{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:16:31Z","timestamp":1783181791140,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006109","name":"Scientific Grant Agency of the M\u0160VVa\u0160 and the SAV","doi-asserted-by":"publisher","award":["1\/0030\/24"],"award-info":[{"award-number":["1\/0030\/24"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.resp.2026.104586","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:24:13Z","timestamp":1777591453000},"page":"104586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluating the effects of A-803467, a selective NaV1.8 blocker, on cough response in guinea pigs with allergic rhinitis"],"prefix":"10.1016","volume":"343","author":[{"given":"Mariana","family":"Brozmanova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janka","family":"Jakusova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Buday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Jurcakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Mestanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Plevkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2026.104586_bib1","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.intimp.2008.06.010","article-title":"Validation of guinea pig model of allergic rhinitis by oral and topical drugs","volume":"8","author":"Bahekar","year":"2008","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.resp.2026.104586_bib2","first-page":"57","article-title":"Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs","volume":"58","author":"Brozmanova","year":"2007","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2026.104586_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2022.103856","article-title":"The effect of the voltage-gated sodium channel NaV1.7 blocker PF-05089771 on cough in the guinea pig","volume":"299","author":"Brozmanova","year":"2022","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2026.104586_bib4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.33549\/physiolres.930840","article-title":"Early and late allergic phase related cough response in sensitized guinea pigs with experimental allergic rhinitis","volume":"55","author":"Brozmanova","year":"2006","journal-title":"Physiol. Res."},{"key":"10.1016\/j.resp.2026.104586_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejphar.2012.05.048","article-title":"Comparison of TRPA1-versus TRPV1-mediated cough in guinea pigs","volume":"689","author":"Brozmanova","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2026.104586_bib6","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.33549\/physiolres.934395","article-title":"The prospect for potent sodium voltage-gated channel blockers to relieve an excessive cough","author":"Brozmanova","year":"2020","journal-title":"Physiol. Res."},{"issue":"6","key":"10.1016\/j.resp.2026.104586_bib7","first-page":"153","article-title":"Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis","volume":"59","author":"Brozmanova","year":"2008","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"10.1016\/j.resp.2026.104586_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2019.103267","article-title":"The voltage-gated sodium channel NaV1.8 blocker A-803467 inhibits cough in the guinea pig","volume":"270","author":"Brozmanova","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2026.104586_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pupt.2009.01.003","article-title":"Central regulation of the cough reflex: therapeutic implications","volume":"22","author":"Canning","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2026.104586_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1440-1843.2003.00473.x","article-title":"Bronchopulmonary afferent nerves","volume":"8","author":"Carr","year":"2003","journal-title":"Respirology"},{"key":"10.1016\/j.resp.2026.104586_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1430760","article-title":"The role of nociceptive neurons in allergic rhinitis","volume":"15","author":"Cong","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.resp.2026.104586_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1343","article-title":"From bench to bedside: the role of cough hypersensitivity in chronic cough","volume":"13","author":"Drake","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.resp.2026.104586_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pupt.2017.01.010","article-title":"Central mechanisms of airway sensation and cough hypersensitivity","volume":"47","author":"Driessen","year":"2017","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2026.104586_bib14","series-title":"Airway Pharmacology and Treatment","first-page":"PA329","article-title":"Critical role of sensory neuronal TRPA1 signals in mediating cough hypersensitivity in allergic rhinitis","author":"Fu","year":"2024"},{"key":"10.1016\/j.resp.2026.104586_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1398409","article-title":"Insights into the voltage-gated sodium channel, NaV1.8, and its role in visceral pain perception","volume":"15","author":"Heinle","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.resp.2026.104586_bib16","first-page":"5","article-title":"A review regarding the connections between allergic rhinitis and asthma - epidemiology, diagnosis and treatment","volume":"49","author":"Iordache","year":"2023","journal-title":"Curr. Health Sci. J."},{"key":"10.1016\/j.resp.2026.104586_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2024.104387","article-title":"Effectiveness of selective NaV1.7 blocker PF-05089771 in reducing cough associated with allergic rhinitis in guinea pigs","volume":"333","author":"Jakusova","year":"2025","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2026.104586_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/MLG.0b013e3181625d5a","article-title":"Increased nerve fiber expression of sensory sodium channels Nav1.7, Nav1.8, and Nav1.9 in rhinitis","volume":"118","author":"Keh","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.resp.2026.104586_bib19","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1113\/JP275698","article-title":"Different role of TTX-sensitive voltage-gated sodium channel (NaV 1) subtypes in action potential initiation and conduction in vagal airway nociceptors","volume":"596","author":"Kollarik","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2026.104586_bib20","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1113\/jphysiol.2007.146365","article-title":"Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs","volume":"586","author":"Kwong","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2026.104586_bib21","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2147\/JAA.S420328","article-title":"Common allergens and immune responses associated with allergic rhinitis in China","volume":"16","author":"Li","year":"2023","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.resp.2026.104586_bib22","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2026.104586_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00408-013-9533-x","article-title":"Targeting voltage gated sodium channels NaV1.7, NaV1.8, and NaV1.9 for treatment of pathological cough","volume":"192","author":"Muroi","year":"2014","journal-title":"Lung"},{"key":"10.1016\/j.resp.2026.104586_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.alit.2020.04.001","article-title":"Japanese guidelines for allergic rhinitis 2020","volume":"69","author":"Okubo","year":"2020","journal-title":"Allergol. Int."},{"key":"10.1016\/j.resp.2026.104586_bib25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.resp.2004.06.006","article-title":"Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigs","volume":"142","author":"Plevkova","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2026.104586_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5415\/apallergy.2013.3.2.127","article-title":"Chronic cough in subjects with upper airway diseases - analysis of mechanisms and clinical applications","volume":"3","author":"Plevkova","year":"2013","journal-title":"Asia Pac. Allergy"},{"key":"10.1016\/j.resp.2026.104586_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2021.0570","article-title":"Allergic rhinitis: diagnosis and management","volume":"83","author":"Siddiqui","year":"2022","journal-title":"Br. J. Hosp. Med."},{"key":"10.1016\/j.resp.2026.104586_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13601-015-0069-4","article-title":"Cough hypersensitivity as a neuro-immune interaction","volume":"5","author":"Song","year":"2015","journal-title":"Clin. Transl. Allergy"},{"key":"10.1016\/j.resp.2026.104586_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pupt.2017.05.010","article-title":"Blocking voltage-gated sodium channels as a strategy to suppress pathological cough","volume":"47","author":"Sun","year":"2017","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2026.104586_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing nociceptor neurons reduces allergic airway inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.resp.2026.104586_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pupt.2008.11.014","article-title":"Mechanisms of the cough associated with rhinosinusitis","volume":"22","author":"Tatar","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2026.104586_bib32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2500\/aap.2024.45.240009","article-title":"Comparison of clinical traits for seasonal and perennial allergic rhinitis during allergen exposure","volume":"45","author":"Wang","year":"2024","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.resp.2026.104586_bib33","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMcp1412282","article-title":"Allergic rhinitis","volume":"372","author":"Wheatley","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2026.104586_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1282130","article-title":"Neuroimmune communication in allergic rhinitis","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Neurol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904826000455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904826000455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:24:30Z","timestamp":1783178670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904826000455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":34,"alternative-id":["S1569904826000455"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2026.104586","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the effects of A-803467, a selective NaV1.8 blocker, on cough response in guinea pigs with allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2026.104586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104586"}}