{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:32:06Z","timestamp":1787038326897,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,28]],"date-time":"2027-01-28T00:00:00Z","timestamp":1801094400000},"content-version":"am","delay-in-days":302,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002773","name":"Cain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["1P01HL137630"],"award-info":[{"award-number":["1P01HL137630"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R00HL164957"],"award-info":[{"award-number":["R00HL164957"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029109","name":"Carl B. and Florence E. King Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100029109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.resp.2026.104546","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:10:21Z","timestamp":1769533821000},"page":"104546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ventilatory limitation to exercise in patients with HFpEF and obesity: No room to breathe"],"prefix":"10.1016","volume":"341","author":[{"given":"Tony G.","family":"Babb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce N.","family":"Balmain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"Hynan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"MacNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyam","family":"Sarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2026.104546_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2025.104488","article-title":"Respiratory effects of obesity on the ventilatory response to exercise in older adults: the impact of a shift in operational lung volumes","author":"Abulimiti","year":"2025","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"1","key":"10.1016\/j.resp.2026.104546_bib2","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00005768-199901001-00003","article-title":"Mechanical ventilatory constraints in aging, lung disease, and obesity: perspectives and brief review","volume":"31","author":"Babb","year":"1999","journal-title":"Med Sci. Sports Exerc"},{"key":"10.1016\/j.resp.2026.104546_bib3","first-page":"145","article-title":"Estimation of mechanical ventilatory limitation","volume":"26","author":"Babb","year":"2005","journal-title":"J. Qinghai Med. Coll."},{"key":"10.1016\/j.resp.2026.104546_bib4","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1249\/00005768-199209000-00004","article-title":"Exercise capacity and breathing mechanics in patients with airflow limitation","volume":"24","author":"Babb","year":"1992","journal-title":"Med Sci. Sports Exerc"},{"key":"10.1016\/j.resp.2026.104546_bib5","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1152\/jappl.1993.74.4.2016","article-title":"Estimation of ventilatory capacity during submaximal exercise","volume":"74","author":"Babb","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2026.104546_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1152\/jappl.1991.70.1.223","article-title":"Effect of mild to moderate airflow limitation on exercise capacity","volume":"70","author":"Babb","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2026.104546_bib7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1164\/rccm.200706-875OC","article-title":"Dyspnea on exertion in obese women: association with an increased oxygen cost of breathing","volume":"178","author":"Babb","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2026.104546_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resp.2023.104167","article-title":"Ventilatory limitations in patients with HFpEF and obesity","volume":"318","author":"Babb","year":"2023","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"7","key":"10.1016\/j.resp.2026.104546_bib9","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1513\/AnnalsATS.202006-746OC","article-title":"Obesity Blunts the Ventilatory Response to Exercise in Men and Women","volume":"18","author":"Balmain","year":"2021","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"6","key":"10.1016\/j.resp.2026.104546_bib10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.chest.2022.06.016","article-title":"Alveolar Dead Space Is Augmented During Exercise in Patients With Heart Failure With Preserved Ejection Fraction","volume":"162","author":"Balmain","year":"2022","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.resp.2026.104546_bib11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1152\/japplphysiol.00786.2021","article-title":"Physiological dead space during exercise in patients with heart failure with preserved ejection fraction","volume":"132","author":"Balmain","year":"2022","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"1","key":"10.1016\/j.resp.2026.104546_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1152\/japplphysiol.00474.2021","article-title":"Estimating exercise Pa(CO(2)) in patients with heart failure with preserved ejection fraction","volume":"132","author":"Balmain","year":"2022","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.resp.2026.104546_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2023.04.003","article-title":"Reducing pulmonary capillary wedge pressure during exercise exacerbates exertional dyspnea in patients with HFpEF: implications for ventilation-perfusion mismatch","author":"Balmain","year":"2023","journal-title":"Chest"},{"key":"10.1016\/j.resp.2026.104546_bib14","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.chest.2023.04.003","article-title":"Reducing Pulmonary Capillary Wedge Pressure During Exercise Exacerbates Exertional Dyspnea in Patients With Heart Failure With Preserved Ejection Fraction: Implications for V \/Q Mismatch","volume":"164","author":"Balmain","year":"2023","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.resp.2026.104546_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1378\/chest.12-2885","article-title":"Respiratory symptom perception differs in obese women with strong or mild breathlessness during constant-load exercise","volume":"145","author":"Bernhardt","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.resp.2026.104546_bib16","first-page":"A3520","article-title":"Modest Weight Loss Significantly Reduces Oxygen Cost Of Breathing In Obese Women","volume":"189","author":"Bhammar","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2026.104546_bib17","doi-asserted-by":"crossref","DOI":"10.1113\/EP090309","article-title":"Sex differences in the ventilatory responses to exercise in mild to moderate obesity","author":"Bhammar","year":"2022","journal-title":"Exp. Physiol."},{"issue":"22","key":"10.1016\/j.resp.2026.104546_bib18","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.jacc.2016.08.072","article-title":"Obesity Contributes to Exercise Intolerance in Heart Failure With Preserved Ejection Fraction","volume":"68","author":"Carbone","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.resp.2026.104546_bib19","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/jappl.1980.48.6.1065","article-title":"Chemical and nonchemical components of ventilation during hypercapnic exercise in man","volume":"48","author":"Clark","year":"1980","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2026.104546_bib20","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1152\/jappl.1999.87.6.1997","article-title":"Exercise-induced arterial hypoxemia","volume":"87","author":"Dempsey","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2026.104546_bib21","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/15298668191420378","article-title":"Physiological responses to resistance breathing during short and prolonged exercise","volume":"42","author":"Deno","year":"1981","journal-title":"Am. Ind. Hyg. Assoc. J."},{"issue":"3","key":"10.1016\/j.resp.2026.104546_bib22","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1249\/JES.0000000000000188","article-title":"Sex Differences in the Pulmonary System Influence the Integrative Response to Exercise","volume":"47","author":"Dominelli","year":"2019","journal-title":"Exerc Sport Sci. Rev."},{"issue":"8","key":"10.1016\/j.resp.2026.104546_bib23","first-page":"e70","article-title":"Standardization of Spirometry 2019 Update. American Thoracic Society","volume":"200","author":"Graham","year":"2019"},{"key":"10.1016\/j.resp.2026.104546_bib24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1378\/chest.07-0619","article-title":"Mixed-expired and end-tidal CO2 distinguish between ventilation and perfusion defects during exercise testing in patients with lung and heart diseases","volume":"132","author":"Hansen","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.resp.2026.104546_bib25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1113\/jphysiol.1980.sp013524","article-title":"The relationship between maximal ventilation, breathing pattern and mechanical limitation of ventilation","volume":"309","author":"Jensen","year":"1980","journal-title":"J. Physiol. Lond."},{"issue":"2","key":"10.1016\/j.resp.2026.104546_bib26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1378\/chest.116.2.488","article-title":"Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop","volume":"116","author":"Johnson","year":"1999","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.resp.2026.104546_bib27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1378\/chest.117.2.321","article-title":"Ventilatory constraints during exercise in patients with chronic heart failure","volume":"117","author":"Johnson","year":"2000","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.resp.2026.104546_bib28","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1378\/chest.130.3.827","article-title":"The effects of body mass index on lung volumes","volume":"130","author":"Jones","year":"2006","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.resp.2026.104546_bib29","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/ehf2.12458","article-title":"Prognostic impact of Framingham heart failure criteria in heart failure with preserved ejection fraction","volume":"6","author":"Lofstrom","year":"2019","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.resp.2026.104546_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1152\/jappl.1963.18.3.497","article-title":"Relation between work output of respiratory muscles and end-tidal CO2 tension","volume":"18","author":"Milic-Emili","year":"1963","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.resp.2026.104546_bib31","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1152\/japplphysiol.00608.2017","article-title":"The effects of age and sex on mechanical ventilatory constraint and dyspnea during exercise in healthy humans","volume":"124","author":"Molgat-Seon","year":"2018","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"30","key":"10.1016\/j.resp.2026.104546_bib32","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1093\/eurheartj\/ehy268","article-title":"Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction","volume":"39","author":"Obokata","year":"2018","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.resp.2026.104546_bib33","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jchf.2016.03.001","article-title":"Impaired Pulmonary Diffusion in Heart Failure With Preserved Ejection Fraction","volume":"4","author":"Olson","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.resp.2026.104546_bib34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1164\/arrd.1983.128.3.501","article-title":"Effects of obesity on respiratory function","volume":"128","author":"Ray","year":"1983","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2026.104546_bib35","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1152\/japplphysiol.00694.2009","article-title":"Physiology of obesity and effects on lung function","volume":"108","author":"Salome","year":"2010","journal-title":"J. Appl. Physiol."},{"issue":"5","key":"10.1016\/j.resp.2026.104546_bib36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/CIRCULATIONAHA.122.061828","article-title":"Challenging the Hemodynamic Hypothesis in Heart Failure With Preserved Ejection Fraction: Is Exercise Capacity Limited by Elevated Pulmonary Capillary Wedge Pressure?","volume":"147","author":"Sarma","year":"2023","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.resp.2026.104546_bib37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1113\/EP085371","article-title":"Sex differences in the physiology of exercise: an integrative perspective","volume":"101","author":"Sheel","year":"2016","journal-title":"Exp. Physiol."},{"issue":"4","key":"10.1016\/j.resp.2026.104546_bib38","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.chest.2019.04.111","article-title":"Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension","volume":"156","author":"Singh","year":"2019","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.resp.2026.104546_bib39","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.chest.2019.04.109","article-title":"Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction: Role of Pulmonary Vascular Dysfunction","volume":"156","author":"Singh","year":"2019","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.resp.2026.104546_bib40","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1113\/EP087183","article-title":"Ventilatory constraints influence physiological dead space in heart failure","volume":"104","author":"Smith","year":"2019","journal-title":"Exp. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2026.104546_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1152\/japplphysiol.01105.2017","article-title":"Resistive and elastic work of breathing in older and younger adults during exercise","volume":"125","author":"Smith","year":"2018","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"4","key":"10.1016\/j.resp.2026.104546_bib42","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.cardfail.2019.02.015","article-title":"Exercise Ventilatory Efficiency in Older and Younger Heart Failure Patients With Preserved Ejection Fraction","volume":"25","author":"Smith","year":"2019","journal-title":"J. Card. Fail"},{"key":"10.1016\/j.resp.2026.104546_bib43","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijcard.2018.09.007","article-title":"Exercise ventilatory inefficiency in heart failure and chronic obstructive pulmonary disease","volume":"274","author":"Smith","year":"2019","journal-title":"Int J. Cardiol."},{"issue":"5","key":"10.1016\/j.resp.2026.104546_bib44","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018574","article-title":"Sex Differences in Heart Failure With Preserved Ejection Fraction","volume":"10","author":"Sotomi","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.resp.2026.104546_bib45","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01499-2021","article-title":"ERS\/ATS technical standard on interpretive strategies for routine lung function tests","volume":"60","author":"Stanojevic","year":"2022","journal-title":"Eur. Respir. J."},{"issue":"6","key":"10.1016\/j.resp.2026.104546_bib46","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.chest.2022.01.021","article-title":"Using Cardiopulmonary Exercise Testing to Understand Dyspnea and Exercise Intolerance in Respiratory Disease","volume":"161","author":"Stickland","year":"2022","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.resp.2026.104546_bib47","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1164\/rccm.2202033","article-title":"Ventilatory efficiency during exercise in healthy subjects","volume":"166","author":"Sun","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.resp.2026.104546_bib48","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/ejhf.913","article-title":"Physiological dead space and arterial carbon dioxide contributions to exercise ventilatory inefficiency in patients with reduced or preserved ejection fraction heart failure","volume":"19","author":"Van Iterson","year":"2017","journal-title":"Eur. J. Heart Fail"},{"key":"10.1016\/j.resp.2026.104546_bib49","article-title":"Higher Work of Breathing During Exercise in Heart Failure With Preserved Ejection Fraction","author":"Villarraga","year":"2022","journal-title":"Chest"},{"key":"10.1016\/j.resp.2026.104546_bib50","article-title":"Principles of exercise testing and interpretation","author":"Wasserman","year":"1987","journal-title":"Phila. Lea Febiger"},{"key":"10.1016\/j.resp.2026.104546_bib51","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1164\/arrd.1984.129.2P2.S17","article-title":"Ventilatory responses to exercise and their control in man. [Review","volume":"129","author":"Whipp","year":"1984","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2026.104546_bib52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0272-5231(21)00242-2","article-title":"Interpretation of Clinical Exercise Testing in Respiratory Disease","volume":"5","author":"Younes","year":"1984","journal-title":"Clin. Chest Med"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904826000054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904826000054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:58:58Z","timestamp":1771520338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904826000054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":52,"alternative-id":["S1569904826000054"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2026.104546","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ventilatory limitation to exercise in patients with HFpEF and obesity: No room to breathe","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2026.104546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104546"}}