{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:03:43Z","timestamp":1777989823223,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.resp.2025.104401","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T17:00:00Z","timestamp":1738602000000},"page":"104401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effect of ambient temperature on dexmedetomidine-induced metabolic and cardiorespiratory suppression in spontaneously breathing newborn rats"],"prefix":"10.1016","volume":"335","author":[{"given":"Eishi","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana Sato","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinata","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Ide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2025.104401_bib1","article-title":"Guiding principles for research involving animals and human beings","volume":"282","author":"American Physiological Society","year":"2022","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1124\/pr.118.016311","article-title":"Imidazoline receptor system: the past, the present, and the future","volume":"72","author":"Bousquet","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.resp.2025.104401_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129709","article-title":"Dexmedetomidine reduces shivering during mild hypothermia in waking subjects","volume":"10","author":"Callaway","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2025.104401_bib4","doi-asserted-by":"crossref","first-page":"R411","DOI":"10.1152\/ajpregu.00223.2021","article-title":"Sex differences in sympathetic neurovascular and neurohemodynamic relationships during cold pressor test","volume":"322","author":"Coovadia","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1651-2227.1958.tb07879.x","article-title":"The gaseous metabolism of the newborn infant breathing 15% oxygen","volume":"47","author":"Cross","year":"1958","journal-title":"Acta Paediatr. (Stockh)"},{"key":"10.1016\/j.resp.2025.104401_bib6","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1113\/EP089085","article-title":"Effects of hypoxia on the respiratory and metabolic responses to progressive cooling in newborn rodents that range in heterothermic expression","volume":"106","author":"Dzal","year":"2021","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2019.103313","article-title":"Postnatal changes in O2 and CO2 sensitivity in rodents","volume":"272","author":"Dzal","year":"2020","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2025.104401_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/hpeds.2023-007403","article-title":"Dexmedetomidine during therapeutic hypothermia: a multicenter quality initiative","volume":"14","author":"Elliott","year":"2024","journal-title":"Hosp. Pediatr."},{"key":"10.1016\/j.resp.2025.104401_bib9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jclinane.2006.08.011","article-title":"Hypothermia-induced bradycardia in a neonate receiving dexmedetomidine","volume":"19","author":"Finkel","year":"2007","journal-title":"J. Clin. Anesth."},{"key":"10.1016\/j.resp.2025.104401_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0291170","article-title":"Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: a scoping review","volume":"18","author":"Joshi","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2025.104401_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01524","article-title":"Heat acclimation does not modify Q10 and thermal cardiac reactivity","volume":"10","author":"Kampmann","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262263","article-title":"Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats","volume":"17","author":"Kitajima","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.resp.2025.104401_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1463784","article-title":"Sex differences in autonomic functions and cognitive performance during cold-air exposure and cold-water partial immersion","volume":"15","author":"Kong","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1126\/science.273.5276.803","article-title":"Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c","volume":"273","author":"Link","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.resp.2025.104401_bib15","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1523\/JNEUROSCI.4701-12.2013","article-title":"\u03b12 adrenergic receptor\u2013mediated inhibition of thermogenesis","volume":"33","author":"Madden","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2025.104401_bib16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1213\/ANE.0b013e31822b8629","article-title":"Dexmedetomidine in children: current knowledge and future applications","volume":"113","author":"Mason","year":"2011","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.resp.2025.104401_bib17","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/pr.2015.45","article-title":"Dexmedetomidine reduces cranial temperature in hypothermic neonatal rats","volume":"77","author":"McAdams","year":"2015","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.resp.2025.104401_bib18","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12688","article-title":"Cardiorespiratory control and cytokine profile in response to heat stress, hypoxia, and lipopolysaccharide (LPS) exposure during early neonatal period","volume":"4","author":"McDonald","year":"2016","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.resp.2025.104401_bib19","series-title":"Respiratory physiology of newborn mammals a comparative perspective","author":"Mortola","year":"2001"},{"key":"10.1016\/j.resp.2025.104401_bib20","first-page":"R267","article-title":"Effects of hypoxia and ambient temperature on gaseous metabolism of newborn rats","volume":"263","author":"Mortola","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1569-9048(02)00040-X","article-title":"Circadian patterns of breathing","volume":"131","author":"Mortola","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2025.104401_bib22","doi-asserted-by":"crossref","first-page":"R1207","DOI":"10.1152\/ajpregu.00109.2011","article-title":"Central circuitries for body temperature regulation and fever","volume":"301","author":"Nakamura","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib23","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1476-5381.1995.tb14963.x","article-title":"The role of \u03b12-adrenoceptors in the vasculature of the rat tail","volume":"114","author":"Redfern","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2025.104401_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1113\/jphysiol.1996.sp021213","article-title":"Effect of CO2 on the metabolic and ventilatory responses to ambient temperature in conscious Cadult and newborn rats","volume":"491","author":"Saiki","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib25","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1152\/jappl.1994.76.4.1594","article-title":"Metabolic-ventilatory interaction in conscious rats: effect of hypoxia and ambient temperature","volume":"76","author":"Saiki","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/pan.13107","article-title":"Imidazoline 1 receptor activation preserves respiratory drive in spontaneously breathing newborn rats during dexmedetomidine administration","volume":"27","author":"Sato","year":"2017","journal-title":"Paediatr. Anaesth."},{"key":"10.1016\/j.resp.2025.104401_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3389\/fphys.2019.00371","article-title":"The Pulse-Respiration Quotient: a powerful but untapped parameter for modern studies about human physiology and pathophysiology","volume":"10","author":"Scholkmann","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2025.104401_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2014.06.010","article-title":"Dexmedetomidine decreases inhibitory but not excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguous","volume":"1574","author":"Sharp","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2025.104401_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/dev.1030","article-title":"Competition and cooperation among huddling infant rats","volume":"39","author":"Sokoloff","year":"2001","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.resp.2025.104401_bib30","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/pan.12530","article-title":"Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats","volume":"24","author":"Tamiya","year":"2014","journal-title":"Pediatr. Anesth."},{"key":"10.1016\/j.resp.2025.104401_bib31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neulet.2015.04.035","article-title":"Effects of \u03b12-adorenoceptor agonist dexmedetomidine on respiratory rhythm generation of newborn rats","volume":"597","author":"Tsuzawa","year":"2015","journal-title":"Neurosci. Lett."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904825000126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904825000126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T23:01:28Z","timestamp":1746831688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904825000126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":31,"alternative-id":["S1569904825000126"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2025.104401","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of ambient temperature on dexmedetomidine-induced metabolic and cardiorespiratory suppression in spontaneously breathing newborn rats","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2025.104401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104401"}}