{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:12Z","timestamp":1778825292348,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010783","name":"Slovensk\u00e1 Akad\u00e9mia Vied","doi-asserted-by":"publisher","award":["1\/0041\/23"],"award-info":[{"award-number":["1\/0041\/23"]}],"id":[{"id":"10.13039\/100010783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"Scientific Grant Agency of the M\u0160VVa\u0160 and the SAV","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-22-0052"],"award-info":[{"award-number":["APVV-22-0052"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.resp.2024.104302","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:22:48Z","timestamp":1721110968000},"page":"104302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Advancing cough research: Methodological insights into cough challenge in guinea pig models using double chamber vs whole-body plethysmography"],"prefix":"10.1016","volume":"327","author":[{"given":"Jana","family":"Plevkova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janka","family":"Jakusova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Brozmanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Biringerova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Buday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2024.104302_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/08958370600748687","article-title":"Airflow distribution in the human lung and its influence on particle deposition","volume":"18","author":"Asgharian","year":"2006","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.resp.2024.104302_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/pupt.2002.0349","article-title":"Summary: animal models for cough","volume":"15","author":"Belvisi","year":"2002","journal-title":"Pulm. Pharm. Ther."},{"key":"10.1016\/j.resp.2024.104302_bib3","doi-asserted-by":"crossref","unstructured":"Belvisi, M.G., Hele, D.J., 2003. Animal Models of Cough, in: Chung, K.F., Widdicombe, J.G., Boushey, H.A. (Eds.), Cough: Causes, Mechanisms and Therapy. Blackwell Publishing Ltd, Malden, Massachusetts, USA, pp. 217\u2013222. https:\/\/doi.org\/10.1002\/9780470755846.ch21.","DOI":"10.1002\/9780470755846.ch21"},{"key":"10.1016\/j.resp.2024.104302_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0034-5687(01)00193-1","article-title":"Chronic tobacco smoke exposure increases cough to capsaicin in awake guinea pigs","volume":"126","author":"Bergren","year":"2001","journal-title":"Respir. Physiol."},{"issue":"Suppl 6","key":"10.1016\/j.resp.2024.104302_bib5","first-page":"153","article-title":"Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis","volume":"59","author":"Brozmanova","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2024.104302_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2023.104043","article-title":"Influence of combined voltage-gated sodium channel NaV1.7 and NaV1.8 inhibitors on cough in a guinea pig model","volume":"312","author":"Brozmanova","year":"2023","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104302_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.resp.2006.03.001","article-title":"Vagal afferent nerves regulating the cough reflex","volume":"152","author":"Canning","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104302_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0006-8993(92)90666-W","article-title":"Modification of medullary respiratory-related discharge patterns by behaviors and states of arousal","volume":"571","author":"Chang","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2024.104302_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1183\/09031936.93.05030296","article-title":"Sensitivity of the cough reflex in patients with chronic cough","volume":"5","author":"Choudry","year":"1992","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2024.104302_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-022-00370-w","article-title":"Cough hypersensitivity and chronic cough","volume":"8","author":"Chung","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.resp.2024.104302_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1056-8719(02)00191-0","article-title":"Pulmonary function assessment by whole-body plethysmography in restrained versus unrestrained mice","volume":"47","author":"DeLorme","year":"2002","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.resp.2024.104302_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph1215s62","article-title":"Harvesting, isolation, and functional assessment of primary vagal ganglia cells","volume":"62","author":"Dubuis","year":"2013","journal-title":"CP Pharmacol."},{"key":"10.1016\/j.resp.2024.104302_bib13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0143-4179(97)90039-1","article-title":"Biochemical and pharmacological activities of SR 144190, a new potent non-peptide tachykinin NK2 receptor antagonist","volume":"31","author":"Emonds-Alt","year":"1997","journal-title":"Neuropeptides"},{"key":"10.1016\/j.resp.2024.104302_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0952-0600(88)90008-7","article-title":"Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig","volume":"1","author":"Forsberg","year":"1988","journal-title":"Pulm. Pharm."},{"key":"10.1016\/j.resp.2024.104302_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/pulp.1996.0044","article-title":"Modulation of cough and airway sensory fibres","volume":"9","author":"Fox","year":"1996","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.resp.2024.104302_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/jphysiol.1993.sp019802","article-title":"An in vitro study of the properties of single vagal afferents innervating guinea-pig airways","volume":"469","author":"Fox","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2024.104302_bib17","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm0796-814","article-title":"Bradykinin\u2013evoked sensitization of airway sensory nerves: a mechanism for ACE\u2013inhibitor cough","volume":"2","author":"Fox","year":"1996","journal-title":"Nat. Med"},{"key":"10.1016\/j.resp.2024.104302_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1172\/JCI119187","article-title":"Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig","volume":"99","author":"Fox","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2024.104302_bib19","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s40262-022-01126-1","article-title":"Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 receptor antagonist eliapixant (BAY 1817080) in healthy subjects: double-blind randomized study","volume":"61","author":"Friedrich","year":"2022","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.resp.2024.104302_bib20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1124\/jpet.300.1.314","article-title":"Nonpeptide Tachykinin Receptor Antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs","volume":"300","author":"Hay","year":"2002","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.resp.2024.104302_bib21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/sj.bjp.0704950","article-title":"Anandamide induces cough in conscious guinea-pigs through VR1 receptors","volume":"137","author":"Jia","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2024.104302_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1164\/rccm.200308-1139OC","article-title":"Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P","volume":"169","author":"Joad","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.resp.2024.104302_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2023.104067","article-title":"Cough response in specific pathogen-free guinea pig animal model","volume":"313","author":"Kopcova","year":"2023","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104302_bib24","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs","volume":"79","author":"Lalloo","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104302_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/pulp.1993.1023","article-title":"A Comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in Guinea-pig and man","volume":"6","author":"Laude","year":"1993","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.resp.2024.104302_bib26","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1152\/japplphysiol.00080.2002","article-title":"A reevaluation of the validity of unrestrained plethysmography in mice","volume":"93","author":"Lundblad","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104302_bib27","series-title":"in: Dosage Form Design Parameters","first-page":"621","article-title":"Guiding Principles for Human and Animal Research During Pharmaceutical Product Development","author":"Maheshwari","year":"2018"},{"key":"10.1016\/j.resp.2024.104302_bib28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/sj.bjp.0703954","article-title":"Nociceptin inhibits cough in the guinea-pig by activation of ORL 1 receptors","volume":"132","author":"McLeod","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2024.104302_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00408-007-9032-z","article-title":"TRPV1 antagonists as potential antitussive agents","volume":"186","author":"McLeod","year":"2008","journal-title":"Lung"},{"key":"10.1016\/j.resp.2024.104302_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1034\/j.1600-0773.2000.pto870607.x","article-title":"Inhibiting effect of ammonia on citric acid-induced cough in pigs: a possible involvement of substance P","volume":"87","author":"Moreaux","year":"2000","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.resp.2024.104302_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.0306-5251.2001.01475.x","article-title":"Cough challenge in the assessment of cough reflex","volume":"52","author":"Morice","year":"2001","journal-title":"Brit J. Clin. Pharma"},{"key":"10.1016\/j.resp.2024.104302_bib32","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00101006","article-title":"ERS guidelines on the assessment of cough","volume":"29","author":"Morice","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2024.104302_bib33","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1183\/09031936.00217813","article-title":"A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response","volume":"44","author":"Morice","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2024.104302_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.resp.2004.06.006","article-title":"Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigs","volume":"142","author":"Plevkova","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104302_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.resp.2016.12.006","article-title":"Role of gender in basic cough research","volume":"245","author":"Plevkova","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104302_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2021.103656","article-title":"Animal models of cough","volume":"290","author":"Plevkova","year":"2021","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2024.104302_bib37","unstructured":"Praud, J.P., Macquin-Mavier, I., Wirquin, V., Meignan, M., Harf, A., 1986. Particle size influences aerosol deposition in guinea pigs during bronchoconstriction, in: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States). United States."},{"key":"10.1016\/j.resp.2024.104302_bib38","first-page":"S171","article-title":"Female guinea pig model for cough studies and its response to most common tussive substances","author":"Sterusky","year":"2020","journal-title":"Physiol. Res. 69 Suppl. 1"},{"key":"10.1016\/j.resp.2024.104302_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1254\/jphs.FPJ05014X","article-title":"Mechanisms of capsaicin- and citric-acid-induced cough reflexes in guinea pigs","volume":"99","author":"Tanaka","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.resp.2024.104302_bib40","article-title":"Experimental modulation of the cough reflex","author":"Tatar","year":"2002","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.resp.2024.104302_bib41","first-page":"539","article-title":"Sensitivity of the cough reflex in awake guinea pigs, rats and rabbits","volume":"98","author":"Tat\u00e1r","year":"1997","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2024.104302_bib42","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/thx.2003.012930","article-title":"Antitussive activity of iodo-resiniferatoxin in guinea pigs","volume":"59","author":"Trevisani","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.resp.2024.104302_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/pupt.2002.0362","article-title":"Physiology and plasticity of putative cough fibres in the guinea pig","volume":"15","author":"Undem","year":"2002","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2024.104302_bib44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vascn.2010.02.015","article-title":"Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs","volume":"61","author":"Venkatasamy","year":"2010","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.resp.2024.104302_bib45","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1152\/jappl.1998.85.5.1847","article-title":"Effects of airway inflammation on cough response in the guinea pig","volume":"85","author":"Xiang","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2024.104302_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217366","article-title":"An advanced recording and analysis system for the differentiation of guinea pig cough responses to citric acid and prostaglandin E2 in real time","volume":"14","author":"Zhuang","year":"2019","journal-title":"PLoS One"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904824000958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904824000958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:17:54Z","timestamp":1778822274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904824000958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":46,"alternative-id":["S1569904824000958"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2024.104302","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing cough research: Methodological insights into cough challenge in guinea pig models using double chamber vs whole-body plethysmography","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2024.104302","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104302"}}