{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:13:52Z","timestamp":1762553632647,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.resp.2025.104410","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T17:09:45Z","timestamp":1739293785000},"page":"104410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Modulating respiratory mechanics and inflammation in hepatopulmonary syndrome: Aerobic exercise as a therapeutic strategy"],"prefix":"10.1016","volume":"335","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3544-6999","authenticated-orcid":false,"given":"C\u00e9sar Augusto","family":"Melo-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter Moreno Campos","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloisa Sanches Pereira","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Marques","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello Rodrigues","family":"Roza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suellen","family":"Silva-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilcelly","family":"Machado-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gleiciane Gontijo","family":"Avelar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ot\u00e1vio Toledo","family":"N\u00f3brega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica Moreira","family":"Amado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2025.104410_bib1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1164\/rccm.202301-0106PP","article-title":"Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary","volume":"207","author":"Agust\u00ed","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2025.104410_bib2","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1152\/japplphysiol.01061.2011","article-title":"Regular and moderate exercise before experimental sepsis reduces the risk of lung and distal organ injury","volume":"112","author":"de Ara\u00fajo","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2025.104410_bib3","doi-asserted-by":"crossref","first-page":"L843","DOI":"10.1152\/ajplung.00192.2010","article-title":"A comparison of fixation methods on lung morphology in a murine model of emphysema","volume":"299","author":"Braber","year":"2010","journal-title":"Am. J. Physiol. -Lung C."},{"key":"10.1016\/j.resp.2025.104410_bib4","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1161\/CIR.0000000000001289","article-title":"Exercise, core components of cardiac rehabilitation programs: 2024 update: a scientific statement from the american heart association and the American Association of Cardiovascular and Pulmonary Rehabilitation","volume":"150","author":"Brown","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2025.104410_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1061353","article-title":"Physical exercise, health, and disease treatment: the role of macrophages","volume":"14","author":"Callegari","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.resp.2025.104410_bib6","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4187\/respcare.04923","article-title":"Effect of aerobic exercise training on ventilatory efficiency and respiratory drive in obese subjects","volume":"62","author":"Chlif","year":"2017","journal-title":"Respir. Care"},{"key":"10.1016\/j.resp.2025.104410_bib7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1123\/jpah.2019-0237","article-title":"Physical exercise as an immunomodulator of chronic diseases in aging","volume":"17","author":"Ciolac","year":"2020","journal-title":"J. Phys. Act. Heal."},{"key":"10.1016\/j.resp.2025.104410_bib8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","author":"E.A. for the S. of the Liver","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.resp.2025.104410_bib9","first-page":"G779","article-title":"Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome","volume":"272","author":"Fallon","year":"1997","journal-title":"Am. J. Physiol. -Gastr L"},{"key":"10.1016\/j.resp.2025.104410_bib10","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1053\/j.gastro.2008.06.038","article-title":"Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates","volume":"135","author":"Fallon","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.resp.2025.104410_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res Methods"},{"key":"10.1016\/j.resp.2025.104410_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1665-2681(19)31276-1","article-title":"Exercise capacity of cirrhotic patients with hepatopulmonary syndrome","volume":"14","author":"Faustini-Pereira","year":"2015","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.resp.2025.104410_bib13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.resp.2013.08.006","article-title":"Levofloxacin decreased chest wall mechanical inhomogeneities and airway and vascular remodeling in rats with induced hepatopulmonary syndrome","volume":"189","author":"Gaio","year":"2013","journal-title":"Resp. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2025.104410_bib14","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1186\/cc11807","article-title":"Protective effects of aerobic exercise on acute lung injury induced by LPS in mice","volume":"16","author":"Gon\u00e7alves","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.resp.2025.104410_bib15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1378\/chest.102.4.1235","article-title":"Maneuver-free determination of compliance and resistance in ventilated ARDS patients","volume":"102","author":"Guttmann","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.resp.2025.104410_bib16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1152\/jappl.1992.72.1.168","article-title":"Input impedance and peripheral inhomogeneity of dog lungs","volume":"72","author":"Hantos","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2025.104410_bib17","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s10620-024-08447-0","article-title":"Effectiveness of exercise interventions on body composition, exercise capacity, fatigue, and quality of life in patients with liver cirrhosis: a meta-analysis of randomized controlled trials","volume":"69","author":"Hsieh","year":"2024","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.resp.2025.104410_bib18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/BF01002502","article-title":"Reduced collagen content and fibre bundle disorganization in skin biopsies of patients with Ehlers-Danlos syndrome","volume":"17","author":"Junqueira","year":"1985","journal-title":"Histochem. J."},{"key":"10.1016\/j.resp.2025.104410_bib19","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1097\/TP.0000000000001229","article-title":"International liver transplant society practice guidelines","volume":"100","author":"Krowka","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.resp.2025.104410_bib20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.dld.2012.09.022","article-title":"Response to exercise in patients with liver cirrhosis: Implications for liver transplantation","volume":"45","author":"Lemyze","year":"2013","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.resp.2025.104410_bib21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.resp.2011.10.001","article-title":"Respiratory mechanics and lung tissue remodeling in a hepatopulmonary syndrome rat model","volume":"179","author":"Melo-Silva","year":"2011","journal-title":"Resp. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2025.104410_bib22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1590\/S0102-8650201400150004","article-title":"L.A.C. D\u2019Albuquerque, Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome","volume":"29","author":"Nacif","year":"2014","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.resp.2025.104410_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120112","article-title":"Combined exercise training improved exercise capacity and lung inflammation in rats with hepatopulmonary syndrome","volume":"287","author":"Nascimento","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2025.104410_bib24","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1152\/japplphysiol.00290.2014","article-title":"Aerobic exercise attenuates pulmonary inflammation induced by Streptococcus pneumoniae","volume":"117","author":"Olivo","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2025.104410_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1590\/s0004-2803.202000000-49","article-title":"Capacity of exercise and survival in patients with cirrhosis with and without hepatopulmonary syndrome after liver transplantation","volume":"57","author":"Pereira","year":"2020","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.resp.2025.104410_bib26","doi-asserted-by":"crossref","first-page":"L879","DOI":"10.1152\/ajplung.00263.2003","article-title":"Impact of microvascular circulation on peripheral lung stability","volume":"287","author":"Pet\u00e1k","year":"2004","journal-title":"Am. J. Physiol. -Lung C."},{"key":"10.1016\/j.resp.2025.104410_bib27","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2025.104410_bib28","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1172\/JCI19711","article-title":"Antigen-specific CD4+\u2009T cells drive airway smooth muscle remodeling in experimental asthma","volume":"115","author":"Ramos-Barb\u00f3n","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.resp.2025.104410_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1475-2840-6-38","article-title":"Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats","volume":"6","author":"Rodrigues","year":"2007","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.resp.2025.104410_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151652","article-title":"Effects of an exercise programme on functional capacity, body composition and risk of falls in patients with cirrhosis: a randomized clinical trial","volume":"11","author":"Rom\u00e1n","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.resp.2025.104410_bib31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1510\/icvts.2009.222018","article-title":"Influence of lung mechanical properties and alveolar architecture on the pathogenesis of ischemia-reperfusion injury","volume":"11","author":"Silva","year":"2010","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"10.1016\/j.resp.2025.104410_bib32","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1183\/09031936.00049509","article-title":"Aerobic training reverses airway inflammation and remodelling in an asthma murine model","volume":"35","author":"Silva","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2025.104410_bib33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/sms.12411","article-title":"Exercise reverses OVA-induced inhibition of glucocorticoid receptor and increases anti-inflammatory cytokines in asthma","volume":"26","author":"Silva","year":"2016","journal-title":"Scand. J. Med Sci. Spor"},{"key":"10.1016\/j.resp.2025.104410_bib34","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1097\/01.TP.0000061612.78954.6C","article-title":"Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France","volume":"75","author":"Taille","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.resp.2025.104410_bib35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1590\/S0004-28032005000400010","article-title":"Ligadura de ducto biliar como modelo de estudo da s\u00edndrome hepatopulmonar e estresse oxidativo","volume":"42","author":"Tieppo","year":"2005","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.resp.2025.104410_bib36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1183\/09031936.00003411","article-title":"Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke","volume":"39","author":"Toledo","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2025.104410_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113451","article-title":"Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS)","volume":"9","author":"Yang","year":"2014","journal-title":"Plos One"},{"key":"10.1016\/j.resp.2025.104410_bib38","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.cgh.2014.04.016","article-title":"Eight weeks of exercise training increases aerobic capacity and muscle mass and reduces fatigue in patients with cirrhosis","volume":"12","author":"Zenith","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.resp.2025.104410_bib39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrgastro.2012.123","article-title":"Hepatopulmonary syndrome: update on pathogenesis and clinical features","volume":"9","author":"Zhang","year":"2012","journal-title":"Nat. Rev. Gastroentero"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904825000217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904825000217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:10:24Z","timestamp":1762553424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904825000217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":39,"alternative-id":["S1569904825000217"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2025.104410","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulating respiratory mechanics and inflammation in hepatopulmonary syndrome: Aerobic exercise as a therapeutic strategy","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2025.104410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104410"}}