{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:38:35Z","timestamp":1790876315948,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Resuscitation Plus"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.resplu.2025.101044","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T16:02:55Z","timestamp":1753459375000},"page":"101044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Cerebral oxygen saturation in relation to end-tidal CO2 in cardiopulmonary resuscitation \u2013 Separate views of brain and body?"],"prefix":"10.1016","volume":"25","author":[{"given":"Andrea","family":"Kornfehl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Veigl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Firich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Gatterbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Girsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grassmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zajicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Spiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Testori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Holzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Krammel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Uray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-8200","authenticated-orcid":false,"given":"Sebastian","family":"Schnaubelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resplu.2025.101044_b0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.resuscitation.2021.02.007","article-title":"European Resuscitation Council guidelines 2021: epidemiology of cardiac arrest in Europe","volume":"161","author":"Gr\u00e4sner","year":"2021","journal-title":"Resuscitation"},{"issue":"6","key":"10.1016\/j.resplu.2025.101044_b0010","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jemermed.2017.08.026","article-title":"Capnography in the emergency department: a review of uses, waveforms, and limitations","volume":"53","author":"Long","year":"2017","journal-title":"J Emerg Med"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13049-021-00857-7","article-title":"Monitoring tissue oxygenation index using near-infrared spectroscopy during pre-hospital resuscitation among out-of-hospital cardiac arrest patients: a pilot study","volume":"29","author":"Tsukuda","year":"2021","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.1016\/j.resplu.2025.101044_b0020","doi-asserted-by":"crossref","first-page":"A80","DOI":"10.1016\/j.resuscitation.2020.09.012","article-title":"Adult advanced life support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations","volume":"156","author":"Soar","year":"2020","journal-title":"Resuscitation"},{"key":"10.1016\/j.resplu.2025.101044_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resuscitation.2017.12.003","article-title":"The use of end-tidal carbon dioxide (ETCO2) measurement to guide management of cardiac arrest: a systematic review","volume":"123","author":"Paiva","year":"2018","journal-title":"Resuscitation"},{"key":"10.1016\/j.resplu.2025.101044_b0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.resuscitation.2017.11.040","article-title":"Predicting ROSC in out-of-hospital cardiac arrest using expiratory carbon dioxide concentration: is trend-detection instead of absolute threshold values the key?","volume":"122","author":"Brinkrolf","year":"2018","journal-title":"Resuscitation"},{"key":"10.1016\/j.resplu.2025.101044_b0035","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.resuscitation.2019.04.006","article-title":"End tidal CO2 and cerebral oximetry for the prediction of return of spontaneous circulation during cardiopulmonary resuscitation","volume":"139","author":"Engel","year":"2019","journal-title":"Resuscitation"},{"key":"10.1016\/j.resplu.2025.101044_b0040","article-title":"Near-infrared spectroscopy assessments of regional cerebral oxygen saturation for the prediction of clinical outcomes in patients with cardiac arrest: a review of clinical impact, evolution, and future directions","volume":"7","author":"Takegawa","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.resplu.2025.101044_b0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.resuscitation.2018.01.028","article-title":"Regional cerebral oxygen saturation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation and favourable neurological outcome - a review of the current literature","volume":"125","author":"Schnaubelt","year":"2018","journal-title":"Resuscitation"},{"issue":"8","key":"10.1016\/j.resplu.2025.101044_b0050","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/acem.12980","article-title":"Near-infrared spectroscopy monitoring during cardiac arrest: a systematic review and meta-analysis","volume":"23","author":"Cournoyer","year":"2016","journal-title":"Acad Emerg Med"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/nyas.14706","article-title":"Cerebral oximetry: a developing tool for monitoring cerebral oxygenation during cardiopulmonary resuscitation","volume":"1509","author":"Huppert","year":"2022","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.resplu.2025.101044_b0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.resuscitation.2018.03.031","article-title":"Cerebral saturation in cardiac arrest patients measured with near-infrared technology during pre-hospital advanced life support. Results from Copernicus I cohort study","volume":"129","author":"Genbrugge","year":"2018","journal-title":"Resuscitation"},{"key":"10.1016\/j.resplu.2025.101044_b0065","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.resuscitation.2019.07.038","article-title":"The need for comprehensive NIRS-measurement from on-scene treatment to post-ROSC phase","volume":"144","author":"Schnaubelt","year":"2019","journal-title":"Resuscitation"},{"key":"10.1016\/j.resplu.2025.101044_b0070","unstructured":"SenSmart X-100. Nonin n.d. https:\/\/www.nonin.com\/support\/x100\/. Accessed 1 March 2022."},{"key":"10.1016\/j.resplu.2025.101044_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.resplu.2023.100494","article-title":"Prehospital emergency medicine research by additional teams on scene - concepts and lessons learned","volume":"16","author":"Mueller","year":"2023","journal-title":"Resusc Plus"},{"key":"10.1016\/j.resplu.2025.101044_b0080","unstructured":"https:\/\/www.stryker.com\/de\/de\/emergency-care\/products\/lifepak-15\/index-eu-eemea.html. Accessed 20 March 2025."},{"key":"10.1016\/j.resplu.2025.101044_b0085","unstructured":"https:\/\/www.schiller.ch\/de-at\/produkte\/argus-pro-lifecare-2-p202. Accessed 20 March 2025."},{"key":"10.1016\/j.resplu.2025.101044_b0090","unstructured":"https:\/\/www.zoll.com\/de-DE\/Products\/Emergency-Care\/Monitors-and-Defibrillators\/X-Series. Accessed 20 March 2025."},{"key":"10.1016\/j.resplu.2025.101044_b0095","unstructured":"https:\/\/corpuls.world\/produkte\/corpuls3\/. Acessed 20 March 2025."},{"issue":"7\u20138","key":"10.1016\/j.resplu.2025.101044_b0100","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12471-021-01602-6","article-title":"Towards individualised treatment of out-of-hospital cardiac arrest patients: an update on technical innovations in the prehospital chain of survival","volume":"30","author":"Thannhauser","year":"2022","journal-title":"Neth Heart J"},{"key":"10.1016\/j.resplu.2025.101044_b0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.resuscitation.2021.02.012","article-title":"European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care","volume":"161","author":"Nolan","year":"2021","journal-title":"Resuscitation"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12028-023-01871-6","article-title":"Critical care management of patients after cardiac arrest: a scientific statement from the American Heart Association and Neurocritical Care Society","volume":"40","author":"Hirsch","year":"2024","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.resplu.2025.101044_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.resplu.2021.100109","article-title":"PLS ILCOR Task Force. Focused echocardiography, end-tidal carbon dioxide, arterial blood pressure or near-infrared spectroscopy monitoring during paediatric cardiopulmonary resuscitation: a scoping review","volume":"6","author":"Kool","year":"2021","journal-title":"Resusc Plus"},{"key":"10.1016\/j.resplu.2025.101044_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.resplu.2021.100093","article-title":"Pre-hospital portable monitoring of cerebral regional oxygen saturation (rSO2) by ambulance personnel during cardiopulmonary resuscitation: a prospective observational analysis of 87 cases in Osaka city, Japan","volume":"6","author":"Sakai","year":"2021","journal-title":"Resusc Plus"},{"key":"10.1016\/j.resplu.2025.101044_b0125","doi-asserted-by":"crossref","unstructured":"Putowski M, Dudzikowska M, Siudak Z. Assessment of regional cerebral oxygen saturation and end-tidal carbon dioxide in prediction of a return of spontaneous circulation and patient outcome after in-hospital cardiac arrest. 2025 Jan 2 [cited 2025 Apr 5]. Available from: https:\/\/www.mp.pl\/paim\/issue\/article\/16914.","DOI":"10.20452\/pamw.16914"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12028-009-9313-x","article-title":"Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension","volume":"12","author":"Nissen","year":"2010","journal-title":"Neurocrit Care"},{"issue":"2","key":"10.1016\/j.resplu.2025.101044_b0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/bja\/aer150","article-title":"Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients","volume":"107","author":"Meng","year":"2011","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10877-017-0007-1","article-title":"Low near infrared spectroscopic somatic oxygen saturation at admission is associated with need for lifesaving interventions among unplanned admissions to the pediatric intensive care unit","volume":"32","author":"Balakrishnan","year":"2018","journal-title":"J Clin Monit Comput"},{"issue":"24","key":"10.1016\/j.resplu.2025.101044_b0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13049-016-0234-3","article-title":"Good neurological outcome despite very low regional cerebral oxygen saturation during resuscitation\u2013a prospective preclinical trial in 29 patients","volume":"6","author":"Storm","year":"2016","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"5","key":"10.1016\/j.resplu.2025.101044_b0150","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1016\/j.resuscitation.2011.12.027","article-title":"A potential novel rule for therapeutic decision-making in the cardiocerebral resuscitation of patients with cardiac arrest on arrival","volume":"83","author":"Ito","year":"2012","journal-title":"Resuscitation."},{"issue":"4","key":"10.1016\/j.resplu.2025.101044_b0155","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.resuscitation.2013.12.007","article-title":"A feasibility study of cerebral oximetry monitoring during the post-resuscitation period in comatose patients following cardiac arrest","volume":"85","author":"Ahn","year":"2014","journal-title":"Resuscitation"},{"issue":"4","key":"10.1016\/j.resplu.2025.101044_b0160","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.1987.03390040128031","article-title":"End-tidal carbon dioxide monitoring during cardiopulmonary resuscitation","volume":"257","author":"Garnett","year":"1987","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.resplu.2025.101044_b0165","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9991944","article-title":"Association between paramedic workforce and survival rate in prehospital advanced life support in out-of-hospital cardiac arrest patients","volume":"2022","author":"Han","year":"2022","journal-title":"Emerg Med Int"},{"key":"10.1016\/j.resplu.2025.101044_b0170","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.resuscitation.2014.11.013","article-title":"A systematic review of the outcomes reported in cardiac arrest clinical trials: the need for a core outcome set","volume":"88","author":"Whitehead","year":"2015","journal-title":"Resuscitation"},{"issue":"22","key":"10.1016\/j.resplu.2025.101044_b0175","doi-asserted-by":"crossref","first-page":"e783","DOI":"10.1161\/CIR.0000000000000562","article-title":"COSCA (Core Outcome Set for Cardiac Arrest) in adults: an advisory statement from the International Liaison Committee on Resuscitation","volume":"137","author":"Haywood","year":"2018","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0180","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cnc.2023.08.001","article-title":"Understanding near-infrared spectroscopy: an update","volume":"36","author":"Marin","year":"2024","journal-title":"Crit Care Nurs Clin North Am"},{"issue":"4","key":"10.1016\/j.resplu.2025.101044_b0185","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10877-017-0061-8","article-title":"A \u2018NIRS\u2019 death experience: a reduction in cortical oxygenation by time-resolved near-infrared spectroscopy preceding cardiac arrest","volume":"32","author":"Lanks","year":"2018","journal-title":"J Clin Monit Comput"},{"issue":"2","key":"10.1016\/j.resplu.2025.101044_b0190","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/cc12546","article-title":"Feasibility of absolute cerebral tissue oxygen saturation during cardiopulmonary resuscitation","volume":"17","author":"Meex","year":"2013","journal-title":"Crit Care"},{"issue":"22","key":"10.1016\/j.resplu.2025.101044_b0195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13049-014-0058-y","article-title":"Monitoring of cerebral oxygen saturation during resuscitation in out-of-hospital cardiac arrest: a feasibility study in a physician staffed emergency medical system","volume":"5","author":"Schewe","year":"2014","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ajem.2013.09.010","article-title":"Near infrared spectrophotometry (cerebral oximetry) in predicting the return of spontaneous circulation in out-of-hospital cardiac arrest","volume":"32","author":"Asim","year":"2014","journal-title":"Am J Emerg Med"},{"issue":"3","key":"10.1016\/j.resplu.2025.101044_b0205","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.amj.2019.03.005","article-title":"Near-infrared spectroscopy in transport with a patient in multi-factorial shock","volume":"38","author":"Parker","year":"2019","journal-title":"Air Med J"},{"issue":"1","key":"10.1016\/j.resplu.2025.101044_b0210","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1038\/s41598-023-31637-1","article-title":"Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model","volume":"13","author":"Raschdorf","year":"2023","journal-title":"Sci Rep"}],"container-title":["Resuscitation Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266652042500181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266652042500181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:26:35Z","timestamp":1772918795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266652042500181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":42,"alternative-id":["S266652042500181X"],"URL":"https:\/\/doi.org\/10.1016\/j.resplu.2025.101044","relation":{},"ISSN":["2666-5204"],"issn-type":[{"value":"2666-5204","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebral oxygen saturation in relation to end-tidal CO2 in cardiopulmonary resuscitation \u2013 Separate views of brain and body?","name":"articletitle","label":"Article Title"},{"value":"Resuscitation Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resplu.2025.101044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101044"}}