{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:15:53Z","timestamp":1788552953329,"version":"build-2803163510"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["141884\/2020-7"],"award-info":[{"award-number":["141884\/2020-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Cod. 001"],"award-info":[{"award-number":["Cod. 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2025\/05255-4"],"award-info":[{"award-number":["2025\/05255-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.resp.2026.104634","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:11:50Z","timestamp":1785539510000},"page":"104634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Luteolin increases baseline apneas and downregulates brainstem HIF in normoxia and chronic intermittent hypoxia"],"prefix":"10.1016","volume":"345","author":[{"given":"Bolival Apparecido Mendon\u00e7a","family":"Junior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Ac\u00e1cio","family":"Souza da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Sasso-Cerri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelita Maria","family":"Stabile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Breseghello","family":"Zoccal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Colombari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2026.104634_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroscience.2011.06.005","article-title":"Caudal nuclei of the rat nucleus of the solitary tract differentially innervate respiratory compartments within the ventrolateral medulla","volume":"190","author":"Alheid","year":"2011","journal-title":"Neuroscience"},{"issue":"47","key":"10.1016\/j.resp.2026.104634_bib2","doi-asserted-by":"crossref","first-page":"16736","DOI":"10.1523\/JNEUROSCI.2654-12.2012","article-title":"Chronic Intermittent Hypoxia Depresses Afferent Neurotransmission in NTS Neurons by a Reduction in the Number of Active Synapses","volume":"32","author":"Almado","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2026.104634_bib3","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.bcp.2010.02.004","article-title":"Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism","volume":"79","author":"Ans\u00f3","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.resp.2026.104634_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12031-018-1094-2","article-title":"The flavone luteolin improves central nervous system disorders by different mechanisms: A Review","volume":"65","author":"Ashaari","year":"2018","journal-title":"J. Mol. Neurosci."},{"issue":"4\u20135","key":"10.1016\/j.resp.2026.104634_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0361-9230(89)90213-X","article-title":"Cardiorespiratory responses following electrical stimulation of caudal sites in the rat medulla","volume":"23","author":"Barraco","year":"1989","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/andr.13513","article-title":"Role of serotonin, estrogen, and TNF-\u03b1 in the paroxetine-impaired steroidogenesis and testicular macrophages polarization","volume":"12","author":"Beltrame","year":"2024","journal-title":"Andrology"},{"issue":"16","key":"10.1016\/j.resp.2026.104634_bib7","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1093\/emboj\/cdg392","article-title":"HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia","volume":"22","author":"Berra","year":"2003","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1113\/EP087928","article-title":"Postnatal intermittent hypoxia enhances phrenic and reduces vagal upper airway motor activities in rats by epigenetic mechanisms","volume":"105","author":"Bittencourt-Silva","year":"2020","journal-title":"Exp. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbrc.2016.01.002","article-title":"Luteolin inhibits recruitment of monocytes and migration of Lewis lung carcinoma cells by suppressing chemokine (C\u2013C motif) ligand 2 expression in tumor-associated macrophage","volume":"470","author":"Choi","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.resp.2026.104634_bib10","doi-asserted-by":"crossref","first-page":"R1220","DOI":"10.1152\/ajpregu.1996.270.6.R1220","article-title":"Commissural NTS contributes to pressor responses to glutamate injected into the medial NTS of awake rats","volume":"270","author":"Colombari","year":"1996","journal-title":"Am. J. Physiol. -Regul. Integr. Comp. Physiol."},{"issue":"12","key":"10.1016\/j.resp.2026.104634_bib11","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1152\/japplphysiol.01617.2011","article-title":"Hypoxic intensity: a determinant for the contribution of ATP and adenosine to the genesis of carotid body chemosensory activity","volume":"112","author":"Conde","year":"2012","journal-title":"J. Appl. Physiol."},{"issue":"6","key":"10.1016\/j.resp.2026.104634_bib12","doi-asserted-by":"crossref","first-page":"R785","DOI":"10.1152\/ajpregu.00363.2011","article-title":"Chronic intermittent hypoxia alters glutamatergic control of sympathetic and respiratory activities in the commissural NTS of rats","volume":"302","author":"Costa-Silva","year":"2012","journal-title":"Am. J. Physiol. -Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib13","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1038\/s41467-019-10044-z","article-title":"A RASSF1A-HIF1\u03b1 loop drives Warburg effect in cancer and pulmonary hypertension","volume":"10","author":"Dabral","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.resp.2013.05.022","article-title":"Rodent models of sleep apnea","volume":"188","author":"Davis","year":"2013","journal-title":"Respir. Physiol. & Neurobiol."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib15","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1152\/japplphysiol.00892.2003","article-title":"Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons","volume":"96","author":"Dean","year":"2004","journal-title":"J. Appl. Physiol."},{"issue":"6","key":"10.1016\/j.resp.2026.104634_bib16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41583-018-0003-6","article-title":"Breathing matters","volume":"19","author":"Del Negro","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1542\/peds.16.1.81","article-title":"A barometric method for measuring ventilation in newborn infants","volume":"16","author":"Drorbaugh","year":"1955","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.resp.2026.104634_bib18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cell.2010.08.014","article-title":"Iron-Export Ferroxidase Activity of \u03b2-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer\u2019s Disease","volume":"142","author":"Duce","year":"2010","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.resp.2026.104634_bib19","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300611R","article-title":"Bioflavonoid luteolin prevents <scp>sFlt<\/scp> -1 release via <scp>HIF<\/scp> -1\u03b1 inhibition in cultured human placenta","volume":"37","author":"Eddy","year":"2023","journal-title":"FASEB J."},{"issue":"11","key":"10.1016\/j.resp.2026.104634_bib20","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.3390\/ijms21113802","article-title":"Looking for a treatment for the early stage of Alzheimer\u2019s Disease: preclinical evidence with co-ultramicronized palmitoylethanolamide and luteolin","volume":"21","author":"Facchinetti","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrn1871","article-title":"Looking for inspiration: new perspectives on respiratory rhythm","volume":"7","author":"Feldman","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.resp.2026.104634_bib22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0006-8993(92)90458-L","article-title":"The central organization of carotid body afferent projections to the brainstem of the rat","volume":"572","author":"Finley","year":"1992","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41419-025-08028-7","article-title":"HIF1 activity in photoreceptors drives type 3 neovascularization and retinal atrophy in a new mouse model of age-related macular degeneration","volume":"16","author":"Geiger","year":"2025","journal-title":"Cell. Death & Dis."},{"issue":"8076","key":"10.1016\/j.resp.2026.104634_bib24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41586-025-09217-2","article-title":"Non-antibiotics disrupt colonization resistance against enteropathogens","volume":"644","author":"Grie\u00dfhammer","year":"2025","journal-title":"Nature"},{"issue":"S1","key":"10.1016\/j.resp.2026.104634_bib25","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.31.1_supplement.1053.1","article-title":"Redox Modulation of Breathing Control: Lessons from The Effects Of The Phenothiazinium Chromophore Methylene Blue In Spontaneously Breathing Rats","volume":"31","author":"Haouzi","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2026.104634_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108612","article-title":"Luteolin, a flavonoid, as an anticancer agent: A review","volume":"112","author":"Imran","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1113\/expphysiol.2014.079525","article-title":"Inflammation and oxidative stress during intermittent hypoxia: the impact on chemoreception","volume":"100","author":"Iturriaga","year":"2015","journal-title":"Exp. Physiol."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib28","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1073\/pnas.022634199","article-title":"Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1\u03b1","volume":"99","author":"Kline","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"17","key":"10.1016\/j.resp.2026.104634_bib29","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1523\/JNEUROSCI.4946-06.2007","article-title":"Adaptive depression in synaptic transmission in the nucleus of the solitary tract after In Vivo chronic intermittent hypoxia: evidence for homeostatic plasticity","volume":"27","author":"Kline","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2026.104634_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.137652","article-title":"Luteolin amends neural neurotransmitters, antioxidants, and inflammatory markers in the cerebral cortex of Adderall exposed rats","volume":"823","author":"Koriem","year":"2024","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2026.104634_bib31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000399407","article-title":"The flavonoids. A class of semi-essential food components: their role in human nutrition","volume":"24","author":"K\u00fchnau","year":"1976","journal-title":"World Rev. Nutr. Diet."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib32","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/jcp.22798","article-title":"Functional regulation of HIF-1\u03b1 under normoxia\u2014is there more than post-translational regulation?","volume":"227","author":"Kuschel","year":"2012","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.resp.2026.104634_bib33","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1183\/09031936.00086608","article-title":"Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link","volume":"33","author":"Lavie","year":"2009","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.resp.2026.104634_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41580-020-0227-y","article-title":"Cellular adaptation to hypoxia through hypoxia inducible factors and beyond","volume":"21","author":"Lee","year":"2020","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.resp.2026.104634_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/apha.70084","article-title":"Respiratory and metabolic effects of active expiration in freely behaving rats","volume":"241","author":"Leir\u00e3o","year":"2025","journal-title":"Acta Physiol."},{"key":"10.1016\/j.resp.2026.104634_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.110114","article-title":"Luteolin ameliorates skin lipid hypersecretion, inflammation and oxidative stress in vivo and in vitro","volume":"148","author":"Li","year":"2026","journal-title":"J. Nutr. Biochem."},{"issue":"7","key":"10.1016\/j.resp.2026.104634_bib37","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2174\/156800908786241050","article-title":"Luteolin, a flavonoid with potential for cancer prevention and therapy","volume":"8","author":"Lin","year":"2008","journal-title":"Curr. Cancer Drug. Targets"},{"issue":"4","key":"10.1016\/j.resp.2026.104634_bib38","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1590\/S0100-879X1997000400015","article-title":"Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii","volume":"30","author":"Machado","year":"1997","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.resp.2026.104634_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.critrevonc.2017.01.013","article-title":"Targeting HIF-2 \u03b1 in clear cell renal cell carcinoma: a promising therapeutic strategy","volume":"111","author":"Mart\u00ednez-S\u00e1ez","year":"2017","journal-title":"Crit. Rev. Oncol. \/Hematol."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1152\/jappl.2001.91.1.379","article-title":"Expression of heme oxygenase in the oxygen-sensing regions of the rostral ventrolateral medulla","volume":"91","author":"Mazza","year":"2001","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib41","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1152\/japplphysiol.00523.2002","article-title":"Invited oroplasticity in respiratory motor control","volume":"94","author":"Mitchell","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2026.104634_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173210","article-title":"Luteolin impairs hypoxia adaptation and progression in human breast and colon cancer cells","volume":"881","author":"Monti","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.resp.2026.104634_bib43","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1113\/JP279331","article-title":"Neuronal HIF-1\u03b1 in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia","volume":"598","author":"Moya","year":"2020","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/japplphysiol.00226.2002","article-title":"Sleep apnea and effect of chemostimulation on breathing instability in mice","volume":"94","author":"Nakamura","year":"2003","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.resp.2026.104634_bib45","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1073\/pnas.0811018106","article-title":"Intermittent hypoxia degrades HIF-2\u03b1 via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities","volume":"106","author":"Nanduri","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.resp.2026.104634_bib46","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1152\/japplphysiol.01128.2001","article-title":"CO 2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness","volume":"92","author":"Nattie","year":"2002","journal-title":"J. Appl. Physiol."},{"issue":"31","key":"10.1016\/j.resp.2026.104634_bib47","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1021\/bi500331y","article-title":"Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor","volume":"53","author":"Nisimoto","year":"2014","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/j.resp.2026.104634_bib48","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1113\/JP279643","article-title":"Ventilatory acclimatization to hypoxia: time to express a critical central message","volume":"598","author":"O\u2019Halloran","year":"2020","journal-title":"J. Physiol."},{"issue":"8","key":"10.1016\/j.resp.2026.104634_bib49","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12092","article-title":"The effect of combined glutamate receptor blockade in the NTS on the hypoxic ventilatory response in awake rats differs from the effect of individual glutamate receptor blockade","volume":"2","author":"Pamenter","year":"2014","journal-title":"Physiol. Rep."},{"issue":"12","key":"10.1016\/j.resp.2026.104634_bib50","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1046\/j.0953-816x.2001.01816.x","article-title":"Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) under in vivo hypoxia in rat brainstem","volume":"14","author":"Pascual","year":"2001","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib51","doi-asserted-by":"crossref","first-page":"L341","DOI":"10.1152\/ajplung.00042.2024","article-title":"Long-term effects on cardiorespiratory and behavioral responses in male and female rats prenatally exposed to cannabinoid","volume":"327","author":"Patrone","year":"2024","journal-title":"Am. J. Physiol. -Lung Cell. Mol. Physiol."},{"issue":"15","key":"10.1016\/j.resp.2026.104634_bib52","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1523\/JNEUROSCI.4768-08.2009","article-title":"NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia","volume":"29","author":"Peng","year":"2009","journal-title":"J. Neurosci."},{"issue":"17","key":"10.1016\/j.resp.2026.104634_bib53","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1073\/pnas.1734109100","article-title":"Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas","volume":"100","author":"Peng","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib54","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3892\/ol.2013.1371","article-title":"Oxygen metabolism in oral cancer: HIF and GLUTs (Review)","volume":"6","author":"Pereira","year":"2013","journal-title":"Oncol. Lett."},{"issue":"1\u20132","key":"10.1016\/j.resp.2026.104634_bib55","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.resp.2008.07.017","article-title":"HIF-1 and ventilatory acclimatization to chronic hypoxia","volume":"164","author":"Powell","year":"2008","journal-title":"Respir. Physiol. & Neurobiol."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0034-5687(98)00026-7","article-title":"Time domains of the hypoxic ventilatory response","volume":"112","author":"Powell","year":"1998","journal-title":"Respir. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.resp.2026.104634_bib57","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.resp.2010.08.021","article-title":"Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia","volume":"174","author":"Prabhakar","year":"2010","journal-title":"Respir. Physiol. & Neurobiol."},{"issue":"10","key":"10.1016\/j.resp.2026.104634_bib58","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1172\/JCI137560","article-title":"Hypoxia-inducible factors and obstructive sleep apnea","volume":"130","author":"Prabhakar","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.resp.2026.104634_bib59","doi-asserted-by":"crossref","unstructured":"Prabhakar, N.R., Peng, Y.-J., & Nanduri, J. (2022). Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia (pp. 103\u2013123). https:\/\/doi.org\/10.1016\/B978-0-323-91534-2.00009-6.","DOI":"10.1016\/B978-0-323-91534-2.00009-6"},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib60","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/physrev.00030.2011","article-title":"Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible Factors 1 and 2","volume":"92","author":"Prabhakar","year":"2012","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib61","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41589-024-01716-z","article-title":"Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors","volume":"21","author":"Qiao","year":"2025","journal-title":"Nat. Chem. Biol."},{"issue":"11","key":"10.1016\/j.resp.2026.104634_bib62","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1097\/00001756-200208070-00007","article-title":"Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem","volume":"13","author":"Ramanathan","year":"2002","journal-title":"Neuroreport"},{"issue":"8","key":"10.1016\/j.resp.2026.104634_bib63","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14060","article-title":"Young and middle-aged mouse breathing behavior during the light and dark cycles","volume":"7","author":"Receno","year":"2019","journal-title":"Physiol. Rep."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11905","article-title":"Genetically and functionally defined NTS to PBN brain circuits mediating anorexia","volume":"7","author":"Roman","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib65","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/cancers13010130","article-title":"Flavonoids Targeting HIF-1: Implications on Cancer Metabolism","volume":"13","author":"Samec","year":"2021","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.resp.2026.104634_bib66","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.3390\/molecules13102628","article-title":"Anti-carcinogenic Effects of the Flavonoid Luteolin","volume":"13","author":"Seelinger","year":"2008","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib67","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.cellbio.15.1.551","article-title":"Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1","volume":"15","author":"Semenza","year":"1999","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib68","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr. Opin. Cell. Biol."},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib69","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-Inducible Factors in Physiology and Medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.resp.2026.104634_bib70","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1152\/japplphysiol.00162.2015","article-title":"Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea","volume":"119","author":"Semenza","year":"2015","journal-title":"J. Appl. Physiol."},{"issue":"15","key":"10.1016\/j.resp.2026.104634_bib71","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1113\/JP275696","article-title":"The role of hypoxia-inducible factors in carotid body (patho) physiology","volume":"596","author":"Semenza","year":"2018","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib72","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3390\/biom15030352","article-title":"Cetuximab and Paclitaxel Drug Response in Head and Neck Tumor Stem Cells","volume":"15","author":"Serafim J\u00fanior","year":"2025","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib73","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13041-021-00751-4","article-title":"Long-range GABAergic projections from the nucleus of the solitary tract","volume":"14","author":"Shi","year":"2021","journal-title":"Mol. Brain"},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.38","article-title":"Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1","volume":"8","author":"Song","year":"2017","journal-title":"Cell. Death Dis."},{"issue":"2","key":"10.1016\/j.resp.2026.104634_bib75","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1210\/endrev\/bnac025","article-title":"Hypoxia-Inducible Factor 2 Alpha (HIF2\u03b1) Inhibitors: Targeting Genetically Driven Tumor Hypoxia","volume":"44","author":"Toledo","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.resp.2026.104634_bib76","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1093\/nar\/gks596","article-title":"Primer3\u2014new capabilities and interfaces","volume":"40","author":"Untergasser","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"14","key":"10.1016\/j.resp.2026.104634_bib77","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1202081109","article-title":"Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-\u03b2 signaling","volume":"109","author":"Wei","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.resp.2026.104634_bib78","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1074\/jbc.M407706200","article-title":"Ca2+\/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia","volume":"280","author":"Yuan","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.resp.2026.104634_bib79","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/jcp.21537","article-title":"Induction of HIF-1\u03b1 expression by intermittent hypoxia: involvement of NADPH oxidase, Ca 2+ signaling, prolyl hydroxylases, and mTOR","volume":"217","author":"Yuan","year":"2008","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.resp.2026.104634_bib80","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1113\/expphysiol.2006.035501","article-title":"Increased sympathetic activity in rats submitted to chronic intermittent hypoxia","volume":"92","author":"Zoccal","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2026.104634_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00238","article-title":"The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities","volume":"5","author":"Zoccal","year":"2014","journal-title":"Front. Physiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904826000935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904826000935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:52:21Z","timestamp":1788551541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904826000935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":81,"alternative-id":["S1569904826000935"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2026.104634","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Luteolin increases baseline apneas and downregulates brainstem HIF in normoxia and chronic intermittent hypoxia","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2026.104634","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104634"}}