{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:30:30Z","timestamp":1774467030400,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["resuscitationjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Resuscitation"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.resuscitation.2013.12.033","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T20:33:54Z","timestamp":1390509234000},"page":"628-636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hypertonic saline infusion during resuscitation from out-of-hospital cardiac arrest: A matched-pair study from the German Resuscitation Registry"],"prefix":"10.1016","volume":"85","author":[{"given":"Christopher","family":"Hahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Breil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Christian","family":"Schewe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Messelken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Thorsten","family":"Gr\u00e4sner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Wnent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Seewald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Bohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resuscitation.2013.12.033_bib0005","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.resuscitation.2010.08.006","article-title":"Global incidences of out-of-hospital cardiac arrest and survival rates: systematic review of 67 prospective studies","volume":"81","author":"Berdowski","year":"2010","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0010","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1001\/jama.300.12.1423","article-title":"Regional variation in out-of-hospital cardiac arrest incidence and outcome","volume":"300","author":"Nichol","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0300-9572(99)00045-3","article-title":"Resuscitation in Europe: a tale of five European regions","volume":"41","author":"Herlitz","year":"1999","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0300-9572(96)01022-2","article-title":"One-year survival after out-of-hospital cardiac arrest in Bonn city: outcome report according to the \u2018Utstein style\u2019","volume":"33","author":"Fischer","year":"1997","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.resuscitation.2012.03.027","article-title":"Chest compression quality management and return of spontaneous circulation: a matched-pair registry study","author":"Lukas","year":"2012","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/jama.293.3.299","article-title":"Quality of cardiopulmonary resuscitation during out-of-hospital cardiac arrest","volume":"293","author":"Wik","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0035","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1001\/jama.2009.1729","article-title":"Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial","volume":"302","author":"Olasveengen","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0040","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.resuscitation.2011.06.029","article-title":"Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomised double-blind placebo-controlled trial","volume":"82","author":"Jacobs","year":"2011","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0045","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1056\/NEJMoa013029","article-title":"Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation","volume":"346","author":"Dorian","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0050","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1056\/NEJM199909163411203","article-title":"Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation","volume":"341","author":"Kudenchuk","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0060","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0065","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/cc10035","article-title":"Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis","volume":"15","author":"Grasner","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0070","doi-asserted-by":"crossref","first-page":"R164","DOI":"10.1186\/cc11516","article-title":"Choice of hospital after out-of-hospital cardiac arrest \u2013 a decision with far-reaching consequences: a study in a large German city","volume":"16","author":"Wnent","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0075","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.resuscitation.2011.05.003","article-title":"Strong and weak aspects of an established post-resuscitation treatment protocol \u2013 a five-year observational study","volume":"82","author":"Tomte","year":"2011","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0080","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00003246-199303000-00020","article-title":"Effects of graded doses of epinephrine on both noninvasive and invasive measures of myocardial perfusion and blood flow during cardiopulmonary resuscitation","volume":"21","author":"Chase","year":"1993","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0085","doi-asserted-by":"crossref","first-page":"H1512","DOI":"10.1152\/ajpheart.2000.279.4.H1512","article-title":"Mechanisms of endothelial cell swelling from lactacidosis studied in vitro","volume":"279","author":"Behmanesh","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0090","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1097\/00005373-199705001-00007","article-title":"Endothelial cell swelling and brain perfusion","volume":"42","author":"Kempski","year":"1997","journal-title":"J Trauma"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0095","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-5223(97)70122-3","article-title":"Continuous antegrade warm blood cardioplegia attenuates augmented coronary endothelium-dependent contraction after cardiac global ischemia and reperfusion","volume":"114","author":"Lin","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0100","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/BF00318570","article-title":"Early endothelial damage and leukocyte accumulation in piglet brains following cardiac arrest","volume":"90","author":"Caceres","year":"1995","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0105","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0735-6757(94)90269-0","article-title":"Hemoconcentration during cardiac arrest and CPR","volume":"12","author":"Jehle","year":"1994","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0110","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0300-9572(96)00953-7","article-title":"Volume expansion during cardiopulmonary resuscitation reduces cerebral no-reflow","volume":"32","author":"Fischer","year":"1996","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0115","first-page":"H1411","article-title":"Attenuation of postischemic microvascular disturbances in striated muscle by hyperosmolar saline dextran","volume":"263","author":"Nolte","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0120","first-page":"407","article-title":"Capillary narrowing in hemorrhagic shock is rectified by hyperosmotic saline-dextran reinfusion","volume":"31","author":"Mazzoni","year":"1990","journal-title":"Circ Shock"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0300-9572(93)90145-G","article-title":"Early volume expansion during cardiopulmonary resuscitation","volume":"26","author":"Jameson","year":"1993","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0300-9572(02)00151-X","article-title":"Effects of hypertonic saline on myocardial blood flow in a porcine model of prolonged cardiac arrest","volume":"54","author":"Fischer","year":"2002","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0135","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0300-9572(02)00377-5","article-title":"Hypertonic saline improves myocardial blood flow during CPR, but is not enhanced further by the addition of hydroxy ethyl starch","volume":"56","author":"Breil","year":"2003","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.resuscitation.2004.03.023","article-title":"Effects of hypertonic versus isotonic infusion therapy on regional cerebral blood flow after experimental cardiac arrest cardiopulmonary resuscitation in pigs","volume":"63","author":"Krep","year":"2004","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0145","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1213\/00000539-200210000-00044","article-title":"Hypertonic\u2013hyperoncotic solutions reduce the release of cardiac troponin I and s-100 after successful cardiopulmonary resuscitation in pigs","volume":"95","author":"Krieter","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0150","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1097\/01.CCM.0000228915.94169.B1","article-title":"An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia","volume":"34","author":"Noppens","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.resuscitation.2006.05.019","article-title":"Hypertonic saline during CPR: feasibility and safety of a new protocol of fluid management during resuscitation","volume":"72","author":"Bender","year":"2007","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0160","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.resuscitation.2011.09.005","article-title":"Randomised study of hypertonic saline infusion during resuscitation from out-of-hospital cardiac arrest","volume":"83","author":"Breil","year":"2012","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0165","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.resuscitation.2008.10.008","article-title":"A national resuscitation registry of out-of-hospital cardiac arrest in Germany \u2013 a pilot study","volume":"80","author":"Grasner","year":"2009","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0170","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1093\/eurheartj\/ehr107","article-title":"ROSC after cardiac arrest \u2013 the RACA score to predict outcome after out-of-hospital cardiac arrest","volume":"32","author":"Grasner","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0175","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.resuscitation.2004.09.008","volume":"63","author":"Jacobs","year":"2004","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0180","doi-asserted-by":"crossref","first-page":"R282","DOI":"10.1186\/cc10566","article-title":"The impact of response time reliability on CPR incidence and resuscitation success: a benchmark study from the German Resuscitation Registry","volume":"15","author":"Neukamm","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0185","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1161\/01.CIR.0000095787.99180.B5","article-title":"Comparison of standard cardiopulmonary resuscitation versus the combination of active compression\u2013decompression cardiopulmonary resuscitation and an inspiratory impedance threshold device for out-of-hospital cardiac arrest","volume":"108","author":"Wolcke","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0190","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0140-6736(10)62103-4","article-title":"Standard cardiopulmonary resuscitation versus active compression\u2013decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trial","volume":"377","author":"Aufderheide","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0195","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.resuscitation.2011.03.024","article-title":"Cardiac arrest survival did not increase in the Resuscitation Outcomes Consortium after implementation of the 2005 AHA CPR and ECC guidelines","volume":"82","author":"Bigham","year":"2011","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0200","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1056\/NEJMoa1010821","article-title":"A trial of an impedance threshold device in out-of-hospital cardiac arrest","volume":"365","author":"Aufderheide","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0205","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1001\/jama.2013.278483","article-title":"Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest","volume":"310","author":"Wissenberg","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0210","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0300-9572(03)00151-5","article-title":"Time course of circulatory and metabolic recovery of cat brain after cardiac arrest assessed by perfusion- and diffusion-weighted imaging and MR-spectroscopy","volume":"58","author":"Krep","year":"2003","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0215","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/BF01726536","article-title":"No-reflow after cardiac arrest","volume":"21","author":"Fischer","year":"1995","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0220","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.resuscitation.2006.05.003","article-title":"Haemodynamic effects of adrenaline (epinephrine) depend on chest compression quality during cardiopulmonary resuscitation in pigs","volume":"71","author":"Pytte","year":"2006","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0225","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCULATIONAHA.109.906859","article-title":"Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest: a randomized controlled trial","volume":"122","author":"Bernard","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0230","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1399-6576.2009.02015.x","article-title":"Prehospital therapeutic hypothermia for comatose survivors of cardiac arrest: a randomized controlled trial","volume":"53","author":"Kamarainen","year":"2009","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0235","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.resuscitation.2011.04.005","article-title":"Cardiac arrest outcomes before and after the 2005 resuscitation guidelines implementation: evidence of improvement?","volume":"82","author":"Deasy","year":"2011","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0240","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1056\/NEJMoa0706873","article-title":"Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation","volume":"359","author":"Gueugniaud","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2013.12.033_bib0245","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1056\/NEJMoa025431","article-title":"A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation","volume":"350","author":"Wenzel","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Resuscitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030095721400015X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030095721400015X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T10:18:39Z","timestamp":1648117119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030095721400015X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S030095721400015X"],"URL":"https:\/\/doi.org\/10.1016\/j.resuscitation.2013.12.033","relation":{},"ISSN":["0300-9572"],"issn-type":[{"value":"0300-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypertonic saline infusion during resuscitation from out-of-hospital cardiac arrest: A matched-pair study from the German Resuscitation Registry","name":"articletitle","label":"Article Title"},{"value":"Resuscitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resuscitation.2013.12.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}