{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:40:13Z","timestamp":1787067613533,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"am","delay-in-days":307,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG070262"],"award-info":[{"award-number":["R01AG070262"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99HL164957"],"award-info":[{"award-number":["K99HL164957"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002773","name":"Cain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002773","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.resp.2025.104488","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T15:39:40Z","timestamp":1757000380000},"page":"104488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Respiratory effects of obesity on the ventilatory response to exercise in older adults: the impact of a shift in operational lung volumes"],"prefix":"10.1016","volume":"338","author":[{"given":"Abidan","family":"Abulimiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce N.","family":"Balmain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica N.","family":"Alcala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raksa B.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Dholakiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Cavazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Elwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah Summerall","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyam","family":"Sarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Mons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony G.","family":"Babb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2025.104488_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.giec.2011.02.001","article-title":"Obesity overview: epidemiology, health and financial impact, and guidelines for qualification for surgical therapy","volume":"21","author":"Azagury","year":"2011","journal-title":"Gastrointest. Endosc. Clin. North Am."},{"key":"10.1016\/j.resp.2025.104488_bib2","first-page":"59","article-title":"Ventilatory response of moderately obese women to submaximal exercise","volume":"15","author":"Babb","year":"1991","journal-title":"Int. J. Obes."},{"issue":"1(","key":"10.1016\/j.resp.2025.104488_bib3","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00005768-199901001-00003","article-title":"Mechanical ventilatory constraints in aging, lung disease, and obesity: perspectives and brief review","volume":"31","author":"Babb","year":"1999","journal-title":"Med Sci. Sports Exerc"},{"issue":"2","key":"10.1016\/j.resp.2025.104488_bib4","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1378\/chest.10-1088","article-title":"Weight loss via diet and exercise improves exercise breathing mechanics in obese men","volume":"140","author":"Babb","year":"2011","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.resp.2025.104488_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.resp.2013.05.019","article-title":"Obesity: challenges to ventilatory control during exercise--a brief review","volume":"189","author":"Babb","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2025.104488_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2023.104167","article-title":"Ventilatory limitations in patients with HFpEF and obesity","volume":"318","author":"Babb","year":"2023","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2025.104488_bib7","first-page":"505","article-title":"Mechanism of reduced maximal expiratory flow with aging","volume":"89","author":"Babb","year":"2000","journal-title":"J. Appl. Phsyiology"},{"key":"10.1016\/j.resp.2025.104488_bib8","first-page":"11","article-title":"Exercise end-expiratory lung volumes in lean and moderately obese women","volume":"13","author":"Babb","year":"1989","journal-title":"Int J. Obes."},{"issue":"7","key":"10.1016\/j.resp.2025.104488_bib9","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1513\/AnnalsATS.202006-746OC","article-title":"Obesity blunts the ventilatory response to exercise in men and women","volume":"18","author":"Balmain","year":"2021","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2025.104488_bib10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1152\/japplphysiol.00786.2021","article-title":"Physiological dead space during exercise in patients with heart failure with preserved ejection fraction","volume":"132","author":"Balmain","year":"2022","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2025.104488_bib11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1152\/japplphysiol.91356.2008","article-title":"Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity","volume":"108","author":"Behazin","year":"2010","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2025.104488_bib12","first-page":"613","article-title":"Respiratory effects of obesity","volume":"80","author":"Cherniack","year":"1959","journal-title":"Can. Med Assoc. J."},{"issue":"3","key":"10.1016\/j.resp.2025.104488_bib13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.resp.2009.06.012","article-title":"Effects of obesity on breathing pattern, ventilatory neural drive and mechanics","volume":"168","author":"Chlif","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"4","key":"10.1016\/j.resp.2025.104488_bib14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4187\/respcare.03206","article-title":"Advanced mechanical ventilatory constraints during incremental exercise in class III obese Male subjects","volume":"60","author":"Chlif","year":"2015","journal-title":"Respir. Care"},{"issue":"6","key":"10.1016\/j.resp.2025.104488_bib15","first-page":"1065","article-title":"Chemical and nonchemical components of ventilation during hypercapnic exercise in man","volume":"48","author":"Clark","year":"1980","journal-title":"J. Appl. Phsyiology"},{"key":"10.1016\/j.resp.2025.104488_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1164\/ajrccm.160.1.9807045","article-title":"Progressive mechanical ventilatory constraints with aging","volume":"160","author":"DeLorey","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.resp.2025.104488_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/17476348.2018.1506331","article-title":"The effect of obesity on lung function","volume":"12","author":"Dixon","year":"2018","journal-title":"Expert Rev. Respir. Med"},{"issue":"6","key":"10.1016\/j.resp.2025.104488_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3810\/pgm.2010.11.2225","article-title":"Cardiopulmonary exercise testing: relevant but underused","volume":"122","author":"Forman","year":"2010","journal-title":"Postgrad. Med."},{"issue":"8","key":"10.1016\/j.resp.2025.104488_bib19","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of spirometry 2019 update. An official American thoracic society and european respiratory society technical statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"14","key":"10.1016\/j.resp.2025.104488_bib20","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/eurheartj\/ehw180","article-title":"2016 focused update: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations","volume":"39","author":"Guazzi","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.resp.2025.104488_bib21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1378\/chest.117.2.321","article-title":"Ventilatory constraints during exercise in patients with chronic heart failure","volume":"117","author":"Johnson","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.resp.2025.104488_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1249\/00003677-199101000-00005","article-title":"Demand vs. Capacity in the aging pulmonary system","volume":"19","author":"Johnson","year":"1991","journal-title":"Exerc Sport Sci. Rev."},{"key":"10.1016\/j.resp.2025.104488_bib23","first-page":"102","article-title":"Effects of aging on the respiratory system","volume":"27","author":"Levitzky","year":"1984","journal-title":"Physiologist"},{"issue":"1","key":"10.1016\/j.resp.2025.104488_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1440-1843.2011.02096.x","article-title":"Impact of obesity on respiratory function","volume":"17","author":"Littleton","year":"2012","journal-title":"Respirology"},{"issue":"6","key":"10.1016\/j.resp.2025.104488_bib25","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1152\/japplphysiol.00898.2006","article-title":"Ventilatory and perceptual responses to cycle exercise in obese women","volume":"102","author":"Ofir","year":"2007","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2025.104488_bib26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1164\/arrd.1983.128.3.501","article-title":"Effects of obesity on respiratory function","volume":"128","author":"Ray","year":"1983","journal-title":"Am. Rev. Respir. Dis."},{"issue":"4","key":"10.1016\/j.resp.2025.104488_bib27","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1378\/chest.14-1749","article-title":"Ventilation\/Perfusion distribution abnormalities in morbidly obese subjects before and after bariatric surgery","volume":"147","author":"Rivas","year":"2015","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.resp.2025.104488_bib28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1152\/japplphysiol.00694.2009","article-title":"Physiology of obesity and effects on lung function","volume":"108","author":"Salome","year":"2010","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2025.104488_bib29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1172\/JCI104957","article-title":"The total work of breathing in normal and obese men","volume":"43","author":"Sharp","year":"1964","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.resp.2025.104488_bib30","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1164\/rccm.2202033","article-title":"Ventilatory efficiency during exercise in healthy subjects","volume":"166","author":"Sun","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.resp.2025.104488_bib31","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1164\/arrd.1984.129.2P2.S90","article-title":"The ventilatory stress of exercise in obesity","volume":"129","author":"Whipp","year":"1984","journal-title":"Am. Rev. Respir. Dis."},{"issue":"5","key":"10.1016\/j.resp.2025.104488_bib32","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11695-008-9437-7","article-title":"Compensatory exercise hyperventilation is restored in the morbidly obese after bariatric surgery","volume":"18","author":"Zavorsky","year":"2008","journal-title":"Obes. Surg."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904825000990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904825000990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:57:55Z","timestamp":1772891875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904825000990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":32,"alternative-id":["S1569904825000990"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2025.104488","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Respiratory effects of obesity on the ventilatory response to exercise in older adults: the impact of a shift in operational lung volumes","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2025.104488","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104488"}}