{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T21:54:32Z","timestamp":1769378072900,"version":"3.49.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","resuscitationjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Resuscitation"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.resuscitation.2015.03.026","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T02:16:00Z","timestamp":1430100960000},"page":"88-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Animal studies of neonatal hypothermic neuroprotection have translated well in to practice"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-7035","authenticated-orcid":false,"given":"Alistair J.","family":"Gunn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Thoresen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resuscitation.2015.03.026_bib0135","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"1","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0140","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0145","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/pr.2011.30","article-title":"Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy","volume":"71","author":"Guillet","year":"2012","journal-title":"Pediatr Res"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0155","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1001\/jama.2014.16058","article-title":"Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial","volume":"312","author":"Shankaran","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0160","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: a safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0165","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/STROKEAHA.114.007330","article-title":"Brain cell death is reduced with cooling by 3.5 degrees C to 5 degrees C but increased with cooling by 8.5 degrees C in a piglet asphyxia model","volume":"46","author":"Alonso-Alconada","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0170","doi-asserted-by":"crossref","DOI":"10.1038\/jcbfm.2014.259","article-title":"How long is too long for cerebral cooling after ischemia in fetal sheep?","author":"Davidson","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0175","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1203\/00006450-199605000-00008","article-title":"Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep","volume":"39","author":"Tan","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs","volume":"99","author":"Gunn","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0185","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1203\/00006450-198905000-00004","article-title":"Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy","volume":"25","author":"Azzopardi","year":"1989","journal-title":"Pediatr Res"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0190","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","article-title":"Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet","volume":"37","author":"Thoresen","year":"1995","journal-title":"Pediatr Res"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0195","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/pr.2012.8","article-title":"Systemic effects of whole-body cooling to 35 degrees C, 33.5 degrees C, and 30 degrees C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia","volume":"71","author":"Kerenyi","year":"2012","journal-title":"Pediatr Res"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0200","first-page":"4658","article-title":"Cooler isn\u2019t better \u2013 hypothermia at three different temperatures does not provide neuroprotection in a rat model of severe neonatal hypoxic-ischaemic encephalopathy","volume":"4650","author":"Wood","year":"2014","journal-title":"E-PAS2014"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0205","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nurx.2006.01.007","article-title":"Hypothermic neuroprotection","volume":"3","author":"Gunn","year":"2006","journal-title":"NeuroRx"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0210","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1161\/STROKEAHA.112.674481","article-title":"Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats","volume":"43","author":"Sabir","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0215","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(94)90488-X","article-title":"Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil","volume":"654","author":"Colbourne","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0220","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1542\/peds.102.5.1098","article-title":"Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0225","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jama.2013.282173","article-title":"Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial","volume":"311","author":"Kim","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0230","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1056\/NEJMoa1101549","article-title":"Mortality after fluid bolus in African children with severe infection","volume":"364","author":"Maitland","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0235","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0240","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","author":"The Hypothermia after Cardiac Arrest Study Group","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0245","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0250","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.resuscitation.2014.12.033","article-title":"Target temperature management of 33\u030aC and 36\u030aC in patients with out-of-hospital cardiac arrest with initial non-shockable rhythm \u2013 a TTM sub-study","volume":"89","author":"Frydland","year":"2015","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0255","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF02740655","article-title":"Postischemic hypothermia. A critical appraisal with implications for clinical treatment","volume":"14","author":"Colbourne","year":"1997","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.resuscitation.2015.03.026_bib0260","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000353948","article-title":"Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns","volume":"104","author":"Thoresen","year":"2013","journal-title":"Neonatology"}],"container-title":["Resuscitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957215001628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957215001628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T23:54:41Z","timestamp":1537660481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300957215001628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":26,"alternative-id":["S0300957215001628"],"URL":"https:\/\/doi.org\/10.1016\/j.resuscitation.2015.03.026","relation":{},"ISSN":["0300-9572"],"issn-type":[{"value":"0300-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Animal studies of neonatal hypothermic neuroprotection have translated well in to practice","name":"articletitle","label":"Article Title"},{"value":"Resuscitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resuscitation.2015.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}