":"Risk factors for opioid-induced excessive respiratory depression","volume":"12","author":"Jungquist","year":"2011","journal-title":"Pain. Manag. Nurs.\u00a0Off. J. Am. Soc. Pain. Manag. Nurses"},{"key":"10.1016\/j.resp.2024.104300_bib17","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/00000542-199812000-00033","article-title":"Differential effects of fentanyl and morphine on intracellular Ca2+ transients and contraction in rat ventricular myocytes","volume":"89","author":"Kanaya","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuropharm.2019.02.008","article-title":"Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl","volume":"151","author":"Kiyatkin","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.resp.2024.104300_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0304-3940(00)00807-7","article-title":"Inhibition by neuropeptide Y of fentanyl-induced muscular rigidity at the locus coeruleus in rats","volume":"280","author":"Lai","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2024.104300_bib20","doi-asserted-by":"crossref","first-page":"R1287","DOI":"10.1152\/ajpregu.00199.2003","article-title":"Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances","volume":"285","author":"Lalley","year":"2003","journal-title":"Am. J. Physiol. Regul., Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2024.104300_bib21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/ALN.0000000000004622","article-title":"Opioid overdose: limitations in naloxone reversal of respiratory depression and prevention of cardiac arrest","volume":"139","author":"van Lemmen","year":"2023","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib22","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1152\/japplphysiol.01101.2005","article-title":"Capsaicin-induced activation of pulmonary vagal C fibers produces reflex laryngeal closure in the rat","volume":"101","author":"Lu","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104300_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0304-3940(89)90252-8","article-title":"Involvement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat","volume":"96","author":"Lui","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2024.104300_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/01480540802587214","article-title":"Effect of exposure to fentanyl aerosol in mice on breathing pattern and respiratory variables","volume":"32","author":"Manral","year":"2009","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.resp.2024.104300_bib25","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.toxrep.2020.08.019","article-title":"Assessment of naloxone as a therapeutic for inhaled carfentanil in the ferret","volume":"7","author":"McCranor","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.resp.2024.104300_bib26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0896-6273(03)00092-8","article-title":"Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation","volume":"37","author":"Mellen","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.resp.2024.104300_bib27","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1113\/jphysiol.2013.261974","article-title":"CrossTalk proposal: the preBotzinger complex is essential for the respiratory depression following systemic administration of opioid analgesics","volume":"592","author":"Montandon","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2024.104300_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1292\/jvms.62.665","article-title":"Effects of perineural capsaicin treatment on cardiopulmonary reflexes elicited by laryngeal instillations of capsaicin and distilled water in sevoflurane-anesthetized dogs","volume":"62","author":"Mutoh","year":"2000","journal-title":"J. Vet. Med Sci."},{"key":"10.1016\/j.resp.2024.104300_bib29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/japplphysiol.00130.2014","article-title":"Recruitment and plasticity in diaphragm, intercostal, and abdominal muscles in unanesthetized rats","volume":"117","author":"Navarrete-Opazo","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104300_bib30","first-page":"391","article-title":"Multi-level regulation of opioid-induced respiratory depression","volume":"35","author":"Palkovic","year":"2020","journal-title":"Physiol. (Bethesda)"},{"key":"10.1016\/j.resp.2024.104300_bib31","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00000542-199902000-00034","article-title":"A review of the use of fentanyl analgesia in the management of acute pain in adults","volume":"90","author":"Peng","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib32","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1152\/jn.00017.2021","article-title":"Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding","volume":"125","author":"Ramirez","year":"2021","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2024.104300_bib33","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1517\/14740338.4.4.643","article-title":"The safety of remifentanil by bolus injection","volume":"4","author":"Richardson","year":"2005","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.resp.2024.104300_bib34","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/00000542-198710000-00004","article-title":"First pass uptake of fentanyl, meperidine, and morphine in the human lung","volume":"67","author":"Roerig","year":"1987","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib35","first-page":"223S","article-title":"Cardiovascular responses to large doses of alfentanil and fentanyl","volume":"55 Suppl 2","author":"Rucquoi","year":"1983","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2024.104300_bib36","doi-asserted-by":"crossref","first-page":"382","DOI":"10.15585\/mmwr.mm6614a2","article-title":"Characteristics of Fentanyl Overdose - Massachusetts, 2014-2016","volume":"66","author":"Somerville","year":"2017","journal-title":"Mmwr. Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.resp.2024.104300_bib37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/bja\/61.4.425","article-title":"Pulmonary kinetics of fentanyl and alfentanil in surgical patients","volume":"61","author":"Taeger","year":"1988","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2024.104300_bib38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0167-0115(94)90132-5","article-title":"Antagonization of fentanyl-induced muscular rigidity by neurotensin at the locus coeruleus of the rat","volume":"51","author":"Wang","year":"1994","journal-title":"Regul. Pept."},{"key":"10.1016\/j.resp.2024.104300_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0014-2999(82)90177-7","article-title":"Opioids increase laryngeal resistance and motoneuron activity in the recurrent laryngeal nerve","volume":"80","author":"Willette","year":"1982","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2024.104300_bib40","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1152\/japplphysiol.00767.2002","article-title":"Acute hypoxia prolongs the apnea induced by right atrial injection of capsaicin","volume":"94","author":"Xu","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104300_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2023.104053","article-title":"Peripheral neuroplasticity of respiratory chemoreflexes, induced by prenatal nicotinic exposure: implication for SIDS","volume":"313","author":"Xu","year":"2023","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104300_bib42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/01.anes.0000270760.46821.67","article-title":"Activation of opioid mu receptors in caudal medullary raphe region inhibits the ventilatory response to hypercapnia in anesthetized rats","volume":"107","author":"Zhang","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib43","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/ALN.0b013e318224cc1f","article-title":"Activation of opioid mu-receptors in the commissural subdivision of the nucleus tractus solitarius abolishes the ventilatory response to hypoxia in anesthetized rats","volume":"115","author":"Zhang","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2024.104300_bib44","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15965","article-title":"Apneic response to fentanyl in adult rats: role of laryngeal afferents","volume":"12","author":"Zhuang","year":"2024","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.resp.2024.104300_bib45","first-page":"R1990","article-title":"Rapid Intravenous Injection of Fentanyl (FNT) causes a vagal-mediated lethal sudden ventilatory arrest in anesthetized rats","volume":"36","author":"Zhuang","year":"2022","journal-title":"FASEB J.\u00a0Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.resp.2024.104300_bib46","doi-asserted-by":"crossref","first-page":"R449","DOI":"10.1152\/ajpregu.00016.2012","article-title":"8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius","volume":"303","author":"Zhuang","year":"2012","journal-title":"Am. J. Physiol. Regul.\u00a0Integr. Comp. Physiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904824000934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904824000934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T13:16:10Z","timestamp":1722863770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904824000934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":46,"alternative-id":["S1569904824000934"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2024.104300","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiorespiratory failure induced by inhalation of aerosolized fentanyl in anesthetized rats","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2024.104300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104300"}}